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Evangelos Messaris, Ph.D., M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kulaylat AS, Schaefer EW, Messaris E, Hollenbeak CS. Truven Health Analytics MarketScan Databases for Clinical Research in Colon and Rectal Surgery. Clin Colon Rectal Surg. 2019 Jan; 32(1):54-60. PMID: 30647546.
    Citations:    
  2. Kulaylat AS, Pappou E, Philp MM, Kuritzkes BA, Ortenzi G, Hollenbeak CS, Choi C, Messaris E. Emergent Colon Resections: Does Surgeon Specialization Influence Outcomes? Dis Colon Rectum. 2019 01; 62(1):79-87. PMID: 30394983.
    Citations:    
  3. Kulaylat AS, Boltz MM, Moyer M, Mathew A, McKenna K, Messaris E. Management of Large Cecal Polyps: When Can the Ileocecal Valve Be Spared? Dis Colon Rectum. 2018 09; 61(9):1089-1095. PMID: 30086058.
    Citations:    Fields:    Translation:Humans
  4. Mirkin KA, Kulaylat AS, Hollenbeak CS, Messaris E. Prognostic Significance of Tumor Deposits in Stage III Colon Cancer. Ann Surg Oncol. 2018 Oct; 25(11):3179-3184. PMID: 30083832.
    Citations:    Fields:    Translation:Humans
  5. Gorrepati VS, Yadav S, Stuart A, Koltun W, Messaris E, Williams ED, Coates MD. Anxiety, depression, and inflammation after restorative proctocolectomy. Int J Colorectal Dis. 2018 Nov; 33(11):1601-1606. PMID: 29959529.
    Citations:    Fields:    Translation:Humans
  6. Crowell KT, Tinsley A, Williams ED, Coates MD, Bobb A, Koltun WA, Messaris E. Vedolizumab as a rescue therapy for patients with medically refractory Crohn's disease. Colorectal Dis. 2018 Oct; 20(10):905-912. PMID: 29673053.
    Citations:    Fields:    
  7. Messaris E. Digestive Tract Damage: A Predictor of Early Surgical Intervention in Patients With Newly Diagnosed Crohn's Disease. Dis Colon Rectum. 2018 02; 61(2):147-148. PMID: 29337765.
    Citations:    Fields:    Translation:Humans
  8. Mirkin KA, Kulaylat AS, Hollenbeak CS, Messaris E. Robotic versus laparoscopic colectomy for stage I-III colon cancer: oncologic and long-term survival outcomes. Surg Endosc. 2018 Jun; 32(6):2894-2901. PMID: 29273877.
    Citations:    Fields:    
  9. Kulaylat AS, Mirkin KA, Puleo FJ, Hollenbeak CS, Messaris E. Robotic versus standard laparoscopic elective colectomy: where are the benefits? J Surg Res. 2018 04; 224:72-78. PMID: 29506855.
    Citations: 1     Fields:    
  10. Moyer MT, Mathew A, Chintanaboina J, Williams E, Puleo F, Messaris E, Tinsley A. Restoration of colonic patency of a completely obstructed Crohn's stricture using the combined antegrade-retrograde dilation procedure. VideoGIE. 2017 Dec; 2(12):359-360. PMID: 29917019.
    Citations:    
  11. Mathers B, Williams E, Bedi G, Messaris E, Tinsley A. An Electronic Alert System Is Associated With a Significant Increase in Pharmacologic Venous Thromboembolism Prophylaxis Rates Among Hospitalized Inflammatory Bowel Disease Patients. J Healthc Qual. 2017 Sep/Oct; 39(5):307-314. PMID: 27153049.
    Citations: 1     Fields:    Translation:Humans
  12. Kulaylat AS, Kulaylat AN, Schaefer EW, Tinsley A, Williams E, Koltun W, Hollenbeak CS, Messaris E. Association of Preoperative Anti-Tumor Necrosis Factor Therapy With Adverse Postoperative Outcomes in Patients Undergoing Abdominal Surgery for Ulcerative Colitis. JAMA Surg. 2017 Aug 16; 152(8):e171538. PMID: 28614561.
