Harvard Catalyst Profiles

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Nathan Ivan Shapiro, M.D.

Title
Institution
Department
Address
Phone
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Mentoring
Non-Invasive Doppler Ultrasound Hemodynamic Cardiac Output Monitoring: Predicting Fluid Responsiveness in Patients in the Emergency Department
Summer, 06/19/06 - 08/11/06

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01HL123022 (TALMOR, DANIEL STUART) Jun 17, 2014 - Apr 30, 2021
    NIH/NHLBI
    Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute Lung
    Role: Principal Investigator
  2. R01HL112815 (TRZECIAK, STEPHEN WALTER) Mar 1, 2013 - Nov 30, 2016
    NIH
    Neurological and cognitive effects of hyperoxia after cardiac arrest
    Role: Co-Investigator
  3. R01GM103799 (JONES, ALAN E) Jun 1, 2012 - May 31, 2017
    NIH
    L-carnitine Treatment for Vasopressor Dependent Septic Shock
    Role: Co-Investigator
  4. R01GM116162 (JUNGER, WOLFGANG G) Jun 15, 2009 - Apr 30, 2019
    NIH/NIGMS
    Autocrine regulation of neutrophil chemotaxis
    Role: Co-Investigator
  5. R01HL091757 (SHAPIRO, NATHAN I) Jun 15, 2008 - May 31, 2014
    NIH/NHLBI
    Endothelial Cell Signaling and Microcirculatory Flow in Severe Sepsis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Andersen MS, Lu S, Lopez GJ, Lassen AT, Shapiro NI, Ghiran IC. A Novel Implementation of Magnetic Levitation to Quantify Leukocyte Size, Morphology, and Magnetic Properties to Identify Patients With Sepsis. Shock. 2019 Feb; 51(2):147-152. PMID: 29561389.
    Citations:    Fields:    
  2. Singleton JM, Bilello LA, Canham LS, Levenson RB, Lopez GJ, Tadiri SP, Shapiro NI, Rosen CL. Chest CT imaging utility for radiographically occult rib fractures in elderly fall-injured patients. J Trauma Acute Care Surg. 2019 Jan 23. PMID: 30676527.
    Citations:    Fields:    
  3. Uchimido R, Schmidt EP, Shapiro NI. The glycocalyx: a novel diagnostic and therapeutic target in sepsis. Crit Care. 2019 Jan 17; 23(1):16. PMID: 30654825.
    Citations:    Fields:    
  4. Roberts BW, Kilgannon JH, Hunter BR, Puskarich MA, Shea L, Donnino M, Jones C, Fuller BM, Kline JA, Jones AE, Shapiro NI, Abella BS, Trzeciak S. Association Between Elevated Mean Arterial Blood Pressure and Neurologic Outcome After Resuscitation From Cardiac Arrest: Results From a Multicenter Prospective Cohort Study. Crit Care Med. 2019 Jan; 47(1):93-100. PMID: 30303836.
    Citations:    Fields:    
  5. Tyler PD, Carey J, Stashko E, Levenson RB, Shapiro NI, Rosen CL. The Potential Role of Ultrasound in the Work-up of Appendicitis in the Emergency Department. J Emerg Med. 2019 Feb; 56(2):191-196. PMID: 30594351.
    Citations:    Fields:    
  6. Wang HE, Donnelly JP, Yende S, Levitan EB, Shapiro NI, Dai Y, Zhao H, Heiss G, Odden M, Newman A, Safford M. Validation of the REGARDS Severe Sepsis Risk Score. J Clin Med. 2018 Dec 11; 7(12). PMID: 30544923.
    Citations:    
  7. Jones AE, Puskarich MA, Shapiro NI, Guirgis FW, Runyon M, Adams JY, Sherwin R, Arnold R, Roberts BW, Kurz MC, Wang HE, Kline JA, Courtney DM, Trzeciak S, Sterling SA, Nandi U, Patki D, Viele K. Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock: The Rapid Administration of Carnitine in Sepsis (RACE) Randomized Clinical Trial. JAMA Netw Open. 2018 Dec 07; 1(8):e186076. PMID: 30646314.
    Citations:    
  8. Massey MJ, Hou PC, Filbin M, Wang H, Ngo L, Huang DT, Aird WC, Novack V, Trzeciak S, Yealy DM, Kellum JA, Angus DC, Shapiro NI. Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial. Crit Care. 2018 Nov 20; 22(1):308. PMID: 30458880.
    Citations:    Fields:    
  9. Hope Kilgannon J, Hunter BR, Puskarich MA, Shea L, Fuller BM, Jones C, Donnino M, Kline JA, Jones AE, Shapiro NI, Abella BS, Trzeciak S, Roberts BW. Partial pressure of arterial carbon dioxide after resuscitation from cardiac arrest and neurological outcome: A prospective multi-center protocol-directed cohort study. Resuscitation. 2019 Feb; 135:212-220. PMID: 30452939.
    Citations:    Fields:    
  10. Peyrony O, Shapiro NI. The 10 signs telling me that my cancer patient in the emergency department is at high risk of becoming critically ill. Intensive Care Med. 2018 Dec; 44(12):2315-2318. PMID: 30421252.
    Citations:    
  11. Self WH, Liu D, Strayer N, Russ S, Ward MJ, Shapiro NI, Rice TW, Semler MW. Charge Reductions Associated With Shorter Time to Recovery in Septic Shock. Chest. 2019 Feb; 155(2):315-321. PMID: 30419234.
    Citations:    Fields:    
  12. Vincent JL, Nielsen ND, Shapiro NI, Gerbasi ME, Grossman A, Doroff R, Zeng F, Young PJ, Russell JA. Mean arterial pressure and mortality in patients with distributive shock: a retrospective analysis of the MIMIC-III database. Ann Intensive Care. 2018 Nov 08; 8(1):107. PMID: 30411243.
    Citations:    
  13. Hippensteel JA, Shapiro NI, Schmidt EP. Challenging Dogma: The Value of Bolus Fluids in the Early Resuscitation of Hyperdynamic Sepsis. Am J Respir Crit Care Med. 2018 Oct 15; 198(8):981-983. PMID: 29940124.
    Citations:    Fields:    
  14. Fabian-Jessing BK, Massey MJ, Filbin MR, Hou PC, Wang HE, Kirkegaard H, Yealy DM, Aird WC, Kellum JA, Angus DC, Shapiro NI. In vivo quantification of rolling and adhered leukocytes in human sepsis. Crit Care. 2018 09 30; 22(1):240. PMID: 30268146.
    Citations:    Fields:    
  15. Skibsted S, Bhasin MK, Henning DJ, Jaminet SC, Lewandowski J, Kirkegaard H, Aird WC, Shapiro NI. Leukocyte Transcriptional Response in Sepsis. Shock. 2018 Sep 11. PMID: 30211758.
    Citations:    Fields:    
  16. Gurley KL, Grossman SA, Janes M, Yu-Moe CW, Song E, Tibbles CD, Shapiro NI, Rosen CL. Comparison of Emergency Medicine Malpractice Cases Involving Residents to Nonresident Cases. Acad Emerg Med. 2018 Sep; 25(9):980-986. PMID: 29665190.
    Citations:    Fields:    
  17. Kothari D, Babineau M, Hall M, Freedman SD, Shapiro NI, Sheth SG. Preventing Hospitalization in Mild Acute Pancreatitis Using a Clinical Pathway in the Emergency Department. J Clin Gastroenterol. 2018 Sep; 52(8):734-741. PMID: 29095424.
    Citations:    Fields:    
  18. Macdonald SP, Shapiro NI. Liberal or restricted fluid resuscitation in critical illness: Shifting the needle back towards equipoise. Emerg Med Australas. 2018 08; 30(4):446-447. PMID: 30129159.
    Citations:    Fields:    
  19. Filbin MR, Thorsen JE, Lynch J, Gillingham TD, Pasakarnis CL, Capp R, Shapiro NI, Mooncai T, Hou PC, Heldt T, Reisner AT. Challenges and Opportunities for Emergency Department Sepsis Screening at Triage. Sci Rep. 2018 Jul 23; 8(1):11059. PMID: 30038408.
