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Oleg Butovsky, Ph.D.

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Tel Aviv University, IsraelB.Sc. cum laude09/1995Biology Science
The Weizmann Institute of Science, IsraelM.Sc. magna cum laude09/2000Neurobiology Science
The Weizmann Institute of Science, IsraelPh.D. summa cum laude09/2005Neuroimmunology
BWH/Harvard Medical School, USAPostdoctoral Training2012Center for Neurologic Diseases
BWH/Harvard Medical School, USAInstructor in Neurology2014Center for Neurologic Diseases
BWH/Harvard Medical School, USAAssistant Professor2018Center for Neurologic Diseases
BWH/Harvard Medical School, USAAssociate ProfessorPresentCenter for Neurologic Diseases
Translational Research Advancing Therapies for ALS award
The Race to Erase MS – Faculty Award
Commitment to Innovation Discovery
Updated Awards: https://orcid.org/0000-0003-0186-8867

My laboratory focuses on basic fundamental questions of microglia biology and developing novel microglia-targeting therapies. One of the important new areas in neuroimmunology is the emerging field of the innate immune system and the interface between microglia and the peripheral innate immune system. Our novel tools and therapeutic approaches are applicable to neurological diseases including Multiple sclerosis, Amyotrophic lateral sclerosis and Alzheimer’s disease that currently lack therapy.

Available: 01/10/22, Expires: 04/01/23

This project will investigate major regulatory signaling of APOE variants in peripheral immunity (neutrophils) and brain (microglia) as targets to treat Alzheimer's disease (AD). We will implement new tools to specifically modulate the crosstalk between APOE4-neutrophils and microglia to ameliorate disease progression using novel mouse models and human samples, including microglia and neutrophils from AD patients. The goal of this project is to define the role of APOE signaling in regulation neutrophil-microglia interactions in neurodegeneration and determine which phenotypes and functions play a role in AD. The outcomes of the project will have considerable impact on both advancing the basic science of AD and opening a novel neutrophil-based immuno-modulating approach for the treatment of AD. The student will utilize 1) Novel genetically modified mouse lines Ly6G-CreERT2 and ApoeKI(E2, E3 and E4)fl/fl to specifically target APOE variants in neutrophils; 2) Innovative methods including multiplexed error robust fluorescence in situ hybridization (MERFISH) to investigate neutrophil-microglia crosstalk and their spatial interactions, validated by single-cell targeted proteomics using Cytec Aurora technology and TMT-quantitative proteomics and 3) human samples and iPSCs-derived microglia to study neutrophil-microglia interactions in AD. Students seek to integrate into this project must be able to work with animals and human brain and blood samples.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R41AG073059 (ILIN, ILYA) Sep 30, 2021 - Aug 31, 2022
    Xenon gas treatment to modulate microglia in neurodegenerative diseases
    Role: Co-Principal Investigator
  2. R21NS104609 (BUTOVSKY, OLEG) Jul 1, 2018 - Dec 31, 2020
    Identification of exosome signature in serum from ALS patients
    Role: Principal Investigator
  3. A222469 (Butovsky, Oleg) Apr 1, 2018 - Mar 1, 2019
    Evaluate the effect of CFMS antagonist on microglia cell phenotypes and gene signatures
    Role Description: The goal of this project is to determine the contribution of CSF1R in microglia modulation of functional properties during processes of tissue injury, neuroinflammation and neurodegeneration.
    Role: Principal Investigator
  4. R01EY027921 (WEINER, HOWARD L) Sep 30, 2017 - Dec 31, 2020
    Role of Microglia in Retinitis Pigementosa
    Role Description: NIH R01EY027921 (PI:Weiner/Co-PI: Butovsky) Role: Co-PI. The focus of this grant proposal is to characterize retinal microglia and how they regulate and/or participate in retinal damage in both animal models of retinitis pigmentosa and in eyes from human subjects. We will investigate whether retinitis pigmentosa in animal models can be treated by specifically targeting and modulating microglia. We will use new technology and approaches to understand features of microglia cells that can then be exploited to develop novel microglia-targeting therapies to treat humans with retinitis pigmentosa.
