Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

profileNathan Ivan Shapiro, M.D.

TitleAssociate Professor of Emergency Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentEmergency Medicine
AddressBeth Israel Deaconess Med Ctr
Emergency Med - CCW-2nd Floor
330 Brookline Ave
Boston MA 02215
Phone617/667-5398
Fax617/264-6848
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse completed student projects
Non-Invasive Doppler Ultrasound Hemodynamic Cardiac Output Monitoring: Predicting Fluid Responsiveness in Patients in the Emergency Department
Summer, 06/19/06 - 08/11/06

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
U01HL123022     (TALMOR, DANIEL STUART)Jun 17, 2014 - Apr 30, 2021
NIH/NHLBI
Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute Lung
Role: Principal Investigator

R01HL091757     (SHAPIRO, NATHAN I)Jun 15, 2008 - May 31, 2014
NIH/NHLBI
Endothelial Cell Signaling and Microcirculatory Flow in Severe Sepsis
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Donnelly JP, Safford MM, Shapiro NI, Baddley JW, Wang HE. Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: a retrospective population-based cohort study. Lancet Infect Dis. 2017 Mar 03. PMID: 28268067.
    View in: PubMed
  2. Henning DJ, Puskarich MA, Self WH, Howell MD, Donnino MW, Yealy DM, Jones AE, Shapiro NI. An Emergency Department Validation of the SEP-3 Sepsis and Septic Shock Definitions and Comparison With 1992 Consensus Definitions. Ann Emerg Med. 2017 Mar 02. PMID: 28262318.
    View in: PubMed
  3. Schuetz P, Birkhahn R, Sherwin R, Jones AE, Singer A, Kline JA, Runyon MS, Self WH, Courtney DM, Nowak RM, Gaieski DF, Ebmeyer S, Johannes S, Wiemer JC, Schwabe A, Shapiro NI. Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study. Crit Care Med. 2017 Mar 02. PMID: 28257335.
    View in: PubMed
  4. Kellum JA, Pike F, Yealy DM, Huang DT, Shapiro NI, Angus DC. Relationship Between Alternative Resuscitation Strategies, Host Response and Injury Biomarkers, and Outcome in Septic Shock: Analysis of the Protocol-Based Care for Early Septic Shock Study. Crit Care Med. 2017 Mar; 45(3):438-445. PMID: 28079606.
    View in: PubMed
  5. Donnelly JP, Nair S, Griffin R, Baddley JW, Safford MM, Wang HE, Shapiro NI. Association of Diabetes and Insulin Therapy With Risk of Hospitalization for Infection and 28-Day Mortality Risk. Clin Infect Dis. 2017 Feb 15; 64(4):435-442. PMID: 28174913.
    View in: PubMed
  6. Cohen J, MacArthur KL, Atsawarungruangkit A, Perillo MC, Martin CR, Berzin TM, Shapiro NI, Sawhney MS, Freedman SD, Sheth SG. Defining the diagnostic value of hyperlipasemia for acute pancreatitis in the critically ill. Pancreatology. 2017 Feb 08. PMID: 28237616.
    View in: PubMed
  7. Hou P, Filbin M, Wang H, Ngo L, Huang DT, Aird WC, Yealy DM, Angus DC, Kellum JA, Shapiro NI. Endothelial Permeability and Hemostasis in Septic Shock: Results from the ProCESS Trial. Chest. 2017 Jan 18. PMID: 28109962.
    View in: PubMed
  8. Oedorf K, Day DE, Lior Y, Novack V, Sanchez LD, Wolfe RE, Kirkegaard H, Shapiro NI, Henning DJ. Serum Lactate Predicts Adverse Outcomes in Emergency Department Patients With and Without Infection. West J Emerg Med. 2017 Feb; 18(2):258-266. PMID: 28210362.
    View in: PubMed
  9. Hou P, Linde-Zwirble W, Sahatjian J, Hansell D, Shapiro N. 1419: ASSOCIATION OF FLUIDS AND OUCOMES IN ED PATIENTS HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA. Crit Care Med. 2016 Dec; 44(12 Suppl 1):430. PMID: 27851055.
    View in: PubMed
  10. Handy B, Jones P, Ostlund R, Schuetz P, Schwabe A, Johannes S, Sherman J, Shapiro N. 1440: VALIDATION OF THE ELECSYS BRAHMS PROCALCITONIN ASSAY IN PATIENTS WITH SEVERE SEPSIS OR SEPTIC SHOCK. Crit Care Med. 2016 Dec; 44(12 Suppl 1):435. PMID: 27851076.
    View in: PubMed
  11. Stowell CP, Whitman G, Granger S, Gomez H, Assmann SF, Massey MJ, Shapiro NI, Steiner ME, Bennett-Guerrero E. The impact of red blood cell storage duration on tissue oxygenation in cardiac surgery. J Thorac Cardiovasc Surg. 2017 Mar; 153(3):610-619.e2. PMID: 28027790.
    View in: PubMed
  12. Wong ML, Chiu D, Shapiro NI, Grossman SA. Utility of Chest Radiography in Emergency Department Patients Presenting with Syncope. West J Emerg Med. 2016 Nov; 17(6):698-701. PMID: 27833675.
    View in: PubMed
  13. Limkakeng AT, Monte AA, Kabrhel C, Puskarich M, Heitsch L, Tsalik EL, Shapiro NI. Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine? Acad Emerg Med. 2016 Oct; 23(10):1097-1106. PMID: 27288269.
    View in: PubMed
  14. Atefi G, Aisiku O, Shapiro N, Hauser C, Dalle Lucca J, Flaumenhaft R, Tsokos GC. Complement Activation in Trauma Patients Alters Platelet Function. Shock. 2016 Sep; 46(3 Suppl 1):83-8. PMID: 27355402.
    View in: PubMed
  15. Hou PC, Filbin MR, Napoli A, Feldman J, Pang PS, Sankoff J, Lo BM, Dickey-White H, Birkhahn RH, Shapiro NI. Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Patients with Sepsis. Shock. 2016 Aug; 46(2):132-8. PMID: 26925867; PMCID: PMC4957967.
  16. Henning DJ, Carey JR, Oedorf K, Day DE, Redfield CS, Huguenel CJ, Roberts JC, Novack V, Sanchez LD, Wolfe RE, Shapiro NI. Assessing The Predictive Value of Clinical Factors Used to Determine The Presence of Sepsis Causing Shock in the Emergency Department. Shock. 2016 Jul; 46(1):27-32. PMID: 26752661.
    View in: PubMed
  17. Day DE, Shapiro NI, Henning DJ. The Utility of Inflammatory and Endothelial Markers to Identify Infection in Emergency Department Patients. Shock. 2016 Jul; 46(1):108-9. PMID: 26849626.
    View in: PubMed
  18. Wang HE, Donnelly JP, Griffin R, Levitan EB, Shapiro NI, Howard G, Safford MM. Derivation of Novel Risk Prediction Scores for Community-Acquired Sepsis and Severe Sepsis. Crit Care Med. 2016 Jul; 44(7):1285-94. PMID: 27031381; PMCID: PMC4911244 [Available on 07/01/17].