    Citations: 3     Fields:    Translation:Humans
  13. Crowell KT, Julian KG, Katzman M, Berg AS, Tinsley A, Williams ED, Koltun WA, Messaris E. Compliance with Clostridium difficile treatment guidelines: effect on patient outcomes. Epidemiol Infect. 2017 08; 145(11):2185-2192. PMID: 28578710.
    Citations:    Fields:    Translation:HumansCells
  14. Wilson MZ, Enomoto LM, Messaris E, Hollenbeak CS. Misapplication of Statistical Methods May Lead to Misinformation. Ann Surg. 2017 06; 265(6):E78-E79. PMID: 28486296.
    Citations:    Fields:    Translation:Humans
  15. Mirkin KA, Hollenbeak CS, Mohamed A, Jia Y, El-Deiry WS, Messaris E. Impact of perineural invasion on survival in node negative colon cancer. Cancer Biol Ther. 2017 Sep 02; 18(9):740-745. PMID: 28475454.
    Citations:    Fields:    Translation:Humans
  16. Wilson MZ, Messaris E. Reply to Letter: "Ulcerative Colitis Is Associated With an Increased Risk of Venous Thromboembolism in the Postoperative Period: The Results of a Matched Cohort Analysis". Ann Surg. 2017 04; 265(4):e44-e45. PMID: 28266985.
    Citations:    Fields:    Translation:Humans
  17. Stokes AL, Adhikary SD, Quintili A, Puleo FJ, Choi CS, Hollenbeak CS, Messaris E. Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery. Dis Colon Rectum. 2017 Feb; 60(2):170-177. PMID: 28059913.
    Citations: 5     Fields:    Translation:Humans
  18. Andrew RE, Messaris E. Update on medical and surgical options for patients with acute severe ulcerative colitis: What is new? World J Gastrointest Surg. 2016 Sep 27; 8(9):598-605. PMID: 27721922.
    Citations: 1     
  19. Connelly TM, Devane L, Kelly JC, Wrafter P, Messaris E. The 100 classic papers in ulcerative colitis: a bibliometric analysis. Expert Rev Gastroenterol Hepatol. 2016 Oct; 10(10):1187-1195. PMID: 27531253.
    Citations: 1     Fields:    
  20. Crowell KT, Messaris E. Risk factors and implications of anastomotic complications after surgery for Crohn's disease. World J Gastrointest Surg. 2015 Oct 27; 7(10):237-42. PMID: 26523211.
    Citations: 3     
  21. Sangster W, Messaris E, Berg AS, Stewart DB. Single-Site Laparoscopic Colorectal Surgery Provides Similar Clinical Outcomes Compared With Standard Laparoscopic Surgery: An Analysis of 626 Patients. Dis Colon Rectum. 2015 Sep; 58(9):862-9. PMID: 26252848.
    Citations:    Fields:    Translation:HumansPHPublic Health
  22. Wilson MZ, Connelly TM, Tinsley A, Hollenbeak CS, Koltun WA, Messaris E. Ulcerative Colitis Is Associated With an Increased Risk of Venous Thromboembolism in the Postoperative Period: The Results of a Matched Cohort Analysis. Ann Surg. 2015 Jun; 261(6):1160-6. PMID: 24983992.
    Citations: 2     Fields:    Translation:Humans
  23. Wilson MZ, Messaris E. Reply to Letter: "Ulcerative Colitis Is Associated With an Increased Risk of Venous Thromboembolism in the Postoperative Period: The Results of a Matched Cohort Analysis". Ann Surg. 2015 May 27. PMID: 26020108.
    Citations:    Fields:    
  24. Messaris E, Connelly TM, Kulaylat AN, Miller J, Gusani NJ, Ortenzi G, Wong J, Bhayani N. Is a diverting ostomy needed in mid-high rectal cancer patients undergoing a low anterior resection after neoadjuvant chemoradiation? An NSQIP analysis. Surgery. 2015 Sep; 158(3):686-91. PMID: 26008960.
