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Richard T. Lee, M.D.

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Overview
My research laboratory studies the development of new approaches to cardiovascular diseases by applying fundamentals of molecular biology. The central theme of our laboratory is that merging rigorous molecular biology approaches can yield new approaches to cardiovascular and metabolic diseases. Thus, we work at this interface using techniques in genomics, imaging, physiology, cell biology, and molecular biology. Projects in the laboratory range from stem cell biology, aging, diabetes, and molecular aspects of proteins that participate in diabetes and cardiovascular pathophysiology. For over 9 years, I was Director of the Brigham and Women's Hospital Noninvasive Cardiac Laboratory, where I supervised the training of over 100 clinical and research fellows in echocardiography. I resigned from this position in January, 1999 in order to open my research laboratory, but I maintain an active role in clinical practice and teaching. I have had an outpatient cardiology practice and attend on the inpatient cardiology service at Brigham and Women’s Hospital twice per year. I also teach physical diagnosis to Harvard medical students while volunteering to see patients in a Boston homeless shelter. I enjoy my role as a mentor for both graduate students, research fellows and physician scientists who wish to pursue questions at the interface of molecular biology and molecular medicine. I hope that one of my projects leads to a therapy for patients, but I would be just as happy if one of my students or trainees accomplishes this because they were excited about how science can benefit medicine.

Mentoring
The Effect of Exercise on the Serum Concentrations of a Novel Soluble Receptor and IL-13 Signaling
Summer, 06/09/14 - 08/15/14

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL151684 (LEE, RICHARD T) Apr 5, 2020 - Mar 31, 2024
    NIH/NHLBI
    Molecular Quiescence and Cardiomyocyte Maturation
    Role: Principal Investigator
  2. R01AG063341 (LEE, RICHARD T) Sep 1, 2018 - May 31, 2023
    NIH/NIA
    Novel Age-Dependent DNA Modifications
    Role: Principal Investigator
  3. R03AG059129 (LEE, RICHARD T.) Aug 15, 2018 - Jun 30, 2020
    NIH/NIA
    Myocardial Effects of Caloric Restriction in Primates
    Role: Principal Investigator
  4. R01HL137710 (LEE, RICHARD T.) Apr 1, 2018 - Feb 28, 2022
    NIH/NHLBI
    Complement Activation and Initiation of Heart Regeneration
    Role: Principal Investigator
  5. R01DK107396 (LEE, RICHARD T) Sep 1, 2016 - Jun 30, 2021
    NIH/NIDDK
    Regulation of Fructose Transport by Thioredoxin-Interacting Protein
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lee RT. Adult Cardiac Stem Cell Concept and the Process of Science. Circulation. 2018 12 18; 138(25):2940-2942. PMID: 30566005.
    Citations:    
  2. Mahmoud AI, Galdos FX, Dinan KA, Jedrychowski MP, Davis JC, Vujic A, Rachmin I, Shigley C, Pancoast JR, Lee S, Hollister-Lock J, MacGillivray CM, Gygi SP, Melton DA, Weir GC, Lee RT. Apolipoprotein E is a pancreatic extracellular factor that maintains mature ß-cell gene expression. PLoS One. 2018; 13(10):e0204595. PMID: 30303984.
    Citations:    Fields:    
  3. Vujic A, Lerchenmüller C, Wu TD, Guillermier C, Rabolli CP, Gonzalez E, Senyo SE, Liu X, Guerquin-Kern JL, Steinhauser ML, Lee RT, Rosenzweig A. Exercise induces new cardiomyocyte generation in the adult mammalian heart. Nat Commun. 2018 04 25; 9(1):1659. PMID: 29695718.
    Citations:    
  4. Natarajan N, Abbas Y, Bryant DM, Gonzalez-Rosa JM, Sharpe M, Uygur A, Cocco-Delgado LH, Ho NN, Gerard NP, Gerard CJ, MacRae CA, Burns CE, Burns CG, Whited JL, Lee RT. Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation. 2018 05 15; 137(20):2152-2165. PMID: 29348261.
    Citations:    Fields:    
  5. Rachmin I, O'Meara CC, Ricci-Blair EM, Feng Y, Christensen EM, Duffy JF, Zitting KM, Czeisler CA, Pancoast JR, Cannon CP, O'Donoghue ML, Morrow DA, Lee RT. Soluble interleukin-13ra1: a circulating regulator of glucose. Am J Physiol Endocrinol Metab. 2017 12 01; 313(6):E663-E671. PMID: 28874358.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Walker RG, Czepnik M, Goebel EJ, McCoy JC, Vujic A, Cho M, Oh J, Aykul S, Walton KL, Schang G, Bernard DJ, Hinck AP, Harrison CA, Martinez-Hackert E, Wagers AJ, Lee RT, Thompson TB. Structural basis for potency differences between GDF8 and GDF11. BMC Biol. 2017 03 03; 15(1):19. PMID: 28257634.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  7. Dotimas JR, Lee AW, Schmider AB, Carroll SH, Shah A, Bilen J, Elliott KR, Myers RB, Soberman RJ, Yoshioka J, Lee RT. Diabetes regulates fructose absorption through thioredoxin-interacting protein. Elife. 2016 10 11; 5. PMID: 27725089.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. Lee RT, Walsh K. The Future of Cardiovascular Regenerative Medicine. Circulation. 2016 Jun 21; 133(25):2618-25. PMID: 27324357.
    Citations: 1     Fields:    Translation:HumansAnimals
  9. Walker RG, Poggioli T, Katsimpardi L, Buchanan SM, Oh J, Wattrus S, Heidecker B, Fong YW, Rubin LL, Ganz P, Thompson TB, Wagers AJ, Lee RT. Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation. Circ Res. 2016 Apr 01; 118(7):1125-41; discussion 1142. PMID: 27034275.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  10. Uygur A, Lee RT. Mechanisms of Cardiac Regeneration. Dev Cell. 2016 Feb 22; 36(4):362-74. PMID: 26906733.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  11. Poggioli T, Vujic A, Yang P, Macias-Trevino C, Uygur A, Loffredo FS, Pancoast JR, Cho M, Goldstein J, Tandias RM, Gonzalez E, Walker RG, Thompson TB, Wagers AJ, Fong YW, Lee RT. Circulating Growth Differentiation Factor 11/8 Levels Decline With Age. Circ Res. 2016 Jan 08; 118(1):29-37. PMID: 26489925.
    Citations: 33     Fields:    Translation:Animals
  12. O'Meara CC, Lee RT. Peering Into the Cardiomyocyte Nuclear Epigenetic State. Circ Res. 2015 Aug 14; 117(5):392-4. PMID: 26271534.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Mahmoud AI, O'Meara CC, Gemberling M, Zhao L, Bryant DM, Zheng R, Gannon JB, Cai L, Choi WY, Egnaczyk GF, Burns CE, Burns CG, MacRae CA, Poss KD, Lee RT. Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. Dev Cell. 2015 Aug 24; 34(4):387-99. PMID: 26256209.