  19. Cartwright M, Rottman M, Shapiro NI, Seiler B, Lombardo P, Gamini N, Tomolonis J, Watters AL, Waterhouse A, Leslie D, Bolgen D, Graveline A, Kang JH, Didar T, Dimitrakakis N, Cartwright D, Super M, Ingber DE. A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood. EBioMedicine. 2016 Jul; 9:217-27. PMID: 27333027; PMCID: PMC4972566.
  20. Puskarich MA, Shapiro NI, Massey MJ, Kline JA, Jones AE. Lactate Clearance in Septic Shock Is Not a Surrogate for Improved Microcirculatory Flow. Acad Emerg Med. 2016 Jun; 23(6):690-3. PMID: 26825368.
    View in: PubMed
  21. Henning DJ, Shapiro NI. Goal-Directed Resuscitation in Septic Shock: A Critical Analysis. Clin Chest Med. 2016 06; 37(2):231-9. PMID: 27229640.
    View in: PubMed
  22. Pollack CV, Diercks DB, Thomas SH, Shapiro NI, Fanikos J, Mace SE, Rafique Z, Todd KH. Patient-reported Outcomes from A National, Prospective, Observational Study of Emergency Department Acute Pain Management With an Intranasal Nonsteroidal Anti-inflammatory Drug, Opioids, or Both. Acad Emerg Med. 2016 Mar; 23(3):331-41. PMID: 26782787.
    View in: PubMed
  23. Massey MJ, Shapiro NI. A guide to human in vivo microcirculatory flow image analysis. Crit Care. 2016 Feb 10; 20:35. PMID: 26861691; PMCID: PMC4748457.
  24. Jessen MK, Mackenhauer J, Hvass AM, Ellermann-Eriksen S, Skibsted S, Kirkegaard H, Schønheyder HC, Shapiro NI. Prediction of bacteremia in the emergency department: an external validation of a clinical decision rule. Eur J Emerg Med. 2016 Feb; 23(1):44-9. PMID: 25222426.
    View in: PubMed
  25. Khoory J, Estanislau J, Elkhal A, Lazaar A, Melhorn MI, Brodsky A, Illigens B, Hamachi I, Kurishita Y, Ivanov AR, Shevkoplyas S, Shapiro NI, Ghiran IC. Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function. PLoS One. 2016; 11(1):e0141206. PMID: 26784696; PMCID: PMC4718526.
  26. Sambursky R, Shapiro N. Evaluation of a combined MxA and CRP point-of-care immunoassay to identify viral and/or bacterial immune response in patients with acute febrile respiratory infection. Eur Clin Respir J. 2015; 2:28245. PMID: 26672961; PMCID: PMC4676840.
  27. Grossman AM, Volz KA, Shapiro NI, Salem R, Sanchez LD, Smulowitz P, Grossman SA. Comparison of 1-Day Emergency Department Observation and Inpatient Ward for 1-Day Admissions in Syncope Patients. J Emerg Med. 2016 Feb; 50(2):217-22. PMID: 26682847.
    View in: PubMed
  28. Henning DJ, Oedorf K, Day DE, Redfield CS, Huguenel CJ, Roberts JC, Sanchez LD, Wolfe RE, Shapiro NI. Derivation and Validation of Predictive Factors for Clinical Deterioration after Admission in Emergency Department Patients Presenting with Abnormal Vital Signs Without Shock. West J Emerg Med. 2015 Dec; 16(7):1059-66. PMID: 26759655; PMCID: PMC4703194.
  29. Gavillet M, Martinod K, Renella R, Harris C, Shapiro NI, Wagner DD, Williams DA. Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples. Am J Hematol. 2015 Dec; 90(12):1155-8. PMID: 26347989; PMCID: PMC4715743 [Available on 12/01/16].
  30. Day DE, Oedorf K, Kogan S, Novack V, Sanchez LD, Wolfe RE, Shapiro NI, Henning DJ. The Utility of Inflammatory and Endothelial Markers to Identify Infection in Emergency Department Patients. Shock. 2015 Sep; 44(3):215-20. PMID: 26009826.
    View in: PubMed
  31. Jessen MK, Skibsted S, Shapiro NI. Number of organ dysfunctions predicts mortality in emergency department patients with suspected infection: a multicenter validation study. Eur J Emerg Med. 2015 Aug 26. PMID: 26313315.
    View in: PubMed
  32. Lin M, Wolfe RE, Shapiro NI, Novack V, Lior Y, Grossman SA. Observation vs admission in syncope: can we predict short length of stays? Am J Emerg Med. 2015 Nov; 33(11):1684-6. PMID: 26342395.
    View in: PubMed
  33. Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, Zhang J, Robson SC, Shapiro NI, Junger WG. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016 Feb 01; 213(3):456-64. PMID: 26150546; PMCID: PMC4704665 [Available on 02/01/17].
  34. Kristensen AK, Holler JG, Hallas J, Lassen A, Shapiro NI. Is Shock Index a Valid Predictor of Mortality in Emergency Department Patients With Hypertension, Diabetes, High Age, or Receipt of ß- or Calcium Channel Blockers? Ann Emerg Med. 2016 Jan; 67(1):106-113.e6. PMID: 26144893.
    View in: PubMed
  35. Chasm RM, Pei YV, Pallin DJ, Shapiro N, Snyder B, Sullivan AF, Camargo CA, Hasegawa K. Sex differences in risk of hospitalization among emergency department patients with acute asthma. Ann Allergy Asthma Immunol. 2015 Jul; 115(1):70-2.e1. PMID: 25956241.
    View in: PubMed
  36. Troyer JL, Jones AE, Shapiro NI, Mitchell AM, Hewer I, Kline JA. Cost-effectiveness of quantitative pretest probability intended to reduce unnecessary medical radiation exposure in emergency department patients with chest pain and dyspnea. Acad Emerg Med. 2015 May; 22(5):525-35. PMID: 25899550.
    View in: PubMed
  37. Wang HE, Addis DR, Donnelly JP, Shapiro NI, Griffin RL, Safford MM, Baddley JW. Discharge diagnoses versus medical record review in the identification of community-acquired sepsis. Crit Care. 2015 Feb 16; 19:42. PMID: 25879803; PMCID: PMC4340494.
  38. Vellinga NA, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Machado FR, Fries M, Akarsu-Ayazoglu T, Pranskunas A, Hollenberg S, Balestra G, van Iterson M, van der Voort PH, Sadaka F, Minto G, Aypar U, Hurtado FJ, Martinelli G, Payen D, van Haren F, Holley A, Pattnaik R, Gomez H, Mehta RL, Rodriguez AH, Ruiz C, Canales HS, Duranteau J, Spronk PE, Jhanji S, Hubble S, Chierego M, Jung C, Martin D, Sorbara C, Tijssen JG, Bakker J, Ince C. International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med. 2015 Jan; 43(1):48-56. PMID: 25126880.