    Citations: 1     Fields:    Translation:Humans
  25. Connelly TM, Tappouni R, Mathew P, Salgado J, Messaris E. Risk factors for the development of an incisional hernia after sigmoid resection for diverticulitis: an analysis of 33 patients, operative and disease-associated factors. Am Surg. 2015 May; 81(5):492-7. PMID: 25975334.
    Citations: 1     Fields:    Translation:Humans
  26. Wilson MZ, Enomoto LM, Messaris E, Hollenbeak CS. Misapplication of Statistical Methods May Lead to Misinformation. Ann Surg. 2015 Mar 27. PMID: 25822682.
    Citations:    Fields:    
  27. Tappouni R, Mathew P, Connelly TM, Luke F, Messaris E. Measurement of visceral fat on preoperative computed tomography predicts complications after sigmoid colectomy for diverticular disease. Am J Surg. 2015 Aug; 210(2):285-90. PMID: 25840842.
    Citations: 1     Fields:    Translation:Humans
  28. Sangster W, Kulaylat AN, Stewart DB, Schubart JR, Koltun WA, Messaris E. Hernia incidence following single-site vs standard laparoscopic colorectal surgery. Colorectal Dis. 2015 Mar; 17(3):250-6. PMID: 25307082.
    Citations: 4     Fields:    Translation:Humans
  29. Sun S, Messaris E. Soluble CD73 can predict future organ failure in pancreatitis: simple, low cost, but not perfect*. Crit Care Med. 2014 Dec; 42(12):2641-2. PMID: 25402289.
    Citations:    Fields:    Translation:Humans
  30. Connelly TM, Messaris E. Predictors of recurrence of Crohn's disease after ileocolectomy: a review. World J Gastroenterol. 2014 Oct 21; 20(39):14393-406. PMID: 25339826.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  31. Connelly TM, Juza RM, Sangster W, Sehgal R, Tappouni RF, Messaris E. Volumetric fat ratio and not body mass index is predictive of ileocolectomy outcomes in Crohn's disease patients. Dig Surg. 2014; 31(3):219-24. PMID: 25277149.
    Citations: 5     Fields:    Translation:Humans
  32. Vuong JT, McQuillan PM, Messaris E, Adhikary SD. Transversus abdominis plane block as the primary anesthetic for laparotomy. J Anaesthesiol Clin Pharmacol. 2014 Jul; 30(3):419-21. PMID: 25190958.
    Citations: 1     
  33. Wilson MZ, Connelly TM, Hollenbeak CS, Messaris E. Organ space infection following ileocolectomy for Crohn's disease: a National Surgical Quality Improvement Project study. Am J Surg. 2014 Nov; 208(5):749-755. PMID: 25096262.
    Citations: 2     Fields:    Translation:Humans
  34. Messaris E, Sun S. Genetic correlations between murine and human trauma: time to focus only on highly selected genetic pathways. Crit Care Med. 2014 Jun; 42(6):1552-3. PMID: 24836793.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  35. Pogacnik JS, Messaris E, Deiling SM, Connelly TM, Berg AS, Stewart DB, McKenna KJ, Poritz LS, Koltun WA. Increased risk of incisional hernia after sigmoid colectomy for diverticulitis compared with colon cancer. J Am Coll Surg. 2014 May; 218(5):920-8. PMID: 24745565.
    Citations: 5     Fields:    Translation:Humans
  36. Stewart DB, Berg A, Messaris E. Single-site laparoscopic colorectal surgery provides similar lengths of hospital stay and similar costs compared with standard laparoscopy: results of a retrospective cohort study. J Gastrointest Surg. 2014 Apr; 18(4):774-81. PMID: 24408181.
    Citations: 1     Fields:    Translation:Humans
  37. Kline CL, Schiccitano A, Zhu J, Beachler C, Sheikh H, Harvey HA, Mackley HB, McKenna K, Staveley-O'Carroll K, Poritz L, Messaris E, Stewart D, Sivik J, El-Deiry WS. Personalized dosing via pharmacokinetic monitoring of 5-fluorouracil might reduce toxicity in early- or late-stage colorectal cancer patients treated with infusional 5-fluorouracil-based chemotherapy regimens. Clin Colorectal Cancer. 2014 Jun; 13(2):119-26. PMID: 24461492.
