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Beltran, Himisha
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Himisha Beltran, M.D.
Title
Associate Professor of Medicine
Institution
Dana-Farber Cancer Institute
Department
Medicine
Address
Dana-Farber Cancer Institute
44 Binney St
Boston MA 02115
Phone
646/962-2072
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research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R37CA241486
(BELTRAN, HIMISHA)
Apr 15, 2020 - Mar 31, 2025
NIH
Molecular mechanisms underlying lineage plasticity in prostate cancer
Role: Principal Investigator
P50CA090381
(BELTRAN, HIMISHA)
Apr 1, 2001 - Jun 30, 2019
NIH
DF/HCC SPORE in Prostate Cancer
Role: Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Schwartzberg L, Broder MS, Ailawadhi S,
Beltran H
, Blakely LJ, Budd GT, Carr L, Cecchini M, Cobb P, Kansal A, Kim A, Monk BJ, Wong DJ, Campos C, Yermilov I. Impact of early detection on cancer curability: A modified Delphi panel study. PLoS One. 2022; 17(12):e0279227.
PMID:
36542647
; PMCID:
PMC9770338
.
Citations:
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
PH
Public Health
Gillessen S, Bossi A, Davis ID, de Bono J, Fizazi K, James ND, Mottet N, Shore N, Small E, Smith M, Sweeney C, Tombal B, Antonarakis ES, Aparicio AM, Armstrong AJ, Attard G, Beer TM,
Beltran H
, Bjartell A, Blanchard P, Briganti A, Bristow RG, Bulbul M, Caffo O, Castellano D, Castro E, Cheng HH, Chi KN, Chowdhury S, Clarke CS, Clarke N, Daugaard G, De Santis M, Duran I, Eeles R, Efstathiou E,
Efstathiou J
, Ngozi Ekeke O, Evans CP, Fanti S, Feng FY, Fonteyne V, Fossati N, Frydenberg M, George D, Gleave M, Gravis G, Halabi S, Heinrich D, Herrmann K, Higano C, Hofman MS, Horvath LG, Hussain M, Jereczek-Fossa BA, Jones R, Kanesvaran R, Kellokumpu-Lehtinen PL, Khauli RB, Klotz L, Kramer G, Leibowitz R, Logothetis CJ, Mahal BA, Maluf F, Mateo J, Matheson D, Mehra N, Merseburger A,
Morgans AK
, Morris MJ, Mrabti H, Mukherji D, Murphy DG, Murthy V,
Nguyen PL
, Oh WK, Ost P, O'Sullivan JM, Padhani AR, Pezaro C, Poon DMC, Pritchard CC, Rabah DM, Rathkopf D, Reiter RE, Rubin MA, Ryan CJ, Saad F, Pablo Sade J, Sartor OA, Scher HI, Sharifi N, Skoneczna I, Soule H, Spratt DE, Srinivas S, Sternberg CN, Steuber T, Suzuki H, Sydes MR,
Taplin ME
, Tilki D, Türkeri L, Turco F, Uemura H, Uemura H, Ürün Y, Vale CL, van Oort I, Vapiwala N, Walz J, Yamoah K, Ye D, Yu EY, Zapatero A, Zilli T, Omlin A. Management of Patients with Advanced Prostate Cancer. Part I: Intermediate-/High-risk and Locally Advanced Disease, Biochemical Relapse, and Side Effects of Hormonal Treatment: Report of the Advanced Prostate Cancer Consensus Conference 2022. Eur Urol. 2023 Mar; 83(3):267-293.
PMID:
36494221
.
Citations:
Fields:
Uro
Urology
Translation:
Humans
Quaglia F, Krishn SR, Sossey-Alaoui K, Rana PS, Pluskota E, Park PH, Shields CD, Lin S, McCue P, Kossenkov AV, Wang Y, Goodrich DW,
Ku SY
,
Beltran H
, Kelly WK, Corey E, Klose M, Bandtlow C, Liu Q, Altieri DC, Plow EF, Languino LR. The NOGO receptor NgR2, a novel aVß3 integrin effector, induces neuroendocrine differentiation in prostate cancer. Sci Rep. 2022 11 07; 12(1):18879.
PMID:
36344556
; PMCID:
PMC9640716
.
Citations:
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Yao J, Bergsland E, Aggarwal R, Aparicio A,
Beltran H
, Crabtree JS, Hann CL, Ibrahim T, Byers LA, Sasano H, Umejiego J, Pavel M. DLL3 as an Emerging Target for the Treatment of Neuroendocrine Neoplasms. Oncologist. 2022 11 03; 27(11):940-951.
PMID:
35983951
; PMCID:
PMC9632312
.
Citations:
2
Fields:
Neo
Neoplasms
Translation:
Humans
Cheng ML, Lee JK, Kumar R, Klein H, Raskina K, Schrock AB, Michael KS, Mazor T,
Cerami E
, Oxnard GR, Liu D,
Beltran H
,
Sholl LM
, Nishino M, Jänne PA. Response to MEK Inhibitor Therapy in MAP2K1 (MEK1) K57N Non-Small-Cell Lung Cancer and Genomic Landscape of MAP2K1 Mutations in Non-Small-Cell Lung Cancer. JCO Precis Oncol. 2022 11; 6:e2200382.
PMID:
36455195
.
Citations:
Fields:
Neo
Neoplasms
Translation:
Humans
Zhao SG, Sperger JM, Schehr JL, McKay RR, Emamekhoo H, Singh A, Schultz ZD, Bade RM, Stahlfeld CN, Gilsdorf CS, Hernandez CI, Wolfe SK, Mayberry RD, Krause HM, Bootsma M, Helzer KT, Rydzewski N, Bakhtiar H, Shi Y, Blitzer G, Kyriakopoulos CE, Kosoff D, Wei XX, Floberg J, Sethakorn N, Sharifi M, Harari PM, Huang W,
Beltran H
,
Choueiri TK
, Scher HI, Rathkopf DE, Halabi S, Armstrong AJ, Beebe DJ, Yu M, Sundling KE,
Taplin ME
, Lang JM. A clinical-grade liquid biomarker detects neuroendocrine differentiation in prostate cancer. J Clin Invest. 2022 11 01; 132(21).
PMID:
36317634
; PMCID:
PMC9621140
.
Citations:
1
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Li H, Wang Y, Lin K,
Venkadakrishnan VB
,
Bakht M
, Shi W, Meng C, Zhang J, Tremble K, Liang X, Song JH, Feng X, Van V, Deng P, Burks JK, Aparicio A, Keyomarsi K, Chen J, Lu Y,
Beltran H
, Zhao D. CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2. Cancer Res. 2022 09 02; 82(17):3088-3101.
PMID:
35771632
; PMCID:
PMC9444962
.
Citations:
Fields:
Neo
Neoplasms
Mateo J,
Beltran H
. Moving Precision Oncology for Advanced Prostate Cancer from Theory to Practice. Eur Urol Focus. 2023 01; 9(1):110-113.
PMID:
35999168
.
Citations:
Fields:
Uro
Urology
Translation:
Humans
Mizuno K
,
Beltran H
. Future directions for precision oncology in prostate cancer. Prostate. 2022 08; 82 Suppl 1:S86-S96.
PMID:
35657153
; PMCID:
PMC9942493
.
Citations:
Fields:
Uro
Urology
Translation:
Humans
Cells
Nixon AB, Halabi S, Liu Y, Starr MD, Brady JC, Shterev I, Luo B, Hurwitz HI, Febbo PG, Rini BI,
Beltran H
, Small EJ, Morris MJ, George DJ. Predictive Biomarkers of Overall Survival in Patients with Metastatic Renal Cell Carcinoma Treated with IFNa ± Bevacizumab: Results from CALGB 90206 (Alliance). Clin Cancer Res. 2022 07 01; 28(13):2771-2778.
PMID:
34965953
; PMCID:
PMC9240110
.
Citations:
1
Fields:
Neo
Neoplasms
Translation:
Humans
Tang F, Xu D, Wang S, Wong CK, Martinez-Fundichely A, Lee CJ, Cohen S, Park J, Hill CE, Eng K, Bareja R, Han T, Liu EM, Palladino A, Di W, Gao D, Abida W, Beg S, Puca L, Meneses M, de Stanchina E, Berger MF, Gopalan A, Dow LE, Mosquera JM,
Beltran H
, Sternberg CN, Chi P, Scher HI, Sboner A, Chen Y, Khurana E. Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets. Science. 2022 05 27; 376(6596):eabe1505.
PMID:
35617398
; PMCID:
PMC9299269
.
Citations:
Fields:
Sci
Science
Translation:
Humans
Cells
Orlando F, Romanel A, Trujillo B, Sigouros M, Wetterskog D, Quaini O, Leone G, Xiang JZ, Wingate A, Tagawa S, Jayaram A, Linch M, Jamal-Hanjani M, Swanton C, Rubin MA, Wyatt AW,
Beltran H
, Attard G, Demichelis F. Allele-informed copy number evaluation of plasma DNA samples from metastatic prostate cancer patients: the PCF_SELECT consortium assay. NAR Cancer. 2022 Jun; 4(2):zcac016.
PMID:
35664542
; PMCID:
PMC9154344
.
Citations:
Beltran H
. Recent clinical trial data of androgen receptor inhibitors in patients with nonmetastatic castration-resistant prostate cancer. Clin Adv Hematol Oncol. 2022 05; 20 Suppl 9(5):2-8.
PMID:
35579578
.
Citations:
Fields:
Hem
Hematology
Neo
Neoplasms
Translation:
Humans
Rettig MB,
Beltran H
, Oh WK. Factors that guide selection among androgen receptor inhibitors in patients with nonmetastatic castration-resistant prostate cancer. Clin Adv Hematol Oncol. 2022 May; 20 Suppl 9(5):1-20.
PMID:
35579577
.
Citations:
Fields:
Hem
Hematology
Neo
Neoplasms
Translation:
Humans
Tombal B,
Beltran H
. Editorial: Metastatic prostate cancer: a wealth of data to put into practice. Curr Opin Urol. 2022 05 01; 32(3):267-268.
PMID:
35552307
.
Citations:
Fields:
Uro
Urology
Translation:
Humans
Gillessen S, Armstrong A, Attard G, Beer TM,
Beltran H
, Bjartell A, Bossi A, Briganti A, Bristow RG, Bulbul M, Caffo O, Chi KN, Clarke CS, Clarke N, Davis ID, de Bono JS, Duran I, Eeles R, Efstathiou E,
Efstathiou J
, Ekeke ON, Evans CP, Fanti S, Feng FY, Fizazi K, Frydenberg M, George D, Gleave M, Halabi S, Heinrich D, Higano C, Hofman MS, Hussain M, James N, Jones R, Kanesvaran R, Khauli RB, Klotz L, Leibowitz R, Logothetis C, Maluf F, Millman R,
Morgans AK
, Morris MJ, Mottet N, Mrabti H, Murphy DG, Murthy V, Oh WK, Ost P, O'Sullivan JM, Padhani AR, Parker C, Poon DMC, Pritchard CC, Rabah DM, Rathkopf D, Reiter RE, Rubin M, Ryan CJ, Saad F, Sade JP, Sartor O, Scher HI, Shore N, Skoneczna I, Small E, Smith M, Soule H, Spratt DE, Sternberg CN, Suzuki H, Sweeney C, Sydes MR,
Taplin ME
, Tilki D, Tombal B, Türkeri L, Uemura H, Uemura H, van Oort I, Yamoah K, Ye D, Zapatero A, Omlin A. Management of Patients with Advanced Prostate Cancer: Report from the Advanced Prostate Cancer Consensus Conference 2021. Eur Urol. 2022 07; 82(1):115-141.
PMID:
35450732
.