    View in: PubMed
  39. Shogilev DJ, Duus N, Odom SR, Shapiro NI. Diagnosing appendicitis: evidence-based review of the diagnostic approach in 2014. West J Emerg Med. 2014 Nov; 15(7):859-71. PMID: 25493136; PMCID: PMC4251237.
  40. Wang HE, Griffin R, Shapiro NI, Howard G, Safford MM. Chronic Statin Use and Long-Term Rates of Sepsis: A Population-Based Cohort Study. J Intensive Care Med. 2016 Jul; 31(6):386-96. PMID: 25223827; PMCID: PMC5038131 [Available on 01/01/17].
  41. Singer AJ, Taylor M, Domingo A, Ghazipura S, Khorasonchi A, Thode HC, Shapiro NI. Diagnostic characteristics of a clinical screening tool in combination with measuring bedside lactate level in emergency department patients with suspected sepsis. Acad Emerg Med. 2014 Aug; 21(8):853-7. PMID: 25155163.
    View in: PubMed
  42. Duus N, Shogilev DJ, Skibsted S, Zijlstra HW, Fish E, Oren-Grinberg A, Lior Y, Novack V, Talmor D, Kirkegaard H, Shapiro NI. The reliability and validity of passive leg raise and fluid bolus to assess fluid responsiveness in spontaneously breathing emergency department patients. J Crit Care. 2015 Feb; 30(1):217.e1-5. PMID: 25262530.
    View in: PubMed
  43. Ginde AA, Blatchford PJ, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Rivers EP, Shapiro NI. Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis. Shock. 2014 Aug; 42(2):99-107. PMID: 24978893; PMCID: PMC4101036.
  44. Ledderose C, Bao Y, Lidicky M, Zipperle J, Li L, Strasser K, Shapiro NI, Junger WG. Mitochondria are gate-keepers of T cell function by producing the ATP that drives purinergic signaling. J Biol Chem. 2014 Sep 12; 289(37):25936-45. PMID: 25070895; PMCID: PMC4162192.
  45. Wang HE, Donnelly JP, Shapiro NI, Hohmann SF, Levitan EB. Hospital variations in severe sepsis mortality. Am J Med Qual. 2015 Jul-Aug; 30(4):328-36. PMID: 24814940.
    View in: PubMed
  46. Muroya T, Kannan L, Ghiran IC, Shevkoplyas SS, Paz Z, Tsokos M, Dalle Lucca JJ, Shapiro NI, Tsokos GC. C4d deposits on the surface of RBCs in trauma patients and interferes with their function. Crit Care Med. 2014 May; 42(5):e364-72. PMID: 24448198; PMCID: PMC4099476.
  47. Skibsted S, Shapiro NI. Transcriptomics may pave the biomarker road in sepsis*. Crit Care Med. 2014 Apr; 42(4):974-5. PMID: 24633092.
    View in: PubMed
  48. Chiu DT, Shapiro NI, Sun BC, Mottley JL, Grossman SA. Are echocardiography, telemetry, ambulatory electrocardiography monitoring, and cardiac enzymes in emergency department patients presenting with syncope useful tests? A preliminary investigation. J Emerg Med. 2014 Jul; 47(1):113-8. PMID: 24698512.
    View in: PubMed
  49. Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014 May 01; 370(18):1683-93. PMID: 24635773; PMCID: PMC4101700.
  50. Peitz GW, Troyer J, Jones AE, Shapiro NI, Nelson RD, Hernandez J, Kline JA. Association of body mass index with increased cost of care and length of stay for emergency department patients with chest pain and dyspnea. Circ Cardiovasc Qual Outcomes. 2014 Mar; 7(2):292-8. PMID: 24594550.
    View in: PubMed
  51. Zonneveld R, Martinelli R, Shapiro NI, Kuijpers TW, Plötz FB, Carman CV. Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults. Crit Care. 2014 Feb 18; 18(2):204. PMID: 24602331; PMCID: PMC4014977.
  52. Kennedy M, Enander RA, Tadiri SP, Wolfe RE, Shapiro NI, Marcantonio ER. Delirium risk prediction, healthcare use and mortality of elderly adults in the emergency department. J Am Geriatr Soc. 2014 Mar; 62(3):462-9. PMID: 24512171; PMCID: PMC3959285.
  53. Filbin MR, Hou PC, Massey M, Barche A, Kao E, Bracey A, Skibsted S, Chang Y, Shapiro NI. The microcirculation is preserved in emergency department low-acuity sepsis patients without hypotension. Acad Emerg Med. 2014 Feb; 21(2):154-62. PMID: 24673671.
    View in: PubMed
  54. Wang HE, Szychowski JM, Griffin R, Safford MM, Shapiro NI, Howard G. Long-term mortality after community-acquired sepsis: a longitudinal population-based cohort study. BMJ Open. 2014 Jan 17; 4(1):e004283. PMID: 24441058; PMCID: PMC3902401.
  55. Wiener Z, Chiu DT, Shapiro NI, Grossman SA. Substance abuse in emergency department patients with unexplained syncope. Intern Emerg Med. 2014 Apr; 9(3):331-4. PMID: 24297764.
    View in: PubMed
  56. Kline JA, Jones AE, Shapiro NI, Hernandez J, Hogg MM, Troyer J, Nelson RD. Multicenter, randomized trial of quantitative pretest probability to reduce unnecessary medical radiation exposure in emergency department patients with chest pain and dyspnea. Circ Cardiovasc Imaging. 2014 Jan; 7(1):66-73. PMID: 24275953.
    View in: PubMed
  57. Kline JA, Shapiro NI, Jones AE, Hernandez J, Hogg MM, Troyer J, Nelson RD. Outcomes and radiation exposure of emergency department patients with chest pain and shortness of breath and ultralow pretest probability: a multicenter study. Ann Emerg Med. 2014 Mar; 63(3):281-8. PMID: 24120629.
    View in: PubMed
  58. Skibsted S, Bhasin MK, Aird WC, Shapiro NI. Bench-to-bedside review: future novel diagnostics for sepsis - a systems biology approach. Crit Care. 2013 Oct 04; 17(5):231. PMID: 24093155; PMCID: PMC4057467.
  59. Shapiro NI, Angus DC. A review of therapeutic attempts to recruit the microcirculation in patients with sepsis. Minerva Anestesiol. 2014 Feb; 80(2):225-35. PMID: 24002463.
    View in: PubMed
  60. Massey MJ, Larochelle E, Najarro G, Karmacharla A, Arnold R, Trzeciak S, Angus DC, Shapiro NI. The microcirculation image quality score: development and preliminary evaluation of a proposed approach to grading quality of image acquisition for bedside videomicroscopy. J Crit Care. 2013 Dec; 28(6):913-7. PMID: 23972316.
    View in: PubMed
  61. Grossman SA, Chiu D, Lipsitz L, Mottley JL, Shapiro NI. Can elderly patients without risk factors be discharged home when presenting to the emergency department with syncope? Arch Gerontol Geriatr. 2014 Jan-Feb; 58(1):110-4. PMID: 23993263.