    Citations: 35     Fields:    Translation:AnimalsCells
  14. Bryant DM, O'Meara CC, Ho NN, Gannon J, Cai L, Lee RT. A systematic analysis of neonatal mouse heart regeneration after apical resection. J Mol Cell Cardiol. 2015 Feb; 79:315-8. PMID: 25533939.
    Citations: 23     Fields:    Translation:AnimalsCells
  15. O'Meara CC, Wamstad JA, Gladstone RA, Fomovsky GM, Butty VL, Shrikumar A, Gannon JB, Boyer LA, Lee RT. Transcriptional reversion of cardiac myocyte fate during mammalian cardiac regeneration. Circ Res. 2015 Feb 27; 116(5):804-15. PMID: 25477501.
    Citations: 34     Fields:    Translation:AnimalsCells
  16. Loffredo FS, Nikolova AP, Pancoast JR, Lee RT. Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium. Circ Res. 2014 Jun 20; 115(1):97-107. PMID: 24951760.
    Citations: 33     Fields:    Translation:HumansCells
  17. Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. 2014 May 09; 344(6184):649-52. PMID: 24797481.
    Citations: 181     Fields:    Translation:AnimalsCells
  18. Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. 2014 May 09; 344(6184):630-4. PMID: 24797482.
    Citations: 164     Fields:    Translation:AnimalsCells
  19. Jay SM, Lee RT. Protein engineering for cardiovascular therapeutics: untapped potential for cardiac repair. Circ Res. 2013 Sep 13; 113(7):933-43. PMID: 24030023.
    Citations: 10     Fields:    Translation:HumansAnimals
  20. Yoshioka J, Lee RT. Thioredoxin-interacting protein and myocardial mitochondrial function in ischemia-reperfusion injury. Trends Cardiovasc Med. 2014 Feb; 24(2):75-80. PMID: 23891554.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  21. Jay SM, Murthy AC, Hawkins JF, Wortzel JR, Steinhauser ML, Alvarez LM, Gannon J, Macrae CA, Griffith LG, Lee RT. An engineered bivalent neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation. 2013 Jul 09; 128(2):152-61. PMID: 23757312.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  22. Garbern JC, Lee RT. Cardiac stem cell therapy and the promise of heart regeneration. Cell Stem Cell. 2013 Jun 06; 12(6):689-98. PMID: 23746978.
    Citations: 92     Fields:    Translation:HumansCells
  23. Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013 May 09; 153(4):828-39. PMID: 23663781.
    Citations: 190     Fields:    Translation:HumansAnimalsCells
  24. Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, Abo R, Tabebordbar M, Lee RT, Burge CB, Boyer LA. Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Cell. 2013 Jan 31; 152(3):570-83. PMID: 23352431.
    Citations: 248     Fields:    Translation:HumansAnimalsCells
  25. Steinhauser ML, Lee RT. Pericyte progenitors at the crossroads between fibrosis and regeneration. Circ Res. 2013 Jan 18; 112(2):230-2. PMID: 23329790.
    Citations: 4     Fields:    
  26. Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, Wu TD, Guerquin-Kern JL, Lechene CP, Lee RT. Mammalian heart renewal by pre-existing cardiomyocytes. Nature. 2013 Jan 17; 493(7432):433-6. PMID: 23222518.
    Citations: 322     Fields:    Translation:AnimalsCells
  27. Patwari P, Lee RT. An expanded family of arrestins regulate metabolism. Trends Endocrinol Metab. 2012 May; 23(5):216-22. PMID: 22520962.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  28. Steinhauser ML, Bailey AP, Senyo SE, Guillermier C, Perlstein TS, Gould AP, Lee RT, Lechene CP. Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism. Nature. 2012 Jan 15; 481(7382):516-9. PMID: 22246326.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  29. Kakkar R, Hei H, Dobner S, Lee RT. Interleukin 33 as a mechanically responsive cytokine secreted by living cells. J Biol Chem. 2012 Feb 24; 287(9):6941-8. PMID: 22215666.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  30. Kohli P, Bonaca MP, Kakkar R, Kudinova AY, Scirica BM, Sabatine MS, Murphy SA, Braunwald E, Lee RT, Morrow DA. Role of ST2 in non-ST-elevation acute coronary syndrome in the MERLIN-TIMI 36 trial. Clin Chem. 2012 Jan; 58(1):257-66. PMID: 22096031.
    Citations: 27     Fields:    Translation:Humans
  31. Patwari P, Emilsson V, Schadt EE, Chutkow WA, Lee S, Marsili A, Zhang Y, Dobrin R, Cohen DE, Larsen PR, Zavacki AM, Fong LG, Young SG, Lee RT. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab. 2011 Nov 02; 14(5):671-83. PMID: 21982743.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  32. Segers VF, Lee RT. Biomaterials to enhance stem cell function in the heart. Circ Res. 2011 Sep 30; 109(8):910-22. PMID: 21960724.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  33. Steinhauser ML, Lee RT. Regeneration of the heart. EMBO Mol Med. 2011 Dec; 3(12):701-12. PMID: 22095736.
    Citations: 41     Fields:    Translation:HumansCells
  34. Jay SM, Lee RT. Patching up the myocardium. Circ Res. 2011 Aug 19; 109(5):480-1. PMID: 21852553.
    Citations:    Fields:    
  35. Chutkow WA, Lee RT. Thioredoxin regulates adipogenesis through thioredoxin-interacting protein (Txnip) protein stability. J Biol Chem. 2011 Aug 19; 286(33):29139-45. PMID: 21705327.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  36. Jay SM, Kurtagic E, Alvarez LM, de Picciotto S, Sanchez E, Hawkins JF, Prince RN, Guerrero Y, Treasure CL, Lee RT, Griffith LG. Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes. J Biol Chem. 2011 Aug 05; 286(31):27729-40. PMID: 21622572.
    Citations: 8     Fields:    Translation:HumansCells
  37. Kanki S, Segers VF, Wu W, Kakkar R, Gannon J, Sys SU, Sandrasagra A, Lee RT. Stromal cell-derived factor-1 retention and cardioprotection for ischemic myocardium. Circ Heart Fail. 2011 Jul; 4(4):509-18. PMID: 21606214.
    Citations: 29     Fields:    Translation:Animals
  38. Loffredo FS, Steinhauser ML, Gannon J, Lee RT. Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell. 2011 Apr 08; 8(4):389-98. PMID: 21474103.
    Citations: 156     Fields:    Translation:AnimalsCells
  39. Segers VF, Revin V, Wu W, Qiu H, Yan Z, Lee RT, Sandrasagra A. Protease-resistant stromal cell-derived factor-1 for the treatment of experimental peripheral artery disease. Circulation. 2011 Mar 29; 123(12):1306-15. PMID: 21403096.
    Citations:    
  40. Kanki S, Jaalouk DE, Lee S, Yu AY, Gannon J, Lee RT. Identification of targeting peptides for ischemic myocardium by in vivo phage display. J Mol Cell Cardiol. 2011 May; 50(5):841-8. PMID: 21316369.