Citations:
Fields:
Uro
Urology
Translation:
Humans
Turco F, Armstrong A, Attard G, Beer TM,
Beltran H
, Bjartell A, Bossi A, Briganti A, Bristow RG, Bulbul M, Caffo O, Chi KN, Clarke C, Clarke N, Davis ID, de Bono J, Duran I, Eeles R, Efstathiou E,
Efstathiou J
, Evans CP, Fanti S, Feng FY, Fizazi K, Frydenberg M, George D, Gleave M, Halabi S, Heinrich D, Higano C, Hofman MS, Hussain M, James N, Jones R, Kanesvaran R, Khauli RB, Klotz L, Leibowitz R, Logothetis C, Maluf F, Millman R,
Morgans AK
, Morris MJ, Mottet N, Mrabti H, Murphy DG, Murthy V, Oh WK, Ekeke ON, Ost P, O'Sullivan JM, Padhani AR, Parker C, Poon DMC, Pritchard CC, Rabah DM, Rathkopf D, Reiter RE, Rubin M, Ryan CJ, Saad F, Sade JP, Sartor O, Scher HI, Shore N, Skoneczna I, Small E, Smith M, Soule H, Spratt D, Sternberg CN, Suzuki H, Sweeney C, Sydes M,
Taplin ME
, Tilki D, Tombal B, Türkeri L, Uemura H, Uemura H, van Oort I, Yamoah K, Ye D, Zapatero A, Gillessen S, Omlin A. Corrigendum to "What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021" [Eur Urol 82(1):6-11]. Eur Urol. 2022 Jul; 82(1):e18-e19.
PMID:
35440417
; PMCID:
PMC9012951
.
Citations:
Fields:
Uro
Urology
van der Mijn JC, Eng KW, Chandra P, Fernandez E, Ramazanoglu S, Sigaras A, Oromendia C, Gudas LJ, Tagawa ST, Nanus DM, Faltas BF,
Beltran H
, Sternberg CN, Elemento O, Sboner A, Mosquera JM, Molina AM. The genomic landscape of metastatic clear cell renal cell carcinoma after systemic therapy. Mol Oncol. 2022 06; 16(12):2384-2395.
PMID:
35231161
; PMCID:
PMC9208073
.
Citations:
1
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Cyrta J, Prandi D, Arora A, Hovelson DH, Sboner A, Rodriguez A, Fedrizzi T,
Beltran H
, Robinson DR, Gopalan A, True L, Nelson PS, Robinson BD, Mosquera JM, Tomlins SA, Shen R, Demichelis F, Rubin MA. Comparative genomics of primary prostate cancer and paired metastases: insights from 12 molecular case studies. J Pathol. 2022 07; 257(3):274-284.
PMID:
35220606
; PMCID:
PMC9311708
.
Citations:
1
Fields:
Pat
Pathology
Translation:
Humans
Berchuck JE
,
Baca SC
, McClure HM, Korthauer K,
Tsai HK
,
Nuzzo PV
, Kelleher KM, He M, Steinharter JA, Zacharia S, Spisak S,
Seo JH
, Conteduca V, Elemento O, Auh J, Sigouros M, Corey E,
Hirsch MS
,
Taplin ME
,
Choueiri TK
,
Pomerantz MM
,
Beltran H
,
Freedman ML
. Detecting Neuroendocrine Prostate Cancer Through Tissue-Informed Cell-Free DNA Methylation Analysis. Clin Cancer Res. 2022 Mar 01; 28(5):928-938.
PMID:
34907080
; PMCID:
PMC8898270
.
Citations:
1
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Turco F, Armstrong A, Attard G, Beer TM,
Beltran H
, Bjartell A, Bossi A, Briganti A, Bristow RG, Bulbul M, Caffo O, Chi KN, Clarke C, Clarke N, Davis ID, de Bono J, Duran I, Eeles R, Efstathiou E,
Efstathiou J
, Evans CP, Fanti S, Feng FY, Fizazi K, Frydenberg M, George D, Gleave M, Halabi S, Heinrich D, Higano C, Hofman MS, Hussain M, James N, Jones R, Kanesvaran R, Khauli RB, Klotz L, Leibowitz R, Logothetis C, Maluf F, Millman R,
Morgans AK
, Morris MJ, Mottet N, Mrabti H, Murphy DG, Murthy V, Oh WK, Ekeke Onyeanunam N, Ost P, O'Sullivan JM, Padhani AR, Parker C, Poon DMC, Pritchard CC, Rabah DM, Rathkopf D, Reiter RE, Rubin M, Ryan CJ, Saad F, Pablo Sade J, Sartor O, Scher HI, Shore N, Skoneczna I, Small E, Smith M, Soule H, Spratt D, Sternberg CN, Suzuki H, Sweeney C, Sydes M,
Taplin ME
, Tilki D, Tombal B, Türkeri L, Uemura H, Uemura H, van Oort I, Yamoah K, Ye D, Zapatero A, Gillessen S, Omlin A. What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021. Eur Urol. 2022 07; 82(1):6-11.
PMID:
35393158
; PMCID:
PMC8849852
.
Citations:
2
Fields:
Uro
Urology
Translation:
Humans
PH
Public Health
Bakht MK
, Hayward JJ, Shahbazi-Raz F, Skubal M, Tamura R, Stringer KF, Meister D,
Venkadakrishnan VB
, Xue H, Pillon A, Stover M, Tronchin A, Fifield BA, Mader L,
Ku SY
, Cheon GJ, Kang KW, Wang Y, Dong X,
Beltran H
, Grimm J, Porter LA, Trant JF. Identification of alternative protein targets of glutamate-ureido-lysine associated with PSMA tracer uptake in prostate cancer cells. Proc Natl Acad Sci U S A. 2022 01 25; 119(4).
PMID:
35064078
; PMCID:
PMC8795759
.
Citations:
1
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Morgans AK
,
Beltran H
. Isn't Androgen Deprivation Enough? Optimal Treatment for Newly Diagnosed Metastatic Prostate Cancer. J Clin Oncol. 2022 03 10; 40(8):818-824.
PMID:
34990290
.
Citations:
Fields:
Neo
Neoplasms
Translation:
Humans
Hongo H, Kosaka T, Hayashi H, Nakamura K, Nishihara H, Mikami S,
Beltran H
, Oya M. Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy. Asian J Androl. 2022 Jan-Feb; 24(1):116-118.
PMID:
34045389
; PMCID:
PMC8788613
.
Citations:
1
Fields:
Rep
Reproductive Medicine
Uro
Urology
Translation:
Humans
Cells
Monga J, Adrianto I, Rogers C, Gadgeel S, Chitale D, Alumkal JJ,
Beltran H
, Zoubeidi A, Ghosh J. Tribbles 2 pseudokinase confers enzalutamide resistance in prostate cancer by promoting lineage plasticity. J Biol Chem. 2022 02; 298(2):101556.
PMID:
34973338
; PMCID:
PMC8800106
.
Citations:
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Singh N,
Ramnarine VR
, Song JH, Pandey R, Padi SKR,
Nouri M
, Olive V, Kobelev M, Okumura K, McCarthy D, Hanna MM, Mukherjee P, Sun B, Lee BR, Parker JB, Chakravarti D, Warfel NA, Zhou M, Bearss JJ, Gibb EA, Alshalalfa M, Karnes RJ, Small EJ, Aggarwal R, Feng F, Wang Y, Buttyan R, Zoubeidi A, Rubin M, Gleave M,
Slack FJ
, Davicioni E,
Beltran H
, Collins C, Kraft AS. The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer. Nat Commun. 2021 12 21; 12(1):7349.
PMID:
34934057
; PMCID:
PMC8692330
.
Citations:
9
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Beltran H
,
Choudhury AD
. Towards Biologically Driven Decision-making in Metastatic Hormone-sensitive Prostate Cancer. Eur Urol Oncol. 2021 12; 4(6):924-926.
PMID:
34857503
.
Citations:
Fields:
Neo
Neoplasms
Uro
Urology
Translation:
Humans
Mosquera MJ
, Kim S, Bareja R, Fang Z, Cai S, Pan H, Asad M, Martin ML, Sigouros M, Rowdo FM, Ackermann S, Capuano J, Bernheim J, Cheung C, Doane A, Brady N, Singh R, Rickman DS, Prabhu V, Allen JE, Puca L, Coskun AF, Rubin MA,
Beltran H
, Mosquera JM, Elemento O, Singh A. Extracellular Matrix in Synthetic Hydrogel-Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors. Adv Mater. 2022 Jan; 34(2):e2100096.
PMID:
34676924
; PMCID:
PMC8820841
.
Citations:
2
Fields:
Bio
Biophysics
Che
Chemistry
Translation:
Humans
Animals
Cells
Che M, Chaturvedi A, Munro SA, Pitzen SP, Ling A, Zhang W, Mentzer J,
Ku SY
, Puca L, Zhu Y, Bergman AM, Severson TM, Forster C, Liu Y, Hildebrand J, Daniel M, Wang TY, Selth LA, Hickey T, Zoubeidi A, Gleave M, Bareja R, Sboner A, Tilley W, Carroll JS, Tan W, Kohli M, Yang R, Hsieh AC, Murugan P, Zwart W,
Beltran H
, Huang RS, Dehm SM. Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer. Nat Commun. 2021 11 04; 12(1):6377.
PMID:
34737261
.
Citations:
2
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Beltran H
,
Morgans AK
. Leveraging Real World Genomic Data to Advance Prostate Cancer Precision Oncology. Eur Urol. 2022 01; 81(1):48-49.
PMID:
34742584
.
Citations:
Fields:
Uro
Urology
Translation:
Humans
Conteduca V, Scarpi E, Wetterskog D, Brighi N, Ferroni F, Rossi A, Romanel A, Gurioli G, Bleve S, Gianni C, Schepisi G, Lolli C, Cortesi P, Matteucci F, Barone D, Paganelli G, Demichelis F,
Beltran H
, Attard G, De Giorgi U. Plasma tumor DNA is associated with increased risk of venous thromboembolism in metastatic castration-resistant cancer patients. Int J Cancer. 2022 04 01; 150(7):1166-1173.
PMID:
34605002
.
Citations:
1
Fields:
Neo
Neoplasms
Translation:
Humans
Cejas P
, Xie Y,
Font-Tello A
, Lim K, Syamala S,
Qiu X
,
Tewari AK
, Shah N, Nguyen HM, Patel RA, Brown L, Coleman I, Hackeng WM, Brosens L, Dreijerink KMA, Ellis L, Alaiwi SA,
Seo JH
,
Baca S
,
Beltran H
, Khani F,
Pomerantz M
, Dall'Agnese A, Crowdis J,
Van Allen EM
, Bellmunt J, Morrisey C, Nelson PS,
DeCaprio J
, Farago A,
Dyson N
, Drapkin B, Liu XS,
Freedman M
, Haffner MC, Corey E, Brown M,
Long HW
. Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer. Nat Commun. 2021 10 01; 12(1):5775.
PMID:
34599169
; PMCID:
PMC8486778
.
Citations:
9
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Conteduca V,
Ku SY
, Fernandez L, Dago-Rodriquez A, Lee J, Jendrisak A, Slade M, Gilbertson C, Manohar J, Sigouros M, Wang Y, Dittamore R, Wenstrup R, Mosquera JM, Schonhoft JD,
Beltran H
. Author Correction: Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis. NPJ Precis Oncol. 2021 Sep 13; 5(1):84.
PMID:
34518634
.
Citations:
Davies A, Nouruzi S, Ganguli D, Namekawa T, Thaper D, Linder S, Karaoglanoglu F, Omur ME, Kim S, Kobelev M, Kumar S, Sivak O, Bostock C, Bishop J, Hoogstraat M, Talal A, Stelloo S, van der Poel H, Bergman AM, Ahmed M, Fazli L, Huang H, Tilley W, Goodrich D, Feng FY, Gleave M, He HH, Hach F, Zwart W,
Beltran H
, Selth L, Zoubeidi A. An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer. Nat Cell Biol. 2021 09; 23(9):1023-1034.
PMID:
34489572
; PMCID:
PMC9012003
.
Citations:
8
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Swami N,
Hwang WL
, Guo JA, Hoffman H, Abramowitz MC, Elbakouny Z,
Beltran H
,
Chipidza F
,
Choueiri T
, Pra AD, Huang F, Kaochar S,
Kantoff P
, Kim DW, Kishan AU, Kobetz E,
Marinac C
,
Mucci LA
, Muralidhar V, Pollack A, Sanford NN, Schaeffer EM, Spratt DE, Zhao SG,
Rebbeck TR
,
Nguyen PL
, Feng FY, Mahal BA, Alshalalfa M. Novel genomic signature predictive of response to immune checkpoint blockade: A pan-cancer analysis from project Genomics Evidence Neo-plasia Information Exchange (GENIE). Cancer Genet. 2021 11; 258-259:61-68.
PMID:
34551377
.