    Role: Principal Investigator
  5. R01AG054672 (BUTOVSKY, OLEG) Aug 15, 2017 - Apr 30, 2022
    Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer’s disease
    Role Description: Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer’s disease NIH/NIA R01 AG054672-01 (Butovsky) Role: PI. We hypothesize that danger signals (dead neurons and amyloid-ß peptides) alter functional phenotype of innate immune cells from the homeostatic (M0) to newly discovered neurodegenerative (MGnD) phenotype. We will address our hypothesis in the following aims: 1) targeting Trem2-induced Apoe/miR155 pathway to restore M0-homeostatic microglia in AD mouse models. We will specifically delete miR-155, Apoe and Trem2 in microglia of AD mouse models; 2) restoration of M0-homeostatic microglia via Mertk pathway in humanized APOE4 and AD mice. We will specifically over-express Mertk in microglia of APOE4 humanized mice and AD mouse models. We will validate our findings by investigating AD brains from prodromal to advanced stages. The goal of our investigations is to define new molecular mechanisms of immune and inflammatory processes that contribute to the development and progression of AD, which in turn will provide a basis for new approaches for immune based therapy of the disease.
    Role: Principal Investigator

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. West PK, McCorkindale AN, Guennewig B, Ashhurst TM, Viengkhou B, Hayashida E, Jung SR, Butovsky O, Campbell IL, Hofer MJ. The cytokines interleukin-6 and interferon-a induce distinct microglia phenotypes. J Neuroinflammation. 2022 Apr 16; 19(1):96. PMID: 35429976; PMCID: PMC9013466.
    Citations: 1     Fields:    Translation:AnimalsCells
  2. Cox LM, Calcagno N, Gauthier C, Madore C, Butovsky O, Weiner HL. The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis. Microbiome. 2022 03 11; 10(1):47. PMID: 35272713; PMCID: PMC8915543.
    Citations:    Fields:    Translation:AnimalsCells
  3. Fiore NT, Yin Z, Guneykaya D, Gauthier CD, Hayes JP, D'Hary A, Butovsky O, Moalem-Taylor G. Sex-specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury. Glia. 2022 04; 70(4):675-696. PMID: 35050555; PMCID: PMC8852349.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Moreira TG, Mangani D, Cox LM, Leibowitz J, Lobo ELC, Oliveira MA, Gauthier CD, Nakagaki BN, Willocq V, Song A, Guo L, Lima DCA, Murugaiyan G, Butovsky O, Gabriely G, Anderson AC, Rezende RM, Faria AMC, Weiner HL. PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis. Nat Commun. 2021 08 13; 12(1):4907. PMID: 34389726.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  5. Wang C, Xiong M, Gratuze M, Bao X, Shi Y, Andhey PS, Manis M, Schroeder C, Yin Z, Madore C, Butovsky O, Artyomov M, Ulrich JD, Holtzman DM. Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia. Neuron. 2021 05 19; 109(10):1657-1674.e7. PMID: 33831349; PMCID: PMC8141024.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  6. Zrzavy T, Schwaiger C, Wimmer I, Berger T, Bauer J, Butovsky O, Schwab JM, Lassmann H, Höftberger R. Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury. Brain. 2021 02 12; 144(1):144-161. PMID: 33578421; PMCID: PMC7880675.
    Citations: 20     Fields:    Translation:HumansCells
  7. Madore C, Leyrolle Q, Morel L, Rossitto M, Greenhalgh AD, Delpech JC, Martinat M, Bosch-Bouju C, Bourel J, Rani B, Lacabanne C, Thomazeau A, Hopperton KE, Beccari S, Sere A, Aubert A, De Smedt-Peyrusse V, Lecours C, Bisht K, Fourgeaud L, Gregoire S, Bretillon L, Acar N, Grant NJ, Badaut J, Gressens P, Sierra A, Butovsky O, Tremblay ME, Bazinet RP, Joffre C, Nadjar A, Layé S. Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain. Nat Commun. 2020 11 30; 11(1):6133. PMID: 33257673.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  8. Hagan N, Kane JL, Grover D, Woodworth L, Madore C, Saleh J, Sancho J, Liu J, Li Y, Proto J, Zelic M, Mahan A, Kothe M, Scholte AA, Fitzgerald M, Gisevius B, Haghikia A, Butovsky O, Ofengeim D. CSF1R signaling is a regulator of pathogenesis in progressive MS. Cell Death Dis. 2020 10 23; 11(10):904. PMID: 33097690.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  9. Margeta MA, Letcher SM, Igo RP, Cooke Bailey JN, Pasquale LR, Haines JL, Butovsky O, Wiggs JL. Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE e4. Invest Ophthalmol Vis Sci. 2020 07 01; 61(8):3. PMID: 32614373.
