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Richard T. Lee, M.D.

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Overview
My research laboratory studies the development of new approaches to cardiovascular diseases by applying fundamentals of molecular biology. The central theme of our laboratory is that merging rigorous molecular biology approaches can yield new approaches to cardiovascular and metabolic diseases. Thus, we work at this interface using techniques in genomics, imaging, physiology, cell biology, and molecular biology. Projects in the laboratory range from stem cell biology, aging, diabetes, and molecular aspects of proteins that participate in diabetes and cardiovascular pathophysiology. For over 9 years, I was Director of the Brigham and Women's Hospital Noninvasive Cardiac Laboratory, where I supervised the training of over 100 clinical and research fellows in echocardiography. I resigned from this position in January, 1999 in order to open my research laboratory, but I maintain an active role in clinical practice and teaching. I have had an outpatient cardiology practice and attend on the inpatient cardiology service at Brigham and Women’s Hospital twice per year. I also teach physical diagnosis to Harvard medical students while volunteering to see patients in a Boston homeless shelter. I enjoy my role as a mentor for both graduate students, research fellows and physician scientists who wish to pursue questions at the interface of molecular biology and molecular medicine. I hope that one of my projects leads to a therapy for patients, but I would be just as happy if one of my students or trainees accomplishes this because they were excited about how science can benefit medicine.

Mentoring
The Effect of Exercise on the Serum Concentrations of a Novel Soluble Receptor and IL-13 Signaling
Summer, 06/09/14 - 08/15/14

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG063341 (LEE, RICHARD T) Sep 1, 2018 - May 31, 2023
    NIH/NIA
    Novel Age-Dependent DNA Modifications
    Role: Principal Investigator
  2. R03AG059129 (LEE, RICHARD T) Aug 15, 2018 - Jun 30, 2020
    NIH/NIA
    Myocardial Effects of Caloric Restriction in Primates
    Role: Principal Investigator
  3. R01HL137710 (LEE, RICHARD T) Apr 1, 2018 - Feb 28, 2022
    NIH/NHLBI
    Complement Activation and Initiation of Heart Regeneration
    Role: Principal Investigator
  4. R01DK107396 (LEE, RICHARD T) Sep 1, 2016 - Jun 30, 2021
    NIH/NIDDK
    Regulation of Fructose Transport by Thioredoxin-Interacting Protein
    Role: Principal Investigator
  5. R01HL119230 (LEE, RICHARD T) Jul 1, 2016 - Jun 30, 2020
    NIH/NHLBI
    Reprogramming Non-myocytes to Cardiomyocytes in vivo
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lee RT, Walsh K. The Future of Cardiovascular Regenerative Medicine. Circulation. 2016 Jun 21; 133(25):2618-25. PMID: 27324357; PMCID: PMC4918634.
    Citations: 1     Fields:    Translation:HumansAnimals
  2. Jay SM, Lee RT. Protein engineering for cardiovascular therapeutics: untapped potential for cardiac repair. Circ Res. 2013 Sep 13; 113(7):933-43. PMID: 24030023; PMCID: PMC3868988.
    Citations: 10     Fields:    Translation:HumansAnimals
  3. Jay SM, Murthy AC, Hawkins JF, Wortzel JR, Steinhauser ML, Alvarez LM, Gannon J, Macrae CA, Griffith LG, Lee RT. An engineered bivalent neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation. 2013 Jul 09; 128(2):152-61. PMID: 23757312; PMCID: PMC3753575.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  4. Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013 May 09; 153(4):828-39. PMID: 23663781; PMCID: PMC3677132.
    Citations: 190     Fields:    Translation:HumansAnimalsCells
  5. Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, Abo R, Tabebordbar M, Lee RT, Burge CB, Boyer LA. Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Cell. 2013 Jan 31; 152(3):570-83. PMID: 23352431; PMCID: PMC3563769.
    Citations: 248     Fields:    Translation:HumansAnimalsCells
  6. Steinhauser ML, Lee RT. Pericyte progenitors at the crossroads between fibrosis and regeneration. Circ Res. 2013 Jan 18; 112(2):230-2. PMID: 23329790; PMCID: PMC3829001.
    Citations: 4     Fields:    
  7. Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, Wu TD, Guerquin-Kern JL, Lechene CP, Lee RT. Mammalian heart renewal by pre-existing cardiomyocytes. Nature. 2013 Jan 17; 493(7432):433-6. PMID: 23222518; PMCID: PMC3548046.