Citations:
1
Fields:
Gen
Genetics
Neo
Neoplasms
Translation:
Humans
Conteduca V,
Ku SY
, Fernandez L, Dago-Rodriquez A, Lee J, Jendrisak A, Slade M, Gilbertson C, Manohar J, Sigouros M, Wang Y, Dittamore R, Wenstrup R, Mosquera JM, Schonhoft JD,
Beltran H
. Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis. NPJ Precis Oncol. 2021 Aug 12; 5(1):76.
PMID:
34385567
.
Citations:
5
Sandhu S, Moore CM, Chiong E,
Beltran H
, Bristow RG, Williams SG. Prostate cancer. Lancet. 2021 09 18; 398(10305):1075-1090.
PMID:
34370973
.
Citations:
21
Fields:
Med
Medicine (General)
Translation:
Humans
Mansfield AS, Hong DS, Hann CL, Farago AF,
Beltran H
, Waqar SN, Hendifar AE, Anthony LB, Taylor MH, Bryce AH, Tagawa ST, Lewis K, Niu J, Chung CH,
Cleary JM
, Rossi M, Ludwig C, Valenzuela R, Luo Y, Aggarwal R. A phase I/II study of rovalpituzumab tesirine in delta-like 3-expressing advanced solid tumors. NPJ Precis Oncol. 2021 Aug 05; 5(1):74.
PMID:
34354225
.
Citations:
4
Beltran H
, Demichelis F. Therapy considerations in neuroendocrine prostate cancer: what next? Endocr Relat Cancer. 2021 07 15; 28(8):T67-T78.
PMID:
34111024
; PMCID:
PMC8289743
.
Citations:
6
Fields:
End
Endocrinology
Neo
Neoplasms
Translation:
Humans
Cells
Jasu J, Tolonen T, Antonarakis ES,
Beltran H
, Halabi S, Eisenberger MA, Carducci MA, Loriot Y, Van der Eecken K, Lolkema M, Ryan CJ, Taavitsainen S, Gillessen S, Högnäs G, Talvitie T, Taylor RJ, Koskenalho A, Ost P, Murtola TJ, Rinta-Kiikka I, Tammela T, Auvinen A, Kujala P, Smith TJ, Kellokumpu-Lehtinen PL, Isaacs WB, Nykter M, Kesseli J, Bova GS. Combined Longitudinal Clinical and Autopsy Phenomic Assessment in Lethal Metastatic Prostate Cancer: Recommendations for Advancing Precision Medicine. Eur Urol Open Sci. 2021 Aug; 30:47-62.
PMID:
34337548
; PMCID:
PMC8317817
.
Citations:
Conteduca V, Hess J, Yamada Y,
Ku SY
,
Beltran H
. Epigenetics in prostate cancer: clinical implications. Transl Androl Urol. 2021 Jul; 10(7):3104-3116.
PMID:
34430414
; PMCID:
PMC8350251
.
Citations:
4
Gjyrezi A, Galletti G, Zhang J, Worroll D, Sigouros M, Kim S, Cooley V, Ballman KV, Ocean AJ, Shah MA, Scandura JM, Sboner A, Nanus DM,
Beltran H
, Tagawa S, Giannakakou P. Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage. Commun Biol. 2021 06 24; 4(1):785.
PMID:
34168263
; PMCID:
PMC8225618
.
Citations:
1
Translation:
Humans
Cells
Yamada Y,
Beltran H
. The treatment landscape of metastatic prostate cancer. Cancer Lett. 2021 10 28; 519:20-29.
PMID:
34153403
; PMCID:
PMC8403655
.
Citations:
1
Fields:
Neo
Neoplasms
Translation:
Humans
Kim DH, Sun D, Storck WK, Welker Leng K, Jenkins C, Coleman DJ, Sampson D, Guan X, Kumaraswamy A, Rodansky ES, Urrutia JA, Schwartzman JA, Zhang C,
Beltran H
, Labrecque MP, Morrissey C, Lucas JM, Coleman IM, Nelson PS, Corey E, Handelman SK, Sexton JZ, Aggarwal R, Abida W, Feng FY, Small EJ, Spratt DE, Bankhead A, Rao A, Gesner EM, Attwell S, Lakhotia S, Campeau E, Yates JA, Xia Z, Alumkal JJ. BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program. Clin Cancer Res. 2021 09 01; 27(17):4923-4936.
PMID:
34145028
; PMCID:
PMC8416959
.
Citations:
8
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Brady NJ, Bagadion AM, Singh R, Conteduca V, Van Emmenis L, Arceci E, Pakula H, Carelli R, Khani F,
Bakht M
, Sigouros M, Bareja R, Sboner A, Elemento O, Tagawa S, Nanus DM,
Loda M
,
Beltran H
, Robinson B, Rickman DS. Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer. Nat Commun. 2021 06 07; 12(1):3372.
PMID:
34099734
; PMCID:
PMC8185096
.
Citations:
4
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Sugita M, Wilkes DC, Bareja R, Eng KW, Nataraj S, Jimenez-Flores RA, Yan L, De Leon JP, Croyle JA, Kaner J, Merugu S, Sharma S, MacDonald TY, Noorzad Z, Panchal P, Pancirer D, Cheng S, Xiang JZ, Olson L, Van Besien K, Rickman DS, Mathew S, Tam W, Rubin MA,
Beltran H
, Sboner A, Hassane DC, Chiosis G, Elemento O, Roboz GJ, Mosquera JM, Guzman ML. Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia. NPJ Precis Oncol. 2021 May 26; 5(1):44.
PMID:
34040147
.
Citations:
5
Baca SC
, Takeda DY,
Seo JH
, Hwang J,
Ku SY
,
Arafeh R
, Arnoff T, Agarwal S, Bell C, O'Connor E,
Qiu X
, Alaiwi SA, Corona RI, Fonseca MAS, Giambartolomei C,
Cejas P
, Lim K, He M, Sheahan A, Nassar A,
Berchuck JE
, Brown L, Nguyen HM, Coleman IM, Kaipainen A, De Sarkar N, Nelson PS, Morrissey C, Korthauer K,
Pomerantz MM
, Ellis L, Pasaniuc B, Lawrenson K, Kelly K, Zoubeidi A,
Hahn WC
,
Beltran H
,
Long HW
, Brown M, Corey E,
Freedman ML
. Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer. Nat Commun. 2021 03 30; 12(1):1979.
PMID:
33785741
.
Citations:
13
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
He MX, Cuoco MS, Crowdis J, Bosma-Moody A, Zhang Z, Bi K, Kanodia A, Su MJ,
Ku SY
, Garcia MM, Sweet AR, Rodman C, DelloStritto L, Silver R, Steinharter J, Shah P, Izar B, Walk NC,
Burke KP
, Bakouny Z,
Tewari AK
,
Liu D
, Camp SY, Vokes NI,
Salari K
, Park J, Vigneau S, Fong L,
Russo JW
,
Yuan X
,
Balk SP
,
Beltran H
, Rozenblatt-Rosen O, Regev A,
Rotem A
,
Taplin ME
,
Van Allen EM
. Transcriptional mediators of treatment resistance in lethal prostate cancer. Nat Med. 2021 03; 27(3):426-433.
PMID:
33664492
; PMCID:
PMC7960507
.
Citations:
23
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Cells
Unno K, Chalmers ZR, Pamarthy S, Vatapalli R, Rodriguez Y, Lysy B, Mok H, Sagar V, Han H, Yoo YA,
Ku SY
,
Beltran H
, Zhao Y, Abdulkadir SA. Activated ALK Cooperates with N-Myc via Wnt/ß-Catenin Signaling to Induce Neuroendocrine Prostate Cancer. Cancer Res. 2021 04 15; 81(8):2157-2170.
PMID:
33637566
; PMCID:
PMC8137566
.
Citations:
7
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Berchuck JE
, Viscuse PV,
Beltran H
, Aparicio A. Clinical considerations for the management of androgen indifferent prostate cancer. Prostate Cancer Prostatic Dis. 2021 09; 24(3):623-637.
PMID:
33568748
; PMCID:
PMC8353003
.
Citations:
10
Fields:
Neo
Neoplasms
Uro
Urology
Translation:
Humans
Cells
Yamada Y,
Beltran H
. Clinical and Biological Features of Neuroendocrine Prostate Cancer. Curr Oncol Rep. 2021 01 12; 23(2):15.
PMID:
33433737
.
Citations:
16
Fields:
Neo
Neoplasms
Translation:
Humans
Hofmann MR, Hussain M, Dehm SM,
Beltran H
, Wyatt AW, Halabi S, Sweeney C, Scher HI, Ryan CJ, Feng FY, Attard G, Klein E, Miyahira AK, Soule HR, Sharifi N. Prostate Cancer Foundation Hormone-Sensitive Prostate Cancer Biomarker Working Group Meeting Summary. Urology. 2021 09; 155:165-171.
PMID:
33373705
.
Citations:
3
Fields:
Uro
Urology
Translation:
Humans
Vosoughi A, Zhang T, Shohdy KS, Vlachostergios PJ, Wilkes DC, Bhinder B, Tagawa ST, Nanus DM, Molina AM,
Beltran H
, Sternberg CN, Motanagh S, Robinson BD, Xiang J, Fan X, Chung WK, Rubin MA, Elemento O, Sboner A, Mosquera JM, Faltas BM. Common germline-somatic variant interactions in advanced urothelial cancer. Nat Commun. 2020 12 03; 11(1):6195.
PMID:
33273457
.
Citations:
4
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Mateo J, McKay R, Abida W, Aggarwal R, Alumkal J, Alva A, Feng F, Gao X, Graff J, Hussain M, Karzai F, Montgomery B, Oh W, Patel V, Rathkopf D, Rettig M, Schultz N, Smith M, Solit D, Sternberg C,
Van Allen E
, VanderWeele D, Vinson J, Soule HR, Chinnaiyan A, Small E, Simons JW, Dahut W, Miyahira AK,
Beltran H
. Accelerating precision medicine in metastatic prostate cancer. Nat Cancer. 2020 11; 1(11):1041-1053.
PMID:
34258585
; PMCID:
PMC8274325
.
Citations:
12
Translation:
Humans
Beg S, Bareja R, Ohara K, Eng KW, Wilkes DC, Pisapia DJ, Zoughbi WA, Kudman S, Zhang W, Rao R, Manohar J, Kane T, Sigouros M, Xiang JZ, Khani F, Robinson BD, Faltas BM, Sternberg CN, Sboner A,
Beltran H
, Elemento O, Mosquera JM. Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology. Transl Oncol. 2021 Jan; 14(1):100944.
PMID:
33190043
.
Citations:
1
Cyrta J, Augspach A, De Filippo MR, Prandi D, Thienger P, Benelli M, Cooley V, Bareja R, Wilkes D, Chae SS, Cavaliere P, Dephoure N, Uldry AC, Lagache SB, Roma L, Cohen S, Jaquet M, Brandt LP, Alshalalfa M, Puca L, Sboner A, Feng F, Wang S,
Beltran H
, Lotan T, Spahn M, Kruithof-de Julio M, Chen Y, Ballman KV, Demichelis F, Piscuoglio S, Rubin MA. Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity. Nat Commun. 2020 11 03; 11(1):5549.
PMID:
33144576
.
Citations:
22
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Ruiz de Porras V, Wang XC, Palomero L, Marin-Aguilera M, Solé-Blanch C, Indacochea A, Jimenez N, Bystrup S,
Bakht M
, Conteduca V, Piulats JM, Buisan O, Suarez JF, Pardo JC, Castro E, Olmos D,
Beltran H
, Mellado B, Martinez-Balibrea E, Font A, Aytes A. Taxane-induced Attenuation of the CXCR2/BCL-2 Axis Sensitizes Prostate Cancer to Platinum-based Treatment. Eur Urol. 2021 06; 79(6):722-733.
PMID:
33153817
; PMCID:
PMC8088452
.
Citations:
5
Fields:
Uro
Urology
Translation:
Humans
Animals
Schmid S, Omlin A, Higano C, Sweeney C, Martinez Chanza N, Mehra N, Kuppen MCP,
Beltran H
, Conteduca V, Vargas Pivato de Almeida D, Cotait Maluf F, Oh WK, Tsao CK, Sartor O, Ledet E, Di Lorenzo G, Yip SM, Chi KN, Bianchini D, De Giorgi U, Hansen AR, Beer TM, Lavaud P, Morales-Barrera R, Tucci M, Castro E, Karalis K, Bergman AM, Le ML, Zürrer-Härdi U, Pezaro C, Suzuki H, Zivi A, Klingbiel D, Schär S, Gillessen S. Activity of Platinum-Based Chemotherapy in Patients With Advanced Prostate Cancer With and Without DNA Repair Gene Aberrations. JAMA Netw Open. 2020 10 01; 3(10):e2021692.