    Citations:    Fields:    
  20. Shapiro NI, Self WH, Rosen J, Sharp SC, Filbin MR, Hou PC, Parekh AD, Kurz MC, Sambursky R. A prospective, multi-centre US clinical trial to determine accuracy of FebriDx point-of-care testing for acute upper respiratory infections with and without a confirmed fever. Ann Med. 2018 Aug; 50(5):420-429. PMID: 29775092.
    Citations:    Fields:    
  21. Fernando SM, Reardon PM, Rochwerg B, Shapiro NI, Yealy DM, Seely AJE, Perry JJ, Barnaby DP, Murphy K, Tanuseputro P, Kyeremanteng K. Sepsis-3 Septic Shock Criteria and Associated Mortality Among Infected Hospitalized Patients Assessed by a Rapid Response Team. Chest. 2018 Aug; 154(2):309-316. PMID: 29778659.
    Citations:    Fields:    
  22. Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, Yealy DM, Douglas IS, Shapiro NI. Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial. Ann Emerg Med. 2018 Oct; 72(4):457-466. PMID: 29753517.
    Citations:    Fields:    
  23. Goto T, Camargo CA, Gimenez-Zapiola C, Pallin DJ, Shapiro NI, Ferro TJ, Rainville C, Stoyanov S, Hasegawa K. Comparing Ran-Out Status of Inhaled Short-Acting Beta-Agonists in Emergency Department Patients with Acute Asthma: 1996-1998 versus 2015-2017. J Allergy Clin Immunol Pract. 2018 Nov - Dec; 6(6):1999-2005.e3. PMID: 29653218.
    Citations:    Fields:    
  24. Fernando SM, Barnaby DP, Herry CL, Gallagher EJ, Shapiro NI, Seely AJE. Helpful Only When Elevated: Initial Serum Lactate in Stable Emergency Department Patients with Sepsis Is Specific, but Not Sensitive for Future Deterioration. J Emerg Med. 2018 06; 54(6):766-773. PMID: 29548723.
    Citations:    Fields:    Translation:Humans
  25. Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM. Tie2 protects the vasculature against thrombus formation in systemic inflammation. J Clin Invest. 2018 Apr 02; 128(4):1471-1484. PMID: 29360642.
    Citations: 5     Fields:    
  26. Ince C, Boerma EC, Cecconi M, De Backer D, Shapiro NI, Duranteau J, Pinsky MR, Artigas A, Teboul JL, Reiss IKM, Aldecoa C, Hutchings SD, Donati A, Maggiorini M, Taccone FS, Hernandez G, Payen D, Tibboel D, Martin DS, Zarbock A, Monnet X, Dubin A, Bakker J, Vincent JL, Scheeren TWL. Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine. Intensive Care Med. 2018 03; 44(3):281-299. PMID: 29411044.
    Citations: 4     Fields:    
  27. Roberts BW, Kilgannon JH, Hunter BR, Puskarich MA, Pierce L, Donnino M, Leary M, Kline JA, Jones AE, Shapiro NI, Abella BS, Trzeciak S. Association Between Early Hyperoxia Exposure After Resuscitation From Cardiac Arrest and Neurological Disability: Prospective Multicenter Protocol-Directed Cohort Study. Circulation. 2018 May 15; 137(20):2114-2124. PMID: 29437118.
    Citations: 3     Fields:    
  28. Henning DJ, Kearney KE, Hall MK, Mahr C, Shapiro NI, Nichol G. Identification of Hypotensive Emergency Department Patients with Cardiogenic Etiologies. Shock. 2018 02; 49(2):131-136. PMID: 28719490.
    Citations: 1     Fields:    
  29. Macdonald SP, Williams JM, Shetty A, Bellomo R, Finfer S, Shapiro N, Keijzers G. Review article: Sepsis in the emergency department - Part 1: Definitions and outcomes. Emerg Med Australas. 2017 Dec; 29(6):619-625. PMID: 29094474.
    Citations:    Fields:    Translation:Humans
  30. Moskowitz A, Patel PV, Grossestreuer AV, Chase M, Shapiro NI, Berg K, Cocchi MN, Holmberg MJ, Donnino MW. Quick Sequential Organ Failure Assessment and Systemic Inflammatory Response Syndrome Criteria as Predictors of Critical Care Intervention Among Patients With Suspected Infection. Crit Care Med. 2017 11; 45(11):1813-1819. PMID: 28759474.
    Citations: 3     Fields:    Translation:Humans
  31. Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, van der Voort PHJ, Dondorp AM, Bafi T, Fries M, Akarsu-Ayazoglu T, Pranskunas A, Hollenberg S, Balestra G, van Iterson M, Sadaka F, Minto G, Aypar U, Hurtado FJ, Martinelli G, Payen D, van Haren F, Holley A, Gomez H, Mehta RL, Rodriguez AH, Ruiz C, Canales HS, Duranteau J, Spronk PE, Jhanji S, Hubble S, Chierego M, Jung C, Martin D, Sorbara C, Bakker J, Ince C. Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis. Crit Care. 2017 10 18; 21(1):255. PMID: 29047411.
    Citations:    Fields:    Translation:Humans
  32. Andersen MS, Howard E, Lu S, Richard M, Gregory M, Ogembo G, Mazor O, Gorelik P, Shapiro NI, Sharda AV, Ghiran I. Detection of membrane-bound and soluble antigens by magnetic levitation. Lab Chip. 2017 10 11; 17(20):3462-3473. PMID: 28905952.
    Citations: 1     Fields:    Translation:HumansCells
  33. Self WH, Rosen J, Sharp SC, Filbin MR, Hou PC, Parekh AD, Kurz MC, Shapiro NI. Diagnostic Accuracy of FebriDx: A Rapid Test to Detect Immune Responses to Viral and Bacterial Upper Respiratory Infections. J Clin Med. 2017 Oct 07; 6(10). PMID: 28991170.
    Citations: 1     
  34. Henning DJ, Shapiro NI. In reply. Ann Emerg Med. 2017 10; 70(4):601. PMID: 28946987.
    Citations:    Fields:    
  35. Schuetz P, Ebmeyer S, Johannes S, Wiemer JC, Schwabe A, Shapiro NI. The authors reply. Crit Care Med. 2017 Oct; 45(10):e1098-e1099. PMID: 28915194.
    Citations:    Fields:    
  36. Ganetsky M, Lopez G, Coreanu T, Novack V, Horng S, Shapiro NI, Bauer KA. Risk of Intracranial Hemorrhage in Ground-level Fall With Antiplatelet or Anticoagulant Agents. Acad Emerg Med. 2017 10; 24(10):1258-1266. PMID: 28475282.
    Citations: 1     Fields:    Translation:Humans
  37. Henning DJ, Carey JR, Oedorf K, Day DE, Redfield CS, Huguenel CJ, Roberts JC, Sanchez LD, Wolfe RE, Shapiro NI. The Absence of Fever Is Associated With Higher Mortality and Decreased Antibiotic and IV Fluid Administration in Emergency Department Patients With Suspected Septic Shock. Crit Care Med. 2017 Jun; 45(6):e575-e582. PMID: 28333759.
    Citations: 4     Fields:    Translation:Humans
  38. Jessen MK, Skibsted S, Shapiro NI. Number of organ dysfunctions predicts mortality in emergency department patients with suspected infection: a multicenter validation study. Eur J Emerg Med. 2017 Jun; 24(3):176-182. PMID: 26313315.
    Citations: 2     Fields:    Translation:Humans
  39. Schuetz P, Birkhahn R, Sherwin R, Jones AE, Singer A, Kline JA, Runyon MS, Self WH, Courtney DM, Nowak RM, Gaieski DF, Ebmeyer S, Johannes S, Wiemer JC, Schwabe A, Shapiro NI. Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study. Crit Care Med. 2017 May; 45(5):781-789. PMID: 28257335.
    Citations: 11     Fields:    Translation:Humans
  40. Horng S, Sontag DA, Halpern Y, Jernite Y, Shapiro NI, Nathanson LA. Creating an automated trigger for sepsis clinical decision support at emergency department triage using machine learning. PLoS One. 2017; 12(4):e0174708. PMID: 28384212.
    Citations: 4     Fields:    Translation:Humans
  41. Donnelly JP, Safford MM, Shapiro NI, Baddley JW, Wang HE. Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: a retrospective population-based cohort study. Lancet Infect Dis. 2017 06; 17(6):661-670. PMID: 28268067.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  42. Henning DJ, Puskarich MA, Self WH, Howell MD, Donnino MW, Yealy DM, Jones AE, Shapiro NI. An Emergency Department Validation of the SEP-3 Sepsis and Septic Shock Definitions and Comparison With 1992 Consensus Definitions. Ann Emerg Med. 2017 Oct; 70(4):544-552.e5. PMID: 28262318.