    Citations: 7     Fields:    Translation:Humans
  38. Garcia L, Messaris E. Predicting mortality in patients admitted with sepsis using endotoxin activity: will it help us see through the crystal ball?*. Crit Care Med. 2013 Jun; 41(6):1575-6. PMID: 23685580.
    Citations:    Fields:    Translation:Humans
  39. Stewart DB, Messaris E. Adequate margins for anorectal cancer can be achieved by single-site laparoscopy. J Laparoendosc Adv Surg Tech A. 2013 Apr; 23(4):316-22. PMID: 23414124.
    Citations: 1     Fields:    Translation:Humans
  40. Allen JE, Krigsfeld G, Mayes PA, Patel L, Dicker DT, Patel AS, Dolloff NG, Messaris E, Scata KA, Wang W, Zhou JY, Wu GS, El-Deiry WS. Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects. Sci Transl Med. 2013 Feb 06; 5(171):171ra17. PMID: 23390247.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  41. Rotramel A, Poritz LS, Messaris E, Berg A, Stewart DB. PPI therapy and albumin are better predictors of recurrent Clostridium difficile colitis than choice of antibiotics. J Gastrointest Surg. 2012 Dec; 16(12):2267-73. PMID: 23007285.
    Citations: 8     Fields:    Translation:HumansCells
  42. Messaris E, Sehgal R, Deiling S, Koltun WA, Stewart D, McKenna K, Poritz LS. Dehydration is the most common indication for readmission after diverting ileostomy creation. Dis Colon Rectum. 2012 Feb; 55(2):175-80. PMID: 22228161.
    Citations: 42     Fields:    Translation:Humans
  43. Stewart DB, Messaris E. Outcomes for consecutive patients undergoing single-site laparoscopic colorectal surgery. J Gastrointest Surg. 2012 Apr; 16(4):849-56. PMID: 22125171.
    Citations: 4     Fields:    Translation:Humans
  44. Stewart DB, Messaris E. Early experience with single-site laparoscopic surgery for complicated ileocolic Crohn's disease at a tertiary-referral center. Surg Endosc. 2012 Mar; 26(3):777-82. PMID: 21993940.
    Citations: 3     Fields:    Translation:Humans
  45. Markogiannakis H, Memos N, Messaris E, Dardamanis D, Larentzakis A, Papanikolaou D, Zografos GC, Manouras A. Predictive value of procalcitonin for bowel ischemia and necrosis in bowel obstruction. Surgery. 2011 Mar; 149(3):394-403. PMID: 20869092.
    Citations: 13     Fields:    Translation:Humans
  46. Messaris E, Chandolias N, Grand D, Pricolo V. Role of magnetic resonance enterography in the management of Crohn disease. Arch Surg. 2010 May; 145(5):471-5. PMID: 20479346.
    Citations: 13     Fields:    Translation:Humans
  47. Messaris E, Nicastri G, Dudrick SJ. Total extraperitoneal laparoscopic inguinal hernia repair without mesh fixation: prospective study with 1-year follow-up results. Arch Surg. 2010 Apr; 145(4):334-8. PMID: 20404282.
    Citations: 5     Fields:    Translation:Humans
  48. Messaris E, Betrosian AP, Memos N, Chatzigianni E, Boutsikou M, Economou V, Dontas I, Theodossiades G, Konstadoulakis MM, Douzinas EE. Administration of human protein C improves survival in an experimental model of sepsis. Crit Care Med. 2010 Jan; 38(1):209-16. PMID: 19726977.
    Citations: 3     Fields:    Translation:HumansAnimals
  49. Memos N, Betrosian A, Messaris E, Boutsikou M, Kataki A, Chatzigianni E, Nikolopoulou M, Leandros E, Konstadoulakis M. Administration of Human Protein-C concentrate prevents apoptotic brain cell death after experimental sepsis. Brain Res. 2009 Apr 06; 1264:119-26. PMID: 19368819.
