Harvard Catalyst Profiles

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Richard T. Lee, M.D.

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My research laboratory studies the development of new approaches to cardiovascular diseases by applying fundamentals of molecular biology. The central theme of our laboratory is that merging rigorous molecular biology approaches can yield new approaches to cardiovascular and metabolic diseases. Thus, we work at this interface using techniques in genomics, imaging, physiology, cell biology, and molecular biology. Projects in the laboratory range from stem cell biology, aging, diabetes, and molecular aspects of proteins that participate in diabetes and cardiovascular pathophysiology. For over 9 years, I was Director of the Brigham and Women's Hospital Noninvasive Cardiac Laboratory, where I supervised the training of over 100 clinical and research fellows in echocardiography. I resigned from this position in January, 1999 in order to open my research laboratory, but I maintain an active role in clinical practice and teaching. I have had an outpatient cardiology practice and attend on the inpatient cardiology service at Brigham and Women’s Hospital twice per year. I also teach physical diagnosis to Harvard medical students while volunteering to see patients in a Boston homeless shelter. I enjoy my role as a mentor for both graduate students, research fellows and physician scientists who wish to pursue questions at the interface of molecular biology and molecular medicine. I hope that one of my projects leads to a therapy for patients, but I would be just as happy if one of my students or trainees accomplishes this because they were excited about how science can benefit medicine.

The Effect of Exercise on the Serum Concentrations of a Novel Soluble Receptor and IL-13 Signaling
Summer, 06/09/14 - 08/15/14

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK126688 (LEE, RICHARD T) Jan 1, 2021 - Dec 31, 2024
    Molecular Mechanisms of Arrestin-Domain Containing Proteins in Metabolism
    Role: Principal Investigator
  2. R56AG062468 (LEE, RICHARD T) Sep 15, 2020 - Aug 31, 2021
    In vivo Structure-Function relationships of GDF11 and GDF8
    Role: Principal Investigator
  3. R01HL151684 (LEE, RICHARD T) Apr 5, 2020 - Mar 31, 2024
    Molecular Quiescence and Cardiomyocyte Maturation
    Role: Principal Investigator
  4. R01AG063341 (LEE, RICHARD T) Sep 1, 2018 - May 31, 2023
    Novel Age-Dependent DNA Modifications
    Role: Principal Investigator
  5. R03AG059129 (LEE, RICHARD T) Aug 15, 2018 - Oct 31, 2020
    Myocardial Effects of Caloric Restriction in Primates
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gu W, Wang H, Huang X, Kraiczy J, Singh PNP, Ng C, Dagdeviren S, Houghton S, Pellon-Cardenas O, Lan Y, Nie Y, Zhang J, Banerjee KK, Onufer EJ, Warner BW, Spence J, Scherl E, Rafii S, Lee RT, Verzi MP, Redmond D, Longman R, Helin K, Shivdasani RA, Zhou Q. SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell Stem Cell. 2021 Sep 22. PMID: 34582804.
    Citations:    Fields:    
  2. Dans M, Kutner JS, Agarwal R, Baker JN, Bauman JR, Beck AC, Campbell TC, Carey EC, Case AA, Dalal S, Doberman DJ, Epstein AS, Fecher L, Jones J, Kapo J, Lee RT, Loggers ET, McCammon S, Mitchell W, Ogunseitan AB, Portman DG, Ramchandran K, Sutton L, Temel J, Teply ML, Terauchi SY, Thomas J, Walling AM, Zachariah F, Bergman MA, Ogba N, Campbell M. NCCN Guidelines® Insights: Palliative Care, Version 2.2021. J Natl Compr Canc Netw. 2021 07 28; 19(7):780-788. PMID: 34340208.
    Citations:    Fields:    
  3. Chen MS, Lee RT, Garbern JC. Senescence mechanisms and targets in the heart. Cardiovasc Res. 2021 May 07. PMID: 33963378.