    Citations: 4     Fields:    Translation:Humans
  10. Kempthorne L, Yoon H, Madore C, Smith S, Wszolek ZK, Rademakers R, Kim J, Butovsky O, Dickson DW. Correction to: Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy. Acta Neuropathol Commun. 2020 06 24; 8(1):90. PMID: 32580749.
    Citations: 1     Fields:    
  11. Clarke J, Yaqubi M, Futhey NC, Sedaghat S, Baufeld C, Blain M, Baranzini S, Butovsky O, Antel J, White JH, Healy LM. Vitamin D Regulates MerTK-Dependent Phagocytosis in Human Myeloid Cells. J Immunol. 2020 07 15; 205(2):398-406. PMID: 32540991.
    Citations: 5     Fields:    Translation:HumansCells
  12. Kempthorne L, Yoon H, Madore C, Smith S, Wszolek ZK, Rademakers R, Kim J, Butovsky O, Dickson DW. Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy. Acta Neuropathol Commun. 2020 05 19; 8(1):72. PMID: 32430064.
    Citations: 22     Fields:    Translation:HumansCells
  13. Roy ER, Wang B, Wan YW, Chiu G, Cole A, Yin Z, Propson NE, Xu Y, Jankowsky JL, Liu Z, Lee VM, Trojanowski JQ, Ginsberg SD, Butovsky O, Zheng H, Cao W. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. J Clin Invest. 2020 04 01; 130(4):1912-1930. PMID: 31917687; PMCID: PMC7108898.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  14. Ikezu S, Yeh H, Delpech JC, Woodbury ME, Van Enoo AA, Ruan Z, Sivakumaran S, You Y, Holland C, Guillamon-Vivancos T, Yoshii-Kitahara A, Botros MB, Madore C, Chao PH, Desani A, Manimaran S, Kalavai SV, Johnson WE, Butovsky O, Medalla M, Luebke JI, Ikezu T. Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Mol Psychiatry. 2021 06; 26(6):1808-1831. PMID: 32071385; PMCID: PMC7431382.
    Citations: 10     Fields:    Translation:AnimalsCells
  15. Madore C, Yin Z, Leibowitz J, Butovsky O. Microglia, Lifestyle Stress, and Neurodegeneration. Immunity. 2020 02 18; 52(2):222-240. PMID: 31924476.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  16. Götzl JK, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo AV, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, Bartenstein P, Rominger A, Tahirovic S, Smith ST, Madore C, Butovsky O, Capell A, Haass C. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO Mol Med. 2019 06; 11(6). PMID: 31122931; PMCID: PMC6554672.
    Citations: 34     Fields:    Translation:AnimalsCells
  17. Hartmann K, Sepulveda-Falla D, Rose IVL, Madore C, Muth C, Matschke J, Butovsky O, Liddelow S, Glatzel M, Krasemann S. Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia. Acta Neuropathol Commun. 2019 05 22; 7(1):83. PMID: 31118110; PMCID: PMC6530067.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  18. Dodiya HB, Kuntz T, Shaik SM, Baufeld C, Leibowitz J, Zhang X, Gottel N, Zhang X, Butovsky O, Gilbert JA, Sisodia SS. Sex-specific effects of microbiome perturbations on cerebral Aß amyloidosis and microglia phenotypes. J Exp Med. 2019 07 01; 216(7):1542-1560. PMID: 31097468; PMCID: PMC6605759.