    Citations: 8     Fields:    Translation:AnimalsCells
  41. Amadi OC, Steinhauser ML, Nishi Y, Chung S, Kamm RD, McMahon AP, Lee RT. A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment. Biomed Microdevices. 2010 Dec; 12(6):1027-41. PMID: 20661647.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  42. Miller RE, Grodzinsky AJ, Cummings K, Plaas AH, Cole AA, Lee RT, Patwari P. Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate. Arthritis Rheum. 2010 Dec; 62(12):3686-94. PMID: 20722014.
    Citations: 15     Fields:    Translation:AnimalsCells
  43. Segers VF, Lee RT. Protein therapeutics for cardiac regeneration after myocardial infarction. J Cardiovasc Transl Res. 2010 Oct; 3(5):469-77. PMID: 20607468.
    Citations:    
  44. Prince RN, Schreiter ER, Zou P, Wiley HS, Ting AY, Lee RT, Lauffenburger DA. The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release. J Cell Sci. 2010 Jul 01; 123(Pt 13):2308-18. PMID: 20530570.
    Citations:    
  45. Kaieda S, Shin K, Nigrovic PA, Seki K, Lee RT, Stevens RL, Lee DM. Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1). J Biol Chem. 2010 Jul 09; 285(28):21478-86. PMID: 20427273.
    Citations: 21     Fields:    Translation:AnimalsCells
  46. Chutkow WA, Birkenfeld AL, Brown JD, Lee HY, Frederick DW, Yoshioka J, Patwari P, Kursawe R, Cushman SW, Plutzky J, Shulman GI, Samuel VT, Lee RT. Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity. Diabetes. 2010 Jun; 59(6):1424-34. PMID: 20299477.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  47. Lee S, Lee RT. Mechanical stretch and intimal hyperplasia: the missing link? Arterioscler Thromb Vasc Biol. 2010 Mar; 30(3):459-60. PMID: 20167664.
    Citations:    
  48. Kakkar R, Lee RT. Intramyocardial fibroblast myocyte communication. Circ Res. 2010 Jan 08; 106(1):47-57. PMID: 20056945.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  49. Kakkar R, Lee RT. ST2 and adrenomedullin in heart failure. Heart Fail Clin. 2009 Oct; 5(4):515-27. PMID: 19631176.
    Citations:    Fields:    Translation:Humans
  50. Seki K, Sanada S, Kudinova AY, Steinhauser ML, Handa V, Gannon J, Lee RT. Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling. Circ Heart Fail. 2009 Nov; 2(6):684-91. PMID: 19919994.
    Citations: 80     Fields:    Translation:AnimalsCells
  51. Padin-Iruegas ME, Misao Y, Davis ME, Segers VF, Esposito G, Tokunou T, Urbanek K, Hosoda T, Rota M, Anversa P, Leri A, Lee RT, Kajstura J. Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction. Circulation. 2009 Sep 08; 120(10):876-87. PMID: 19704095.
    Citations: 71     Fields:    Translation:AnimalsCells
  52. Chan SS, Chen JH, Hwang SM, Wang IJ, Li HJ, Lee RT, Hsieh PC. Salvianolic acid B-vitamin C synergy in cardiac differentiation from embryonic stem cells. Biochem Biophys Res Commun. 2009 Oct 02; 387(4):723-8. PMID: 19643081.
    Citations:    
  53. Patwari P, Chutkow WA, Cummings K, Verstraeten VL, Lammerding J, Schreiter ER, Lee RT. Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. J Biol Chem. 2009 Sep 11; 284(37):24996-5003. PMID: 19605364.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  54. Huang H, Macgillivray C, Kwon HS, Lammerding J, Robbins J, Lee RT, So P. Three-dimensional cardiac architecture determined by two-photon microtomy. J Biomed Opt. 2009 Jul-Aug; 14(4):044029. PMID: 19725740.
    Citations: 3     Fields:    Translation:Animals
  55. Kuhn E, Addona T, Keshishian H, Burgess M, Mani DR, Lee RT, Sabatine MS, Gerszten RE, Carr SA. Developing multiplexed assays for troponin I and interleukin-33 in plasma by peptide immunoaffinity enrichment and targeted mass spectrometry. Clin Chem. 2009 Jun; 55(6):1108-17. PMID: 19372185.
    Citations: 75     Fields:    Translation:HumansCells
  56. Murry CE, Lee RT. Development biology. Turnover after the fallout. Science. 2009 Apr 03; 324(5923):47-8. PMID: 19342577.
    Citations:    
  57. Steinhauser ML, Lee RT. Cardiovascular regeneration: pushing and pulling on progenitors. Cell Stem Cell. 2009 Apr 03; 4(4):277-8. PMID: 19341614.
    Citations: 4     Fields:    Translation:Animals
  58. Maloyan A, Osinska H, Lammerding J, Lee RT, Cingolani OH, Kass DA, Lorenz JN, Robbins J. Biochemical and mechanical dysfunction in a mouse model of desmin-related myopathy. Circ Res. 2009 Apr 24; 104(8):1021-8. PMID: 19299643.
    Citations: 22     Fields:    Translation:AnimalsCells
  59. Deguchi JO, Huang H, Libby P, Aikawa E, Whittaker P, Sylvan J, Lee RT, Aikawa M. Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II. Lab Invest. 2009 Mar; 89(3):315-26. PMID: 19153555.
    Citations: 19     Fields:    Translation:Animals
  60. Lammerding J, Lee RT. Mechanical properties of interphase nuclei probed by cellular strain application. Methods Mol Biol. 2009; 464:13-26. PMID: 18951177.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  61. Yoshioka J, Lee RT. Vascularization as a potential enemy in valvular heart disease. Circulation. 2008 Oct 21; 118(17):1694-6. PMID: 18936337.
    Citations: 3     Fields:    Translation:HumansAnimals
  62. Kakkar R, Lee RT. The IL-33/ST2 pathway: therapeutic target and novel biomarker. Nat Rev Drug Discov. 2008 Oct; 7(10):827-40. PMID: 18827826.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  63. Dubois G, Segers VF, Bellamy V, Sabbah L, Peyrard S, Bruneval P, Hagège AA, Lee RT, Menasché P. Self-assembling peptide nanofibers and skeletal myoblast transplantation in infarcted myocardium. J Biomed Mater Res B Appl Biomater. 2008 Oct; 87(1):222-8. PMID: 18386833.
    Citations:    
  64. Patwari P, Lee RT. Mechanical control of tissue morphogenesis. Circ Res. 2008 Aug 01; 103(3):234-43. PMID: 18669930.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  65. Loffredo F, Lee RT. Therapeutic vasculogenesis: it takes two. Circ Res. 2008 Jul 18; 103(2):128-30. PMID: 18635829.
    Citations: 11     Fields:    Translation:HumansCells
  66. Sabatine MS, Morrow DA, Higgins LJ, MacGillivray C, Guo W, Bode C, Rifai N, Cannon CP, Gerszten RE, Lee RT. Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial infarction. Circulation. 2008 Apr 15; 117(15):1936-44. PMID: 18378613.
    Citations: 65     Fields:    Translation:HumansCells
  67. Verstraeten VL, Ji JY, Cummings KS, Lee RT, Lammerding J. Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors. Aging Cell. 2008 Jun; 7(3):383-93. PMID: 18331619.