    Citations: 10     Fields:    Translation:Humans
  43. Kellum JA, Pike F, Yealy DM, Huang DT, Shapiro NI, Angus DC. Relationship Between Alternative Resuscitation Strategies, Host Response and Injury Biomarkers, and Outcome in Septic Shock: Analysis of the Protocol-Based Care for Early Septic Shock Study. Crit Care Med. 2017 Mar; 45(3):438-445. PMID: 28079606.
    Citations: 6     Fields:    Translation:Humans
  44. Donnelly JP, Nair S, Griffin R, Baddley JW, Safford MM, Wang HE, Shapiro NI. Association of Diabetes and Insulin Therapy With Risk of Hospitalization for Infection and 28-Day Mortality Risk. Clin Infect Dis. 2017 02 15; 64(4):435-442. PMID: 28174913.
    Citations:    Fields:    Translation:HumansPHPublic Health
  45. Cohen J, MacArthur KL, Atsawarungruangkit A, Perillo MC, Martin CR, Berzin TM, Shapiro NI, Sawhney MS, Freedman SD, Sheth SG. Defining the diagnostic value of hyperlipasemia for acute pancreatitis in the critically ill. Pancreatology. 2017 Mar - Apr; 17(2):176-181. PMID: 28237616.
    Citations:    Fields:    Translation:Humans
  46. Hou PC, Filbin MR, Wang H, Ngo L, Huang DT, Aird WC, Yealy DM, Angus DC, Kellum JA, Shapiro NI. Endothelial Permeability and Hemostasis in Septic Shock: Results From the ProCESS Trial. Chest. 2017 07; 152(1):22-31. PMID: 28109962.
    Citations: 3     Fields:    Translation:HumansCells
  47. Oedorf K, Day DE, Lior Y, Novack V, Sanchez LD, Wolfe RE, Kirkegaard H, Shapiro NI, Henning DJ. Serum Lactate Predicts Adverse Outcomes in Emergency Department Patients With and Without Infection. West J Emerg Med. 2017 Feb; 18(2):258-266. PMID: 28210362.
    Citations: 2     Fields:    Translation:Humans
  48. Hou P, Linde-Zwirble W, Sahatjian J, Hansell D, Shapiro N. 1419: ASSOCIATION OF FLUIDS AND OUCOMES IN ED PATIENTS HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA. Crit Care Med. 2016 Dec; 44(12 Suppl 1):430. PMID: 27851055.
    Citations:    
  49. Handy B, Jones P, Ostlund R, Schuetz P, Schwabe A, Johannes S, Sherman J, Shapiro N. 1440: VALIDATION OF THE ELECSYS BRAHMS PROCALCITONIN ASSAY IN PATIENTS WITH SEVERE SEPSIS OR SEPTIC SHOCK. Crit Care Med. 2016 Dec; 44(12 Suppl 1):435. PMID: 27851076.
    Citations:    
  50. Stowell CP, Whitman G, Granger S, Gomez H, Assmann SF, Massey MJ, Shapiro NI, Steiner ME, Bennett-Guerrero E. The impact of red blood cell storage duration on tissue oxygenation in cardiac surgery. J Thorac Cardiovasc Surg. 2017 Mar; 153(3):610-619.e2. PMID: 28027790.
    Citations: 2     Fields:    
  51. Wong ML, Chiu D, Shapiro NI, Grossman SA. Utility of Chest Radiography in Emergency Department Patients Presenting with Syncope. West J Emerg Med. 2016 Nov; 17(6):698-701. PMID: 27833675.
    Citations:    Fields:    Translation:Humans
  52. Limkakeng AT, Monte AA, Kabrhel C, Puskarich M, Heitsch L, Tsalik EL, Shapiro NI. Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine? Acad Emerg Med. 2016 10; 23(10):1097-1106. PMID: 27288269.
    Citations:    Fields:    Translation:Humans
  53. Atefi G, Aisiku O, Shapiro N, Hauser C, Dalle Lucca J, Flaumenhaft R, Tsokos GC. Complement Activation in Trauma Patients Alters Platelet Function. Shock. 2016 09; 46(3 Suppl 1):83-8. PMID: 27355402.
    Citations: 2     Fields:    Translation:HumansCells
  54. Hou PC, Filbin MR, Napoli A, Feldman J, Pang PS, Sankoff J, Lo BM, Dickey-White H, Birkhahn RH, Shapiro NI. Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Patients with Sepsis. Shock. 2016 08; 46(2):132-8. PMID: 26925867.
    Citations: 1     Fields:    Translation:Humans
  55. Wang HE, Donnelly JP, Griffin R, Levitan EB, Shapiro NI, Howard G, Safford MM. Derivation of Novel Risk Prediction Scores for Community-Acquired Sepsis and Severe Sepsis. Crit Care Med. 2016 07; 44(7):1285-94. PMID: 27031381.
    Citations: 6     Fields:    Translation:Humans
  56. Day DE, Shapiro NI, Henning DJ. The Utility of Inflammatory and Endothelial Markers to Identify Infection in Emergency Department Patients. Shock. 2016 07; 46(1):108-9. PMID: 26849626.
    Citations:    Fields:    Translation:Humans
  57. Henning DJ, Carey JR, Oedorf K, Day DE, Redfield CS, Huguenel CJ, Roberts JC, Novack V, Sanchez LD, Wolfe RE, Shapiro NI. Assessing The Predictive Value of Clinical Factors Used to Determine The Presence of Sepsis Causing Shock in the Emergency Department. Shock. 2016 07; 46(1):27-32. PMID: 26752661.
    Citations:    Fields:    Translation:Humans
  58. Cartwright M, Rottman M, Shapiro NI, Seiler B, Lombardo P, Gamini N, Tomolonis J, Watters AL, Waterhouse A, Leslie D, Bolgen D, Graveline A, Kang JH, Didar T, Dimitrakakis N, Cartwright D, Super M, Ingber DE. A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood. EBioMedicine. 2016 Jul; 9:217-227. PMID: 27333027; PMCID: PMC4972566.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  59. Puskarich MA, Shapiro NI, Massey MJ, Kline JA, Jones AE. Lactate Clearance in Septic Shock Is Not a Surrogate for Improved Microcirculatory Flow. Acad Emerg Med. 2016 06; 23(6):690-3. PMID: 26825368.
    Citations: 2     Fields:    Translation:Humans
  60. Henning DJ, Shapiro NI. Goal-Directed Resuscitation in Septic Shock: A Critical Analysis. Clin Chest Med. 2016 06; 37(2):231-9. PMID: 27229640.
    Citations:    Fields:    Translation:Humans
  61. Pollack CV, Diercks DB, Thomas SH, Shapiro NI, Fanikos J, Mace SE, Rafique Z, Todd KH. Patient-reported Outcomes from A National, Prospective, Observational Study of Emergency Department Acute Pain Management With an Intranasal Nonsteroidal Anti-inflammatory Drug, Opioids, or Both. Acad Emerg Med. 2016 Mar; 23(3):331-41. PMID: 26782787.
    Citations:    Fields:    Translation:Humans
  62. Massey MJ, Shapiro NI. A guide to human in vivo microcirculatory flow image analysis. Crit Care. 2016 Feb 10; 20:35. PMID: 26861691; PMCID: PMC4748457.
    Citations: 9     Fields:    Translation:Humans
  63. Jessen MK, Mackenhauer J, Hvass AM, Ellermann-Eriksen S, Skibsted S, Kirkegaard H, Schønheyder HC, Shapiro NI. Prediction of bacteremia in the emergency department: an external validation of a clinical decision rule. Eur J Emerg Med. 2016 Feb; 23(1):44-9. PMID: 25222426.
    Citations: 2     Fields:    Translation:Humans
  64. Khoory J, Estanislau J, Elkhal A, Lazaar A, Melhorn MI, Brodsky A, Illigens B, Hamachi I, Kurishita Y, Ivanov AR, Shevkoplyas S, Shapiro NI, Ghiran IC. Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function. PLoS One. 2016; 11(1):e0141206. PMID: 26784696.