    View in: PubMed
  62. Wang HE, Shapiro NI, Safford MM, Griffin R, Judd S, Rodgers JB, Warnock DG, Cushman M, Howard G. High-sensitivity C-reactive protein and risk of sepsis. PLoS One. 2013; 8(7):e69232. PMID: 23935961; PMCID: PMC3720576.
  63. Omar YG, Massey M, Andersen LW, Giberson TA, Berg K, Cocchi MN, Shapiro NI, Donnino MW. Sublingual microcirculation is impaired in post-cardiac arrest patients. Resuscitation. 2013 Dec; 84(12):1717-22. PMID: 23871865; PMCID: PMC3864773.
  64. Wang HE, Griffin R, Judd S, Shapiro NI, Safford MM. Obesity and risk of sepsis: a population-based cohort study. Obesity (Silver Spring). 2013 Dec; 21(12):E762-9. PMID: 23526732; PMCID: PMC3795990.
  65. Skibsted S, Arnold R, Sherwin R, Singh S, Lundy D, Nelson T, Puskarich MA, Trzeciak S, Jones AE, Shapiro NI. The association of near infrared spectroscopy-derived StO2 measurements and biomarkers of endothelial activation in sepsis. Intern Emerg Med. 2013 Sep; 8(6):529-36. PMID: 23824446.
    View in: PubMed
  66. Sterling SA, Puskarich MA, Shapiro NI, Trzeciak S, Kline JA, Summers RL, Jones AE. Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock. Shock. 2013 Jul; 40(1):11-4. PMID: 23649098; PMCID: PMC3982587.
  67. Traub SJ, Mitchell AM, Jones AE, Tang A, O'Connor J, Nelson T, Kellum J, Shapiro NI. N-acetylcysteine plus intravenous fluids versus intravenous fluids alone to prevent contrast-induced nephropathy in emergency computed tomography. Ann Emerg Med. 2013 Nov; 62(5):511-520.e25. PMID: 23769807.
    View in: PubMed
  68. Puskarich MA, Trzeciak S, Shapiro NI, Albers AB, Heffner AC, Kline JA, Jones AE. Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest. 2013 Jun; 143(6):1548-53. PMID: 23740148; PMCID: PMC3673659.
  69. Zhang G, Yang L, Kim GS, Ryan K, Lu S, O'Donnell RK, Spokes K, Shapiro N, Aird WC, Kluk MJ, Yano K, Sanchez T. Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood. 2013 Jul 18; 122(3):443-55. PMID: 23723450; PMCID: PMC3716205.
  70. Ginde AA, Moss M, Shapiro NI, Schwartz RS. Impact of older age and nursing home residence on clinical outcomes of US emergency department visits for severe sepsis. J Crit Care. 2013 Oct; 28(5):606-11. PMID: 23683561; PMCID: PMC3770757.
  71. Wiener Z, Shapiro NI, Chiu DT, Grossman SA. The prevalence of psychiatric disease in emergency department patients with unexplained syncope. Intern Emerg Med. 2013 Aug; 8(5):427-30. PMID: 23645509.
    View in: PubMed
  72. Skibsted S, Jones AE, Puskarich MA, Arnold R, Sherwin R, Trzeciak S, Schuetz P, Aird WC, Shapiro NI. Biomarkers of endothelial cell activation in early sepsis. Shock. 2013 May; 39(5):427-32. PMID: 23524845; PMCID: PMC3670087.
  73. Arnold RC, Sherwin R, Shapiro NI, O'Connor JL, Glaspey L, Singh S, Medado P, Trzeciak S, Jones AE. Multicenter observational study of the development of progressive organ dysfunction and therapeutic interventions in normotensive sepsis patients in the emergency department. Acad Emerg Med. 2013 May; 20(5):433-40. PMID: 23672356.
    View in: PubMed
  74. Odom SR, Howell MD, Silva GS, Nielsen VM, Gupta A, Shapiro NI, Talmor D. Lactate clearance as a predictor of mortality in trauma patients. J Trauma Acute Care Surg. 2013 Apr; 74(4):999-1004. PMID: 23511137.
    View in: PubMed
  75. Berger T, Green J, Horeczko T, Hagar Y, Garg N, Suarez A, Panacek E, Shapiro N. Shock index and early recognition of sepsis in the emergency department: pilot study. West J Emerg Med. 2013 Mar; 14(2):168-74. PMID: 23599863; PMCID: PMC3628475.
  76. Wang HE, Shapiro NI, Griffin R, Safford MM, Judd S, Howard G. Inflammatory and endothelial activation biomarkers and risk of sepsis: a nested case-control study. J Crit Care. 2013 Oct; 28(5):549-55. PMID: 23414982; PMCID: PMC3814035.
  77. Kashani K, Al-Khafaji A, Ardiles T, Artigas A, Bagshaw SM, Bell M, Bihorac A, Birkhahn R, Cely CM, Chawla LS, Davison DL, Feldkamp T, Forni LG, Gong MN, Gunnerson KJ, Haase M, Hackett J, Honore PM, Hoste EA, Joannes-Boyau O, Joannidis M, Kim P, Koyner JL, Laskowitz DT, Lissauer ME, Marx G, McCullough PA, Mullaney S, Ostermann M, Rimmelé T, Shapiro NI, Shaw AD, Shi J, Sprague AM, Vincent JL, Vinsonneau C, Wagner L, Walker MG, Wilkerson RG, Zacharowski K, Kellum JA. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care. 2013 Feb 06; 17(1):R25. PMID: 23388612; PMCID: PMC4057242.
  78. Traub SJ, Kellum JA, Tang A, Cataldo L, Kancharla A, Shapiro NI. Risk factors for radiocontrast nephropathy after emergency department contrast-enhanced computerized tomography. Acad Emerg Med. 2013 Jan; 20(1):40-5. PMID: 23570477.
    View in: PubMed
  79. Volz KA, Canham L, Kaplan E, Sanchez LD, Shapiro NI, Grossman SA. Identifying patients with cellulitis who are likely to require inpatient admission after a stay in an ED observation unit. Am J Emerg Med. 2013 Feb; 31(2):360-4. PMID: 23158603.
    View in: PubMed
  80. David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM. Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med. 2012 Nov; 40(11):3034-41. PMID: 22890252; PMCID: PMC3705559.
  81. Grossman SA, Babineau M, Kulchycki L, Mottley L, Kancharla A, Nencioni A, Shapiro N. Further thoughts on whether outcomes of near syncope parallel syncope. Am J Emerg Med. 2012 Nov; 30(9):2064. PMID: 23158060.
    View in: PubMed
  82. Wang HE, Shapiro NI, Griffin R, Safford MM, Judd S, Howard G. Chronic medical conditions and risk of sepsis. PLoS One. 2012; 7(10):e48307. PMID: 23118977; PMCID: PMC3485139.
  83. Mahler SA, Miller CD, Hollander JE, Nagurney JT, Birkhahn R, Singer AJ, Shapiro NI, Glynn T, Nowak R, Safdar B, Peberdy M, Counselman FL, Chandra A, Kosowsky J, Neuenschwander J, Schrock JW, Plantholt S, Diercks DB, Peacock WF. Identifying patients for early discharge: performance of decision rules among patients with acute chest pain. Int J Cardiol. 2013 Sep 30; 168(2):795-802. PMID: 23117012; PMCID: PMC3565031.