    Citations: 60     Fields:    Translation:HumansCells
  68. Segers VF, Lee RT. Stem-cell therapy for cardiac disease. Nature. 2008 Feb 21; 451(7181):937-42. PMID: 18288183.
    Citations: 327     Fields:    Translation:HumansCells
  69. Tokunou T, Miller R, Patwari P, Davis ME, Segers VF, Grodzinsky AJ, Lee RT. Engineering insulin-like growth factor-1 for local delivery. FASEB J. 2008 Jun; 22(6):1886-93. PMID: 18285400.
    Citations: 11     Fields:    Translation:AnimalsCells
  70. Chutkow WA, Patwari P, Yoshioka J, Lee RT. Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production. J Biol Chem. 2008 Jan 25; 283(4):2397-406. PMID: 17998203.
    Citations: 59     Fields:    Translation:AnimalsCells
  71. Yoshioka J, Imahashi K, Gabel SA, Chutkow WA, Burds AA, Gannon J, Schulze PC, MacGillivray C, London RE, Murphy E, Lee RT. Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ Res. 2007 Dec 07; 101(12):1328-38. PMID: 17916779.
    Citations: 41     Fields:    Translation:Animals
  72. Segers VF, Tokunou T, Higgins LJ, MacGillivray C, Gannon J, Lee RT. Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction. Circulation. 2007 Oct 09; 116(15):1683-92. PMID: 17875967.
    Citations: 99     Fields:    Translation:AnimalsCells
  73. Hsieh PC, Segers VF, Davis ME, MacGillivray C, Gannon J, Molkentin JD, Robbins J, Lee RT. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med. 2007 Aug; 13(8):970-4. PMID: 17660827.
    Citations: 274     Fields:    Translation:AnimalsCells
  74. Lammerding J, Lee RT. Torn apart: membrane rupture in muscular dystrophies and associated cardiomyopathies. J Clin Invest. 2007 Jul; 117(7):1749-52. PMID: 17607350.
    Citations: 4     Fields:    Translation:HumansAnimals
  75. Segers VF, Lee RT. Local delivery of proteins and the use of self-assembling peptides. Drug Discov Today. 2007 Jul; 12(13-14):561-8. PMID: 17631251.
    Citations: 19     Fields:    Translation:Humans
  76. Sanada S, Hakuno D, Higgins LJ, Schreiter ER, McKenzie AN, Lee RT. IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system. J Clin Invest. 2007 Jun; 117(6):1538-49. PMID: 17492053.
    Citations: 200     Fields:    Translation:HumansAnimalsCells
  77. Ji JY, Lee RT, Vergnes L, Fong LG, Stewart CL, Reue K, Young SG, Zhang Q, Shanahan CM, Lammerding J. Cell nuclei spin in the absence of lamin b1. J Biol Chem. 2007 Jul 06; 282(27):20015-26. PMID: 17488709.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  78. Parikh H, Carlsson E, Chutkow WA, Johansson LE, Storgaard H, Poulsen P, Saxena R, Ladd C, Schulze PC, Mazzini MJ, Jensen CB, Krook A, Björnholm M, Tornqvist H, Zierath JR, Ridderstråle M, Altshuler D, Lee RT, Vaag A, Groop LC, Mootha VK. TXNIP regulates peripheral glucose metabolism in humans. PLoS Med. 2007 May; 4(5):e158. PMID: 17472435.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  79. Patwari P, Lee RT. Thioredoxins, mitochondria, and hypertension. Am J Pathol. 2007 Mar; 170(3):805-8. PMID: 17322366.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  80. Ragan T, Sylvan JD, Kim KH, Huang H, Bahlmann K, Lee RT, So PT. High-resolution whole organ imaging using two-photon tissue cytometry. J Biomed Opt. 2007 Jan-Feb; 12(1):014015. PMID: 17343490.
    Citations: 23     Fields:    Translation:AnimalsCells
  81. Yoshioka J, Schreiter ER, Lee RT. Role of thioredoxin in cell growth through interactions with signaling molecules. Antioxid Redox Signal. 2006 Nov-Dec; 8(11-12):2143-51. PMID: 17034356.
    Citations: 39     Fields:    Translation:HumansCells
  82. Engel FB, Hsieh PC, Lee RT, Keating MT. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15546-51. PMID: 17032753.
    Citations: 105     Fields:    Translation:AnimalsCells
  83. Schulze PC, Liu H, Choe E, Yoshioka J, Shalev A, Bloch KD, Lee RT. Nitric oxide-dependent suppression of thioredoxin-interacting protein expression enhances thioredoxin activity. Arterioscler Thromb Vasc Biol. 2006 Dec; 26(12):2666-72. PMID: 17023680.
    Citations: 30     Fields:    Translation:AnimalsCells
  84. Hsieh PC, MacGillivray C, Gannon J, Cruz FU, Lee RT. Local controlled intramyocardial delivery of platelet-derived growth factor improves postinfarction ventricular function without pulmonary toxicity. Circulation. 2006 Aug 15; 114(7):637-44. PMID: 16894033.
    Citations: 35     Fields:    Translation:Animals
  85. Lammerding J, Fong LG, Ji JY, Reue K, Stewart CL, Young SG, Lee RT. Lamins A and C but not lamin B1 regulate nuclear mechanics. J Biol Chem. 2006 Sep 01; 281(35):25768-80. PMID: 16825190.
    Citations: 162     Fields:    Translation:AnimalsCells
  86. Patwari P, Higgins LJ, Chutkow WA, Yoshioka J, Lee RT. The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange. J Biol Chem. 2006 Aug 04; 281(31):21884-91. PMID: 16766796.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  87. Davis ME, Hsieh PC, Takahashi T, Song Q, Zhang S, Kamm RD, Grodzinsky AJ, Anversa P, Lee RT. Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8155-60. PMID: 16698918.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  88. Cruz F, Lee RT, Huang H. Three-dimensional reconstruction of tissues. Curr Protoc Mol Biol. 2006 May; Chapter 14:Unit 14.16. PMID: 18265375.
    Citations:    
  89. Fong LG, Ng JK, Lammerding J, Vickers TA, Meta M, Coté N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennett CF, Bergo MO, Young SG. Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J Clin Invest. 2006 Mar; 116(3):743-52. PMID: 16511604.
    Citations: 77     Fields:    Translation:AnimalsCells
  90. Hsieh PC, Davis ME, Lisowski LK, Lee RT. Endothelial-cardiomyocyte interactions in cardiac development and repair. Annu Rev Physiol. 2006; 68:51-66. PMID: 16460266.
    Citations:    
  91. Hsieh PC, Davis ME, Gannon J, MacGillivray C, Lee RT. Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers. J Clin Invest. 2006 Jan; 116(1):237-48. PMID: 16357943.
    Citations: 88     Fields:    Translation:AnimalsCells
  92. Perlstein TS, Lee RT. Smoking, metalloproteinases, and vascular disease. Arterioscler Thromb Vasc Biol. 2006 Feb; 26(2):250-6. PMID: 16339501.