    Citations: 59     Fields:    Translation:AnimalsCells
  19. Okunuki Y, Mukai R, Nakao T, Tabor SJ, Butovsky O, Dana R, Ksander BR, Connor KM. Retinal microglia initiate neuroinflammation in ocular autoimmunity. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):9989-9998. PMID: 31023885.
    Citations: 37     Fields:    Translation:AnimalsCells
  20. Duffy SS, Keating BA, Perera CJ, Lees JG, Tonkin RS, Makker PGS, Carrive P, Butovsky O, Moalem-Taylor G. Regulatory T Cells and Their Derived Cytokine, Interleukin-35, Reduce Pain in Experimental Autoimmune Encephalomyelitis. J Neurosci. 2019 03 20; 39(12):2326-2346. PMID: 30651334; PMCID: PMC6433755.
    Citations: 21     Fields:    Translation:AnimalsCells
  21. Faustino J, Chip S, Derugin N, Jullienne A, Hamer M, Haddad E, Butovsky O, Obenaus A, Vexler ZS. CX3CR1-CCR2-dependent monocyte-microglial signaling modulates neurovascular leakage and acute injury in a mouse model of childhood stroke. J Cereb Blood Flow Metab. 2019 10; 39(10):1919-1935. PMID: 30628839; PMCID: PMC6775594.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  22. Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, Tahirovic S, Herms J, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Grathwohl SA, Neher JJ, Holtzman DM, Meyer-Luehmann M, Haass C. Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nat Neurosci. 2019 02; 22(2):191-204. PMID: 30617257; PMCID: PMC6417433.
    Citations: 146     Fields:    Translation:HumansAnimalsCells
  23. Lund H, Pieber M, Parsa R, Han J, Grommisch D, Ewing E, Kular L, Needhamsen M, Espinosa A, Nilsson E, Överby AK, Butovsky O, Jagodic M, Zhang XM, Harris RA. Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells. Nat Commun. 2018 11 19; 9(1):4845. PMID: 30451869.
    Citations: 56     Fields:    Translation:AnimalsCells
  24. Rubino SJ, Mayo L, Wimmer I, Siedler V, Brunner F, Hametner S, Madi A, Lanser A, Moreira T, Donnelly D, Cox L, Rezende RM, Butovsky O, Lassmann H, Weiner HL. Acute microglia ablation induces neurodegeneration in the somatosensory system. Nat Commun. 2018 11 01; 9(1):4578. PMID: 30385785; PMCID: PMC6212411.
    Citations: 23     Fields:    Translation:AnimalsCells
  25. Butovsky O, Weiner HL. Microglial signatures and their role in health and disease. Nat Rev Neurosci. 2018 10; 19(10):622-635. PMID: 30206328; PMCID: PMC7255106.
    Citations: 214     Fields:    Translation:HumansAnimalsCells
  26. Zrzavy T, Höftberger R, Berger T, Rauschka H, Butovsky O, Weiner H, Lassmann H. Pro-inflammatory activation of microglia in the brain of patients with sepsis. Neuropathol Appl Neurobiol. 2019 04; 45(3):278-290. PMID: 29804289.
    Citations: 33     Fields:    Translation:HumansCells
  27. Okunuki Y, Mukai R, Pearsall EA, Klokman G, Husain D, Park DH, Korobkina E, Weiner HL, Butovsky O, Ksander BR, Miller JW, Connor KM. Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):E6264-E6273. PMID: 29915052; PMCID: PMC6142210.
    Citations: 41     Fields:    Translation:AnimalsCells
  28. Calcagno N, Baufeld C, Madore C, Butovsky O. TREMendous 2 Be Social. Immunity. 2018 05 15; 48(5):842-843. PMID: 29768169.
    Citations: 1     Fields:    Translation:AnimalsCells
  29. Lund H, Pieber M, Parsa R, Grommisch D, Ewing E, Kular L, Han J, Zhu K, Nijssen J, Hedlund E, Needhamsen M, Ruhrmann S, Guerreiro-Cacais AO, Berglund R, Forteza MJ, Ketelhuth DFJ, Butovsky O, Jagodic M, Zhang XM, Harris RA. Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-ß signaling. Nat Immunol. 2018 05; 19(5):1-7. PMID: 29662171; PMCID: PMC7309278.