    Citations: 1     Fields:    
  4. Marian AJ, Asatryan B, Bolli R, Cheedipudi SM, Dhalla NS, Finkel T, Frangogiannis NG, Gurha P, Belmonte JCI, Hare JM, Hong K, Kirshenbaum LA, Lee RT, Leesar MA, Libby P, Madonna R, Nagueh SF, Roberts R, Rosenzweig A, Rouhi L, Sadoshima J, Sussman MA, Taffet GE, Tanaka H, Torella D, Wang Y, Wang DW. Editors' Preamble to The Journal of Cardiovascular Aging. J Cardiovasc Aging. 2021; 1. PMID: 34327514.
  5. Garbern JC, Lee RT. Mitochondria and metabolic transitions in cardiomyocytes: lessons from development for stem cell-derived cardiomyocytes. Stem Cell Res Ther. 2021 03 12; 12(1):177. PMID: 33712058.
    Citations: 4     Fields:    Translation:HumansCells
  6. Shah A, Dagdeviren S, Lewandowski JP, Schmider AB, Ricci-Blair EM, Natarajan N, Hundal H, Noh HL, Friedline RH, Vidoudez C, Kim JK, Wagers AJ, Soberman RJ, Lee RT. Thioredoxin Interacting Protein Is Required for a Chronic Energy-Rich Diet to Promote Intestinal Fructose Absorption. iScience. 2020 Sep 02; 23(9):101521. PMID: 32927265.
    Citations: 2     
  7. Sarikhani M, Garbern JC, Ma S, Sereda R, Conde J, Krähenbühl G, Escalante GO, Ahmed A, Buenrostro JD, Lee RT. Sustained Activation of AMPK Enhances Differentiation of Human iPSC-Derived Cardiomyocytes via Sirtuin Activation. Stem Cell Reports. 2020 08 11; 15(2):498-514. PMID: 32649901.
    Citations: 3     Fields:    Translation:HumansCells
  8. Roh JD, Houstis N, Yu A, Chang B, Yeri A, Li H, Hobson R, Lerchenmüller C, Vujic A, Chaudhari V, Damilano F, Platt C, Zlotoff D, Lee RT, Shah R, Jerosch-Herold M, Rosenzweig A. Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice. Aging Cell. 2020 06; 19(6):e13159. PMID: 32441410.
    Citations: 8     Fields:    Translation:HumansAnimals
  9. Walker RG, Barrandon O, Poggioli T, Dagdeviren S, Carroll SH, Mills MJ, Mendello KR, Gomez Y, Loffredo FS, Pancoast JR, Macias-Trevino C, Marts C, LeClair KB, Noh HL, Kim T, Banks AS, Kim JK, Cohen DE, Wagers AJ, Melton DA, Lee RT. Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice. Sci Rep. 2020 03 12; 10(1):4561. PMID: 32165710.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Batista TM, Dagdeviren S, Carroll SH, Cai W, Melnik VY, Noh HL, Saengnipanthkul S, Kim JK, Kahn CR, Lee RT. Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver. Proc Natl Acad Sci U S A. 2020 03 24; 117(12):6733-6740. PMID: 32156724.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Garbern JC, Escalante GO, Lee RT. Pluripotent stem cell-derived cardiomyocytes for treatment of cardiomyopathic damage: Current concepts and future directions. Trends Cardiovasc Med. 2021 02; 31(2):85-90. PMID: 31983535.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  12. Goldstein JM, Valido A, Lewandowski JP, Walker RG, Mills MJ, Messemer KA, Besseling P, Lee KH, Wattrus SJ, Cho M, Lee RT, Wagers AJ. Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus. Sci Rep. 2019 12 09; 9(1):18613. PMID: 31819086.
    Citations:    Fields:    Translation:AnimalsCells
  13. Goldstein JM, Sengul H, Messemer KA, Fernández-Alfara M, Garbern JC, Kristl AC, Lee RT, Wagers AJ. Steady-state and regenerative hematopoiesis occurs normally in mice in the absence of GDF11. Blood. 2019 11 14; 134(20):1712-1716. PMID: 31530563.