    Citations: 6     Fields:    Translation:HumansCells
  65. Sambursky R, Shapiro N. Evaluation of a combined MxA and CRP point-of-care immunoassay to identify viral and/or bacterial immune response in patients with acute febrile respiratory infection. Eur Clin Respir J. 2015; 2:28245. PMID: 26672961; PMCID: PMC4676840.
    Citations: 4     
  66. Grossman AM, Volz KA, Shapiro NI, Salem R, Sanchez LD, Smulowitz P, Grossman SA. Comparison of 1-Day Emergency Department Observation and Inpatient Ward for 1-Day Admissions in Syncope Patients. J Emerg Med. 2016 Feb; 50(2):217-22. PMID: 26682847.
    Citations: 1     Fields:    Translation:Humans
  67. Henning DJ, Oedorf K, Day DE, Redfield CS, Huguenel CJ, Roberts JC, Sanchez LD, Wolfe RE, Shapiro NI. Derivation and Validation of Predictive Factors for Clinical Deterioration after Admission in Emergency Department Patients Presenting with Abnormal Vital Signs Without Shock. West J Emerg Med. 2015 Dec; 16(7):1059-66. PMID: 26759655.
    Citations: 3     Fields:    Translation:Humans
  68. Gavillet M, Martinod K, Renella R, Harris C, Shapiro NI, Wagner DD, Williams DA. Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples. Am J Hematol. 2015 Dec; 90(12):1155-8. PMID: 26347989; PMCID: PMC4715743.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  69. Day DE, Oedorf K, Kogan S, Novack V, Sanchez LD, Wolfe RE, Shapiro NI, Henning DJ. The Utility of Inflammatory and Endothelial Markers to Identify Infection in Emergency Department Patients. Shock. 2015 Sep; 44(3):215-20. PMID: 26009826.
    Citations: 1     Fields:    Translation:HumansCells
  70. Lin M, Wolfe RE, Shapiro NI, Novack V, Lior Y, Grossman SA. Observation vs admission in syncope: can we predict short length of stays? Am J Emerg Med. 2015 Nov; 33(11):1684-6. PMID: 26342395.
    Citations: 2     Fields:    Translation:Humans
  71. Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, Zhang J, Robson SC, Shapiro NI, Junger WG. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016 Feb 01; 213(3):456-64. PMID: 26150546; PMCID: PMC4704665.
    Citations: 5     Fields:    Translation:HumansCells
  72. Kristensen AK, Holler JG, Hallas J, Lassen A, Shapiro NI. Is Shock Index a Valid Predictor of Mortality in Emergency Department Patients With Hypertension, Diabetes, High Age, or Receipt of ß- or Calcium Channel Blockers? Ann Emerg Med. 2016 Jan; 67(1):106-113.e6. PMID: 26144893.
    Citations: 6     Fields:    Translation:Humans
  73. Chasm RM, Pei YV, Pallin DJ, Shapiro N, Snyder B, Sullivan AF, Camargo CA, Hasegawa K. Sex differences in risk of hospitalization among emergency department patients with acute asthma. Ann Allergy Asthma Immunol. 2015 Jul; 115(1):70-2.e1. PMID: 25956241.
    Citations: 1     Fields:    Translation:Humans
  74. Troyer JL, Jones AE, Shapiro NI, Mitchell AM, Hewer I, Kline JA. Cost-effectiveness of quantitative pretest probability intended to reduce unnecessary medical radiation exposure in emergency department patients with chest pain and dyspnea. Acad Emerg Med. 2015 May; 22(5):525-35. PMID: 25899550.
    Citations: 1     Fields:    Translation:Humans
  75. Wang HE, Addis DR, Donnelly JP, Shapiro NI, Griffin RL, Safford MM, Baddley JW. Discharge diagnoses versus medical record review in the identification of community-acquired sepsis. Crit Care. 2015 Feb 16; 19:42. PMID: 25879803; PMCID: PMC4340494.
    Citations: 10     Fields:    Translation:Humans
  76. Vellinga NA, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Machado FR, Fries M, Akarsu-Ayazoglu T, Pranskunas A, Hollenberg S, Balestra G, van Iterson M, van der Voort PH, Sadaka F, Minto G, Aypar U, Hurtado FJ, Martinelli G, Payen D, van Haren F, Holley A, Pattnaik R, Gomez H, Mehta RL, Rodriguez AH, Ruiz C, Canales HS, Duranteau J, Spronk PE, Jhanji S, Hubble S, Chierego M, Jung C, Martin D, Sorbara C, Tijssen JG, Bakker J, Ince C. International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med. 2015 Jan; 43(1):48-56. PMID: 25126880.
    Citations: 21     Fields:    Translation:Humans
  77. Shogilev DJ, Duus N, Odom SR, Shapiro NI. Diagnosing appendicitis: evidence-based review of the diagnostic approach in 2014. West J Emerg Med. 2014 Nov; 15(7):859-71. PMID: 25493136; PMCID: PMC4251237.
    Citations: 18     Fields:    Translation:Humans
  78. Wang HE, Griffin R, Shapiro NI, Howard G, Safford MM. Chronic Statin Use and Long-Term Rates of Sepsis: A Population-Based Cohort Study. J Intensive Care Med. 2016 Jul; 31(6):386-96. PMID: 25223827; PMCID: PMC5038131.
    Citations: 5     Fields:    Translation:Humans
  79. Singer AJ, Taylor M, Domingo A, Ghazipura S, Khorasonchi A, Thode HC, Shapiro NI. Diagnostic characteristics of a clinical screening tool in combination with measuring bedside lactate level in emergency department patients with suspected sepsis. Acad Emerg Med. 2014 Aug; 21(8):853-7. PMID: 25155163.
    Citations: 8     Fields:    Translation:Humans
  80. Duus N, Shogilev DJ, Skibsted S, Zijlstra HW, Fish E, Oren-Grinberg A, Lior Y, Novack V, Talmor D, Kirkegaard H, Shapiro NI. The reliability and validity of passive leg raise and fluid bolus to assess fluid responsiveness in spontaneously breathing emergency department patients. J Crit Care. 2015 Feb; 30(1):217.e1-5. PMID: 25262530.
    Citations: 8     Fields:    Translation:Humans
  81. Ginde AA, Blatchford PJ, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Rivers EP, Shapiro NI. Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis. Shock. 2014 Aug; 42(2):99-107. PMID: 24978893; PMCID: PMC4101036.
    Citations: 5     Fields:    Translation:Humans
  82. Ledderose C, Bao Y, Lidicky M, Zipperle J, Li L, Strasser K, Shapiro NI, Junger WG. Mitochondria are gate-keepers of T cell function by producing the ATP that drives purinergic signaling. J Biol Chem. 2014 Sep 12; 289(37):25936-45. PMID: 25070895; PMCID: PMC4162192.
    Citations: 23     Fields:    Translation:HumansCells
  83. Wang HE, Donnelly JP, Shapiro NI, Hohmann SF, Levitan EB. Hospital variations in severe sepsis mortality. Am J Med Qual. 2015 Jul-Aug; 30(4):328-36. PMID: 24814940.
    Citations: 4     Fields:    Translation:Humans
  84. Muroya T, Kannan L, Ghiran IC, Shevkoplyas SS, Paz Z, Tsokos M, Dalle Lucca JJ, Shapiro NI, Tsokos GC. C4d deposits on the surface of RBCs in trauma patients and interferes with their function. Crit Care Med. 2014 May; 42(5):e364-72. PMID: 24448198; PMCID: PMC4099476.
    Citations: 4     Fields:    Translation:HumansCells
  85. Skibsted S, Shapiro NI. Transcriptomics may pave the biomarker road in sepsis*. Crit Care Med. 2014 Apr; 42(4):974-5. PMID: 24633092.
    Citations: 1     Fields:    Translation:Humans
  86. Chiu DT, Shapiro NI, Sun BC, Mottley JL, Grossman SA. Are echocardiography, telemetry, ambulatory electrocardiography monitoring, and cardiac enzymes in emergency department patients presenting with syncope useful tests? A preliminary investigation. J Emerg Med. 2014 Jul; 47(1):113-8. PMID: 24698512.
    Citations: 4     Fields:    Translation:Humans
  87. Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014 May 01; 370(18):1683-93. PMID: 24635773.