    Citations: 1     Fields:    Translation:AnimalsCells
  50. Messaris E, Memos N, Chatzigianni E, Kataki A, Nikolopoulou M, Manouras A, Albanopoulos K, Konstadoulakis MM, Bramis J. Apoptotic death of renal tubular cells in experimental sepsis. Surg Infect (Larchmt). 2008 Jun; 9(3):377-88. PMID: 18570579.
    Citations: 5     Fields:    Translation:Animals
  51. Markogiannakis H, Sanidas E, Messaris E, Koutentakis D, Alpantaki K, Kafetzakis A, Tsiftsis D. Predictors of in-hospital mortality of trauma patients injured in vehicle accidents. Ulus Travma Acil Cerrahi Derg. 2008 Apr; 14(2):125-31. PMID: 18523903.
    Citations: 6     Fields:    Translation:Humans
  52. Messaris E, Kekis P, Memos N, Chatzigianni E, Menenakos E, Leandros E, Konstadoulakis MM. Sepsis: prognostic role of apoptosis regulators in gastrointestinal cells. World J Surg. 2007 Apr; 31(4):787-94. PMID: 17372670.
    Citations: 2     Fields:    Translation:AnimalsCells
  53. Messaris E. Actin-binding plasma gelsolin: a potential future ally in the fight against sepsis. Crit Care Med. 2007 Mar; 35(3):970-1. PMID: 17421099.
    Citations:    Fields:    Translation:Animals
  54. Markogiannakis H, Messaris E, Dardamanis D, Pararas N, Tzertzemelis D, Giannopoulos P, Larentzakis A, Lagoudianakis E, Manouras A, Bramis I. Acute mechanical bowel obstruction: clinical presentation, etiology, management and outcome. World J Gastroenterol. 2007 Jan 21; 13(3):432-7. PMID: 17230614.
    Citations: 27     Fields:    Translation:Humans
  55. Markogiannakis H, Sanidas E, Messaris E, Michalakis I, Kasotakis G, Melissas J, Tsiftsis D. Management of blunt hepatic and splenic trauma in a Greek level I trauma centre. Acta Chir Belg. 2006 Sep-Oct; 106(5):566-71. PMID: 17168271.
    Citations: 2     Fields:    Translation:Humans
  56. Messaris E, Memos N, Frantzeskaki F, Economou V, Betrosian A. Comment on: "The effects of supra-normal protein C levels on markers of coagulation, fibrinolysis and inflammation in a human model of endotoxemia" by Spiel et al. Thromb Haemost. 2006 Jun; 95(6):1048-9. PMID: 16732392.
    Citations:    Fields:    Translation:HumansAnimals
  57. Markogiannakis H, Sanidas E, Messaris E, Koutentakis D, Alpantaki K, Kafetzakis A, Tsiftsis D. Motor vehicle trauma: analysis of injury profiles by road-user category. Emerg Med J. 2006 Jan; 23(1):27-31. PMID: 16373799.
    Citations: 13     Fields:    Translation:Humans
  58. Zografos GC, Simeonidis KM, Messaris EG, Parasi AS, Sotiriou HG, Dontas IA. Adhesion formation and intraperitoneal catheters: histologic findings in a rat model. Fertil Steril. 2005 Feb; 83(2):516-8. PMID: 15705410.
    Citations: 2     Fields:    Translation:Animals
  59. Messaris E, Memos N, Chatzigianni E, Konstadoulakis MM, Menenakos E, Katsaragakis S, Voumvourakis C, Androulakis G. Time-dependent mitochondrial-mediated programmed neuronal cell death prolongs survival in sepsis. Crit Care Med. 2004 Aug; 32(8):1764-70. PMID: 15286556.
    Citations: 17     Fields:    Translation:AnimalsCells
  60. Messaris E, Antonakis PT, Memos N, Chatzigianni E, Leandros E, Konstadoulakis MM. Deferoxamine administration in septic animals: improved survival and altered apoptotic gene expression. Int Immunopharmacol. 2004 Mar; 4(3):455-9. PMID: 15037222.