    Citations: 5     Fields:    Translation:AnimalsCells
  14. Garbern JC, Helman A, Sereda R, Sarikhani M, Ahmed A, Escalante GO, Ogurlu R, Kim SL, Zimmerman JF, Cho A, MacQueen L, Bezzerides VJ, Parker KK, Melton DA, Lee RT. Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence. Circulation. 2020 01 28; 141(4):285-300. PMID: 31707831.
    Citations: 13     Fields:    Translation:HumansCells
  15. Vujic A, Natarajan N, Lee RT. Molecular mechanisms of heart regeneration. Semin Cell Dev Biol. 2020 04; 100:20-28. PMID: 31587963.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  16. Natarajan N, Vujic A, Das J, Wang AC, Phu KK, Kiehm SH, Ricci-Blair EM, Zhu AY, Vaughan KL, Colman RJ, Mattison JA, Lee RT. Effect of dietary fat and sucrose consumption on cardiac fibrosis in mice and rhesus monkeys. JCI Insight. 2019 09 19; 4(18). PMID: 31415241.
    Citations:    Fields:    Translation:HumansAnimalsCells
  17. Hajipour MJ, Mehrani M, Abbasi SH, Amin A, Kassaian SE, Garbern JC, Caracciolo G, Zanganeh S, Chitsazan M, Aghaverdi H, Kamali Shahri SM, Ashkarran A, Raoufi M, Bauser-Heaton H, Zhang J, Muehlschlegel JD, Moore A, Lee RT, Wu JC, Serpooshan V, Mahmoudi M. Nanoscale Technologies for Prevention and Treatment of Heart Failure: Challenges and Opportunities. Chem Rev. 2019 11 13; 119(21):11352-11390. PMID: 31490059.
    Citations: 8     Fields:    Translation:HumansAnimals
  18. Triposkiadis F, Butler J, Abboud FM, Armstrong PW, Adamopoulos S, Atherton JJ, Backs J, Bauersachs J, Burkhoff D, Bonow RO, Chopra VK, de Boer RA, de Windt L, Hamdani N, Hasenfuss G, Heymans S, Hulot JS, Konstam M, Lee RT, Linke WA, Lunde IG, Lyon AR, Maack C, Mann DL, Mebazaa A, Mentz RJ, Nihoyannopoulos P, Papp Z, Parissis J, Pedrazzini T, Rosano G, Rouleau J, Seferovic PM, Shah AM, Starling RC, Tocchetti CG, Trochu JN, Thum T, Zannad F, Brutsaert DL, Segers VF, De Keulenaer GW. The continuous heart failure spectrum: moving beyond an ejection fraction classification. Eur Heart J. 2019 07 01; 40(26):2155-2163. PMID: 30957868.
    Citations: 45     Fields:    Translation:HumansCells
  19. Garbern J, Kristl AC, Bassaneze V, Vujic A, Schoemaker H, Sereda R, Peng L, Ricci-Blair EM, Goldstein JM, Walker RG, Bhasin S, Wagers AJ, Lee RT. Analysis of Cre-mediated genetic deletion of Gdf11 in cardiomyocytes of young mice. . 2019 07 01; 317(1):H201-H212. PMID: 31125255.