    Citations: 28     Fields:    Translation:AnimalsCells
  30. O'Loughlin E, Madore C, Lassmann H, Butovsky O. Microglial Phenotypes and Functions in Multiple Sclerosis. Cold Spring Harb Perspect Med. 2018 02 01; 8(2). PMID: 29419406.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  31. Katsumoto A, Miranda AS, Butovsky O, Teixeira AL, Ransohoff RM, Lamb BT. Laquinimod attenuates inflammation by modulating macrophage functions in traumatic brain injury mouse model. J Neuroinflammation. 2018 Jan 30; 15(1):26. PMID: 29382353.
    Citations: 11     Fields:    Translation:AnimalsCells
  32. Zrzavy T, Machado-Santos J, Christine S, Baumgartner C, Weiner HL, Butovsky O, Lassmann H. Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts. Brain Pathol. 2018 11; 28(6):791-805. PMID: 29222823; PMCID: PMC6334527.
    Citations: 43     Fields:    Translation:HumansCells
  33. Baufeld C, O'Loughlin E, Calcagno N, Madore C, Butovsky O. Differential contribution of microglia and monocytes in neurodegenerative diseases. J Neural Transm (Vienna). 2018 05; 125(5):809-826. PMID: 29063348.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  34. Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, McCue L, Xiong C, Del-Aguila JL, Morris JC, Cruchaga C, Fagan AM, Miller BL, Boxer AL, Seeley WW, Butovsky O, Barres BA, Paul SM, Holtzman DM. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. 2017 09 28; 549(7673):523-527. PMID: 28959956; PMCID: PMC5641217.
    Citations: 370     Fields:    Translation:HumansAnimalsCells
  35. Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 2017 09 19; 47(3):566-581.e9. PMID: 28930663.
    Citations: 706     Fields:    Translation:HumansAnimalsCells
  36. Zrzavy T, Hametner S, Wimmer I, Butovsky O, Weiner HL, Lassmann H. Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis. Brain. 2017 Jul 01; 140(7):1900-1913. PMID: 28541408; PMCID: PMC6057548.
    Citations: 204     Fields:    Translation:HumansCells
  37. Madore C, Baufeld C, Butovsky O. Microglial confetti party. Nat Neurosci. 2017 05 25; 20(6):762-763. PMID: 28542157; PMCID: PMC7034697.
    Citations: 3     Fields:    Translation:Cells
  38. Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trümbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, Butovsky O, Haass C. TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. EMBO Rep. 2017 07; 18(7):1186-1198. PMID: 28483841; PMCID: PMC5494532.
    Citations: 110     Fields:    Translation:HumansCells
  39. Colonna M, Butovsky O. Microglia Function in the Central Nervous System During Health and Neurodegeneration. Annu Rev Immunol. 2017 04 26; 35:441-468. PMID: 28226226.
    Citations: 478     Fields:    Translation:HumansAnimalsCells
  40. Makker PG, Duffy SS, Lees JG, Perera CJ, Tonkin RS, Butovsky O, Park SB, Goldstein D, Moalem-Taylor G. Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy. PLoS One. 2017; 12(1):e0170814. PMID: 28125674.
    Citations: 83     Fields:    Translation:AnimalsCells
  41. Drokhlyansky E, Göz Aytürk D, Soh TK, Chrenek R, O'Loughlin E, Madore C, Butovsky O, Cepko CL. The brain parenchyma has a type I interferon response that can limit virus spread. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):E95-E104. PMID: 27980033; PMCID: PMC5224383.
    Citations: 27     Fields:    Translation:AnimalsCells
  42. Muth C, Schröck K, Madore C, Hartmann K, Fanek Z, Butovsky O, Glatzel M, Krasemann S. Activation of microglia by retroviral infection correlates with transient clearance of prions from the brain but does not change incubation time. Brain Pathol. 2017 Sep; 27(5):590-602. PMID: 27558169; PMCID: PMC6625757.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  43. Delpech JC, Wei L, Hao J, Yu X, Madore C, Butovsky O, Kaffman A. Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain Behav Immun. 2016 Oct; 57:79-93. PMID: 27301858; PMCID: PMC5010940.