  84. Singer AJ, Thode HC, Peacock WF, Hollander JE, Diercks D, Birkhahn R, Shapiro N, Glynn T, Nowack R, Safdar B, Miller C, Lewandrowski E, Nagurney J. The association between self-reported exercise intensity and acute coronary syndrome in emergency department chest pain patients. J Emerg Med. 2013 Jan; 44(1):17-22. PMID: 23103065.
    View in: PubMed
  85. Puskarich MA, Shapiro NI, Trzeciak S, Kline JA, Jones AE. Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsis. Shock. 2012 Oct; 38(4):337-40. PMID: 22777124; PMCID: PMC3664931.
  86. Grossman SA, Babineau M, Burke L, Kancharla A, Mottley L, Nencioni A, Shapiro NI. Applying the Boston syncope criteria to near syncope. J Emerg Med. 2012 Dec; 43(6):958-63. PMID: 22981659.
    View in: PubMed
  87. Chase M, Klasco RS, Joyce NR, Donnino MW, Wolfe RE, Shapiro NI. Predictors of bacteremia in emergency department patients with suspected infection. Am J Emerg Med. 2012 Nov; 30(9):1691-7. PMID: 22626814.
    View in: PubMed
  88. Schuetz P, Kennedy M, Lucas JM, Howell MD, Aird WC, Yealy DM, Shapiro NI. Initial management of septic patients with hyperglycemia in the noncritical care inpatient setting. Am J Med. 2012 Jul; 125(7):670-8. PMID: 22608986.
    View in: PubMed
  89. Arnold RC, Dellinger RP, Parrillo JE, Chansky ME, Lotano VE, McCoy JV, Jones AE, Shapiro NI, Hollenberg SM, Trzeciak S. Discordance between microcirculatory alterations and arterial pressure in patients with hemodynamic instability. J Crit Care. 2012 Oct; 27(5):531.e1-7. PMID: 22591569.
    View in: PubMed
  90. Vellinga NA, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Bakker J, Ince C. Study Design of the Microcirculatory Shock Occurrence in Acutely Ill Patients (microSOAP): an International Multicenter Observational Study of Sublingual Microcirculatory Alterations in Intensive Care Patients. Crit Care Res Pract. 2012; 2012:121752. PMID: 22666566; PMCID: PMC3359769.
  91. van Meurs M, Castro P, Shapiro NI, Lu S, Yano M, Maeda N, Funahashi T, Shimomura I, Zijlstra JG, Molema G, Parikh SM, Aird WC, Yano K. Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis. Shock. 2012 Apr; 37(4):392-8. PMID: 22258235.
    View in: PubMed
  92. Roberson RS, Lockhart E, Shapiro NI, Bandarenko N, McMahon TJ, Massey MJ, White WD, Bennett-Guerrero E. Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. Transfusion. 2012 Nov; 52(11):2459-64. PMID: 22452273; PMCID: PMC3387324.
  93. Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Heffner AC, Kline JA, Jones AE. Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. Acad Emerg Med. 2012 Mar; 19(3):252-8. PMID: 22435856; PMCID: PMC3313083.
  94. Kilgannon JH, Trzeciak S, Parrillo JE, Dellinger RP, Milcarek B, Hunter K, Jones AE, Shapiro NI. Reply to letters regarding article, "relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest". Circulation. 2012 Jan 24; 125(3):e289. PMID: 22271855.
    View in: PubMed
  95. Diercks DB, Peacock WF, Hollander JE, Singer AJ, Birkhahn R, Shapiro N, Glynn T, Nowack R, Safdar B, Miller CD, Lewandrowski E, Nagurney JT. Diagnostic accuracy of a point-of-care troponin I assay for acute myocardial infarction within 3 hours after presentation in early presenters to the emergency department with chest pain. Am Heart J. 2012 Jan; 163(1):74-80.e4. PMID: 22172439.
    View in: PubMed
  96. Wang HE, Shapiro NI, Yealy DM. Characteristics of out-of-hospital shock care. Crit Care Med. 2011 Nov; 39(11):2431-9. PMID: 21705898.
    View in: PubMed
  97. Peacock WF, Nagurney J, Birkhahn R, Singer A, Shapiro N, Hollander J, Glynn T, Nowak R, Safdar B, Miller C, Peberdy M, Counselman F, Chandra A, Kosowsky J, Neuenschwander J, Schrock J, Plantholt S, Lewandrowski E, Wong V, Kupfer K, Diercks D. Myeloperoxidase in the diagnosis of acute coronary syndromes: the importance of spectrum. Am Heart J. 2011 Nov; 162(5):893-9. PMID: 22093206.
    View in: PubMed
  98. Shapiro NI, Arnold R, Sherwin R, O'Connor J, Najarro G, Singh S, Lundy D, Nelson T, Trzeciak SW, Jones AE. The association of near-infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency department patients with sepsis. Crit Care. 2011; 15(5):R223. PMID: 21939529; PMCID: PMC3334769.
  99. Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Horton JM, Studnek JR, Kline JA, Jones AE. Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med. 2011 Sep; 39(9):2066-71. PMID: 21572327; PMCID: PMC3158284.
  100. Schuetz P, Jones AE, Aird WC, Shapiro NI. Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock. 2011 Aug; 36(2):104-8. PMID: 21522043; PMCID: PMC3139767.
  101. Grossman SA, Shapiro NI, Mottley JL, Sanchez L, Ullman E, Wolfe RE. Is telemetry useful in evaluating chest pain patients in an observation unit? Intern Emerg Med. 2011 Dec; 6(6):543-6. PMID: 21739228.
    View in: PubMed
  102. Puskarich MA, Trzeciak S, Shapiro NI, Heffner AC, Kline JA, Jones AE. Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation. 2011 Oct; 82(10):1289-93. PMID: 21752522; PMCID: PMC3179778.
  103. Schuetz P, Jones AE, Howell MD, Trzeciak S, Ngo L, Younger JG, Aird W, Shapiro NI. Diabetes is not associated with increased mortality in emergency department patients with sepsis. Ann Emerg Med. 2011 Nov; 58(5):438-44. PMID: 21683473; PMCID: PMC3425373.
  104. Kilgannon JH, Jones AE, Parrillo JE, Dellinger RP, Milcarek B, Hunter K, Shapiro NI, Trzeciak S. Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation. 2011 Jun 14; 123(23):2717-22. PMID: 21606393.
    View in: PubMed
  105. McGillicuddy DC, O'Connell FJ, Shapiro NI, Calder SA, Mottley LJ, Roberts JC, Sanchez LD. Emergency department abnormal vital sign "triggers" program improves time to therapy. Acad Emerg Med. 2011 May; 18(5):483-7. PMID: 21521399.
    View in: PubMed
  106. Ginde AA, Camargo CA, Shapiro NI. Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad Emerg Med. 2011 May; 18(5):551-4. PMID: 21518095.