    Citations: 16     Fields:    Translation:Humans
  93. Hakuno D, Takahashi T, Lammerding J, Lee RT. Focal adhesion kinase signaling regulates cardiogenesis of embryonic stem cells. J Biol Chem. 2005 Nov 25; 280(47):39534-44. PMID: 16157602.
    Citations: 32     Fields:    Translation:AnimalsCells
  94. Lindsey ML, Escobar GP, Dobrucki LW, Goshorn DK, Bouges S, Mingoia JT, McClister DM, Su H, Gannon J, MacGillivray C, Lee RT, Sinusas AJ, Spinale FG. Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction. Am J Physiol Heart Circ Physiol. 2006 Jan; 290(1):H232-9. PMID: 16126817.
    Citations: 78     Fields:    Translation:AnimalsCells
  95. Lammerding J, Hsiao J, Schulze PC, Kozlov S, Stewart CL, Lee RT. Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells. J Cell Biol. 2005 Aug 29; 170(5):781-91. PMID: 16115958.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  96. Narmoneva DA, Oni O, Sieminski AL, Zhang S, Gertler JP, Kamm RD, Lee RT. Self-assembling short oligopeptides and the promotion of angiogenesis. Biomaterials. 2005 Aug; 26(23):4837-46. PMID: 15763263.
    Citations: 38     Fields:    Translation:HumansCells
  97. Schulze PC, Fang J, Kassik KA, Gannon J, Cupesi M, MacGillivray C, Lee RT, Rosenthal N. Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction. Circ Res. 2005 Sep 02; 97(5):418-26. PMID: 16051886.
    Citations: 39     Fields:    Translation:AnimalsCells
  98. Yoshioka J, Prince RN, Huang H, Perkins SB, Cruz FU, MacGillivray C, Lauffenburger DA, Lee RT. Cardiomyocyte hypertrophy and degradation of connexin43 through spatially restricted autocrine/paracrine heparin-binding EGF. Proc Natl Acad Sci U S A. 2005 Jul 26; 102(30):10622-7. PMID: 16020536.
    Citations: 24     Fields:    Translation:AnimalsCells
  99. Davis ME, Hsieh PC, Grodzinsky AJ, Lee RT. Custom design of the cardiac microenvironment with biomaterials. Circ Res. 2005 Jul 08; 97(1):8-15. PMID: 16002755.
    Citations: 58     Fields:    Translation:HumansAnimalsPHPublic Health
  100. Lee RT. The PEACE study: limiting the role of angiotensin-converting enzyme inhibitors in stable coronary artery disease. Curr Atheroscler Rep. 2005 May; 7(3):211-2. PMID: 15811255.
    Citations:    
  101. Schulze PC, Lee RT. Oxidative stress and atherosclerosis. Curr Atheroscler Rep. 2005 May; 7(3):242-8. PMID: 15811260.
    Citations: 14     Fields:    Translation:HumansCells
  102. Davis ME, Motion JP, Narmoneva DA, Takahashi T, Hakuno D, Kamm RD, Zhang S, Lee RT. Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells. Circulation. 2005 Feb 01; 111(4):442-50. PMID: 15687132.
    Citations: 124     Fields:    Translation:AnimalsCells
  103. Lammerding J, Lee RT. The nuclear membrane and mechanotransduction: impaired nuclear mechanics and mechanotransduction in lamin A/C deficient cells. Novartis Found Symp. 2005; 264:264-73; discussion 273-8. PMID: 15773759.
    Citations: 12     Fields:    Translation:AnimalsCells
  104. Weinberg EO, Scherrer-Crosbie M, Picard MH, Nasseri BA, MacGillivray C, Gannon J, Lian Q, Bloch KD, Lee RT. Rosuvastatin reduces experimental left ventricular infarct size after ischemia-reperfusion injury but not total coronary occlusion. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1802-9. PMID: 15563531.
    Citations: 9     Fields:    Translation:AnimalsCells
  105. Cheng GC, Schulze PC, Lee RT, Sylvan J, Zetter BR, Huang H. Oxidative stress and thioredoxin-interacting protein promote intravasation of melanoma cells. Exp Cell Res. 2004 Nov 01; 300(2):297-307. PMID: 15474995.
    Citations: 11     Fields:    Translation:Humans
  106. Maly IV, Lee RT, Lauffenburger DA. A model for mechanotransduction in cardiac muscle: effects of extracellular matrix deformation on autocrine signaling. Ann Biomed Eng. 2004 Oct; 32(10):1319-35. PMID: 15535051.
    Citations:    
  107. Huang H, Sylvan J, Jonas M, Barresi R, So PT, Campbell KP, Lee RT. Cell stiffness and receptors: evidence for cytoskeletal subnetworks. Am J Physiol Cell Physiol. 2005 Jan; 288(1):C72-80. PMID: 15385268.
    Citations: 8     Fields:    Translation:HumansCells
  108. Narmoneva DA, Vukmirovic R, Davis ME, Kamm RD, Lee RT. Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration. Circulation. 2004 Aug 24; 110(8):962-8. PMID: 15302801.
    Citations: 98     Fields:    Translation:AnimalsCells
  109. Kaazempur-Mofrad MR, Isasi AG, Younis HF, Chan RC, Hinton DP, Sukhova G, LaMuraglia GM, Lee RT, Kamm RD. Characterization of the atherosclerotic carotid bifurcation using MRI, finite element modeling, and histology. Ann Biomed Eng. 2004 Jul; 32(7):932-46. PMID: 15298431.
    Citations: 31     Fields:    Translation:HumansCTClinical Trials
  110. Zee RY, Cook NR, Cheng S, Erlich HA, Lindpaintner K, Lee RT, Ridker PM. Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction. Atherosclerosis. 2004 Jul; 175(1):91-4. PMID: 15186951.
    Citations: 13     Fields:    Translation:Humans
  111. Shimizu K, Shichiri M, Libby P, Lee RT, Mitchell RN. Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas. J Clin Invest. 2004 Jul; 114(2):300-8. PMID: 15254597.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  112. Mack PJ, Kaazempur-Mofrad MR, Karcher H, Lee RT, Kamm RD. Force-induced focal adhesion translocation: effects of force amplitude and frequency. Am J Physiol Cell Physiol. 2004 Oct; 287(4):C954-62. PMID: 15189816.
    Citations: 19     Fields:    Translation:AnimalsCells
  113. Agrawal RS, Muangman S, Layne MD, Melo L, Perrella MA, Lee RT, Zhang L, Lopez-Ilasaca M, Dzau VJ. Pre-emptive gene therapy using recombinant adeno-associated virus delivery of extracellular superoxide dismutase protects heart against ischemic reperfusion injury, improves ventricular function and prolongs survival. Gene Ther. 2004 Jun; 11(12):962-9. PMID: 15029230.
    Citations: 14     Fields:    Translation:AnimalsCells
  114. Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem. 2004 Jul 16; 279(29):30369-74. PMID: 15128745.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  115. Yoshioka J, Schulze PC, Cupesi M, Sylvan JD, MacGillivray C, Gannon J, Huang H, Lee RT. Thioredoxin-interacting protein controls cardiac hypertrophy through regulation of thioredoxin activity. Circulation. 2004 Jun 01; 109(21):2581-6. PMID: 15123525.