    Citations: 3     Fields:    Translation:Animals
  61. Kosmadakis N, Messaris E, Maris A, Katsaragakis S, Leandros E, Konstadoulakis MM, Androulakis G. Perioperative erythropoietin administration in patients with gastrointestinal tract cancer: prospective randomized double-blind study. Ann Surg. 2003 Mar; 237(3):417-21. PMID: 12616127.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  62. Kataki A, Sotirianakos S, Memos N, Karayiannis M, Messaris E, Leandros E, Manouras A, Androulakis G. P53 and C-FOS overexpression in patients with thyroid cancer: an immunohistochemical study. Neoplasma. 2003; 50(1):26-30. PMID: 12687275.
    Citations: 6     Fields:    Translation:Humans
  63. Konstadoulakis MM, Messaris E, Zografos G, Ricaniadis N, Androulakis G, Karakousis C. Common prognostic factors for stage III melanoma patients and for stage I and II melanoma patients with recurrence to their regional lymph nodes. Melanoma Res. 2002 Aug; 12(4):357-64. PMID: 12170185.
    Citations: 1     Fields:    Translation:Humans
  64. Dimitrakakis C, Konstadoulakis M, Messaris E, Kymionis G, Karayannis M, Panoussopoulos D, Michalas S, Androulakis G. Molecular markers in breast cancer: can we use c-erbB-2, p53, bcl-2 and bax gene expression as prognostic factors? Breast. 2002 Aug; 11(4):279-85. PMID: 14965683.
    Citations: 5     Fields:    
  65. Zografos GC, Simeonidis KM, Parasi AS, Messaris EG, Menenakos EE, Dontas IA, Marti KC, Androulakis GA. Adhesion formation: intraperitoneal catheters in surgical practice. J Invest Surg. 2002 Jan-Feb; 15(1):37-43. PMID: 11931493.
    Citations: 3     Fields:    Translation:Animals
  66. Diakomanolis E, Haidopoulos D, Rodolakis A, Messaris E, Sakellaropoulos G, Calpaktsoglou C, Michalas S. Treating intraepithelial lesions of the uterine cervix by laser CO2. Evaluation of the past, appraisal for the future. Eur J Gynaecol Oncol. 2002; 23(5):463-8. PMID: 12440828.
    Citations:    Fields:    Translation:Humans
  67. Liacos C, Katsaragakis S, Konstadoulakis MM, Messaris EG, Papanicolaou M, Georgiadis GG, Menenakos E, Vasiliadi-Chioti A, Androulakis G. Apoptosis in cells of bronchoalveolar lavage: a cellular reaction in patients who die with sepsis and respiratory failure. Crit Care Med. 2001 Dec; 29(12):2310-7. PMID: 11801832.
    Citations: 4     Fields:    Translation:HumansCells
  68. Konstadoulakis MM, Messaris EG. Are cancer patients adequate candidates for studying apoptosis in septic and ARDS models? Am J Respir Crit Care Med. 2001 May; 163(6):1500. PMID: 11371424.
    Citations: 1     Fields:    Translation:Humans
  69. Konstadoulakis MM, Messaris E, Zografos G, Androulakis G, Karakousis C. Prognostic factors in malignant melanoma patients with solitary or multiple brain metastases. Is there a role for surgery? J Neurosurg Sci. 2000 Dec; 44(4):211-8; discussion 219. PMID: 11327290.
    Citations: 3     Fields:    Translation:Humans
  70. Charalambous GK, Gomatos IP, Konstadoulakis MM, Messaris EG, Manouras AJ, Apostolou AE, Leandros EA, Karayannis MK, Androulakis GA. Protein expression of bax, bcl-2, and p53 in patients with non-Hodgkin's gastric lymphoma: prognostic significance. World J Surg. 2000 May; 24(5):608-14. PMID: 10787085.
    Citations: 3     Fields:    Translation:Humans
  71. Zografos G, Papadimitriou C, Kouerinis I, Messaris E, Petraki K, Androulakis G. An adult patient with a mixed germ cell tumor of the spermatic cord. Urology. 2000 Mar; 55(3):436. PMID: 10754174.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.