PMID:
33112397
.
Citations:
16
Fields:
Med
Medicine (General)
Translation:
Humans
Eastham JA, Heller G, Halabi S, Monk JP,
Beltran H
, Gleave M, Evans CP, Clinton SK, Szmulewitz RZ, Coleman J, Hillman DW, Watt CR, George S, Sanda MG, Hahn OM,
Taplin ME
, Parsons JK, Mohler JL, Small EJ, Morris MJ. Cancer and Leukemia Group B 90203 (Alliance): Radical Prostatectomy With or Without Neoadjuvant Chemohormonal Therapy in Localized, High-Risk Prostate Cancer. J Clin Oncol. 2020 09 10; 38(26):3042-3050.
PMID:
32706639
; PMCID:
PMC7479762
.
Citations:
10
Fields:
Neo
Neoplasms
Translation:
Humans
Giri VN, Knudsen KE, Kelly WK, Cheng HH, Cooney KA, Cookson MS, Dahut W, Weissman S, Soule HR, Petrylak DP, Dicker AP,
AlDubayan SH
, Toland AE, Pritchard CC, Pettaway CA, Daly MB, Mohler JL, Parsons JK, Carroll PR, Pilarski R, Blanco A, Woodson A, Rahm A,
Taplin ME
, Polascik TJ, Helfand BT, Hyatt C,
Morgans AK
, Feng F, Mullane M, Powers J, Concepcion R, Lin DW, Wender R, Mark JR, Costello A, Burnett AL, Sartor O, Isaacs WB, Xu J, Weitzel J, Andriole GL,
Beltran H
, Briganti A, Byrne L, Calvaresi A, Chandrasekar T, Chen DYT, Den RB, Dobi A, Crawford ED, Eastham J, Eggener S,
Freedman ML
,
Garnick M
, Gomella PT, Handley N, Hurwitz MD, Izes J, Karnes RJ, Lallas C, Languino L, Loeb S, Lopez AM,
Loughlin KR
, Lu-Yao G, Malkowicz SB, Mann M, Mille P, Miner MM, Morgan T, Moreno J,
Mucci L
, Myers RE, Nielsen SM, O'Neil B, Pinover W, Pinto P, Poage W, Raj GV,
Rebbeck TR
, Ryan C, Sandler H, Schiewer M, Scott EMD, Szymaniak B, Tester W, Trabulsi EJ, Vapiwala N, Yu EY, Zeigler-Johnson C, Gomella LG. Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019. J Clin Oncol. 2020 08 20; 38(24):2798-2811.
PMID:
32516092
.
Citations:
54
Fields:
Neo
Neoplasms
Translation:
Humans
Quaglia F, Krishn SR, Daaboul GG, Sarker S, Pippa R, Domingo-Domenech J, Kumar G, Fortina P, McCue P, Kelly WK,
Beltran H
, Liu Q, Languino LR. Small extracellular vesicles modulated by aVß3 integrin induce neuroendocrine differentiation in recipient cancer cells. J Extracell Vesicles. 2020 May 24; 9(1):1761072.
PMID:
32922691
.
Citations:
13
Fields:
Bio
Biomedical Engineering
Cel
Cell Biology
Casiraghi N, Orlando F, Ciani Y, Xiang J, Sboner A, Elemento O, Attard G,
Beltran H
, Demichelis F, Romanel A. ABEMUS: platform-specific and data-informed detection of somatic SNVs in cfDNA. Bioinformatics. 2020 05 01; 36(9):2665-2674.
PMID:
31922552
; PMCID:
PMC7203757
.
Citations:
1
Fields:
Com
Computational Biology
Translation:
Humans
Singh N, Padi SKR, Bearss JJ, Pandey R, Okumura K,
Beltran H
, Song JH, Kraft AS, Olive V. PIM protein kinases regulate the level of the long noncoding RNA H19 to control stem cell gene transcription and modulate tumor growth. Mol Oncol. 2020 05; 14(5):974-990.
PMID:
32146726
.
Citations:
8
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Cells
Beltran H
, Romanel A, Conteduca V, Casiraghi N, Sigouros M, Franceschini GM, Orlando F, Fedrizzi T,
Ku SY
, Dann E, Alonso A, Mosquera JM, Sboner A, Xiang J, Elemento O, Nanus DM, Tagawa ST, Benelli M, Demichelis F. Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer. J Clin Invest. 2020 04 01; 130(4):1653-1668.
PMID:
32091413
; PMCID:
PMC7108892
.
Citations:
41
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
CT
Clinical Trials
Conteduca V,
Ku SY
, Puca L, Slade M, Fernandez L, Hess J, Bareja R, Vlachostergios PJ, Sigouros M, Mosquera JM, Sboner A, Nanus DM, Elemento O, Dittamore R, Tagawa ST,
Beltran H
. SLFN11 Expression in Advanced Prostate Cancer and Response to Platinum-based Chemotherapy. Mol Cancer Ther. 2020 05; 19(5):1157-1164.
PMID:
32127465
.
Citations:
20
Fields:
Ant
Antineoplastic Agents
Translation:
Humans
Cells
Beltran H
, Morris MJ. Docetaxel for Early Prostate Cancer: What Have We Learned? Eur Urol. 2020 05; 77(5):573-575.
PMID:
32037142
.
Citations:
2
Fields:
Uro
Urology
Translation:
Humans
Eggener SE, Rumble RB,
Beltran H
. Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline Summary. JCO Oncol Pract. 2020 06; 16(6):340-343.
PMID:
32048932
.
Citations:
5
Fields:
Neo
Neoplasms
Translation:
Humans
Gillessen S, Attard G, Beer TM,
Beltran H
, Bjartell A, Bossi A, Briganti A, Bristow RG, Chi KN, Clarke N, Davis ID, de Bono J, Drake CG, Duran I, Eeles R, Efstathiou E, Evans CP, Fanti S, Feng FY, Fizazi K, Frydenberg M, Gleave M, Halabi S, Heidenreich A, Heinrich D, Higano CTS, Hofman MS, Hussain M, James N, Kanesvaran R,
Kantoff P
, Khauli RB, Leibowitz R, Logothetis C, Maluf F, Millman R,
Morgans AK
, Morris MJ, Mottet N, Mrabti H, Murphy DG, Murthy V, Oh WK, Ost P, O'Sullivan JM, Padhani AR, Parker C, Poon DMC, Pritchard CC, Reiter RE, Roach M, Rubin M, Ryan CJ, Saad F, Sade JP, Sartor O, Scher HI, Shore N, Small E, Smith M, Soule H, Sternberg CN, Steuber T, Suzuki H, Sweeney C, Sydes MR,
Taplin ME
, Tombal B, Türkeri L, van Oort I, Zapatero A, Omlin A. Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019. Eur Urol. 2020 04; 77(4):508-547.
PMID:
32001144
.
Citations:
91
Fields:
Uro
Urology
Translation:
Humans
Tiwari R, Manzar N, Bhatia V, Yadav A, Nengroo MA, Datta D, Carskadon S, Gupta N, Sigouros M, Khani F, Poutanen M, Zoubeidi A,
Beltran H
, Palanisamy N, Ateeq B. Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer. Nat Commun. 2020 01 20; 11(1):384.
PMID:
31959826
.
Citations:
32
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Mahal BA, Alshalalfa M, Zhao SG,
Beltran H
, Chen WS,
Chipidza F
, Davicioni E, Karnes RJ,
Ku SY
, Lotan TL, Muralidhar V,
Rebbeck TR
, Schaeffer EM, Spratt DE, Feng FY,
Nguyen PL
. Genomic and clinical characterization of stromal infiltration markers in prostate cancer. Cancer. 2020 04 01; 126(7):1407-1412.
PMID:
31905251
; PMCID:
PMC7332205
.
Citations:
4
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Eggener SE, Rumble RB, Armstrong AJ, Morgan TM, Crispino T, Cornford P, van der Kwast T, Grignon DJ, Rai AJ, Agarwal N, Klein EA, Den RB,
Beltran H
. Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline. J Clin Oncol. 2020 05 01; 38(13):1474-1494.
PMID:
31829902
.
Citations:
32
Fields:
Neo
Neoplasms
Translation:
Humans
Gillessen S, Omlin A, Attard G, de Bono JS, Efstathiou E, Fizazi K, Halabi S, Nelson PS, Sartor O, Smith MR, Soule HR, Akaza H, Beer TM,
Beltran H
, Chinnaiyan AM, Daugaard G, Davis ID, De Santis M, Drake CG, Eeles RA, Fanti S, Gleave ME, Heidenreich A, Hussain M, James ND, Lecouvet FE, Logothetis CJ, Mastris K, Nilsson S, Oh WK, Olmos D, Padhani AR, Parker C, Rubin MA, Schalken JA, Scher HI, Sella A, Shore ND, Small EJ, Sternberg CN, Suzuki H, Sweeney CJ, Tannock IF, Tombal B. Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015. Ann Oncol. 2019 12; 30(12):e3.
PMID:
32041688
.
Citations:
Sivakumar R, Chan M, Shin JS, Nishida-Aoki N, Kenerson HL, Elemento O,
Beltran H
, Yeung R, Gujral TS. Organotypic tumor slice cultures provide a versatile platform for immuno-oncology and drug discovery. Oncoimmunology. 2019; 8(12):e1670019.
PMID:
31741771
.
Citations:
20
Fields:
All
Allergy and Immunology
Neo
Neoplasms
Ku SY
, Gleave ME,
Beltran H
. Towards precision oncology in advanced prostate cancer. Nat Rev Urol. 2019 11; 16(11):645-654.
PMID:
31591549
.
Citations:
65
Fields:
Uro
Urology
Translation:
Humans
Sweeney CJ,
Beltran H
. The Balancing Act: Assessing Treatment Burden Versus Treatment Benefit with Evolving Metastatic Hormone-sensitive Prostate Cancer Data. Eur Urol. 2019 12; 76(6):729-731.
PMID:
31590937
.
Citations:
Fields:
Uro
Urology
Translation:
Humans
Sailer V, Eng KW, Zhang T, Bareja R, Pisapia DJ, Sigaras A, Bhinder B, Romanel A, Wilkes D, Sticca E, Cyrta J, Rao R, Sahota S, Pauli C, Beg S, Motanagh S, Kossai M, Fontunge J, Puca L, Rennert H, Zhaoying Xiang J, Greco N, Kim R, MacDonald TY, McNary T, Blattner-Johnson M, Schiffman MH, Faltas BM, Greenfield JP, Rickman D, Andreopoulou E, Holcomb K, Vahdat LT, Scherr DS, van Besien K, Barbieri CE, Robinson BD, Fine HA, Ocean AJ, Molina A, Shah MA, Nanus DM, Pan Q, Demichelis F, Tagawa ST, Song W, Mosquera JM, Sboner A, Rubin MA, Elemento O,
Beltran H
. Integrative Molecular Analysis of Patients With Advanced and Metastatic Cancer. JCO Precis Oncol. 2019; 3.
PMID:
31592503
; PMCID:
PMC6778956
.
Citations:
12
Fields:
Neo
Neoplasms
Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, Nanus DM, Tagawa ST, Ballman KV,
Beltran H
. Clinical features of neuroendocrine prostate cancer. Eur J Cancer. 2019 11; 121:7-18.
PMID:
31525487
; PMCID:
PMC6803064
.
Citations:
61
Fields:
Neo
Neoplasms
Translation:
Humans
Liu B, Li L, Yang G, Geng C, Luo Y, Wu W, Manyam GC, Korentzelos D, Park S, Tang Z, Wu C, Dong Z, Sigouros M, Sboner A,
Beltran H
, Chen Y, Corn PG, Tetzlaff MT, Troncoso P, Broom B, Thompson TC. PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer. Clin Cancer Res. 2019 11 15; 25(22):6839-6851.
PMID:
31439587
; PMCID:
PMC6858969
.
Citations:
14
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Persi E, Prandi D, Wolf YI, Pozniak Y, Barnabas GD, Levanon K, Barshack I, Barbieri C, Gasperini P,
Beltran H
, Faltas BM, Rubin MA, Geiger T, Koonin EV, Demichelis F, Horn D. Proteomic and genomic signatures of repeat instability in cancer and adjacent normal tissues. Proc Natl Acad Sci U S A. 2019 08 20; 116(34):16987-16996.