    Citations: 322     Fields:    Translation:AnimalsCells
  8. Steinhauser ML, Bailey AP, Senyo SE, Guillermier C, Perlstein TS, Gould AP, Lee RT, Lechene CP. Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism. Nature. 2012 Jan 15; 481(7382):516-9. PMID: 22246326; PMCID: PMC3267887.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  9. Segers VF, Lee RT. Biomaterials to enhance stem cell function in the heart. Circ Res. 2011 Sep 30; 109(8):910-22. PMID: 21960724.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  10. Steinhauser ML, Lee RT. Regeneration of the heart. EMBO Mol Med. 2011 Dec; 3(12):701-12. PMID: 22095736; PMCID: PMC3377117.
    Citations: 41     Fields:    Translation:HumansCells
  11. Jay SM, Lee RT. Patching up the myocardium. Circ Res. 2011 Aug 19; 109(5):480-1. PMID: 21852553.
    Citations:    Fields:    
  12. Jay SM, Kurtagic E, Alvarez LM, de Picciotto S, Sanchez E, Hawkins JF, Prince RN, Guerrero Y, Treasure CL, Lee RT, Griffith LG. Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes. J Biol Chem. 2011 Aug 05; 286(31):27729-40. PMID: 21622572; PMCID: PMC3149363.
    Citations: 8     Fields:    Translation:HumansCells
  13. Kanki S, Segers VF, Wu W, Kakkar R, Gannon J, Sys SU, Sandrasagra A, Lee RT. Stromal cell-derived factor-1 retention and cardioprotection for ischemic myocardium. Circ Heart Fail. 2011 Jul; 4(4):509-18. PMID: 21606214.
    Citations: 29     Fields:    Translation:Animals
  14. Loffredo FS, Steinhauser ML, Gannon J, Lee RT. Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell. 2011 Apr 08; 8(4):389-98. PMID: 21474103; PMCID: PMC4148018.
    Citations: 156     Fields:    Translation:AnimalsCells
  15. Kanki S, Jaalouk DE, Lee S, Yu AY, Gannon J, Lee RT. Identification of targeting peptides for ischemic myocardium by in vivo phage display. J Mol Cell Cardiol. 2011 May; 50(5):841-8. PMID: 21316369; PMCID: PMC3075368.
    Citations: 8     Fields:    Translation:AnimalsCells
  16. Amadi OC, Steinhauser ML, Nishi Y, Chung S, Kamm RD, McMahon AP, Lee RT. A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment. Biomed Microdevices. 2010 Dec; 12(6):1027-41. PMID: 20661647; PMCID: PMC3119200.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  17. Seki K, Sanada S, Kudinova AY, Steinhauser ML, Handa V, Gannon J, Lee RT. Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling. Circ Heart Fail. 2009 Nov; 2(6):684-91. PMID: 19919994.
    Citations: 80     Fields:    Translation:AnimalsCells
  18. Steinhauser ML, Lee RT. Cardiovascular regeneration: pushing and pulling on progenitors. Cell Stem Cell. 2009 Apr 03; 4(4):277-8. PMID: 19341614.
    Citations: 4     Fields:    Translation:Animals
  19. Segers VF, Lee RT. Stem-cell therapy for cardiac disease. Nature. 2008 Feb 21; 451(7181):937-42. PMID: 18288183.
    Citations: 327     Fields:    Translation:HumansCells
  20. Yoshioka J, Imahashi K, Gabel SA, Chutkow WA, Burds AA, Gannon J, Schulze PC, MacGillivray C, London RE, Murphy E, Lee RT. Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ Res. 2007 Dec 07; 101(12):1328-38. PMID: 17916779.
    Citations: 41     Fields:    Translation:Animals
  21. Segers VF, Tokunou T, Higgins LJ, MacGillivray C, Gannon J, Lee RT. Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction. Circulation. 2007 Oct 09; 116(15):1683-92. PMID: 17875967.
    Citations: 99     Fields:    Translation:AnimalsCells
  22. Hsieh PC, Segers VF, Davis ME, MacGillivray C, Gannon J, Molkentin JD, Robbins J, Lee RT. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med. 2007 Aug; 13(8):970-4. PMID: 17660827; PMCID: PMC2754571.