    Citations: 452     Fields:    Translation:Humans
  88. Peitz GW, Troyer J, Jones AE, Shapiro NI, Nelson RD, Hernandez J, Kline JA. Association of body mass index with increased cost of care and length of stay for emergency department patients with chest pain and dyspnea. Circ Cardiovasc Qual Outcomes. 2014 Mar; 7(2):292-8. PMID: 24594550.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  89. Zonneveld R, Martinelli R, Shapiro NI, Kuijpers TW, Plötz FB, Carman CV. Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults. Crit Care. 2014 Feb 18; 18(2):204. PMID: 24602331; PMCID: PMC4014977.
    Citations: 31     Fields:    Translation:Humans
  90. Kennedy M, Enander RA, Tadiri SP, Wolfe RE, Shapiro NI, Marcantonio ER. Delirium risk prediction, healthcare use and mortality of elderly adults in the emergency department. J Am Geriatr Soc. 2014 Mar; 62(3):462-9. PMID: 24512171; PMCID: PMC3959285.
    Citations: 9     Fields:    Translation:Humans
  91. Filbin MR, Hou PC, Massey M, Barche A, Kao E, Bracey A, Skibsted S, Chang Y, Shapiro NI. The microcirculation is preserved in emergency department low-acuity sepsis patients without hypotension. Acad Emerg Med. 2014 Feb; 21(2):154-62. PMID: 24673671.
    Citations: 5     Fields:    Translation:Humans
  92. Wang HE, Szychowski JM, Griffin R, Safford MM, Shapiro NI, Howard G. Long-term mortality after community-acquired sepsis: a longitudinal population-based cohort study. BMJ Open. 2014 Jan 17; 4(1):e004283. PMID: 24441058; PMCID: PMC3902401.
    Citations: 18     Fields:    Translation:Humans
  93. Wiener Z, Chiu DT, Shapiro NI, Grossman SA. Substance abuse in emergency department patients with unexplained syncope. Intern Emerg Med. 2014 Apr; 9(3):331-4. PMID: 24297764.
    Citations:    Fields:    Translation:Humans
  94. Kline JA, Jones AE, Shapiro NI, Hernandez J, Hogg MM, Troyer J, Nelson RD. Multicenter, randomized trial of quantitative pretest probability to reduce unnecessary medical radiation exposure in emergency department patients with chest pain and dyspnea. Circ Cardiovasc Imaging. 2014 Jan; 7(1):66-73. PMID: 24275953.
    Citations: 7     Fields:    Translation:Humans
  95. Kline JA, Shapiro NI, Jones AE, Hernandez J, Hogg MM, Troyer J, Nelson RD. Outcomes and radiation exposure of emergency department patients with chest pain and shortness of breath and ultralow pretest probability: a multicenter study. Ann Emerg Med. 2014 Mar; 63(3):281-8. PMID: 24120629.
    Citations: 2     Fields:    Translation:Humans
  96. Skibsted S, Bhasin MK, Aird WC, Shapiro NI. Bench-to-bedside review: future novel diagnostics for sepsis - a systems biology approach. Crit Care. 2013 Oct 04; 17(5):231. PMID: 24093155; PMCID: PMC4057467.
    Citations: 15     Fields:    Translation:Humans
  97. Shapiro NI, Angus DC. A review of therapeutic attempts to recruit the microcirculation in patients with sepsis. Minerva Anestesiol. 2014 Feb; 80(2):225-35. PMID: 24002463.
    Citations: 3     Fields:    Translation:Humans
  98. Massey MJ, Larochelle E, Najarro G, Karmacharla A, Arnold R, Trzeciak S, Angus DC, Shapiro NI. The microcirculation image quality score: development and preliminary evaluation of a proposed approach to grading quality of image acquisition for bedside videomicroscopy. J Crit Care. 2013 Dec; 28(6):913-7. PMID: 23972316.
    Citations: 21     Fields:    Translation:Humans
  99. Grossman SA, Chiu D, Lipsitz L, Mottley JL, Shapiro NI. Can elderly patients without risk factors be discharged home when presenting to the emergency department with syncope? Arch Gerontol Geriatr. 2014 Jan-Feb; 58(1):110-4. PMID: 23993263.
    Citations: 2     Fields:    Translation:Humans
  100. Wang HE, Shapiro NI, Safford MM, Griffin R, Judd S, Rodgers JB, Warnock DG, Cushman M, Howard G. High-sensitivity C-reactive protein and risk of sepsis. PLoS One. 2013; 8(7):e69232. PMID: 23935961; PMCID: PMC3720576.
    Citations: 17     Fields:    Translation:Humans
  101. Omar YG, Massey M, Andersen LW, Giberson TA, Berg K, Cocchi MN, Shapiro NI, Donnino MW. Sublingual microcirculation is impaired in post-cardiac arrest patients. Resuscitation. 2013 Dec; 84(12):1717-22. PMID: 23871865; PMCID: PMC3864773.
    Citations: 7     Fields:    Translation:Humans
  102. Wang HE, Griffin R, Judd S, Shapiro NI, Safford MM. Obesity and risk of sepsis: a population-based cohort study. Obesity (Silver Spring). 2013 Dec; 21(12):E762-9. PMID: 23526732; PMCID: PMC3795990.
    Citations: 13     Fields:    Translation:Humans
  103. Skibsted S, Arnold R, Sherwin R, Singh S, Lundy D, Nelson T, Puskarich MA, Trzeciak S, Jones AE, Shapiro NI. The association of near infrared spectroscopy-derived StO2 measurements and biomarkers of endothelial activation in sepsis. Intern Emerg Med. 2013 Sep; 8(6):529-36. PMID: 23824446.
    Citations: 1     Fields:    Translation:Humans
  104. Sterling SA, Puskarich MA, Shapiro NI, Trzeciak S, Kline JA, Summers RL, Jones AE. Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock. Shock. 2013 Jul; 40(1):11-4. PMID: 23649098; PMCID: PMC3982587.
    Citations: 8     Fields:    Translation:Humans
  105. Traub SJ, Mitchell AM, Jones AE, Tang A, O'Connor J, Nelson T, Kellum J, Shapiro NI. N-acetylcysteine plus intravenous fluids versus intravenous fluids alone to prevent contrast-induced nephropathy in emergency computed tomography. Ann Emerg Med. 2013 Nov; 62(5):511-520.e25. PMID: 23769807.
    Citations: 6     Fields:    Translation:Humans
  106. Puskarich MA, Trzeciak S, Shapiro NI, Albers AB, Heffner AC, Kline JA, Jones AE. Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest. 2013 Jun; 143(6):1548-1553. PMID: 23740148; PMCID: PMC3673659.
    Citations: 33     Fields:    Translation:Humans
  107. Zhang G, Yang L, Kim GS, Ryan K, Lu S, O'Donnell RK, Spokes K, Shapiro N, Aird WC, Kluk MJ, Yano K, Sanchez T. Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood. 2013 Jul 18; 122(3):443-55. PMID: 23723450; PMCID: PMC3716205.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  108. Ginde AA, Moss M, Shapiro NI, Schwartz RS. Impact of older age and nursing home residence on clinical outcomes of US emergency department visits for severe sepsis. J Crit Care. 2013 Oct; 28(5):606-11. PMID: 23683561; PMCID: PMC3770757.
    Citations: 8     Fields:    Translation:Humans
  109. Wiener Z, Shapiro NI, Chiu DT, Grossman SA. The prevalence of psychiatric disease in emergency department patients with unexplained syncope. Intern Emerg Med. 2013 Aug; 8(5):427-30. PMID: 23645509.
    Citations:    Fields:    Translation:Humans
  110. Skibsted S, Jones AE, Puskarich MA, Arnold R, Sherwin R, Trzeciak S, Schuetz P, Aird WC, Shapiro NI. Biomarkers of endothelial cell activation in early sepsis. Shock. 2013 May; 39(5):427-32. PMID: 23524845; PMCID: PMC3670087.
    Citations: 33     Fields:    Translation:HumansCells
  111. Arnold RC, Sherwin R, Shapiro NI, O'Connor JL, Glaspey L, Singh S, Medado P, Trzeciak S, Jones AE. Multicenter observational study of the development of progressive organ dysfunction and therapeutic interventions in normotensive sepsis patients in the emergency department. Acad Emerg Med. 2013 May; 20(5):433-40. PMID: 23672356.