PMID:
31387980
; PMCID:
PMC6708321
.
Citations:
3
Fields:
Sci
Science
Translation:
Humans
Fernandez EM, Eng K, Beg S,
Beltran H
, Faltas BM, Mosquera JM, Nanus DM, Pisapia DJ, Rao RA, Robinson BD, Rubin MA, Elemento O, Sboner A, Shah MA, Song W. Cancer-Specific Thresholds Adjust for Whole Exome Sequencing-based Tumor Mutational Burden Distribution. JCO Precis Oncol. 2019; 3.
PMID:
31475242
; PMCID:
PMC6716608
.
Citations:
8
Fields:
Neo
Neoplasms
Beltran H
, Hruszkewycz A, Scher HI, Hildesheim J, Isaacs J, Yu EY, Kelly K, Lin D, Dicker A, Arnold J, Hecht T, Wicha M, Sears R, Rowley D, White R, Gulley JL, Lee J, Diaz Meco M, Small EJ, Shen M, Knudsen K, Goodrich DW, Lotan T, Zoubeidi A, Sawyers CL, Rudin CM,
Loda M
, Thompson T, Rubin MA, Tawab-Amiri A, Dahut W, Nelson PS. The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance. Clin Cancer Res. 2019 12 01; 25(23):6916-6924.
PMID:
31363002
.
Citations:
86
Fields:
Neo
Neoplasms
Translation:
Humans
Robinson BD, Vlachostergios PJ, Bhinder B, Liu W, Li K, Moss TJ, Bareja R, Park K, Tavassoli P, Cyrta J, Tagawa ST, Nanus DM,
Beltran H
, Molina AM, Khani F, Miguel Mosquera J, Xylinas E, Shariat SF, Scherr DS, Rubin MA, Lerner SP, Matin SF, Elemento O, Faltas BM. Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling. Nat Commun. 2019 07 05; 10(1):2977.
PMID:
31278255
.
Citations:
45
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Berger A, Brady NJ, Bareja R, Robinson B, Conteduca V, Augello MA, Puca L, Ahmed A, Dardenne E, Lu X, Hwang I, Bagadion AM, Sboner A, Elemento O, Paik J, Yu J, Barbieri CE, Dephoure N,
Beltran H
, Rickman DS. N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer. J Clin Invest. 2019 07 01; 129(9):3924-3940.
PMID:
31260412
; PMCID:
PMC6715370
.
Citations:
49
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Armenia J, Wankowicz SAM, Liu D, Gao J, Kundra R, Reznik E, Chatila WK, Chakravarty D, Han GC, Coleman I, Montgomery B, Pritchard C, Morrissey C, Barbieri CE,
Beltran H
, Sboner A, Zafeiriou Z, Miranda S, Bielski CM, Penson AV, Tolonen C, Huang FW, Robinson D, Wu YM, Lonigro R, Garraway LA, Demichelis F,
Kantoff PW
,
Taplin ME
, Abida W, Taylor BS, Scher HI, Nelson PS, de Bono JS, Rubin MA, Sawyers CL, Chinnaiyan AM, Schultz N,
Van Allen EM
. Publisher Correction: The long tail of oncogenic drivers in prostate cancer. Nat Genet. 2019 Jul; 51(7):1194.
PMID:
31152158
.
Citations:
4
Fields:
Gen
Genetics
Terry S, El-Sayed IY, Destouches D, Maillé P, Nicolaiew N, Ploussard G, Semprez F, Pimpie C,
Beltran H
, Londono-Vallejo A, Allory Y, de la Taille A, Salomon DS, Vacherot F. Erratum: CRIPTO overexpression promotes mesenchymal differentiation in prostate carcinoma cells through parallel regulation of AKT and FGFR activities. Oncotarget. 2019 06 25; 10(41):4247-4248.
PMID:
31289621
.
Citations:
Fields:
Neo
Neoplasms
Alshalalfa M,
Nguyen PL
,
Beltran H
, Chen WS, Davicioni E, Zhao SG,
Rebbeck TR
, Schaeffer EM, Lotan TL, Feng FY, Mahal BA. Transcriptomic and Clinical Characterization of Neuropeptide Y Expression in Localized and Metastatic Prostate Cancer: Identification of Novel Prostate Cancer Subtype with Clinical Implications. Eur Urol Oncol. 2019 07; 2(4):405-412.
PMID:
31164324
.
Citations:
5
Fields:
Neo
Neoplasms
Uro
Urology
Translation:
Humans
Cells
Choudhury AD
,
Beltran H
. Retinoblastoma Loss in Cancer: Casting a Wider Net. Clin Cancer Res. 2019 07 15; 25(14):4199-4201.
PMID:
31101725
; PMCID:
PMC6635068
.
Citations:
2
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Augello MA, Liu D, Deonarine LD, Robinson BD, Huang D, Stelloo S, Blattner M, Doane AS, Wong EWP, Chen Y, Rubin MA,
Beltran H
, Elemento O, Bergman AM, Zwart W, Sboner A, Dephoure N, Barbieri CE. CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis. Cancer Cell. 2019 May 13; 35(5):817-819.
PMID:
31085180
.
Citations:
13
Fields:
Neo
Neoplasms
Abida W, Cyrta J, Heller G, Prandi D, Armenia J, Coleman I, Cieslik M, Benelli M, Robinson D,
Van Allen EM
, Sboner A, Fedrizzi T, Mosquera JM, Robinson BD, De Sarkar N, Kunju LP, Tomlins S, Wu YM, Nava Rodrigues D,
Loda M
, Gopalan A, Reuter VE, Pritchard CC, Mateo J, Bianchini D, Miranda S, Carreira S, Rescigno P, Filipenko J, Vinson J, Montgomery RB,
Beltran H
, Heath EI, Scher HI,
Kantoff PW
,
Taplin ME
, Schultz N, deBono JS, Demichelis F, Nelson PS, Rubin MA, Chinnaiyan AM, Sawyers CL. Genomic correlates of clinical outcome in advanced prostate cancer. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11428-11436.
PMID:
31061129
; PMCID:
PMC6561293
.
Citations:
304
Fields:
Sci
Science
Translation:
Humans
Notarangelo M, Zucal C, Modelska A, Pesce I, Scarduelli G, Potrich C, Lunelli L, Pederzolli C, Pavan P, la Marca G, Pasini L, Ulivi P,
Beltran H
, Demichelis F, Provenzani A, Quattrone A, D'Agostino VG. Ultrasensitive detection of cancer biomarkers by nickel-based isolation of polydisperse extracellular vesicles from blood. EBioMedicine. 2019 May; 43:114-126.
PMID:
31047861
; PMCID:
PMC6558028
.
Citations:
17
Fields:
Gen
Genetics
Med
Medicine (General)
Translation:
Humans
Cells
Tagawa ST, Vallabhajosula S, Christos PJ, Jhanwar YS, Batra JS, Lam L, Osborne J,
Beltran H
, Molina AM, Goldsmith SJ, Bander NH, Nanus DM. Phase 1/2 study of fractionated dose lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 (177 Lu-J591) for metastatic castration-resistant prostate cancer. Cancer. 2019 08 01; 125(15):2561-2569.
PMID:
31012963
.
Citations:
37
Fields:
Neo
Neoplasms
Translation:
Humans
CT
Clinical Trials
Vlachostergios PJ, Geyer JT, Miller J, Kosloff R,
Beltran H
, Tagawa ST. Exceptional Response to Pembrolizumab in a Patient With Castration-Resistant Prostate Cancer With Pancytopenia From Myelophthisis. J Oncol Pract. 2019 06; 15(6):343-345.
PMID:
30964731
.
Citations:
2
Fields:
Neo
Neoplasms
Translation:
Humans
Augello MA, Liu D, Deonarine LD, Robinson BD, Huang D, Stelloo S, Blattner M, Doane AS, Wong EWP, Chen Y, Rubin MA,
Beltran H
, Elemento O, Bergman AM, Zwart W, Sboner A, Dephoure N, Barbieri CE. CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis. Cancer Cell. 2019 04 15; 35(4):603-617.e8.
PMID:
30930119
.
Citations:
20
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Puca L, Gavyert K, Sailer V, Conteduca V, Dardenne E, Sigouros M, Isse K, Kearney M, Vosoughi A, Fernandez L, Pan H, Motanagh S, Hess J, Donoghue AJ, Sboner A, Wang Y, Dittamore R, Rickman D, Nanus DM, Tagawa ST, Elemento O, Mosquera JM, Saunders L,
Beltran H
. Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer. Sci Transl Med. 2019 03 20; 11(484).
PMID:
30894499
; PMCID:
PMC6525633
.
Citations:
42
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
CT
Clinical Trials
Reina-Campos M, Linares JF, Duran A, Cordes T, L'Hermitte A, Badur MG, Bhangoo MS, Thorson PK, Richards A, Rooslid T, Garcia-Olmo DC, Nam-Cha SY, Salinas-Sanchez AS, Eng K,
Beltran H
, Scott DA, Metallo CM, Moscat J, Diaz-Meco MT. Increased Serine and One-Carbon Pathway Metabolism by PKC?/? Deficiency Promotes Neuroendocrine Prostate Cancer. Cancer Cell. 2019 03 18; 35(3):385-400.e9.
PMID:
30827887
.
Citations:
58
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Musselman K, Glynn S, Mosquera JM, Elemento O, Sboner A,
Beltran H
, Holcomb K. Identification of a therapeutic target using molecular sequencing for treatment of recurrent uterine serous adenocarcinoma. Gynecol Oncol Rep. 2019 May; 28:54-57.
PMID:
30906838
; PMCID:
PMC6411491
.
Citations:
4
Davies A, Conteduca V, Zoubeidi A,
Beltran H
. Biological Evolution of Castration-resistant Prostate Cancer. Eur Urol Focus. 2019 03; 5(2):147-154.
PMID:
30772358
.
Citations:
23
Fields:
Uro
Urology
Translation:
Humans
Puca L, Vlachostergios PJ,
Beltran H
. Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models, and Therapies. Cold Spring Harb Perspect Med. 2019 02 01; 9(2).
PMID:
29844220
.
Citations:
25
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Glynn S, Lipkin S, Zhang T, Sboner A, Elemento O, Van Besien K,
Beltran H
. The application of precision medicine in diagnosing familial Mediterranean fever. Leuk Lymphoma. 2019 08; 60(8):2091-2093.
PMID:
30698071
.
Citations:
Fields:
Hem
Hematology
Neo
Neoplasms
Translation:
Humans
Cells
Guo H, Ci X, Ahmed M, Hua JT, Soares F, Lin D, Puca L, Vosoughi A, Xue H, Li E, Su P, Chen S, Nguyen T, Liang Y, Zhang Y, Xu X, Xu J, Sheahan AV, Ba-Alawi W, Zhang S, Mahamud O, Vellanki RN, Gleave M, Bristow RG, Haibe-Kains B, Poirier JT, Rudin CM, Tsao MS, Wouters BG, Fazli L, Feng FY, Ellis L, van der Kwast T, Berlin A, Koritzinsky M, Boutros PC, Zoubeidi A,
Beltran H
, Wang Y, He HH. ONECUT2 is a driver of neuroendocrine prostate cancer. Nat Commun. 2019 01 17; 10(1):278.
PMID:
30655535
; PMCID:
PMC6336817
.
Citations:
64
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Gerke T,
Beltran H
, Wang X, Lee GM, Sboner A, Karnes RJ, Klein EA, Davicioni E, Yousefi K, Ross AE, Börnigen D,
Huttenhower C
,
Mucci LA
, Trock BJ, Sweeney CJ. Low Tristetraprolin Expression Is Associated with Lethal Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2019 03; 28(3):584-590.
PMID:
30420441
; PMCID:
PMC6494092
.
Citations:
2
Fields:
Bio
Biochemistry
Epi
Epidemiology
Neo
Neoplasms
Translation:
Humans
Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A,
Beltran H
, Rubin MA, Mukherjee S, Cantley LC. Publisher Correction: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. 2018 11; 563(7731):E24.
PMID:
30158705
.