    Citations: 33     Fields:    Translation:AnimalsCells
  116. Shimpo M, Morrow DA, Weinberg EO, Sabatine MS, Murphy SA, Antman EM, Lee RT. Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction. Circulation. 2004 May 11; 109(18):2186-90. PMID: 15117853.
    Citations: 94     Fields:    Translation:Humans
  117. Lammerding J, Schulze PC, Takahashi T, Kozlov S, Sullivan T, Kamm RD, Stewart CL, Lee RT. Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. J Clin Invest. 2004 Feb; 113(3):370-8. PMID: 14755334.
    Citations: 287     Fields:    Translation:AnimalsCells
  118. Karcher H, Lammerding J, Huang H, Lee RT, Kamm RD, Kaazempur-Mofrad MR. A three-dimensional viscoelastic model for cell deformation with experimental verification. Biophys J. 2003 Nov; 85(5):3336-49. PMID: 14581235.
    Citations: 33     Fields:    Translation:AnimalsCells
  119. Schulze PC, de Keulenaer GW, Kassik KA, Takahashi T, Chen Z, Simon DI, Lee RT. Biomechanically induced gene iex-1 inhibits vascular smooth muscle cell proliferation and neointima formation. Circ Res. 2003 Dec 12; 93(12):1210-7. PMID: 14592999.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  120. Yoshioka J, Lee RT. Cardiovascular genomics. Cardiovasc Pathol. 2003 Sep-Oct; 12(5):249-54. PMID: 14507573.
    Citations:    Fields:    Translation:Humans
  121. Schmitt JP, Semsarian C, Arad M, Gannon J, Ahmad F, Duffy C, Lee RT, Seidman CE, Seidman JG. Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomyopathy. Circulation. 2003 Sep 02; 108(9):1133-8. PMID: 12925456.
    Citations: 8     Fields:    Translation:AnimalsCells
  122. Lindsey ML, Yoshioka J, MacGillivray C, Muangman S, Gannon J, Verghese A, Aikawa M, Libby P, Krane SM, Lee RT. Effect of a cleavage-resistant collagen mutation on left ventricular remodeling. Circ Res. 2003 Aug 08; 93(3):238-45. PMID: 12855673.
    Citations: 19     Fields:    Translation:Animals
  123. Lammerding J, Kazarov AR, Huang H, Lee RT, Hemler ME. Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7616-21. PMID: 12805567.
    Citations: 53     Fields:    Translation:AnimalsCells
  124. Frantz S, Ducharme A, Sawyer D, Rohde LE, Kobzik L, Fukazawa R, Tracey D, Allen H, Lee RT, Kelly RA. Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction. J Mol Cell Cardiol. 2003 Jun; 35(6):685-94. PMID: 12788386.
    Citations: 30     Fields:    Translation:Animals
  125. Takahashi T, Lord B, Schulze PC, Fryer RM, Sarang SS, Gullans SR, Lee RT. Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes. Circulation. 2003 Apr 15; 107(14):1912-6. PMID: 12668514.
    Citations: 103     Fields:    Translation:AnimalsCells
  126. Weinberg EO, Mirotsou M, Gannon J, Dzau VJ, Lee RT, Pratt RE. Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload. Physiol Genomics. 2003 Jan 15; 12(2):113-27. PMID: 12454204.
    Citations: 17     Fields:    Translation:Animals
  127. Blake GJ, Ostfeld RJ, Yucel EK, Varo N, Schönbeck U, Blake MA, Gerhard M, Ridker PM, Libby P, Lee RT. Soluble CD40 ligand levels indicate lipid accumulation in carotid atheroma: an in vivo study with high-resolution MRI. Arterioscler Thromb Vasc Biol. 2003 Jan 01; 23(1):e11-4. PMID: 12524242.
    Citations: 4     Fields:    Translation:Humans
  128. Weinberg EO, Shimpo M, De Keulenaer GW, MacGillivray C, Tominaga S, Solomon SD, Rouleau JL, Lee RT. Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. Circulation. 2002 Dec 03; 106(23):2961-6. PMID: 12460879.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  129. Schulze PC, De Keulenaer GW, Yoshioka J, Kassik KA, Lee RT. Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin. Circ Res. 2002 Oct 18; 91(8):689-95. PMID: 12386145.
    Citations: 48     Fields:    Translation:HumansCells
  130. Wang Y, De Keulenaer GW, Weinberg EO, Muangman S, Gualberto A, Landschulz KT, Turi TG, Thompson JF, Lee RT. Direct biomechanical induction of endogenous calcineurin inhibitor Down Syndrome Critical Region-1 in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H533-9. PMID: 12124198.
    Citations: 10     Fields:    Translation:AnimalsCells
  131. Wang Y, De Keulenaer GW, Lee RT. Vitamin D(3)-up-regulated protein-1 is a stress-responsive gene that regulates cardiomyocyte viability through interaction with thioredoxin. J Biol Chem. 2002 Jul 19; 277(29):26496-500. PMID: 12011048.
    Citations:    
  132. De Keulenaer GW, Wang Y, Feng Y, Muangman S, Yamamoto K, Thompson JF, Turi TG, Landschutz K, Lee RT. Identification of IEX-1 as a biomechanically controlled nuclear factor-kappaB target gene that inhibits cardiomyocyte hypertrophy. Circ Res. 2002 Apr 05; 90(6):690-6. PMID: 11934837.
    Citations:    
  133. Ohki R, Yamamoto K, Mano H, Lee RT, Ikeda U, Shimada K. Identification of mechanically induced genes in human monocytic cells by DNA microarrays. J Hypertens. 2002 Apr; 20(4):685-91. PMID: 11910304.
    Citations:    
  134. Lindsey ML, Gannon J, Aikawa M, Schoen FJ, Rabkin E, Lopresti-Morrow L, Crawford J, Black S, Libby P, Mitchell PG, Lee RT. Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation. 2002 Feb 12; 105(6):753-8. PMID: 11839633.
    Citations: 50     Fields:    Translation:Animals
  135. Huang H, Kamm RD, So PT, Lee RT. Receptor-based differences in human aortic smooth muscle cell membrane stiffness. Hypertension. 2001 Nov; 38(5):1158-61. PMID: 11711514.
    Citations: 5     Fields:    Translation:HumansCells
  136. Chae CU, Lee RT, Rifai N, Ridker PM. Blood pressure and inflammation in apparently healthy men. Hypertension. 2001 Sep; 38(3):399-403. PMID: 11566912.
    Citations: 132     Fields:    Translation:Humans
  137. Sakamoto H, Aikawa M, Hill CC, Weiss D, Taylor WR, Libby P, Lee RT. Biomechanical strain induces class a scavenger receptor expression in human monocyte/macrophages and THP-1 cells: a potential mechanism of increased atherosclerosis in hypertension. Circulation. 2001 Jul 03; 104(1):109-14. PMID: 11435347.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  138. Gehrmann J, Frantz S, Maguire CT, Vargas M, Ducharme A, Wakimoto H, Lee RT, Berul CI. Electrophysiological characterization of murine myocardial ischemia and infarction. Basic Res Cardiol. 2001 May-Jun; 96(3):237-50. PMID: 11403417.