    View in: PubMed
  107. Grossman SA, Bar J, Fischer C, Lipsitz LA, Mottley L, Sands K, Zimetbaum P, Shapiro NI. Reducing admissions utilizing the Boston Syncope Criteria. J Emerg Med. 2012 Mar; 42(3):345-52. PMID: 21421292.
    View in: PubMed
  108. Shapiro NI, Aird WC. Sepsis and the broken endothelium. Crit Care. 2011 Mar 21; 15(2):135. PMID: 21457513; PMCID: PMC3219316.
  109. Schuetz P, Castro P, Shapiro NI. Diabetes and sepsis: preclinical findings and clinical relevance. Diabetes Care. 2011 Mar; 34(3):771-8. PMID: 21357364; PMCID: PMC3041224.
  110. Schuetz P, Yano K, Sorasaki M, Ngo L, St Hilaire M, Lucas JM, Aird W, Shapiro NI. Influence of diabetes on endothelial cell response during sepsis. Diabetologia. 2011 May; 54(5):996-1003. PMID: 21286681.
    View in: PubMed
  111. Howell MD, Talmor D, Schuetz P, Hunziker S, Jones AE, Shapiro NI. Proof of principle: the predisposition, infection, response, organ failure sepsis staging system. Crit Care Med. 2011 Feb; 39(2):322-7. PMID: 21099424.
    View in: PubMed
  112. Perman SM, Chang AM, Hollander JE, Gaieski DF, Trzeciak S, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Goyal M, Cairns CB, Ngo L, Rivers EP, Shapiro NI. Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department. Acad Emerg Med. 2011 Feb; 18(2):219-22. PMID: 21314784.
    View in: PubMed
  113. Grossman SA, Babineau M, Burke L, Kancharla A, Mottley L, Nencioni A, Shapiro NI. Do outcomes of near syncope parallel syncope? Am J Emerg Med. 2012 Jan; 30(1):203-6. PMID: 21185670.
    View in: PubMed
  114. Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI, Benjamin LE. RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice. Am J Pathol. 2011 Jan; 178(1):245-52. PMID: 21224061; PMCID: PMC3069827.
  115. Green JP, Berger T, Garg N, Shapiro NI. Serum lactate is a better predictor of short-term mortality when stratified by C-reactive protein in adult emergency department patients hospitalized for a suspected infection. Ann Emerg Med. 2011 Mar; 57(3):291-5. PMID: 21111512.
    View in: PubMed
  116. McGillicuddy DC, de La Pena J, Goudie JS, Fisher J, Shapiro N, Sanchez LD. Adherence to dose of succinylcholine and etomidate in the emergency department. West J Emerg Med. 2010 Dec; 11(5):432-4. PMID: 21293761; PMCID: PMC3027434.
  117. Kaji AH, Lewis RJ, Beavers-May T, Berg R, Bulger E, Cairns C, Callaway C, Camargo CA, Carcillo J, DeBiasi R, Diaz T, Ducharme F, Glickman S, Heilpern K, Hickey R, Hoek TV, Hollander J, Janson S, Jurkovich G, Kellermann A, Kingsmore S, Kline J, Kuppermann N, Lowe R, McLario D, Nathanson L, Nichol G, Peitzman A, Richardson L, Sanders A, Shah M, Shapiro N, Silverman R, Than M, Wilber S, Yealy DM. Summary of NIH Medical-Surgical Emergency Research Roundtable held on April 30 to May 1, 2009. Ann Emerg Med. 2010 Nov; 56(5):522-37. PMID: 21036293.
    View in: PubMed
  118. Shapiro NI, Schuetz P, Yano K, Sorasaki M, Parikh SM, Jones AE, Trzeciak S, Ngo L, Aird WC. The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care. 2010; 14(5):R182. PMID: 20942957; PMCID: PMC3219288.
  119. Kennedy M, Joyce N, Howell MD, Lawrence Mottley J, Shapiro NI. Identifying infected emergency department patients admitted to the hospital ward at risk of clinical deterioration and intensive care unit transfer. Acad Emerg Med. 2010 Oct; 17(10):1080-5. PMID: 21040109; PMCID: PMC3058807.
  120. Seigel TA, Cocchi MN, Salciccioli J, Shapiro NI, Howell M, Tang A, Donnino MW. Inadequacy of temperature and white blood cell count in predicting bacteremia in patients with suspected infection. J Emerg Med. 2012 Mar; 42(3):254-9. PMID: 20674238.
    View in: PubMed
  121. Fischer CM, Yano K, Aird WC, Shapiro NI. Abnormal coagulation tests obtained in the emergency department are associated with mortality in patients with suspected infection. J Emerg Med. 2012 Feb; 42(2):127-32. PMID: 20542399.
    View in: PubMed
  122. Shapiro NI, Khankin EV, Van Meurs M, Shih SC, Lu S, Yano M, Castro PR, Maratos-Flier E, Parikh SM, Karumanchi SA, Yano K. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010 Jul 01; 185(1):517-24. PMID: 20519646; PMCID: PMC3997057.
  123. Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA. 2010 Jun 02; 303(21):2165-71. PMID: 20516417.
    View in: PubMed
  124. Shapiro NI, Bates DW. Response: The Unacceptable Costs of Trying to Achieve "Diagnostic Certainty" J Emerg Med. 2010 Apr 22. PMID: 20456898.
    View in: PubMed
  125. Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson K, Milzman D, Gaieski DF, Goyal M, Cairns CB, Kupfer K, Lee SW, Rivers EP. The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis. Ann Emerg Med. 2010 Jul; 56(1):52-59.e1. PMID: 20363526.
    View in: PubMed
  126. Trzeciak S, Jones AE, Shapiro NI, Pusateri AE, Arnold RC, Rizzuto M, Arora T, Parrillo JE, Dellinger RP. A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation. Crit Care Med. 2010 Apr; 38(4):1092-100. PMID: 20124888.
    View in: PubMed
  127. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA. 2010 Feb 24; 303(8):739-46. PMID: 20179283; PMCID: PMC2918907.
  128. Wang HE, Weaver MD, Shapiro NI, Yealy DM. Opportunities for Emergency Medical Services care of sepsis. Resuscitation. 2010 Feb; 81(2):193-7. PMID: 20006419; PMCID: PMC4028958.
  129. Grossman SA, Fischer C, Kancharla A, Lipsitz LA, Mottley L, Zimetbaum P, Shapiro NI. Can benign etiologies predict benign outcomes in high-risk syncope patients? J Emerg Med. 2011 May; 40(5):592-7. PMID: 19926429.
    View in: PubMed
  130. Trzeciak S, Jones AE, Kilgannon JH, Milcarek B, Hunter K, Shapiro NI, Hollenberg SM, Dellinger P, Parrillo JE. Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med. 2009 Nov; 37(11):2895-903; quiz 2904. PMID: 19866506.
    View in: PubMed
  131. Pope JV, Jones AE, Gaieski DF, Arnold RC, Trzeciak S, Shapiro NI. Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med. 2010 Jan; 55(1):40-46.e1. PMID: 19854541; PMCID: PMC2828585.