Citations:
2
Fields:
Sci
Science
Rodrigues DN, Rescigno P,
Liu D
, Yuan W, Carreira S, Lambros MB, Seed G, Mateo J, Riisnaes R, Mullane S, Margolis C, Miao D, Miranda S, Dolling D, Clarke M, Bertan C, Crespo M, Boysen G, Ferreira A, Sharp A, Figueiredo I, Keliher D,
Aldubayan S
,
Burke KP
, Sumanasuriya S, Fontes MS, Bianchini D, Zafeiriou Z, Mendes LST,
Mouw K
, Schweizer MT, Pritchard CC, Salipante S,
Taplin ME
,
Beltran H
, Rubin MA, Cieslik M, Robinson D, Heath E, Schultz N, Armenia J, Abida W, Scher H, Lord C,
D'Andrea A
, Sawyers CL, Chinnaiyan AM, Alimonti A, Nelson PS, Drake CG,
Van Allen EM
, de Bono JS. Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer. J Clin Invest. 2018 11 01; 128(11):5185.
PMID:
30382943
.
Citations:
22
Fields:
Med
Medicine (General)
Conteduca V, Scarpi E, Salvi S, Casadio V, Lolli C, Gurioli G, Schepisi G, Wetterskog D, Farolfi A, Menna C, De Lisi D, Burgio SL,
Beltran H
, Attard G, De Giorgi U. Plasma androgen receptor and serum chromogranin A in advanced prostate cancer. Sci Rep. 2018 10 18; 8(1):15442.
PMID:
30337589
.
Citations:
7
Fields:
Sci
Science
Translation:
Humans
Mottahedeh J, Haffner MC, Grogan TR, Hashimoto T, Crowell PD,
Beltran H
, Sboner A, Bareja R, Esopi D, Isaacs WB, Yegnasubramanian S, Rettig MB, Elashoff DA, Platz EA, De Marzo AM, Teitell MA, Goldstein AS. CD38 is methylated in prostate cancer and regulates extracellular NAD. Cancer Metab. 2018; 6:13.
PMID:
30258629
; PMCID:
PMC6150989
.
Citations:
21
Beltran H
, Oromendia C, Danila DC, Montgomery B, Hoimes C, Szmulewitz RZ, Vaishampayan U, Armstrong AJ, Stein M, Pinski J, Mosquera JM, Sailer V, Bareja R, Romanel A, Gumpeni N, Sboner A, Dardenne E, Puca L, Prandi D, Rubin MA, Scher HI, Rickman DS, Demichelis F, Nanus DM, Ballman KV, Tagawa ST. A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers. Clin Cancer Res. 2019 01 01; 25(1):43-51.
PMID:
30232224
; PMCID:
PMC6320304
.
Citations:
70
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
CT
Clinical Trials
Morash M, Mitchell H,
Beltran H
, Elemento O, Pathak J. The Role of Next-Generation Sequencing in Precision Medicine: A Review of Outcomes in Oncology. J Pers Med. 2018 Sep 17; 8(3).
PMID:
30227640
; PMCID:
PMC6164147
.
Citations:
28
Li Q, Deng Q, Chao HP, Liu X, Lu Y, Lin K, Liu B, Tang GW, Zhang D, Tracz A, Jeter C, Rycaj K, Calhoun-Davis T, Huang J, Rubin MA,
Beltran H
, Shen J, Chatta G, Puzanov I, Mohler JL, Wang J, Zhao R, Kirk J, Chen X, Tang DG. Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. Nat Commun. 2018 09 06; 9(1):3600.
PMID:
30190514
; PMCID:
PMC6127155
.
Citations:
52
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Nava Rodrigues D, Rescigno P,
Liu D
, Yuan W, Carreira S, Lambros MB, Seed G, Mateo J, Riisnaes R, Mullane S, Margolis C, Miao D, Miranda S, Dolling D, Clarke M, Bertan C, Crespo M, Boysen G, Ferreira A, Sharp A, Figueiredo I, Keliher D,
Aldubayan S
,
Burke KP
, Sumanasuriya S, Fontes MS, Bianchini D, Zafeiriou Z, Teixeira Mendes LS,
Mouw K
, Schweizer MT, Pritchard CC, Salipante S,
Taplin ME
,
Beltran H
, Rubin MA, Cieslik M, Robinson D, Heath E, Schultz N, Armenia J, Abida W, Scher H, Lord C,
D'Andrea A
, Sawyers CL, Chinnaiyan AM, Alimonti A, Nelson PS, Drake CG,
Van Allen EM
, de Bono JS. Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer. J Clin Invest. 2018 10 01; 128(10):4441-4453.
PMID:
30179225
; PMCID:
PMC6159966
.
Citations:
50
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
CT
Clinical Trials
Chedgy EC, Vandekerkhove G, Herberts C, Annala M, Donoghue AJ, Sigouros M, Ritch E, Struss W, Konomura S, Liew J, Parimi S, Vergidis J, Hurtado-Coll A, Sboner A, Fazli L,
Beltran H
, Chi KN, Wyatt AW. Biallelic tumour suppressor loss and DNA repair defects in de novo small-cell prostate carcinoma. J Pathol. 2018 10; 246(2):244-253.
PMID:
30015382
.
Citations:
14
Fields:
Pat
Pathology
Translation:
Humans
Cells
Carlo MI, Giri VN, Paller CJ, Abida W, Alumkal JJ, Beer TM,
Beltran H
, George DJ, Heath EI, Higano CS, McKay RR,
Morgans AK
, Patnaik A, Ryan CJ, Schaeffer EM, Stadler WM,
Taplin ME
, Kauff ND, Vinson J, Antonarakis ES, Cheng HH. Evolving Intersection Between Inherited Cancer Genetics and Therapeutic Clinical Trials in Prostate Cancer: A White Paper From the Germline Genetics Working Group of the Prostate Cancer Clinical Trials Consortium. JCO Precis Oncol. 2018; 2018.
PMID:
30761386
; PMCID:
PMC6370313
.
Citations:
11
Fields:
Neo
Neoplasms
Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, Lloyd P, Gleave M, Evans CP, Youngren J, Beer TM, Rettig M, Wong CK, True L, Foye A, Playdle D, Ryan CJ, Lara P, Chi KN, Uzunangelov V, Sokolov A, Newton Y,
Beltran H
, Demichelis F, Rubin MA, Stuart JM, Small EJ. Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study. J Clin Oncol. 2018 08 20; 36(24):2492-2503.
PMID:
29985747
; PMCID:
PMC6366813
.
Citations:
192
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
CT
Clinical Trials
Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y,
Harris EM
, Sboner A,
Beltran H
, Rubin MA, Mukherjee S, Cantley LC. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. 2018 08; 560(7719):499-503.
PMID:
30051890
; PMCID:
PMC6197057
.
Citations:
200
Fields:
Sci
Science
Translation:
Animals
Cells
Conteduca V, Sigouros M, Sboner A, Pritchard CC,
Beltran H
. BRCA2-Associated Prostate Cancer in a Patient With Spinal and Bulbar Muscular Atrophy. JCO Precis Oncol. 2018; 2.
PMID:
30613824
; PMCID:
PMC6317373
.
Citations:
2
Fields:
Neo
Neoplasms
Puca L, Bareja R, Prandi D, Shaw R, Benelli M, Karthaus WR, Hess J, Sigouros M, Donoghue A, Kossai M, Gao D, Cyrta J, Sailer V, Vosoughi A, Pauli C, Churakova Y, Cheung C, Deonarine LD, McNary TJ, Rosati R, Tagawa ST, Nanus DM, Mosquera JM, Sawyers CL, Chen Y, Inghirami G, Rao RA, Grandori C, Elemento O, Sboner A, Demichelis F, Rubin MA,
Beltran H
. Patient derived organoids to model rare prostate cancer phenotypes. Nat Commun. 2018 06 19; 9(1):2404.
PMID:
29921838
.
Citations:
116
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Ramnarine VR
, Alshalalfa M, Mo F, Nabavi N, Erho N, Takhar M, Shukin R, Brahmbhatt S, Gawronski A, Kobelev M,
Nouri M
, Lin D,
Tsai H
, Lotan TL, Karnes RJ, Rubin MA, Zoubeidi A, Gleave ME, Sahinalp C, Wyatt AW, Volik SV,
Beltran H
, Davicioni E, Wang Y, Collins CC. The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications. Gigascience. 2018 06 01; 7(6).
PMID:
29757368
.
Citations:
26
Fields:
Com
Computational Biology
Gen
Genetics
Translation:
Humans
Animals
Cells
Morash M, Mitchell H, Yu A, Campion T,
Beltran H
, Elemento O, Pathak J. CATCH-KB: Establishing a Pharmacogenomics Variant Repository for Chemotherapy-Induced Cardiotoxicity. AMIA Jt Summits Transl Sci Proc. 2018; 2017:168-177.
PMID:
29888066
; PMCID:
PMC5961780
.
Citations:
2
Armenia J, Wankowicz SAM,
Liu D
, Gao J, Kundra R, Reznik E, Chatila WK, Chakravarty D, Han GC, Coleman I, Montgomery B, Pritchard C, Morrissey C, Barbieri CE,
Beltran H
, Sboner A, Zafeiriou Z, Miranda S, Bielski CM, Penson AV, Tolonen C, Huang FW, Robinson D, Wu YM, Lonigro R, Garraway LA, Demichelis F,
Kantoff PW
,
Taplin ME
, Abida W, Taylor BS, Scher HI, Nelson PS, de Bono JS, Rubin MA, Sawyers CL, Chinnaiyan AM, Schultz N,
Van Allen EM
. The long tail of oncogenic drivers in prostate cancer. Nat Genet. 2018 05; 50(5):645-651.
PMID:
29610475
.
Citations:
265
Fields:
Gen
Genetics
Translation:
Humans
Cells
Davies AH,
Beltran H
, Zoubeidi A. Cellular plasticity and the neuroendocrine phenotype in prostate cancer. Nat Rev Urol. 2018 05; 15(5):271-286.
PMID:
29460922
.
Citations:
110
Fields:
Uro
Urology
Translation:
Humans
Mateo J, Cheng HH,
Beltran H
, Dolling D, Xu W, Pritchard CC, Mossop H, Rescigno P, Perez-Lopez R, Sailer V, Kolinsky M, Balasopoulou A, Bertan C, Nanus DM, Tagawa ST, Thorne H, Montgomery B, Carreira S, Sandhu S, Rubin MA, Nelson PS, de Bono JS. Clinical Outcome of Prostate Cancer Patients with Germline DNA Repair Mutations: Retrospective Analysis from an International Study. Eur Urol. 2018 05; 73(5):687-693.
PMID:
29429804
.
Citations:
33
Fields:
Uro
Urology
Translation:
Humans
Cells
Armstrong AJ, Antonarakis ES, Taplin ME, Kelly WK,
Beltran H
, Fizazi K, Dahut WL, Shore N, Slovin S, George D, Carducci MA, Corn P, Danila D, Dreicer R, Heath E, Rathkopf D, Liu G, Nanus D, Stein M, Smith MR, Sternberg C, Wilding G, Nelson PS, Halabi S,
Kantoff P
, Clarke NW, Evans CP, Heidenreich A, Mottet N, Gleave M, Morris MJ, Scher HI. Naming disease states for clinical utility in prostate cancer: a rose by any other name might not smell as sweet. Ann Oncol. 2018 01 01; 29(1):23-25.
PMID:
29088323
; PMCID:
PMC6248721
.
Citations:
1
Fields:
Neo
Neoplasms
Translation:
Humans
Sailer V, Schiffman MH, Kossai M, Cyrta J, Beg S, Sullivan B, Pua BB, Lee KS, Talenfeld AD, Nanus DM, Tagawa ST, Robinson BD, Rao RA, Pauli C, Bareja R, Beltran LS, Sigaras A, Eng KW, Elemento O, Sboner A, Rubin MA,
Beltran H
, Mosquera JM. Bone biopsy protocol for advanced prostate cancer in the era of precision medicine. Cancer. 2018 03 01; 124(5):1008-1015.
PMID:
29266381
.
Citations:
17
Fields:
Neo
Neoplasms
Translation:
Humans
Shukla S, Cyrta J, Murphy DA, Walczak EG, Ran L, Agrawal P, Xie Y, Chen Y, Wang S, Zhan Y, Li D, Wong EWP, Sboner A,
Beltran H
, Mosquera JM, Sher J, Cao Z, Wongvipat J, Koche RP, Gopalan A, Zheng D, Rubin MA, Scher HI, Chi P, Chen Y. Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Cancer Cell. 2017 Dec 11; 32(6):792-806.e7.