    Citations: 8     Translation:AnimalsCells
  20. Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler S, Chiu I, Austen KF, Geha RS. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 05 21; 50(5):1262-1275.e4. PMID: 31027995.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  21. Yang P, Jiang Y, Pan Y, Ding X, Rhea P, Ding J, Hawke DH, Felsher D, Narla G, Lu Z, Lee RT. Mistletoe extract Fraxini inhibits the proliferation of liver cancer by down-regulating c-Myc expression. Sci Rep. 2019 04 23; 9(1):6428. PMID: 31015523.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  22. Garbern JC, Williams J, Kristl AC, Malick A, Rachmin I, Gaeta B, Ahmed N, Vujic A, Libby P, Lee RT. Dysregulation of IL-33/ST2 signaling and myocardial periarteriolar fibrosis. J Mol Cell Cardiol. 2019 03; 128:179-186. PMID: 30763587.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  23. Ameri AH, Moradi Tuchayi S, Zaalberg A, Park JH, Ngo KH, Li T, Lopez E, Colonna M, Lee RT, Mino-Kenudson M, Demehri S. IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation. Proc Natl Acad Sci U S A. 2019 02 12; 116(7):2646-2651. PMID: 30696763.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  24. Lee RT. Adult Cardiac Stem Cell Concept and the Process of Science. Circulation. 2018 12 18; 138(25):2940-2942. PMID: 30566005.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  25. Mahmoud AI, Galdos FX, Dinan KA, Jedrychowski MP, Davis JC, Vujic A, Rachmin I, Shigley C, Pancoast JR, Lee S, Hollister-Lock J, MacGillivray CM, Gygi SP, Melton DA, Weir GC, Lee RT. Apolipoprotein E is a pancreatic extracellular factor that maintains mature ß-cell gene expression. PLoS One. 2018; 13(10):e0204595. PMID: 30303984.
    Citations: 3     Fields:    Translation:AnimalsCells
  26. Bassaneze V, Lee RT. Molecular events that lead to cardiomyocyte binucleation. Cardiovasc Res. 2018 07 01; 114(8):1053-1054. PMID: 29800235.
    Citations: 1     Fields:    Translation:Cells
  27. Vujic A, Lerchenmüller C, Wu TD, Guillermier C, Rabolli CP, Gonzalez E, Senyo SE, Liu X, Guerquin-Kern JL, Steinhauser ML, Lee RT, Rosenzweig A. Exercise induces new cardiomyocyte generation in the adult mammalian heart. Nat Commun. 2018 04 25; 9(1):1659. PMID: 29695718.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  28. Natarajan N, Abbas Y, Bryant DM, Gonzalez-Rosa JM, Sharpe M, Uygur A, Cocco-Delgado LH, Ho NN, Gerard NP, Gerard CJ, MacRae CA, Burns CE, Burns CG, Whited JL, Lee RT. Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation. 2018 05 15; 137(20):2152-2165. PMID: 29348261.
    Citations: 22     Fields:    Translation:AnimalsCells
  29. Walker RG, McCoy JC, Czepnik M, Mills MJ, Hagg A, Walton KL, Cotton TR, Hyvönen M, Lee RT, Gregorevic P, Harrison CA, Thompson TB. Molecular characterization of latent GDF8 reveals mechanisms of activation. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E866-E875. PMID: 29348202.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  30. Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC. Multiscale technologies for treatment of ischemic cardiomyopathy. Nat Nanotechnol. 2017 09 06; 12(9):845-855. PMID: 28875984.
    Citations: 26     Fields:    Translation:HumansAnimals
  31. Rachmin I, O'Meara CC, Ricci-Blair EM, Feng Y, Christensen EM, Duffy JF, Zitting KM, Czeisler CA, Pancoast JR, Cannon CP, O'Donoghue ML, Morrow DA, Lee RT. Soluble interleukin-13ra1: a circulating regulator of glucose. Am J Physiol Endocrinol Metab. 2017 12 01; 313(6):E663-E671. PMID: 28874358.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  32. Vujic A, Bassaneze V, Lee RT. Genetic insights into mammalian heart regeneration. Nat Genet. 2017 Aug 30; 49(9):1292-1293. PMID: 28854178.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  33. Carroll SH, Zhang E, Wang BF, LeClair KB, Rahman A, Cohen DE, Plutzky J, Patwari P, Lee RT. Correction: Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in ß-adrenergic receptor signaling. PLoS One. 2017; 12(7):e0181492. PMID: 28700749.
    Citations: 1     Fields:    
  34. Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisén J, Giacca M, Hare JM, Houser S, Lee RT, Marbán E, Martin JF, Molkentin JD, Murry CE, Riley PR, Ruiz-Lozano P, Sadek HA, Sussman MA, Hill JA. Cardiomyocyte Regeneration: A Consensus Statement. Circulation. 2017 08 15; 136(7):680-686. PMID: 28684531.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  35. Carroll SH, Zhang E, Wang BF, LeClair KB, Rahman A, Cohen DE, Plutzky J, Patwari P, Lee RT. Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in ß-adrenergic receptor signaling. PLoS One. 2017; 12(3):e0173823. PMID: 28291835.