    Citations: 15     Fields:    Translation:Animals
  139. Rohde LE, Polanczyk CA, Goldman L, Cook EF, Lee RT, Lee TH. Usefulness of transthoracic echocardiography as a tool for risk stratification of patients undergoing major noncardiac surgery. Am J Cardiol. 2001 Mar 01; 87(5):505-9. PMID: 11230829.
    Citations: 21     Fields:    Translation:Humans
  140. Huang H, Virmani R, Younis H, Burke AP, Kamm RD, Lee RT. The impact of calcification on the biomechanical stability of atherosclerotic plaques. Circulation. 2001 Feb 27; 103(8):1051-6. PMID: 11222465.
    Citations: 110     Fields:    Translation:Humans
  141. Aikawa Y, Rohde L, Plehn J, Greaves SC, Menapace F, Arnold MO, Rouleau JL, Pfeffer MA, Lee RT, Solomon SD. Regional wall stress predicts ventricular remodeling after anteroseptal myocardial infarction in the Healing and Early Afterload Reducing Trial (HEART): an echocardiography-based structural analysis. Am Heart J. 2001 Feb; 141(2):234-42. PMID: 11174337.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  142. Lee RT, Yamamoto C, Feng Y, Potter-Perigo S, Briggs WH, Landschulz KT, Turi TG, Thompson JF, Libby P, Wight TN. Mechanical strain induces specific changes in the synthesis and organization of proteoglycans by vascular smooth muscle cells. J Biol Chem. 2001 Apr 27; 276(17):13847-51. PMID: 11278699.
    Citations: 33     Fields:    Translation:HumansCells
  143. Haley KJ, Lilly CM, Yang JH, Feng Y, Kennedy SP, Turi TG, Thompson JF, Sukhova GH, Libby P, Lee RT. Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation. Circulation. 2000 Oct 31; 102(18):2185-9. PMID: 11056090.
    Citations: 45     Fields:    Translation:HumansCells
  144. Ducharme A, Frantz S, Aikawa M, Rabkin E, Lindsey M, Rohde LE, Schoen FJ, Kelly RA, Werb Z, Libby P, Lee RT. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest. 2000 Jul; 106(1):55-62. PMID: 10880048.
    Citations: 217     Fields:    Translation:Animals
  145. Ressler B, Lee RT, Randell SH, Drazen JM, Kamm RD. Molecular responses of rat tracheal epithelial cells to transmembrane pressure. Am J Physiol Lung Cell Mol Physiol. 2000 Jun; 278(6):L1264-72. PMID: 10835333.
    Citations: 25     Fields:    Translation:AnimalsCells
  146. Yang JH, Sakamoto H, Xu EC, Lee RT. Biomechanical regulation of human monocyte/macrophage molecular function. Am J Pathol. 2000 May; 156(5):1797-804. PMID: 10793091.
    Citations:    
  147. Yauch RL, Kazarov AR, Desai B, Lee RT, Hemler ME. Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. J Biol Chem. 2000 Mar 31; 275(13):9230-8. PMID: 10734060.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  148. Feng Y, Yang JH, Huang H, Kennedy SP, Turi TG, Thompson JF, Libby P, Lee RT. Transcriptional profile of mechanically induced genes in human vascular smooth muscle cells. Circ Res. 1999 Dec 3-17; 85(12):1118-23. PMID: 10590237.
    Citations: 17     Fields:    Translation:HumansCells
  149. McConnell MV, Aikawa M, Maier SE, Ganz P, Libby P, Lee RT. MRI of rabbit atherosclerosis in response to dietary cholesterol lowering. Arterioscler Thromb Vasc Biol. 1999 Aug; 19(8):1956-9. PMID: 10446077.
    Citations: 14     Fields:    Translation:Animals
  150. Frantz S, Kobzik L, Kim YD, Fukazawa R, Medzhitov R, Lee RT, Kelly RA. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest. 1999 Aug; 104(3):271-80. PMID: 10430608.
    Citations: 133     Fields:    Translation:HumansAnimalsCells
  151. Yamamoto K, Dang QN, Kennedy SP, Osathanondh R, Kelly RA, Lee RT. Induction of tenascin-C in cardiac myocytes by mechanical deformation. Role of reactive oxygen species. J Biol Chem. 1999 Jul 30; 274(31):21840-6. PMID: 10419501.
    Citations:    
  152. Rohde LE, Arroyo LH, Rifai N, Creager MA, Libby P, Ridker PM, Lee RT. Plasma concentrations of interleukin-6 and abdominal aortic diameter among subjects without aortic dilatation. Arterioscler Thromb Vasc Biol. 1999 Jul; 19(7):1695-9. PMID: 10397687.
    Citations: 17     Fields:    Translation:Humans
  153. Rohde LE, Ducharme A, Arroyo LH, Aikawa M, Sukhova GH, Lopez-Anaya A, McClure KF, Mitchell PG, Libby P, Lee RT. Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice. Circulation. 1999 Jun 15; 99(23):3063-70. PMID: 10368126.
    Citations: 97     Fields:    Translation:Animals
  154. Rohde LE, Aikawa M, Cheng GC, Sukhova G, Solomon SD, Libby P, Pfeffer J, Pfeffer MA, Lee RT. Echocardiography-derived left ventricular end-systolic regional wall stress and matrix remodeling after experimental myocardial infarction. J Am Coll Cardiol. 1999 Mar; 33(3):835-42. PMID: 10080489.
    Citations: 10     Fields:    Translation:AnimalsCells
  155. Rosario LB, Stevenson LW, Solomon SD, Lee RT, Reimold SC. The mechanism of decrease in dynamic mitral regurgitation during heart failure treatment: importance of reduction in the regurgitant orifice size. J Am Coll Cardiol. 1998 Dec; 32(7):1819-24. PMID: 9857857.
    Citations: 12     Fields:    Translation:Humans
  156. Rohde LE, Lee RT, Rivero J, Jamacochian M, Arroyo LH, Briggs W, Rifai N, Libby P, Creager MA, Ridker PM. Circulating cell adhesion molecules are correlated with ultrasound-based assessment of carotid atherosclerosis. Arterioscler Thromb Vasc Biol. 1998 Nov; 18(11):1765-70. PMID: 9812916.
    Citations: 34     Fields:    Translation:Humans
  157. Solomon SD, Aikawa Y, Martini MS, Rosario L, Makker G, Gerson D, Greaves S, Lee RT. Assessment of regional left ventricular wall stress after myocardial infarction by echocardiography-based structural analysis. J Am Soc Echocardiogr. 1998 Oct; 11(10):938-47. PMID: 9804098.
    Citations: 4     Fields:    Translation:Humans
  158. Yamamoto K, Dang QN, Kelly RA, Lee RT. Mechanical strain suppresses inducible nitric-oxide synthase in cardiac myocytes. J Biol Chem. 1998 May 08; 273(19):11862-6. PMID: 9565611.