PMID:
29153843
.
Citations:
32
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Lange KR, Fischer C, Rajappa P, Connors S, Pisapia D, Greenfield JP,
Beltran H
, Rubin M, Mosquera JM, Khakoo Y. Rapid autopsy of a patient with recurrent anaplastic ependymoma. Palliat Support Care. 2018 04; 16(2):238-242.
PMID:
28942746
.
Citations:
2
Fields:
Pal
Palliative Care
Psy
Psychology
Translation:
Humans
Beltran H
, Wyatt AW, Chedgy EC, Donoghue A, Annala M, Warner EW, Beja K, Sigouros M, Mo F, Fazli L, Collins CC, Eastham J, Morris M,
Taplin ME
, Sboner A, Halabi S, Gleave ME. Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy. Clin Cancer Res. 2017 Nov 15; 23(22):6802-6811.
PMID:
28842510
; PMCID:
PMC5690882
.
Citations:
32
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Gillessen S, Attard G, Beer TM,
Beltran H
, Bossi A, Bristow R, Carver B, Castellano D, Chung BH, Clarke N, Daugaard G, Davis ID, de Bono J, Borges Dos Reis R, Drake CG, Eeles R, Efstathiou E, Evans CP, Fanti S, Feng F, Fizazi K, Frydenberg M, Gleave M, Halabi S, Heidenreich A, Higano CS, James N,
Kantoff P
, Kellokumpu-Lehtinen PL, Khauli RB, Kramer G, Logothetis C, Maluf F,
Morgans AK
, Morris MJ, Mottet N, Murthy V, Oh W, Ost P, Padhani AR, Parker C, Pritchard CC, Roach M, Rubin MA, Ryan C, Saad F, Sartor O, Scher H, Sella A, Shore N, Smith M, Soule H, Sternberg CN, Suzuki H, Sweeney C, Sydes MR, Tannock I, Tombal B, Valdagni R, Wiegel T, Omlin A. Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017. Eur Urol. 2018 02; 73(2):178-211.
PMID:
28655541
.
Citations:
162
Fields:
Uro
Urology
Translation:
Humans
Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM, Rajappa P, Souweidane MM, Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F,
Beltran H
, Rubin MA, Mosquera JM. Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models. JCO Precis Oncol. 2017; 2017.
PMID:
29333526
; PMCID:
PMC5761727
.
Citations:
22
Fields:
Neo
Neoplasms
Rickman DS,
Beltran H
, Demichelis F, Rubin MA. Biology and evolution of poorly differentiated neuroendocrine tumors. Nat Med. 2017 Jun 06; 23(6):1-10.
PMID:
28586335
.
Citations:
75
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Wilkes DC, Sailer V, Xue H, Cheng H, Collins CC, Gleave M, Wang Y, Demichelis F,
Beltran H
, Rubin MA, Rickman DS. A germline FANCA alteration that is associated with increased sensitivity to DNA damaging agents. Cold Spring Harb Mol Case Stud. 2017 Sep; 3(5).
PMID:
28864460
.
Citations:
14
Fields:
Gen
Genetics
Translation:
Humans
Cells
Prandi D,
Baca SC
, Romanel A, Barbieri CE, Mosquera JM, Fontugne J,
Beltran H
, Sboner A, Garraway LA, Rubin MA, Demichelis F. Erratum to: Unraveling the clonal hierarchy of somatic genomic aberrations. Genome Biol. 2017 05 02; 18(1):80.
PMID:
28464947
; PMCID:
PMC5412043
.
Citations:
Fields:
Gen
Genetics
Vlachostergios PJ, Puca L,
Beltran H
. Emerging Variants of Castration-Resistant Prostate Cancer. Curr Oncol Rep. 2017 May; 19(5):32.
PMID:
28361223
; PMCID:
PMC5479409
.
Citations:
70
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
O'Rourke KP, Loizou E, Livshits G, Schatoff EM, Baslan T, Manchado E, Simon J, Romesser PB, Leach B, Han T, Pauli C,
Beltran H
, Rubin MA, Dow LE, Lowe SW. Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer. Nat Biotechnol. 2017 06; 35(6):577-582.
PMID:
28459450
; PMCID:
PMC5462850
.
Citations:
90
Fields:
Bio
Biotechnology
Translation:
Animals
Cells
Sailer V, Pauli C, Merzier EC, Mosquera JM,
Beltran H
, Rubin MA, Rao RA. On-site Cytology for Development of Patient-Derived Three-dimensional Organoid Cultures - A Pilot Study. Anticancer Res. 2017 04; 37(4):1569-1573.
PMID:
28373416
.
Citations:
3
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Pauli C, Hopkins BD, Prandi D, Shaw R, Fedrizzi T, Sboner A, Sailer V, Augello M, Puca L, Rosati R, McNary TJ, Churakova Y, Cheung C, Triscott J, Pisapia D, Rao R, Mosquera JM, Robinson B, Faltas BM, Emerling BE, Gadi VK, Bernard B, Elemento O,
Beltran H
, Demichelis F, Kemp CJ, Grandori C, Cantley LC, Rubin MA. Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine. Cancer Discov. 2017 05; 7(5):462-477.
PMID:
28331002
; PMCID:
PMC5413423
.
Citations:
328
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Beltran H
. The clone wars. Sci Transl Med. 2017 02 15; 9(377).
PMID:
28202773
.
Citations:
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Cells
Mu P, Zhang Z, Benelli M, Karthaus WR, Hoover E, Chen CC, Wongvipat J,
Ku SY
, Gao D, Cao Z, Shah N, Adams EJ, Abida W, Watson PA, Prandi D, Huang CH, de Stanchina E, Lowe SW, Ellis L,
Beltran H
, Rubin MA, Goodrich DW, Demichelis F, Sawyers CL. SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer. Science. 2017 01 06; 355(6320):84-88.
PMID:
28059768
; PMCID:
PMC5247742
.
Citations:
373
Fields:
Sci
Science
Translation:
Humans
Cells
Sternberg CN,
Beltran H
. Prostate cancer in 2016: Improved outcomes and precision medicine come within reach. Nat Rev Urol. 2017 Feb; 14(2):71-72.
PMID:
28050016
.
Citations:
3
Fields:
Uro
Urology
Translation:
Humans
Beltran H
. Unleashing the wrath of Ras. Sci Transl Med. 2017 01 04; 9(371).
PMID:
28053152
.
Citations:
Fields:
Med
Medicine (General)
Sci
Science
Friedlander TW, Pritchard CC,
Beltran H
. Personalizing Therapy for Metastatic Prostate Cancer: The Role of Solid and Liquid Tumor Biopsies. Am Soc Clin Oncol Educ Book. 2017; 37:358-369.
PMID:
28561699
.
Citations:
4
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Beltran H
. Synthetic lethality and beyond. Sci Transl Med. 2016 11 16; 8(365):365ec182.
PMID:
27856791
.
Citations:
Fields:
Med
Medicine (General)
Sci
Science
Bishop JL, Thaper D, Vahid S, Davies A, Ketola K, Kuruma H, Jama R, Nip KM, Angeles A, Johnson F, Wyatt AW, Fazli L, Gleave ME, Lin D, Rubin MA, Collins CC, Wang Y,
Beltran H
, Zoubeidi A. The Master Neural Transcription Factor BRN2 Is an Androgen Receptor-Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer. Cancer Discov. 2017 01; 7(1):54-71.
PMID:
27784708
.
Citations:
137
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Faltas BM, Prandi D, Tagawa ST, Molina AM, Nanus DM, Sternberg C, Rosenberg J, Mosquera JM, Robinson B, Elemento O, Sboner A,
Beltran H
, Demichelis F, Rubin MA. Clonal evolution of chemotherapy-resistant urothelial carcinoma. Nat Genet. 2016 12; 48(12):1490-1499.
PMID:
27749842
; PMCID:
PMC5549141
.
Citations:
98
Fields:
Gen
Genetics
Translation:
Humans
Cells
Dardenne E,
Beltran H
, Benelli M, Gayvert K, Berger A, Puca L, Cyrta J, Sboner A, Noorzad Z, MacDonald T, Cheung C, Yuen KS, Gao D, Chen Y, Eilers M, Mosquera JM, Robinson BD, Elemento O, Rubin MA, Demichelis F, Rickman DS. N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer. Cancer Cell. 2016 10 10; 30(4):563-577.
PMID:
27728805
.
Citations:
205
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Rennert H, Eng K, Zhang T, Tan A, Xiang J, Romanel A, Kim R, Tam W, Liu YC, Bhinder B, Cyrta J,
Beltran H
, Robinson B, Mosquera JM, Fernandes H, Demichelis F, Sboner A, Kluk M, Rubin MA, Elemento O. Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care. NPJ Genom Med. 2016; 1.
PMID:
28781886
; PMCID:
PMC5539963
.
Citations:
33
Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W,
Beltran H
, Garofalo A, Gulati R, Carreira S, Eeles R, Elemento O, Rubin MA, Robinson D, Lonigro R, Hussain M, Chinnaiyan A, Vinson J, Filipenko J, Garraway L,
Taplin ME
,
AlDubayan S
, Han GC, Beightol M, Morrissey C, Nghiem B, Cheng HH, Montgomery B,
Walsh T
, Casadei S, Berger M, Zhang L, Zehir A, Vijai J, Scher HI, Sawyers C, Schultz N,
Kantoff PW
, Solit D, Robson M,
Van Allen EM
, Offit K, de Bono J, Nelson PS. Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. N Engl J Med. 2016 Aug 04; 375(5):443-53.
PMID:
27433846
; PMCID:
PMC4986616
.
Citations:
473
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Beltran H
. Update on the biology and management of neuroendocrine prostate cancer. Clin Adv Hematol Oncol. 2016 Jul; 14(7):513-5.
PMID:
27379946
.
Citations:
7
Fields:
Hem
Hematology
Neo
Neoplasms
Translation:
Humans
Li Y, Donmez N, Sahinalp C, Xie N, Wang Y, Xue H, Mo F,
Beltran H
, Gleave M, Wang Y, Collins C, Dong X. SRRM4 Drives Neuroendocrine Transdifferentiation of Prostate Adenocarcinoma Under Androgen Receptor Pathway Inhibition. Eur Urol. 2017 01; 71(1):68-78.
PMID:
27180064
.
Citations:
76
Fields:
Uro
Urology
Translation:
Humans
Cells
Gillessen S, Omlin A, Attard G, de Bono JS, Efstathiou E, Fizazi K, Halabi S, Nelson PS, Sartor O, Smith MR, Soule HR, Akaza H, Beer TM,
Beltran H
, Chinnaiyan AM, Daugaard G, Davis ID, De Santis M, Drake CG, Eeles RA, Fanti S, Gleave ME, Heidenreich A, Hussain M, James ND, Lecouvet FE, Logothetis CJ, Mastris K, Nilsson S, Oh WK, Olmos D, Padhani AR, Parker C, Rubin MA, Schalken JA, Scher HI, Sella A, Shore ND, Small EJ, Sternberg CN, Suzuki H, Sweeney CJ, Tannock IF, Tombal B. Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015. Ann Oncol. 2019 12; 30(12):e3.
PMID:
27141017
.
Citations:
10
Fields:
Neo
Neoplasms
Choe H, Sboner A,
Beltran H
, Nanus D, Tagawa ST. PO-43 - Differential coagulation factor expression in neuroendocrine prostate cancer (PC), metastatic castrate-resistant PC, and localized prostatic adenocarcinoma. Thromb Res. 2016 Apr; 140 Suppl 1:S192.
PMID:
27161731
.
Citations:
2
Fields:
Vas
Vascular Diseases
Beltran H
, Prandi D, Mosquera JM, Benelli M, Puca L, Cyrta J, Marotz C, Giannopoulou E, Chakravarthi BV, Varambally S, Tomlins SA, Nanus DM, Tagawa ST,
Van Allen EM
, Elemento O, Sboner A, Garraway LA, Rubin MA, Demichelis F. Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. Nat Med. 2016 Mar; 22(3):298-305.
PMID:
26855148
; PMCID:
PMC4777652
.
Citations:
577
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Cells
Beltran H
, Antonarakis ES, Morris MJ, Attard G. Emerging Molecular Biomarkers in Advanced Prostate Cancer: Translation to the Clinic. Am Soc Clin Oncol Educ Book. 2016; 35:131-41.