  132. Shapiro NI, Fisher C, Donnino M, Cataldo L, Tang A, Trzeciak S, Horowitz G, Wolfe RE. The feasibility and accuracy of point-of-care lactate measurement in emergency department patients with suspected infection. J Emerg Med. 2010 Jul; 39(1):89-94. PMID: 19717267; PMCID: PMC3205933.
  133. Nencioni A, Trzeciak S, Shapiro NI. The microcirculation as a diagnostic and therapeutic target in sepsis. Intern Emerg Med. 2009 Oct; 4(5):413-8. PMID: 19707845.
    View in: PubMed
  134. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP, Trzeciak S. Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock. 2009 Jul; 32(1):35-9. PMID: 19533847.
    View in: PubMed
  135. Arnold RC, Parrillo JE, Phillip Dellinger R, Chansky ME, Shapiro NI, Lundy DJ, Trzeciak S, Hollenberg SM. Point-of-care assessment of microvascular blood flow in critically ill patients. Intensive Care Med. 2009 Oct; 35(10):1761-6. PMID: 19554307.
    View in: PubMed
  136. Caterino JM, Kulchycki LK, Fischer CM, Wolfe RE, Shapiro NI. Risk factors for death in elderly emergency department patients with suspected infection. J Am Geriatr Soc. 2009 Jul; 57(7):1184-90. PMID: 19558478.
    View in: PubMed
  137. Singer AJ, Thode HC, Green GB, Birkhahn R, Shapiro NI, Cairns C, Baumann BM, Aghababian R, Char D, Hollander JE. The incremental benefit of a shortness-of-breath biomarker panel in emergency department patients with dyspnea. Acad Emerg Med. 2009 Jun; 16(6):488-94. PMID: 19388909.
    View in: PubMed
  138. Shapiro NI, Yano K, Sorasaki M, Fischer C, Shih SC, Aird WC. Skin biopsies demonstrate site-specific endothelial activation in mouse models of sepsis. J Vasc Res. 2009; 46(5):495-502. PMID: 19346756.
    View in: PubMed
  139. Callaway DW, Shapiro NI, Donnino MW, Baker C, Rosen CL. Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients. J Trauma. 2009 Apr; 66(4):1040-4. PMID: 19359912.
    View in: PubMed
  140. Donnino MW, Cocchi MN, Howell M, Clardy P, Talmor D, Cataldo L, Chase M, Al-Marshad A, Ngo L, Shapiro NI. Statin therapy is associated with decreased mortality in patients with infection. Acad Emerg Med. 2009 Mar; 16(3):230-4. PMID: 19281494.
    View in: PubMed
  141. Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Ngo L, Rivers EP. A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis. Crit Care Med. 2009 Jan; 37(1):96-104. PMID: 19050610.
    View in: PubMed
  142. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP, Trzeciak S. Multi-Center Study of Early Lactate Clearance as a Determinant of Survival in Patients with Presumed Sepsis. Shock. 2008 Dec 22. PMID: 19106806.
    View in: PubMed
  143. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP. Multi-Center Study of Early Lactate Clearance as a Determinant of Survival in Patients with Presumed Sepsis. Shock. 2008 Dec 4. PMID: 19060782.
    View in: PubMed
  144. Jones AE, Brown MD, Trzeciak S, Shapiro NI, Garrett JS, Heffner AC, Kline JA. The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med. 2008 Oct; 36(10):2734-9. PMID: 18766093; PMCID: PMC2737059.
  145. Berkman M, Ufberg J, Nathanson LA, Shapiro NI. Anion gap as a screening tool for elevated lactate in patients with an increased risk of developing sepsis in the Emergency Department. J Emerg Med. 2009 May; 36(4):391-4. PMID: 18815002.
    View in: PubMed
  146. Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, Shapiro NI, Parrillo JE, Hollenberg SM. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med. 2008 Dec; 34(12):2210-7. PMID: 18594793; PMCID: PMC2821162.
  147. Shapiro NI, Wolfe RE, Wright SB, Moore R, Bates DW. Who needs a blood culture? A prospectively derived and validated prediction rule. J Emerg Med. 2008 Oct; 35(3):255-64. PMID: 18486413.
    View in: PubMed
  148. Trzeciak S, Cinel I, Phillip Dellinger R, Shapiro NI, Arnold RC, Parrillo JE, Hollenberg SM. Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med. 2008 May; 15(5):399-413. PMID: 18439194; PMCID: PMC2727641.
  149. McGillicuddy DC, Tang A, Cataldo L, Gusev J, Shapiro NI. Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosis. Intern Emerg Med. 2009 Feb; 4(1):41-4. PMID: 18418551.
    View in: PubMed
  150. Talmor D, Greenberg D, Howell MD, Lisbon A, Novack V, Shapiro N. The costs and cost-effectiveness of an integrated sepsis treatment protocol. Crit Care Med. 2008 Apr; 36(4):1168-74. PMID: 18379243.
    View in: PubMed
  151. Shapiro NI, Yano K, Okada H, Fischer C, Howell M, Spokes KC, Ngo L, Angus DC, Aird WC. A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsis. Shock. 2008 Apr; 29(4):452-7. PMID: 18598002.
    View in: PubMed
  152. Jones AE, Shapiro NI, Kilgannon JH, Trzeciak S. Goal-directed hemodynamic optimization in the post-cardiac arrest syndrome: a systematic review. Resuscitation. 2008 Apr; 77(1):26-9. PMID: 18164117.
    View in: PubMed
  153. Wang HE, Shapiro NI, Angus DC, Yealy DM. National estimates of severe sepsis in United States emergency departments. Crit Care Med. 2007 Aug; 35(8):1928-36. PMID: 17581480.
    View in: PubMed
  154. Jones AE, Shapiro NI, Roshon M. Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings. Acad Emerg Med. 2007 Nov; 14(11):1072-8. PMID: 17630356; PMCID: PMC2689941.
  155. Howell MD, Donnino M, Clardy P, Talmor D, Shapiro NI. Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med. 2007 Nov; 33(11):1892-9. PMID: 17618418.
    View in: PubMed
  156. Grossman SA, Fischer C, Lipsitz LA, Mottley L, Sands K, Thompson S, Zimetbaum P, Shapiro NI. Predicting adverse outcomes in syncope. J Emerg Med. 2007 Oct; 33(3):233-9. PMID: 17976548; PMCID: PMC2276584.
  157. Howell MD, Donnino MW, Talmor D, Clardy P, Ngo L, Shapiro NI. Performance of severity of illness scoring systems in emergency department patients with infection. Acad Emerg Med. 2007 Aug; 14(8):709-14. PMID: 17576773.
    View in: PubMed
  158. Kelly SP, Shapiro N, Woodruff M, Corrigan K, Sanchez LD, Wolfe RE. The effects of clinical workload on teaching in the emergency department. Acad Emerg Med. 2007 Jun; 14(6):526-31. PMID: 17483400.