    Citations:    
  159. Yang JH, Briggs WH, Libby P, Lee RT. Small mechanical strains selectively suppress matrix metalloproteinase-1 expression by human vascular smooth muscle cells. J Biol Chem. 1998 Mar 13; 273(11):6550-5. PMID: 9497391.
    Citations: 8     Fields:    Translation:HumansCells
  160. Reimold SC, Orav EJ, Come PC, Caguioa ES, Lee RT. Progressive enlargement of the regurgitant orifice in patients with chronic aortic regurgitation. J Am Soc Echocardiogr. 1998 Mar; 11(3):259-65. PMID: 9560749.
    Citations: 2     Fields:    Translation:Humans
  161. Fleischmann KE, Lee RT, Come PC, Goldman L, Kuntz KM, Johnson PA, Weissman MA, Lee TH. Clinical and echocardiographic correlates of health status in patients with acute chest pain. J Gen Intern Med. 1997 Dec; 12(12):751-6. PMID: 9436894.
    Citations: 1     Fields:    Translation:Humans
  162. Lee RT, Briggs WH, Cheng GC, Rossiter HB, Libby P, Kupper T. Mechanical deformation promotes secretion of IL-1 alpha and IL-1 receptor antagonist. J Immunol. 1997 Nov 15; 159(10):5084-8. PMID: 9366437.
    Citations: 13     Fields:    Translation:HumansCells
  163. Fleischmann KE, Lee RT, Come PC, Goldman L, Cook EF, Weissman MA, Johnson PA, Lee TH. Impact of valvular regurgitation and ventricular dysfunction on long-term survival in patients with chest pain. Am J Cardiol. 1997 Nov 15; 80(10):1266-72. PMID: 9388096.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  164. Rohde LE, Zhi G, Aranki SF, Beckel NE, Lee RT, Reimold SC. Gender-associated differences in left ventricular geometry in patients with aortic valve disease and effect of distinct overload subsets. Am J Cardiol. 1997 Aug 15; 80(4):475-80. PMID: 9285661.
    Citations: 7     Fields:    Translation:Humans
  165. Pfeffer MA, Greaves SC, Arnold JM, Glynn RJ, LaMotte FS, Lee RT, Menapace FJ, Rapaport E, Ridker PM, Rouleau JL, Solomon SD, Hennekens CH. Early versus delayed angiotensin-converting enzyme inhibition therapy in acute myocardial infarction. The healing and early afterload reducing therapy trial. Circulation. 1997 Jun 17; 95(12):2643-51. PMID: 9193433.
    Citations: 23     Fields:    Translation:HumansCTClinical Trials
  166. Fleischmann KE, Lee TH, Come PC, Goldman L, Cook EF, Caguoia E, Johnson PA, Albano MP, Lee RT. Echocardiographic prediction of complications in patients with chest pain. Am J Cardiol. 1997 Feb 01; 79(3):292-8. PMID: 9036747.
    Citations: 2     Fields:    Translation:Humans
  167. Cheng GC, Briggs WH, Gerson DS, Libby P, Grodzinsky AJ, Gray ML, Lee RT. Mechanical strain tightly controls fibroblast growth factor-2 release from cultured human vascular smooth muscle cells. Circ Res. 1997 Jan; 80(1):28-36. PMID: 8978319.
    Citations: 24     Fields:    Translation:HumansCells
  168. Reimold SC, Maier SE, Aggarwal K, Fleischmann KE, Piwnica-Worms D, Kikinis R, Lee RT. Aortic flow velocity patterns in chronic aortic regurgitation: implications for Doppler echocardiography. J Am Soc Echocardiogr. 1996 Sep-Oct; 9(5):675-83. PMID: 8887871.
    Citations: 6     Fields:    Translation:Humans
  169. McConnell MV, Solomon SD, Rayan ME, Come PC, Goldhaber SZ, Lee RT. Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism. Am J Cardiol. 1996 Aug 15; 78(4):469-73. PMID: 8752195.
    Citations: 62     Fields:    Translation:Humans
  170. Lee RT, Schoen FJ, Loree HM, Lark MW, Libby P. Circumferential stress and matrix metalloproteinase 1 in human coronary atherosclerosis. Implications for plaque rupture. Arterioscler Thromb Vasc Biol. 1996 Aug; 16(8):1070-3. PMID: 8696948.
    Citations: 43     Fields:    Translation:Humans
  171. Cheng GC, Libby P, Grodzinsky AJ, Lee RT. Induction of DNA synthesis by a single transient mechanical stimulus of human vascular smooth muscle cells. Role of fibroblast growth factor-2. Circulation. 1996 Jan 01; 93(1):99-105. PMID: 8616949.
    Citations: 5     Fields:    Translation:HumansCells
  172. Lee E, Grodzinsky AJ, Libby P, Clinton SK, Lark MW, Lee RT. Human vascular smooth muscle cell-monocyte interactions and metalloproteinase secretion in culture. Arterioscler Thromb Vasc Biol. 1995 Dec; 15(12):2284-9. PMID: 7489254.
    Citations: 13     Fields:    Translation:HumansCells
  173. Lee RT, Berditchevski F, Cheng GC, Hemler ME. Integrin-mediated collagen matrix reorganization by cultured human vascular smooth muscle cells. Circ Res. 1995 Feb; 76(2):209-14. PMID: 7834831.
    Citations: 36     Fields:    Translation:HumansCells
  174. Greaves SC, Reimold SC, Lee RT, Cooke KA, Aranki SF. Preoperative prediction of prosthetic aortic valve annulus diameter by two-dimensional echocardiography. J Heart Valve Dis. 1995 Jan; 4(1):14-7. PMID: 7742981.
    Citations:    Fields:    Translation:Humans
  175. Lee RT, Loree HM, Fishbein MC. High stress regions in saphenous vein bypass graft atherosclerotic lesions. J Am Coll Cardiol. 1994 Dec; 24(7):1639-44. PMID: 7963109.
    Citations:    
  176. Solomon SD, Kytömaa H, Celi AC, Maas LC, Chou L, Hopkins J, Caguioa E, Lee RT. Myocardial tissue characterization by autocorrelation of two-dimensional ultrasonic backscatter. J Am Soc Echocardiogr. 1994 Nov-Dec; 7(6):631-40. PMID: 7840991.
    Citations:    Fields:    Translation:Humans
  177. Goldhaber SZ, Agnelli G, Levine MN. Reduced dose bolus alteplase vs conventional alteplase infusion for pulmonary embolism thrombolysis. An international multicenter randomized trial. The Bolus Alteplase Pulmonary Embolism Group. Chest. 1994 Sep; 106(3):718-24. PMID: 8082347.
    Citations: 20     Fields:    Translation:HumansCTClinical Trials
  178. Griffin BP, Flachskampf FA, Reimold SC, Lee RT, Thomas JD. Relationship of aortic regurgitant velocity slope and pressure half-time to severity of aortic regurgitation under changing haemodynamic conditions. Eur Heart J. 1994 May; 15(5):681-5.