    Citations: 5     Fields:    Translation:AnimalsCells
  36. Guillermier C, Fazeli PK, Kim S, Lun M, Zuflacht JP, Milian J, Lee H, Francois-Saint-Cyr H, Horreard F, Larson D, Rosen ED, Lee RT, Lechene CP, Steinhauser ML. Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity. JCI Insight. 2017 03 09; 2(5):e90349. PMID: 28289709.
    Citations: 19     Fields:    Translation:HumansCells
  37. Walker RG, Czepnik M, Goebel EJ, McCoy JC, Vujic A, Cho M, Oh J, Aykul S, Walton KL, Schang G, Bernard DJ, Hinck AP, Harrison CA, Martinez-Hackert E, Wagers AJ, Lee RT, Thompson TB. Structural basis for potency differences between GDF8 and GDF11. BMC Biol. 2017 03 03; 15(1):19. PMID: 28257634.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  38. Vujic A, Mahmoud AI, Lee RT. A Breakdown in Cooperativity Leads to Cardiac Identity Crisis. Cell. 2016 12 15; 167(7):1674-1676. PMID: 27984717.
    Citations:    Fields:    Translation:HumansCells
  39. Natarajan N, Lee RT. Basic research: Suffocating the heart to stimulate regeneration. Nat Rev Cardiol. 2016 12 12; 14(1):7-8. PMID: 27941858.
    Citations:    Fields:    Translation:HumansAnimalsCells
  40. Dotimas JR, Lee AW, Schmider AB, Carroll SH, Shah A, Bilen J, Elliott KR, Myers RB, Soberman RJ, Yoshioka J, Lee RT. Diabetes regulates fructose absorption through thioredoxin-interacting protein. Elife. 2016 10 11; 5. PMID: 27725089.
    Citations: 14     Fields:    Translation:AnimalsCells
  41. Liebesny PH, Byun S, Hung HH, Pancoast JR, Mroszczyk KA, Young WT, Lee RT, Frisbie DD, Kisiday JD, Grodzinsky AJ. Growth Factor-Mediated Migration of Bone Marrow Progenitor Cells for Accelerated Scaffold Recruitment. Tissue Eng Part A. 2016 07; 22(13-14):917-27. PMID: 27268956.
    Citations: 7     Fields:    Translation:AnimalsCells
  42. Lee RT, Walsh K. The Future of Cardiovascular Regenerative Medicine. Circulation. 2016 Jun 21; 133(25):2618-25. PMID: 27324357.
    Citations: 7     Fields:    Translation:HumansAnimals
  43. Daley GQ, Hyun I, Apperley JF, Barker RA, Benvenisty N, Bredenoord AL, Breuer CK, Caulfield T, Cedars MI, Frey-Vasconcells J, Heslop HE, Jin Y, Lee RT, McCabe C, Munsie M, Murry CE, Piantadosi S, Rao M, Rooke HM, Sipp D, Studer L, Sugarman J, Takahashi M, Zimmerman M, Kimmelman J. Setting Global Standards for Stem Cell Research and Clinical Translation: The 2016 ISSCR Guidelines. Stem Cell Reports. 2016 06 14; 6(6):787-797. PMID: 27185282.
    Citations: 48     Fields:    Translation:HumansCells
  44. Walker RG, Poggioli T, Katsimpardi L, Buchanan SM, Oh J, Wattrus S, Heidecker B, Fong YW, Rubin LL, Ganz P, Thompson TB, Wagers AJ, Lee RT. Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation. Circ Res. 2016 Apr 01; 118(7):1125-41; discussion 1142. PMID: 27034275.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  45. Uygur A, Lee RT. Mechanisms of Cardiac Regeneration. Dev Cell. 2016 Feb 22; 36(4):362-74. PMID: 26906733.
    Citations: 75     Fields: