Harvard Catalyst Profiles

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Katherine Laura Morel, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Morel KL, Hamid AA, Clohessy JG, Pandell N, Ellis L, Sweeney CJ. NF-?B Blockade with Oral Administration of Dimethylaminoparthenolide (DMAPT), Delays Prostate Cancer Resistance to Androgen Receptor (AR) Inhibition and Inhibits AR Variants. Mol Cancer Res. 2021 07; 19(7):1137-1145. PMID: 33863813; PMCID: PMC8254800.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Morel KL, Sheahan AV, Burkhart DL, Baca SC, Boufaied N, Liu Y, Qiu X, Cañadas I, Roehle K, Heckler M, Calagua C, Ye H, Pantelidou C, Galbo P, Panja S, Mitrofanova A, Wilkinson S, Whitlock NC, Trostel SY, Hamid AA, Kibel AS, Barbie DA, Choudhury AD, Pomerantz MM, Sweeney CJ, Long HW, Einstein DJ, Shapiro GI, Dougan SK, Sowalsky AG, He HH, Freedman ML, Balk SP, Loda M, Labbé DP, Olson BM, Ellis L. EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer. Nat Cancer. 2021 04; 2(4):444-456. PMID: 33899001; PMCID: PMC8061902.
    Citations: 30     Translation:HumansCells
  3. Burkhart DL, Morel KL, Wadosky KM, Labbé DP, Galbo PM, Dalimov Z, Xu B, Loda M, Ellis L. Evidence that EZH2 Deregulation is an Actionable Therapeutic Target for Prevention of Prostate Cancer. Cancer Prev Res (Phila). 2020 12; 13(12):979-988. PMID: 32917647.
    Citations:    Fields:    Translation:HumansAnimals
  4. VanDeusen HR, Ramroop JR, Morel KL, Bae SY, Sheahan AV, Sychev Z, Lau NA, Cheng LC, Tan VM, Li Z, Petersen A, Lee JK, Park JW, Yang R, Hwang JH, Coleman I, Witte ON, Morrissey C, Corey E, Nelson PS, Ellis L, Drake JM. Targeting RET Kinase in Neuroendocrine Prostate Cancer. Mol Cancer Res. 2020 08; 18(8):1176-1188. PMID: 32461304.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  5. Morel KL, Ormsby RJ, Klebe S, Sweeney CJ, Sykes PJ. DMAPT is an Effective Radioprotector from Long-Term Radiation-Induced Damage to Normal Mouse Tissues In Vivo. Radiat Res. 2019 08; 192(2):231-239. PMID: 31095445.
    Citations: 2     Fields:    Translation:AnimalsPHPublic Health
  6. Tran LNK, Kichenadasse G, Morel KL, Lavranos TC, Klebe S, Lower KM, Ormsby RJ, Elliot DJ, Sykes PJ. The Combination of Metformin and Valproic Acid Has a Greater Anti-tumoral Effect on Prostate Cancer Growth In Vivo than Either Drug Alone. In Vivo. 2019 Jan-Feb; 33(1):99-108. PMID: 30587609; PMCID: PMC6364073.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  7. Burkhart DL, Morel KL, Sheahan AV, Richards ZA, Ellis L. The Role of RB in Prostate Cancer Progression. Adv Exp Med Biol. 2019; 1210:301-318. PMID: 31900914.
    Citations: 6     Fields:    Translation:HumansAnimals
  8. Morel KL, Ormsby RJ, Solly EL, Tran LNK, Sweeney CJ, Klebe S, Cordes N, Sykes PJ. Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide. Clin Exp Metastasis. 2018 10; 35(7):649-661. PMID: 29936575.
    Citations: 3     Fields:    Translation:Animals
  9. Tran LNK, Kichenadasse G, Butler LM, Centenera MM, Morel KL, Ormsby RJ, Michael MZ, Lower KM, Sykes PJ. The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer. Mol Cancer Ther. 2017 Dec; 16(12):2689-2700. PMID: 28802253.
    Citations: 12     Fields:    Translation:HumansCells
  10. Morel KL, Ormsby RJ, Bezak E, Sweeney CJ, Sykes PJ. Parthenolide Selectively Sensitizes Prostate Tumor Tissue to Radiotherapy while Protecting Healthy Tissues In Vivo. Radiat Res. 2017 05; 187(5):501-512. PMID: 28398879.
    Citations: 12     Fields:    Translation:AnimalsPHPublic Health
  11. Newman MR, Sykes PJ, Blyth BJ, Bezak E, Lawrence MD, Morel KL, Ormsby RJ. A single whole-body low dose X-irradiation does not affect L1, B1 and IAP repeat element DNA methylation longitudinally. PLoS One. 2014; 9(3):e93016. PMID: 24676381.
    Citations: 7     Fields:    Translation:AnimalsCells
  12. Newman MR, Sykes PJ, Blyth BJ, Bezak E, Lawrence MD, Morel KL, Ormsby RJ. The methylation of DNA repeat elements is sex-dependent and temporally different in response to X radiation in radiosensitive and radioresistant mouse strains. Radiat Res. 2014 Jan; 181(1):65-75. PMID: 24397437.
    Citations: 11     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.