    Citations: 274     Fields:    Translation:AnimalsCells
  23. Segers VF, Lee RT. Local delivery of proteins and the use of self-assembling peptides. Drug Discov Today. 2007 Jul; 12(13-14):561-8. PMID: 17631251.
    Citations: 19     Fields:    Translation:Humans
  24. Patwari P, Lee RT. Thioredoxins, mitochondria, and hypertension. Am J Pathol. 2007 Mar; 170(3):805-8. PMID: 17322366; PMCID: PMC1864871.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  25. Hsieh PC, MacGillivray C, Gannon J, Cruz FU, Lee RT. Local controlled intramyocardial delivery of platelet-derived growth factor improves postinfarction ventricular function without pulmonary toxicity. Circulation. 2006 Aug 15; 114(7):637-44. PMID: 16894033.
    Citations: 35     Fields:    Translation:Animals
  26. Hsieh PC, Davis ME, Gannon J, MacGillivray C, Lee RT. Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers. J Clin Invest. 2006 Jan; 116(1):237-48. PMID: 16357943; PMCID: PMC1312017.
    Citations: 88     Fields:    Translation:AnimalsCells
  27. Lindsey ML, Escobar GP, Dobrucki LW, Goshorn DK, Bouges S, Mingoia JT, McClister DM, Su H, Gannon J, MacGillivray C, Lee RT, Sinusas AJ, Spinale FG. Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction. Am J Physiol Heart Circ Physiol. 2006 Jan; 290(1):H232-9. PMID: 16126817.
    Citations: 78     Fields:    Translation:AnimalsCells
  28. Schulze PC, Lee RT. Oxidative stress and atherosclerosis. Curr Atheroscler Rep. 2005 May; 7(3):242-8. PMID: 15811260.
    Citations: 14     Fields:    Translation:HumansCells
  29. Weinberg EO, Scherrer-Crosbie M, Picard MH, Nasseri BA, MacGillivray C, Gannon J, Lian Q, Bloch KD, Lee RT. Rosuvastatin reduces experimental left ventricular infarct size after ischemia-reperfusion injury but not total coronary occlusion. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1802-9. PMID: 15563531.
    Citations: 9     Fields:    Translation:AnimalsCells
  30. Yoshioka J, Schulze PC, Cupesi M, Sylvan JD, MacGillivray C, Gannon J, Huang H, Lee RT. Thioredoxin-interacting protein controls cardiac hypertrophy through regulation of thioredoxin activity. Circulation. 2004 Jun 01; 109(21):2581-6. PMID: 15123525.
    Citations: 33     Fields:    Translation:AnimalsCells
  31. Yoshioka J, Lee RT. Cardiovascular genomics. Cardiovasc Pathol. 2003 Sep-Oct; 12(5):249-54. PMID: 14507573.
    Citations:    Fields:    Translation:Humans
  32. Schmitt JP, Semsarian C, Arad M, Gannon J, Ahmad F, Duffy C, Lee RT, Seidman CE, Seidman JG. Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomyopathy. Circulation. 2003 Sep 02; 108(9):1133-8. PMID: 12925456.
    Citations: 8     Fields:    Translation:AnimalsCells
  33. Lindsey ML, Yoshioka J, MacGillivray C, Muangman S, Gannon J, Verghese A, Aikawa M, Libby P, Krane SM, Lee RT. Effect of a cleavage-resistant collagen mutation on left ventricular remodeling. Circ Res. 2003 Aug 08; 93(3):238-45. PMID: 12855673.
    Citations: 19     Fields:    Translation:Animals
  34. Weinberg EO, Mirotsou M, Gannon J, Dzau VJ, Lee RT, Pratt RE. Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload. Physiol Genomics. 2003 Jan 15; 12(2):113-27. PMID: 12454204.
    Citations: 17     Fields:    Translation:Animals
  35. Wang Y, De Keulenaer GW, Weinberg EO, Muangman S, Gualberto A, Landschulz KT, Turi TG, Thompson JF, Lee RT. Direct biomechanical induction of endogenous calcineurin inhibitor Down Syndrome Critical Region-1 in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H533-9. PMID: 12124198.
    Citations: 10     Fields:    Translation:AnimalsCells
  36. Lindsey ML, Gannon J, Aikawa M, Schoen FJ, Rabkin E, Lopresti-Morrow L, Crawford J, Black S, Libby P, Mitchell PG, Lee RT. Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation. 2002 Feb 12; 105(6):753-8. PMID: 11839633.
    Citations: 50     Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.