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Christopher McGraw, M.D., Ph.D.

Title
Institution
Department
Address
Phone

Biography
Massachusetts General Hospital, Boston, MAfellowship06/2020Epilepsy
University of California San Francisco (UCSF), San Francisco, CAresidency06/2018Adult Neurology
Baylor College of Medicine, Houston, TXMD, PhD06/2014Medicine/Developmental Biology
Rice University, Houston, TXBA6/2004Biochemistry, Cell Biology
2020 - 2021
Taking Flight Award
2020 - 2025
K08 Mentored Research Scientist Career Development Award

Overview
Dr. Chris McGraw MD, PhD is a physician-scientist with an interest in epilepsy genetics and the use of animal models to better understand a variety of epilepsy disorders and to identify novel treatments.

Dr. McGraw received his BA in Biochemistry and Cell Biology, magna cum laude, at Rice University in 2004 and he completed a combined MD/PhD program at Baylor College of Medicine (BCM), earning a PhD in Developmental Biology under Dr. Huda Y. Zoghbi, MD in 2012 before graduating in 2014. He completed residency in Adult Neurology at University of California San Francisco (UCSF), where he received a competitive R25 award to study epilepsy in zebrafish with Dr. Scott Baraban PhD. He completed an Adult Epilepsy Fellowship at Massachusetts General Hospital (MGH) in 2020.

Dr. McGraw is currently an Instructor in Neurology at MGH and Harvard Medical School (HMS). Clinically, he serves as an Adult Epileptologist on the MGH Epilepsy Service and in the Herscot Center for Tuberous Sclerosis Center at MGH. In the laboratory, his research focuses on the use of zebrafish for functional genetic studies with the goal of understanding the molecular pathways underlying seizure susceptibility in rare and common epilepsies and for identifying novel therapies through genetic and pharmacological screening. He currently works with Dr. Ann Poduri, MD, MPH through the Epilepsy Genetics Program at Boston Children's Hospital (BCH).

Dr. McGraw is site PI for the Epilepsy Learning Healthcare System (ELHS) at MGH, a multi-center initiative to improve the quality of care for patients with epilepsy.

His work is supported by an NINDS K08 Career Development Award to develop a zebrafish model of myoclonic astatic epilepsy due to mutations in SLC6A1 and to develop an in vitro assay for positive modulators of SLC6A1. He is also supported by a CURE Taking Flight Award to identify modifiers of seizure susceptibility in zebrafish as targets for novel anti-epileptic drug development.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS127345 (MCGRAW, CHRISTOPHER) Apr 1, 2022 - Mar 31, 2025
    NIH/NINDS CounterACT
    High-throughput in vivo discovery of novel countermeasures against organophosphate-induced seizure and status epilepticus using zebrafish
    Role: Principal Investigator
  2. CDKL5-21-105-01 (MCGRAW, CHRISTOPHER) May 1, 2021 - Oct 31, 2022
    CDKL5 PROGRAM OF EXCELLENCE GRANT PROGRAM / Orphan Disease Center
    Advancing a mosaic CDKL5 zebrafish model for high-throughput screening approaches
    Role: Principal Investigator
  3. K08NS118107 (MCGRAW, CHRISTOPHER) Jul 15, 2020 - Jun 30, 2025
    NIH
    Developing a zebrafish model of Slc6a1/GAT1 hypofunction and an in vitro assay to identify novel treatments
    Role: Principal Investigator
  4. F31NS073317 (MCGRAW, CHRISTOPHER) Feb 11, 2011 - Feb 10, 2013
    NIH
    Investigating the homeostatic role of MeCP2 in mature brain
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.