Harvard Catalyst Profiles

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Tyler S Beyett, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F32CA247198 (BEYETT, TYLER STEVEN) Jun 4, 2020 - Jun 3, 2023
    Studies of mutant-selective allosteric inhibitors of EGFR for non-small cell lung cancer
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Amrhein JA, Beyett TS, Feng WW, Krämer A, Weckesser J, Schaeffner IK, Rana JK, Jänne PA, Eck MJ, Knapp S, Hanke T. Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19. J Med Chem. 2022 Nov 16. PMID: 36384036.
    Citations:    Fields:    
  2. Beyett TS, To C, Heppner DE, Rana JK, Schmoker AM, Jang J, De Clercq DJH, Gomez G, Scott DA, Gray NS, Jänne PA, Eck MJ. Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nat Commun. 2022 05 09; 13(1):2530. PMID: 35534503; PMCID: PMC9085736.
    Citations:    Fields:    Translation:Humans
  3. Son J, Jang J, Beyett TS, Eum Y, Haikala HM, Verano A, Lin M, Hatcher JM, Kwiatkowski NP, Eser PÖ, Poitras MJ, Wang S, Xu M, Gokhale PC, Cameron MD, Eck MJ, Gray NS, Jänne PA. A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer. Cancer Res. 2022 04 15; 82(8):1633-1645. PMID: 35149586.
    Citations:    Fields:    Translation:Humans
  4. To C, Beyett TS, Jang J, Feng WW, Bahcall M, Haikala HM, Shin BH, Heppner DE, Rana JK, Leeper BA, Soroko KM, Poitras MJ, Gokhale PC, Kobayashi Y, Wahid K, Kurppa KJ, Gero TW, Cameron MD, Ogino A, Mushajiang M, Xu C, Zhang Y, Scott DA, Eck MJ, Gray NS, Jänne PA. An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer. Nat Cancer. 2022 04; 3(4):402-417. PMID: 35422503; PMCID: PMC9248923.
    Citations: 4     Translation:Humans
  5. Gero TW, Heppner DE, Beyett TS, To C, Azevedo SC, Jang J, Bunnell T, Feru F, Li Z, Shin BH, Soroko KM, Gokhale PC, Gray NS, Jänne PA, Eck MJ, Scott DA. Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. Bioorg Med Chem Lett. 2022 07 15; 68:128718. PMID: 35378251.
    Citations:    Fields:    Translation:HumansCells
  6. Waninger JJ, Beyett TS, Gadkari VV, Siebenaler RF, Kenum C, Shankar S, Ruotolo BT, Chinnaiyan AM, Tesmer JJG. Biochemical characterization of the interaction between KRAS and Argonaute 2. Biochem Biophys Rep. 2022 Mar; 29:101191. PMID: 34988297; PMCID: PMC8695255.
    Citations: 1     
  7. Wittlinger F, Heppner DE, To C, Günther M, Shin BH, Rana JK, Schmoker AM, Beyett TS, Berger LM, Berger BT, Bauer N, Vasta JD, Corona CR, Robers MB, Knapp S, Jänne PA, Eck MJ, Laufer SA. Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. J Med Chem. 2022 01 27; 65(2):1370-1383. PMID: 34668706; PMCID: PMC9255384.
    Citations: 1     Fields:    Translation:HumansCells
  8. Nakamura IT, Kohsaka S, Ikegami M, Ikeuchi H, Ueno T, Li K, Beyett TS, Koyama T, Shimizu T, Yamamoto N, Takahashi F, Takahashi K, Eck MJ, Mano H. Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer. NPJ Precis Oncol. 2021 Jul 16; 5(1):66. PMID: 34272467; PMCID: PMC8285406.
    Citations: 3     
  9. Beyett TS, Chen Q, Labudde EJ, Krampen J, Sharma PV, Tesmer JJG. Characterization of a hyperphosphorylated variant of G protein-coupled receptor kinase 5 expressed in E. coli. Protein Expr Purif. 2020 04; 168:105547. PMID: 31786308.
    Citations:    Fields:    Translation:HumansCells
  10. Beyett TS, Fraley AE, Labudde E, Patra D, Coleman RC, Eguchi A, Glukhova A, Chen Q, Williams RM, Koch WJ, Sherman DH, Tesmer JJG. Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. Proc Natl Acad Sci U S A. 2019 08 06; 116(32):15895-15900. PMID: 31337679; PMCID: PMC6689901.
    Citations: 8     Fields:    Translation:Cells
  11. Heppner DE, Beyett TS, Eck MJ. A driving test for oncogenic mutations. J Biol Chem. 2019 06 14; 294(24):9390-9391. PMID: 31201242.
    Citations:    Fields:    Translation:HumansCells
  12. Gan X, Wilson MW, Beyett TS, Wen B, Sun D, Larsen SD, Tesmer JJG, Saltiel AR, Showalter HD. Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes. J Labelled Comp Radiopharm. 2019 05 15; 62(5):202-208. PMID: 30828860; PMCID: PMC6525014.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Beyett TS, Gan X, Reilly SM, Gomez AV, Chang L, Tesmer JJG, Saltiel AR, Showalter HD. Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKe for the treatment of obesity. Bioorg Med Chem. 2018 11 01; 26(20):5443-5461. PMID: 30270002; PMCID: PMC6252132.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  14. Beyett TS, Gan X, Reilly SM, Chang L, Gomez AV, Saltiel AR, Showalter HD, Tesmer JJG. Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKe and Reveal Mechanisms for Selective Inhibition. Mol Pharmacol. 2018 10; 94(4):1210-1219. PMID: 30082428; PMCID: PMC6128810.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  15. Yao XQ, Cato MC, Labudde E, Beyett TS, Tesmer JJG, Grant BJ. Navigating the conformational landscape of G protein-coupled receptor kinases during allosteric activation. J Biol Chem. 2017 09 29; 292(39):16032-16043. PMID: 28808053.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  16. Beyett TS, Bandekar SB, Tesmer JJG. G Protein-Coupled Receptor Kinases. Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily. 2016; 59-74. View Publication.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.