    Citations: 12     Fields:    Translation:Humans
  112. Odom SR, Howell MD, Silva GS, Nielsen VM, Gupta A, Shapiro NI, Talmor D. Lactate clearance as a predictor of mortality in trauma patients. J Trauma Acute Care Surg. 2013 Apr; 74(4):999-1004. PMID: 23511137.
    Citations: 31     Fields:    Translation:Humans
  113. Berger T, Green J, Horeczko T, Hagar Y, Garg N, Suarez A, Panacek E, Shapiro N. Shock index and early recognition of sepsis in the emergency department: pilot study. West J Emerg Med. 2013 Mar; 14(2):168-74. PMID: 23599863; PMCID: PMC3628475.
    Citations: 15     Fields:    
  114. Wang HE, Shapiro NI, Griffin R, Safford MM, Judd S, Howard G. Inflammatory and endothelial activation biomarkers and risk of sepsis: a nested case-control study. J Crit Care. 2013 Oct; 28(5):549-55. PMID: 23414982; PMCID: PMC3814035.
    Citations: 17     Fields:    Translation:Humans
  115. Kashani K, Al-Khafaji A, Ardiles T, Artigas A, Bagshaw SM, Bell M, Bihorac A, Birkhahn R, Cely CM, Chawla LS, Davison DL, Feldkamp T, Forni LG, Gong MN, Gunnerson KJ, Haase M, Hackett J, Honore PM, Hoste EA, Joannes-Boyau O, Joannidis M, Kim P, Koyner JL, Laskowitz DT, Lissauer ME, Marx G, McCullough PA, Mullaney S, Ostermann M, Rimmelé T, Shapiro NI, Shaw AD, Shi J, Sprague AM, Vincent JL, Vinsonneau C, Wagner L, Walker MG, Wilkerson RG, Zacharowski K, Kellum JA. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care. 2013 Feb 06; 17(1):R25. PMID: 23388612; PMCID: PMC4057242.
    Citations: 200     Fields:    Translation:HumansCTClinical Trials
  116. Traub SJ, Kellum JA, Tang A, Cataldo L, Kancharla A, Shapiro NI. Risk factors for radiocontrast nephropathy after emergency department contrast-enhanced computerized tomography. Acad Emerg Med. 2013 Jan; 20(1):40-5. PMID: 23570477.
    Citations: 6     Fields:    Translation:Humans
  117. Volz KA, Canham L, Kaplan E, Sanchez LD, Shapiro NI, Grossman SA. Identifying patients with cellulitis who are likely to require inpatient admission after a stay in an ED observation unit. Am J Emerg Med. 2013 Feb; 31(2):360-4. PMID: 23158603.
    Citations: 6     Fields:    Translation:Humans
  118. David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM. Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med. 2012 Nov; 40(11):3034-41. PMID: 22890252; PMCID: PMC3705559.
    Citations: 51     Fields:    Translation:HumansAnimals
  119. Grossman SA, Babineau M, Kulchycki L, Mottley L, Kancharla A, Nencioni A, Shapiro N. Further thoughts on whether outcomes of near syncope parallel syncope. Am J Emerg Med. 2012 Nov; 30(9):2064. PMID: 23158060.
    Citations:    
  120. Wang HE, Shapiro NI, Griffin R, Safford MM, Judd S, Howard G. Chronic medical conditions and risk of sepsis. PLoS One. 2012; 7(10):e48307. PMID: 23118977; PMCID: PMC3485139.
    Citations: 29     Fields:    Translation:Humans
  121. Mahler SA, Miller CD, Hollander JE, Nagurney JT, Birkhahn R, Singer AJ, Shapiro NI, Glynn T, Nowak R, Safdar B, Peberdy M, Counselman FL, Chandra A, Kosowsky J, Neuenschwander J, Schrock JW, Plantholt S, Diercks DB, Peacock WF. Identifying patients for early discharge: performance of decision rules among patients with acute chest pain. Int J Cardiol. 2013 Sep 30; 168(2):795-802. PMID: 23117012; PMCID: PMC3565031.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  122. Singer AJ, Thode HC, Peacock WF, Hollander JE, Diercks D, Birkhahn R, Shapiro N, Glynn T, Nowack R, Safdar B, Miller C, Lewandrowski E, Nagurney J. The association between self-reported exercise intensity and acute coronary syndrome in emergency department chest pain patients. J Emerg Med. 2013 Jan; 44(1):17-22. PMID: 23103065.
    Citations: 2     Fields:    Translation:Humans
  123. Puskarich MA, Shapiro NI, Trzeciak S, Kline JA, Jones AE. Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsis. Shock. 2012 Oct; 38(4):337-40. PMID: 22777124; PMCID: PMC3664931.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  124. Grossman SA, Babineau M, Burke L, Kancharla A, Mottley L, Nencioni A, Shapiro NI. Applying the Boston syncope criteria to near syncope. J Emerg Med. 2012 Dec; 43(6):958-63. PMID: 22981659.
    Citations: 2     Fields:    Translation:Humans
  125. Chase M, Klasco RS, Joyce NR, Donnino MW, Wolfe RE, Shapiro NI. Predictors of bacteremia in emergency department patients with suspected infection. Am J Emerg Med. 2012 Nov; 30(9):1691-7. PMID: 22626814.
    Citations: 4     Fields:    Translation:HumansCells
  126. Schuetz P, Kennedy M, Lucas JM, Howell MD, Aird WC, Yealy DM, Shapiro NI. Initial management of septic patients with hyperglycemia in the noncritical care inpatient setting. Am J Med. 2012 Jul; 125(7):670-8. PMID: 22608986.
    Citations: 10     Fields:    Translation:Humans
  127. Arnold RC, Dellinger RP, Parrillo JE, Chansky ME, Lotano VE, McCoy JV, Jones AE, Shapiro NI, Hollenberg SM, Trzeciak S. Discordance between microcirculatory alterations and arterial pressure in patients with hemodynamic instability. J Crit Care. 2012 Oct; 27(5):531.e1-7. PMID: 22591569.
    Citations: 7     Fields:    Translation:Humans
  128. Vellinga NA, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Bakker J, Ince C. Study Design of the Microcirculatory Shock Occurrence in Acutely Ill Patients (microSOAP): an International Multicenter Observational Study of Sublingual Microcirculatory Alterations in Intensive Care Patients. Crit Care Res Pract. 2012; 2012:121752. PMID: 22666566; PMCID: PMC3359769.
    Citations: 2     
  129. van Meurs M, Castro P, Shapiro NI, Lu S, Yano M, Maeda N, Funahashi T, Shimomura I, Zijlstra JG, Molema G, Parikh SM, Aird WC, Yano K. Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis. Shock. 2012 Apr; 37(4):392-8. PMID: 22258235.
    Citations: 8     Fields:    Translation:AnimalsCells
  130. Roberson RS, Lockhart E, Shapiro NI, Bandarenko N, McMahon TJ, Massey MJ, White WD, Bennett-Guerrero E. Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. Transfusion. 2012 Nov; 52(11):2459-64. PMID: 22452273; PMCID: PMC3387324.
    Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
  131. Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Heffner AC, Kline JA, Jones AE. Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. Acad Emerg Med. 2012 Mar; 19(3):252-8. PMID: 22435856; PMCID: PMC3313083.
    Citations: 22     Fields:    Translation:Humans
  132. Kilgannon JH, Trzeciak S, Parrillo JE, Dellinger RP, Milcarek B, Hunter K, Jones AE, Shapiro NI. Reply to letters regarding article, "relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest". Circulation. 2012 Jan 24; 125(3):e289. PMID: 22271855.
    Citations:    
  133. Diercks DB, Peacock WF, Hollander JE, Singer AJ, Birkhahn R, Shapiro N, Glynn T, Nowack R, Safdar B, Miller CD, Lewandrowski E, Nagurney JT. Diagnostic accuracy of a point-of-care troponin I assay for acute myocardial infarction within 3 hours after presentation in early presenters to the emergency department with chest pain. Am Heart J. 2012 Jan; 163(1):74-80.e4. PMID: 22172439.
    Citations: 6     Fields:    Translation:Humans
  134. Wang HE, Shapiro NI, Yealy DM. Characteristics of out-of-hospital shock care. Crit Care Med. 2011 Nov; 39(11):2431-9. PMID: 21705898.