    View in: PubMed
  159. Talmor D, Jones AE, Rubinson L, Howell MD, Shapiro NI. Simple triage scoring system predicting death and the need for critical care resources for use during epidemics. Crit Care Med. 2007 May; 35(5):1251-6. PMID: 17417099.
    View in: PubMed
  160. Howell MD, Shapiro NI. Surviving sepsis outside the intensive care unit. Crit Care Med. 2007 May; 35(5):1422-3. PMID: 17446738.
    View in: PubMed
  161. Grossman SA, Fischer C, Bar JL, Lipsitz LA, Mottley L, Sands K, Thompson S, Zimetbaum P, Shapiro NI. The yield of head CT in syncope: a pilot study. Intern Emerg Med. 2007 Mar; 2(1):46-9. PMID: 17551685; PMCID: PMC2780634.
  162. Shapiro NI, Howell MD, Talmor D, Donnino M, Ngo L, Bates DW. Mortality in Emergency Department Sepsis (MEDS) score predicts 1-year mortality. Crit Care Med. 2007 Jan; 35(1):192-8. PMID: 17110874.
    View in: PubMed
  163. Shapiro N, Howell MD, Bates DW, Angus DC, Ngo L, Talmor D. The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med. 2006 Nov; 48(5):583-90, 590.e1. PMID: 17052559.
    View in: PubMed
  164. Reuben AD, Appelboam AV, Higginson I, Lloyd JG, Shapiro NI. Early goal-directed therapy: a UK perspective. Emerg Med J. 2006 Nov; 23(11):828-32. PMID: 17057131; PMCID: PMC2464390.
  165. Talmor D, Shapiro N, Greenberg D, Stone PW, Neumann PJ. When is critical care medicine cost-effective? A systematic review of the cost-effectiveness literature. Crit Care Med. 2006 Nov; 34(11):2738-47. PMID: 16957636.
    View in: PubMed
  166. Strehlow MC, Emond SD, Shapiro NI, Pelletier AJ, Camargo CA. National study of emergency department visits for sepsis, 1992 to 2001. Ann Emerg Med. 2006 Sep; 48(3):326-31, 331.e1-3. PMID: 16934654.
    View in: PubMed
  167. Shapiro NI, Howell MD, Talmor D, Lahey D, Ngo L, Buras J, Wolfe RE, Weiss JW, Lisbon A. Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol. Crit Care Med. 2006 Apr; 34(4):1025-32. PMID: 16484890.
    View in: PubMed
  168. Murray SB, Bates DW, Ngo L, Ufberg JW, Shapiro NI. Charlson Index is associated with one-year mortality in emergency department patients with suspected infection. Acad Emerg Med. 2006 May; 13(5):530-6. PMID: 16551775.
    View in: PubMed
  169. Shapiro NI, Talmor D. Predicting mortality in the intensive care unit: man against machine. Crit Care Med. 2006 Mar; 34(3):932-3. PMID: 16505694.
    View in: PubMed
  170. Sanchez LD, Imperato J, Delapena JE, Shapiro N, Tian L. Accuracy of weight estimation by ED personnel. Am J Emerg Med. 2005 Nov; 23(7):915-6. PMID: 16291458.
    View in: PubMed
  171. Shapiro NI, Donnino MW. Sepsis: the changing times. Crit Care Med. 2005 Nov; 33(11):2700-1. PMID: 16276210.
    View in: PubMed
  172. Grossman SA, Shapiro NI, Van Epp S, Kohen R, Arnold R, Moore R, Lee L, Wolfe RE, Lipsitz LA. Sex differences in the emergency department evaluation of elderly patients with syncope. J Gerontol A Biol Sci Med Sci. 2005 Sep; 60(9):1202-5. PMID: 16183963.
    View in: PubMed
  173. Kennedy M, Bates DW, Wright SB, Ruiz R, Wolfe RE, Shapiro NI. Do emergency department blood cultures change practice in patients with pneumonia? Ann Emerg Med. 2005 Nov; 46(5):393-400. PMID: 16271664.
    View in: PubMed
  174. McGillicuddy DC, Walker O, Shapiro NI, Edlow JA. Guillain-Barré syndrome in the emergency department. Ann Emerg Med. 2006 Apr; 47(4):390-3. PMID: 16546626.
    View in: PubMed
  175. Shapiro N, Howell MD. Sick? Or, not sick? Crit Care Med. 2005 May; 33(5):1151-3. PMID: 15891357.
    View in: PubMed
  176. Shapiro NI, Howell MD, Talmor D, Nathanson LA, Lisbon A, Wolfe RE, Weiss JW. Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med. 2005 May; 45(5):524-8. PMID: 15855951.
    View in: PubMed
  177. Shapiro NI, Howell M, Talmor D. A blueprint for a sepsis protocol. Acad Emerg Med. 2005 Apr; 12(4):352-9. PMID: 15805328.
    View in: PubMed
  178. Shapiro NI, Spear J, Sheehy S, Brown J, Edlow JA. Barriers to the use of outpatient enoxaparin therapy in patients with deep venous thrombosis. Am J Emerg Med. 2005 Jan; 23(1):30-4. PMID: 15672334.
    View in: PubMed
  179. Grossman SA, Van Epp S, Arnold R, Moore R, Lee L, Shapiro NI, Wolfe RE, Lipsitz LA. The value of cardiac enzymes in elderly patients presenting to the emergency department with syncope. J Gerontol A Biol Sci Med Sci. 2003 Nov; 58(11):1055-8. PMID: 14630890.
    View in: PubMed
  180. Pozner CN, Levine M, Shapiro N, Hanrahan JP. Concordance of field and emergency department assessment in the prehospital management of patients with dyspnea. Prehosp Emerg Care. 2003 Oct-Dec; 7(4):440-4. PMID: 14582094.
    View in: PubMed
  181. Shapiro NI, Kociszewski C, Harrison T, Chang Y, Wedel SK, Thomas SH. Isolated prehospital hypotension after traumatic injuries: a predictor of mortality? J Emerg Med. 2003 Aug; 25(2):175-9. PMID: 12902005.
    View in: PubMed
  182. Shapiro NI, Wolfe RE, Moore RB, Smith E, Burdick E, Bates DW. Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med. 2003 Mar; 31(3):670-5. PMID: 12626967.
    View in: PubMed
  183. Small SD, Wuerz RC, Simon R, Shapiro N, Conn A, Setnik G. Demonstration of high-fidelity simulation team training for emergency medicine. Acad Emerg Med. 1999 Apr; 6(4):312-23. PMID: 10230983.
    View in: PubMed
  184. Shapiro NI, Karras DJ, Leech SH, Heilpern KL. Absolute lymphocyte count as a predictor of CD4 count. Ann Emerg Med. 1998 Sep; 32(3 Pt 1):323-8. PMID: 9737494.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For demographic and contact information changes only, HMS/HSDM faculty should contact Human Resources at human_resourceshms.harvard.edu.
Shapiro's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
_
Co-Authors Expand Description
_
Similar People Expand Description
_
Same Department Expand Description
Physical Neighbors Expand Description
_