PMID:
27249694
.
Citations:
12
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Beltran H
, Jendrisak A, Landers M, Mosquera JM, Kossai M, Louw J, Krupa R, Graf RP, Schreiber NA, Nanus DM, Tagawa ST, Marrinucci D, Dittamore R, Scher HI. The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer. Clin Cancer Res. 2016 Mar 15; 22(6):1510-9.
PMID:
26671992
; PMCID:
PMC4990782
.
Citations:
65
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Pauli C, Puca L, Mosquera JM, Robinson BD,
Beltran H
, Rubin MA, Rao RA. An emerging role for cytopathology in precision oncology. Cancer Cytopathol. 2016 Mar; 124(3):167-73.
PMID:
26641771
.
Citations:
9
Fields:
Neo
Neoplasms
Translation:
Humans
Akamatsu S, Wyatt AW, Lin D, Lysakowski S, Zhang F, Kim S, Tse C, Wang K, Mo F, Haegert A, Brahmbhatt S, Bell R, Adomat H, Kawai Y, Xue H, Dong X, Fazli L,
Tsai H
, Lotan TL, Kossai M, Mosquera JM, Rubin MA,
Beltran H
, Zoubeidi A, Wang Y, Gleave ME, Collins CC. The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer. Cell Rep. 2015 Aug 11; 12(6):922-36.
PMID:
26235627
.
Citations:
117
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Beltran H
, Demichelis F. Prostate cancer: Intrapatient heterogeneity in prostate cancer. Nat Rev Urol. 2015 Aug; 12(8):430-1.
PMID:
26215693
.
Citations:
11
Fields:
Uro
Urology
Translation:
Humans
Robinson D,
Van Allen EM
, Wu YM, Schultz N, Lonigro RJ, Mosquera JM, Montgomery B,
Taplin ME
, Pritchard CC, Attard G,
Beltran H
, Abida W, Bradley RK, Vinson J, Cao X, Vats P, Kunju LP, Hussain M, Feng FY, Tomlins SA, Cooney KA, Smith DC, Brennan C, Siddiqui J, Mehra R, Chen Y, Rathkopf DE, Morris MJ, Solomon SB, Durack JC, Reuter VE, Gopalan A, Gao J,
Loda M
, Lis RT, Bowden M, Balk SP, Gaviola G, Sougnez C, Gupta M, Yu EY, Mostaghel EA, Cheng HH, Mulcahy H, True LD, Plymate SR, Dvinge H, Ferraldeschi R, Flohr P, Miranda S, Zafeiriou Z, Tunariu N, Mateo J, Perez-Lopez R, Demichelis F, Robinson BD, Sboner A, Schiffman M, Nanus DM, Tagawa ST, Sigaras A, Eng KW, Elemento O, Sboner A, Heath EI, Scher HI, Pienta KJ,
Kantoff P
, de Bono JS, Rubin MA, Nelson PS, Garraway LA, Sawyers CL, Chinnaiyan AM. Integrative Clinical Genomics of Advanced Prostate Cancer. Cell. 2015 Jul 16; 162(2):454.
PMID:
28843286
.
Citations:
174
Fields:
Cel
Cell Biology
Beltran H
, Eng K, Mosquera JM, Sigaras A, Romanel A, Rennert H, Kossai M, Pauli C, Faltas B, Fontugne J, Park K, Banfelder J, Prandi D, Madhukar N, Zhang T, Padilla J, Greco N, McNary TJ, Herrscher E, Wilkes D, MacDonald TY, Xue H, Vacic V, Emde AK, Oschwald D, Tan AY, Chen Z, Collins C, Gleave ME, Wang Y, Chakravarty D, Schiffman M, Kim R, Campagne F, Robinson BD, Nanus DM, Tagawa ST, Xiang JZ, Smogorzewska A, Demichelis F, Rickman DS, Sboner A, Elemento O, Rubin MA. Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response. JAMA Oncol. 2015 Jul; 1(4):466-74.
PMID:
26181256
.
Citations:
144
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Gillessen S, Omlin A, Attard G, de Bono JS, Efstathiou E, Fizazi K, Halabi S, Nelson PS, Sartor O, Smith MR, Soule HR, Akaza H, Beer TM,
Beltran H
, Chinnaiyan AM, Daugaard G, Davis ID, De Santis M, Drake CG, Eeles RA, Fanti S, Gleave ME, Heidenreich A, Hussain M, James ND, Lecouvet FE, Logothetis CJ, Mastris K, Nilsson S, Oh WK, Olmos D, Padhani AR, Parker C, Rubin MA, Schalken JA, Scher HI, Sella A, Shore ND, Small EJ, Sternberg CN, Suzuki H, Sweeney CJ, Tannock IF, Tombal B. Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015. Ann Oncol. 2015 Aug; 26(8):1589-604.
PMID:
26041764
; PMCID:
PMC4511225
.
Citations:
94
Fields:
Neo
Neoplasms
Translation:
Humans
Robinson D,
Van Allen EM
, Wu YM, Schultz N, Lonigro RJ, Mosquera JM, Montgomery B,
Taplin ME
, Pritchard CC, Attard G,
Beltran H
, Abida W, Bradley RK, Vinson J, Cao X, Vats P, Kunju LP, Hussain M, Feng FY, Tomlins SA, Cooney KA, Smith DC, Brennan C, Siddiqui J, Mehra R, Chen Y, Rathkopf DE, Morris MJ, Solomon SB, Durack JC, Reuter VE, Gopalan A, Gao J,
Loda M
, Lis RT, Bowden M, Balk SP, Gaviola G, Sougnez C, Gupta M, Yu EY, Mostaghel EA, Cheng HH, Mulcahy H, True LD, Plymate SR, Dvinge H, Ferraldeschi R, Flohr P, Miranda S, Zafeiriou Z, Tunariu N, Mateo J, Perez-Lopez R, Demichelis F, Robinson BD, Schiffman M, Nanus DM, Tagawa ST, Sigaras A, Eng KW, Elemento O, Sboner A, Heath EI, Scher HI, Pienta KJ,
Kantoff P
, de Bono JS, Rubin MA, Nelson PS, Garraway LA, Sawyers CL, Chinnaiyan AM. Integrative clinical genomics of advanced prostate cancer. Cell. 2015 May 21; 161(5):1215-1228.
PMID:
26000489
; PMCID:
PMC4484602
.
Citations:
953
Fields:
Cel
Cell Biology
Translation:
Humans
Terry S, El-Sayed IY, Destouches D, Maillé P, Nicolaiew N, Ploussard G, Semprez F, Pimpie C,
Beltran H
, Londono-Vallejo A, Allory Y, de la Taille A, Salomon DS, Vacherot F. CRIPTO overexpression promotes mesenchymal differentiation in prostate carcinoma cells through parallel regulation of AKT and FGFR activities. Oncotarget. 2015 May 20; 6(14):11994-2008.
PMID:
25596738
; PMCID:
PMC4494918
.
Citations:
10
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Attard G,
Beltran H
. Prioritizing precision medicine for prostate cancer. Ann Oncol. 2015 Jun; 26(6):1041-1042.
PMID:
25862438
.
Citations:
5
Fields:
Neo
Neoplasms
Translation:
Humans
Klimstra DS,
Beltran H
, Lilenbaum R, Bergsland E. The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap. Am Soc Clin Oncol Educ Book. 2015; 92-103.
PMID:
25993147
.
Citations:
11
Fields:
Neo
Neoplasms
Translation:
Humans
Galletti G, Matov A,
Beltran H
, Fontugne J, Miguel Mosquera J, Cheung C, MacDonald TY, Sung M, O'Toole S, Kench JG, Suk Chae S, Kimovski D, Tagawa ST, Nanus DM, Rubin MA, Horvath LG, Giannakakou P, Rickman DS. ERG induces taxane resistance in castration-resistant prostate cancer. Nat Commun. 2014 Nov 25; 5:5548.
PMID:
25420520
.
Citations:
44
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Chakravarty D, Sboner A, Nair SS, Giannopoulou E, Li R, Hennig S, Mosquera JM, Pauwels J, Park K, Kossai M, MacDonald TY, Fontugne J, Erho N, Vergara IA, Ghadessi M, Davicioni E, Jenkins RB, Palanisamy N, Chen Z, Nakagawa S, Hirose T, Bander NH,
Beltran H
, Fox AH, Elemento O, Rubin MA. The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nat Commun. 2014 Nov 21; 5:5383.
PMID:
25415230
.
Citations:
216
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Gao D, Vela I, Sboner A, Iaquinta PJ, Karthaus WR, Gopalan A, Dowling C, Wanjala JN, Undvall EA, Arora VK, Wongvipat J, Kossai M, Ramazanoglu S, Barboza LP, Di W, Cao Z, Zhang QF, Sirota I, Ran L, MacDonald TY,
Beltran H
, Mosquera JM, Touijer KA, Scardino PT, Laudone VP, Curtis KR, Rathkopf DE, Morris MJ, Danila DC, Slovin SF, Solomon SB, Eastham JA, Chi P, Carver B, Rubin MA, Scher HI, Clevers H, Sawyers CL, Chen Y. Organoid cultures derived from patients with advanced prostate cancer. Cell. 2014 Sep 25; 159(1):176-187.
PMID:
25201530
.
Citations:
574
Fields:
Cel
Cell Biology
Translation:
Humans
Prandi D,
Baca SC
, Romanel A, Barbieri CE, Mosquera JM, Fontugne J,
Beltran H
, Sboner A, Garraway LA, Rubin MA, Demichelis F. Unraveling the clonal hierarchy of somatic genomic aberrations. Genome Biol. 2014 Aug 26; 15(8):439.
PMID:
25160065
.
Citations:
49
Fields:
Gen
Genetics
Translation:
Humans
Beltran H
, Kaur G, de España CG, Tagawa ST. Exploring the role of anti-angiogenic therapies in prostate cancer: results from the phase 3 trial of sunitinib. Asian J Androl. 2014 Jul-Aug; 16(4):568-9.
PMID:
24875818
.
Citations:
1
Fields:
Rep
Reproductive Medicine
Uro
Urology
Translation:
Humans
Park K, Chen Z, MacDonald TY, Siddiqui J, Ye H, Erbersdobler A, Shevchuk MM, Robinson BD, Sanda MG, Chinnaiyan AM,
Beltran H
, Rubin MA, Mosquera JM. Prostate cancer with Paneth cell-like neuroendocrine differentiation has recognizable histomorphology and harbors AURKA gene amplification. Hum Pathol. 2014 Oct; 45(10):2136-43.
PMID:
25128228
.
Citations:
10
Fields:
Pat
Pathology
Translation:
Humans
Cells
Epstein JI, Amin MB,
Beltran H
, Lotan TL, Mosquera JM, Reuter VE, Robinson BD, Troncoso P, Rubin MA. Proposed morphologic classification of prostate cancer with neuroendocrine differentiation. Am J Surg Pathol. 2014 Jun; 38(6):756-67.
PMID:
24705311
.
Citations:
168
Fields:
Gen
General Surgery
Pat
Pathology
Translation:
Humans
Cells
Beltran H
, Tomlins S, Aparicio A, Arora V, Rickman D, Ayala G, Huang J, True L, Gleave ME, Soule H, Logothetis C, Rubin MA. Aggressive variants of castration-resistant prostate cancer. Clin Cancer Res. 2014 Jun 01; 20(11):2846-50.
PMID:
24727321
.
Citations:
158
Fields:
Neo
Neoplasms
Translation:
Humans
Terry S,
Beltran H
. The many faces of neuroendocrine differentiation in prostate cancer progression. Front Oncol. 2014; 4:60.
PMID:
24724054
.
Citations:
88
Beltran H
. The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential. Mol Cancer Res. 2014 Jun; 12(6):815-22.
PMID:
24589438
.
Citations:
51
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Lin D, Wyatt AW, Xue H, Wang Y, Dong X, Haegert A, Wu R, Brahmbhatt S, Mo F, Jong L, Bell RH, Anderson S, Hurtado-Coll A, Fazli L, Sharma M,
Beltran H
, Rubin M, Cox M, Gout PW, Morris J, Goldenberg L, Volik SV, Gleave ME, Collins CC, Wang Y. High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development. Cancer Res. 2014 Feb 15; 74(4):1272-83.
PMID:
24356420
.