    Citations: 3     Fields:    Translation:Humans
  135. Peacock WF, Nagurney J, Birkhahn R, Singer A, Shapiro N, Hollander J, Glynn T, Nowak R, Safdar B, Miller C, Peberdy M, Counselman F, Chandra A, Kosowsky J, Neuenschwander J, Schrock J, Plantholt S, Lewandrowski E, Wong V, Kupfer K, Diercks D. Myeloperoxidase in the diagnosis of acute coronary syndromes: the importance of spectrum. Am Heart J. 2011 Nov; 162(5):893-9. PMID: 22093206.
    Citations: 7     Fields:    Translation:Humans
  136. Shapiro NI, Arnold R, Sherwin R, O'Connor J, Najarro G, Singh S, Lundy D, Nelson T, Trzeciak SW, Jones AE. The association of near-infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency department patients with sepsis. Crit Care. 2011; 15(5):R223. PMID: 21939529; PMCID: PMC3334769.
    Citations: 27     Fields:    Translation:HumansCTClinical Trials
  137. Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Horton JM, Studnek JR, Kline JA, Jones AE. Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med. 2011 Sep; 39(9):2066-71. PMID: 21572327; PMCID: PMC3158284.
    Citations: 60     Fields:    Translation:Humans
  138. Schuetz P, Jones AE, Aird WC, Shapiro NI. Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock. 2011 Aug; 36(2):104-8. PMID: 21522043; PMCID: PMC3139767.
    Citations: 14     Fields:    Translation:HumansCells
  139. Houlié N, Occhipinti G, Blanchard T, Shapiro N, Lognonné P, Murakami M. New approach to detect seismic surface waves in 1Hz-sampled GPS time series. Sci Rep. 2011; 1:44. PMID: 22355563; PMCID: PMC3216531.
    Citations: 2     Fields:    Translation:PHPublic Health
  140. Grossman SA, Shapiro NI, Mottley JL, Sanchez L, Ullman E, Wolfe RE. Is telemetry useful in evaluating chest pain patients in an observation unit? Intern Emerg Med. 2011 Dec; 6(6):543-6. PMID: 21739228.
    Citations: 2     Fields:    Translation:Humans
  141. Puskarich MA, Trzeciak S, Shapiro NI, Heffner AC, Kline JA, Jones AE. Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation. 2011 Oct; 82(10):1289-93. PMID: 21752522; PMCID: PMC3179778.
    Citations: 27     Fields:    Translation:Humans
  142. Schuetz P, Jones AE, Howell MD, Trzeciak S, Ngo L, Younger JG, Aird W, Shapiro NI. Diabetes is not associated with increased mortality in emergency department patients with sepsis. Ann Emerg Med. 2011 Nov; 58(5):438-44. PMID: 21683473; PMCID: PMC3425373.
    Citations: 10     Fields:    Translation:Humans
  143. Kilgannon JH, Jones AE, Parrillo JE, Dellinger RP, Milcarek B, Hunter K, Shapiro NI, Trzeciak S. Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation. 2011 Jun 14; 123(23):2717-22. PMID: 21606393.
    Citations: 51     Fields:    Translation:Humans
  144. McGillicuddy DC, O'Connell FJ, Shapiro NI, Calder SA, Mottley LJ, Roberts JC, Sanchez LD. Emergency department abnormal vital sign "triggers" program improves time to therapy. Acad Emerg Med. 2011 May; 18(5):483-7. PMID: 21521399.
    Citations: 8     Fields:    Translation:Humans
  145. Ginde AA, Camargo CA, Shapiro NI. Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad Emerg Med. 2011 May; 18(5):551-4. PMID: 21518095.
    Citations: 22     Fields:    Translation:Humans
  146. Grossman SA, Bar J, Fischer C, Lipsitz LA, Mottley L, Sands K, Zimetbaum P, Shapiro NI. Reducing admissions utilizing the Boston Syncope Criteria. J Emerg Med. 2012 Mar; 42(3):345-52. PMID: 21421292.
    Citations: 3     Fields:    Translation:Humans
  147. Shapiro NI, Aird WC. Sepsis and the broken endothelium. Crit Care. 2011 Mar 21; 15(2):135. PMID: 21457513; PMCID: PMC3219316.
    Citations: 6     Fields:    Translation:Humans
  148. Schuetz P, Castro P, Shapiro NI. Diabetes and sepsis: preclinical findings and clinical relevance. Diabetes Care. 2011 Mar; 34(3):771-8. PMID: 21357364; PMCID: PMC3041224.
    Citations: 17     Fields:    Translation:Humans
  149. Schuetz P, Yano K, Sorasaki M, Ngo L, St Hilaire M, Lucas JM, Aird W, Shapiro NI. Influence of diabetes on endothelial cell response during sepsis. Diabetologia. 2011 May; 54(5):996-1003. PMID: 21286681.
    Citations: 8     Fields:    Translation:Humans
  150. Howell MD, Talmor D, Schuetz P, Hunziker S, Jones AE, Shapiro NI. Proof of principle: the predisposition, infection, response, organ failure sepsis staging system. Crit Care Med. 2011 Feb; 39(2):322-7. PMID: 21099424.
    Citations: 38     Fields:    Translation:Humans
  151. Perman SM, Chang AM, Hollander JE, Gaieski DF, Trzeciak S, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Goyal M, Cairns CB, Ngo L, Rivers EP, Shapiro NI. Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department. Acad Emerg Med. 2011 Feb; 18(2):219-22. PMID: 21314784.
    Citations: 10     Fields:    Translation:Humans
  152. Grossman SA, Babineau M, Burke L, Kancharla A, Mottley L, Nencioni A, Shapiro NI. Do outcomes of near syncope parallel syncope? Am J Emerg Med. 2012 Jan; 30(1):203-6. PMID: 21185670.
    Citations: 6     Fields:    Translation:Humans
  153. Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI, Benjamin LE. RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice. Am J Pathol. 2011 Jan; 178(1):245-52. PMID: 21224061; PMCID: PMC3069827.
    Citations: 4     Fields:    Translation:AnimalsCells
  154. Green JP, Berger T, Garg N, Shapiro NI. Serum lactate is a better predictor of short-term mortality when stratified by C-reactive protein in adult emergency department patients hospitalized for a suspected infection. Ann Emerg Med. 2011 Mar; 57(3):291-5. PMID: 21111512.
    Citations: 8     Fields:    Translation:Humans
  155. McGillicuddy DC, de La Pena J, Goudie JS, Fisher J, Shapiro N, Sanchez LD. Adherence to dose of succinylcholine and etomidate in the emergency department. West J Emerg Med. 2010 Dec; 11(5):432-4. PMID: 21293761; PMCID: PMC3027434.
    Citations: 2     Fields:    
  156. Kaji AH, Lewis RJ, Beavers-May T, Berg R, Bulger E, Cairns C, Callaway C, Camargo CA, Carcillo J, DeBiasi R, Diaz T, Ducharme F, Glickman S, Heilpern K, Hickey R, Hoek TV, Hollander J, Janson S, Jurkovich G, Kellermann A, Kingsmore S, Kline J, Kuppermann N, Lowe R, McLario D, Nathanson L, Nichol G, Peitzman A, Richardson L, Sanders A, Shah M, Shapiro N, Silverman R, Than M, Wilber S, Yealy DM. Summary of NIH Medical-Surgical Emergency Research Roundtable held on April 30 to May 1, 2009. Ann Emerg Med. 2010 Nov; 56(5):522-37. PMID: 21036293.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  157. Shapiro NI, Schuetz P, Yano K, Sorasaki M, Parikh SM, Jones AE, Trzeciak S, Ngo L, Aird WC. The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care. 2010; 14(5):R182. PMID: 20942957; PMCID: PMC3219288.
    Citations: 59     Fields:    Translation:HumansCells
  158. Kennedy M, Joyce N, Howell MD, Lawrence Mottley J, Shapiro NI. Identifying infected emergency department patients admitted to the hospital ward at risk of clinical deterioration and intensive care unit transfer. Acad Emerg Med. 2010 Oct; 17(10):1080-5. PMID: 21040109; PMCID: PMC3058807.
    Citations: 9     Fields:    Translation:Humans
  159. Seigel TA, Cocchi MN, Salciccioli J, Shapiro NI, Howell M, Tang A, Donnino MW. Inadequacy of temperature and white blood cell count in predicting bacteremia in patients with suspected infection. J Emerg Med. 2012 Mar; 42(3):254-9. PMID: 20674238.
    Citations: 10     Fields:    Translation:Humans
  160. Fischer CM, Yano K, Aird WC, Shapiro NI. Abnormal coagulation tests obtained in the emergency department are associated with mortality in patients with suspected infection. J Emerg Med. 2012 Feb; 42(2):127-32. PMID: 20542399.
    Citations: 6     Fields:    Translation:Humans
  161. Shapiro NI, Khankin EV, Van Meurs M, Shih SC, Lu S, Yano M, Castro PR, Maratos-Flier E, Parikh SM, Karumanchi SA, Yano K. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010 Jul 01; 185(1):517-24. PMID: 20519646; PMCID: PMC3997057.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  162. Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA. 2010 Jun 02; 303(21):2165-71. PMID: 20516417.
    Citations: 117     Fields:    Translation:Humans
  163. Shapiro NI, Bates DW. Response: The Unacceptable Costs of Trying to Achieve "Diagnostic Certainty" J Emerg Med. 2010 Apr 22. PMID: 20456898.
    Citations:    
  164. Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson K, Milzman D, Gaieski DF, Goyal M, Cairns CB, Kupfer K, Lee SW, Rivers EP. The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis. Ann Emerg Med. 2010 Jul; 56(1):52-59.e1. PMID: 20363526.
    Citations: 35     Fields:    Translation:Humans
  165. Trzeciak S, Jones AE, Shapiro NI, Pusateri AE, Arnold RC, Rizzuto M, Arora T, Parrillo JE, Dellinger RP. A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation. Crit Care Med. 2010 Apr; 38(4):1092-100. PMID: 20124888.
    Citations: 3     Fields:    Translation:Humans
  166. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA. 2010 Feb 24; 303(8):739-46. PMID: 20179283; PMCID: PMC2918907.
    Citations: 215     Fields:    Translation:Humans
  167. Wang HE, Weaver MD, Shapiro NI, Yealy DM. Opportunities for Emergency Medical Services care of sepsis. Resuscitation. 2010 Feb; 81(2):193-7. PMID: 20006419; PMCID: PMC4028958.
    Citations: 16     Fields:    Translation:Humans
  168. Grossman SA, Fischer C, Kancharla A, Lipsitz LA, Mottley L, Zimetbaum P, Shapiro NI. Can benign etiologies predict benign outcomes in high-risk syncope patients? J Emerg Med. 2011 May; 40(5):592-7. PMID: 19926429.
    Citations: 3     Fields:    Translation:Humans
  169. Trzeciak S, Jones AE, Kilgannon JH, Milcarek B, Hunter K, Shapiro NI, Hollenberg SM, Dellinger P, Parrillo JE. Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med. 2009 Nov; 37(11):2895-903; quiz 2904. PMID: 19866506.
    Citations: 32     Fields:    Translation:Humans
  170. Pope JV, Jones AE, Gaieski DF, Arnold RC, Trzeciak S, Shapiro NI. Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med. 2010 Jan; 55(1):40-46.e1. PMID: 19854541; PMCID: PMC2828585.
    Citations: 43     Fields:    Translation:Humans
  171. Shapiro NI, Fisher C, Donnino M, Cataldo L, Tang A, Trzeciak S, Horowitz G, Wolfe RE. The feasibility and accuracy of point-of-care lactate measurement in emergency department patients with suspected infection. J Emerg Med. 2010 Jul; 39(1):89-94. PMID: 19717267; PMCID: PMC3205933.
    Citations: 16     Fields:    Translation:Humans
  172. Nencioni A, Trzeciak S, Shapiro NI. The microcirculation as a diagnostic and therapeutic target in sepsis. Intern Emerg Med. 2009 Oct; 4(5):413-8. PMID: 19707845.
    Citations: 3     Fields:    Translation:Humans
  173. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP, Trzeciak S. Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock. 2009 Jul; 32(1):35-9. PMID: 19533847.
    Citations: 70     Fields:    Translation:Humans
  174. Arnold RC, Parrillo JE, Phillip Dellinger R, Chansky ME, Shapiro NI, Lundy DJ, Trzeciak S, Hollenberg SM. Point-of-care assessment of microvascular blood flow in critically ill patients. Intensive Care Med. 2009 Oct; 35(10):1761-6. PMID: 19554307.
    Citations: 20     Fields:    Translation:Humans
  175. Caterino JM, Kulchycki LK, Fischer CM, Wolfe RE, Shapiro NI. Risk factors for death in elderly emergency department patients with suspected infection. J Am Geriatr Soc. 2009 Jul; 57(7):1184-90. PMID: 19558478.
    Citations: 7     Fields:    Translation:Humans
  176. Singer AJ, Thode HC, Green GB, Birkhahn R, Shapiro NI, Cairns C, Baumann BM, Aghababian R, Char D, Hollander JE. The incremental benefit of a shortness-of-breath biomarker panel in emergency department patients with dyspnea. Acad Emerg Med. 2009 Jun; 16(6):488-94. PMID: 19388909.
    Citations: 2     Fields:    Translation:Humans
  177. Shapiro NI, Yano K, Sorasaki M, Fischer C, Shih SC, Aird WC. Skin biopsies demonstrate site-specific endothelial activation in mouse models of sepsis. J Vasc Res. 2009; 46(5):495-502. PMID: 19346756.
    Citations: 12     Fields:    Translation:AnimalsCells
  178. Callaway DW, Shapiro NI, Donnino MW, Baker C, Rosen CL. Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients. J Trauma. 2009 Apr; 66(4):1040-4. PMID: 19359912.
    Citations: 40     Fields:    Translation:Humans
  179. Donnino MW, Cocchi MN, Howell M, Clardy P, Talmor D, Cataldo L, Chase M, Al-Marshad A, Ngo L, Shapiro NI. Statin therapy is associated with decreased mortality in patients with infection. Acad Emerg Med. 2009 Mar; 16(3):230-4. PMID: 19281494.
    Citations: 19     Fields:    Translation:Humans
  180. Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Ngo L, Rivers EP. A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis. Crit Care Med. 2009 Jan; 37(1):96-104. PMID: 19050610.
    Citations: 55     Fields:    Translation:Humans
  181. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP, Trzeciak S. Multi-Center Study of Early Lactate Clearance as a Determinant of Survival in Patients with Presumed Sepsis. Shock. 2008 Dec 22. PMID: 19106806.
    Citations:    
  182. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP. Multi-Center Study of Early Lactate Clearance as a Determinant of Survival in Patients with Presumed Sepsis. Shock. 2008 Dec 4. PMID: 19060782.
    Citations:    
  183. Jones AE, Brown MD, Trzeciak S, Shapiro NI, Garrett JS, Heffner AC, Kline JA. The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med. 2008 Oct; 36(10):2734-9. PMID: 18766093; PMCID: PMC2737059.
    Citations: 37     Fields:    Translation:Humans
  184. Berkman M, Ufberg J, Nathanson LA, Shapiro NI. Anion gap as a screening tool for elevated lactate in patients with an increased risk of developing sepsis in the Emergency Department. J Emerg Med. 2009 May; 36(4):391-4. PMID: 18815002.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  185. Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, Shapiro NI, Parrillo JE, Hollenberg SM. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med. 2008 Dec; 34(12):2210-7. PMID: 18594793; PMCID: PMC2821162.
    Citations: 100     Fields:    Translation:Humans
  186. Shapiro NI, Wolfe RE, Wright SB, Moore R, Bates DW. Who needs a blood culture? A prospectively derived and validated prediction rule. J Emerg Med. 2008 Oct; 35(3):255-64. PMID: 18486413.
    Citations: 21     Fields:    Translation:Humans
  187. Trzeciak S, Cinel I, Phillip Dellinger R, Shapiro NI, Arnold RC, Parrillo JE, Hollenberg SM. Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med. 2008 May; 15(5):399-413. PMID: 18439194; PMCID: PMC2727641.
    Citations: 48     Fields:    Translation:Humans
  188. McGillicuddy DC, Tang A, Cataldo L, Gusev J, Shapiro NI. Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosis. Intern Emerg Med. 2009 Feb; 4(1):41-4. PMID: 18418551.