    Citations: 64     Fields:    Translation:AnimalsCells
  44. Smith B, Whang J, Butovsky O, Scholz J. (272) Intraspinal chemokine signaling in the spared nerve injury model of neuropathic pain. J Pain. 2016 Apr; 17(4S):S44. PMID: 28162508.
  45. Bisht K, Sharma KP, Lecours C, Sánchez MG, El Hajj H, Milior G, Olmos-Alonso A, Gómez-Nicola D, Luheshi G, Vallières L, Branchi I, Maggi L, Limatola C, Butovsky O, Tremblay MÈ. Dark microglia: A new phenotype predominantly associated with pathological states. Glia. 2016 May; 64(5):826-39. PMID: 26847266.
    Citations: 144     Fields:    Translation:AnimalsCells
  46. Butovsky O, Jedrychowski MP, Cialic R, Murugaiyan G, Wu PM, Doykan CE, Fanek Z, Greco DJ, Kiner O, Lawson RJ, Frosch MP, Pochet N, Krichevsky AM, Gygi SP, Berry J, Cudkowicz ME, Weiner HL. Targeting miR-155 restores dysfunctional microglia and ameliorates disease in the SOD1 model of ALS. Int J Dev Neurosci. 2015 Dec; 47(Pt A):5. PMID: 26531345.
  47. Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL. Identification of a unique molecular and functional microglia signature in health and disease. Int J Dev Neurosci. 2015 Dec; 47(Pt A):5. PMID: 26531346.
  48. Butovsky O, Jedrychowski MP, Cialic R, Murugaiyan G, Wu PM, Doykan CE, Fanek Z, Greco DJ, Kiner O, Lawson RJ, Frosch MP, Pochet N, Krichevsky AM, Gygi SP, Berry J, Cudkowicz ME, Weiner HL. REMOVED: Targeting miR-155 restores dysfunctional microglia and ameliorates disease in the SOD1 model of ALS. Int J Dev Neurosci. 2015 Dec; 47(Pt A):5. PMID: 29887088.
    Citations:    Fields:    
  49. Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL. REMOVED: Identification of a unique molecular and functional microglia signature in health and disease. Int J Dev Neurosci. 2015 Dec; 47(Pt A):5. PMID: 29887087.
    Citations:    Fields:    
  50. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93. PMID: 26436904; PMCID: PMC4694577.
    Citations: 557     Fields:    Translation:AnimalsCells
  51. Verheijden S, Beckers L, Casazza A, Butovsky O, Mazzone M, Baes M. Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal ß-oxidation deficiency. Glia. 2015 Sep; 63(9):1606-20. PMID: 25846981; PMCID: PMC6572738.
    Citations: 17     Fields:    Translation:AnimalsCells
  52. Moore CS, Ase AR, Kinsara A, Rao VT, Michell-Robinson M, Leong SY, Butovsky O, Ludwin SK, Séguéla P, Bar-Or A, Antel JP. P2Y12 expression and function in alternatively activated human microglia. Neurol Neuroimmunol Neuroinflamm. 2015 Apr; 2(2):e80. PMID: 25821842.
    Citations: 72     Fields:    
  53. Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med. 2015 Mar 09; 212(3):287-95. PMID: 25732305; PMCID: PMC4354365.
    Citations: 284     Fields:    Translation:HumansAnimalsCells
  54. Butovsky O, Jedrychowski MP, Cialic R, Krasemann S, Murugaiyan G, Fanek Z, Greco DJ, Wu PM, Doykan CE, Kiner O, Lawson RJ, Frosch MP, Pochet N, Fatimy RE, Krichevsky AM, Gygi SP, Lassmann H, Berry J, Cudkowicz ME, Weiner HL. Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice. Ann Neurol. 2015 Jan; 77(1):75-99. PMID: 25381879; PMCID: PMC4432483.
    Citations: 161     Fields:    Translation:HumansAnimalsCells
  55. Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL. Corrigendum: Identification of a unique TGF-ß-dependent molecular and functional signature in microglia. Nat Neurosci. 2014 Aug 26; 17(9):1286. PMID: 25157514.
  56. Yamasaki R, Lu H, Butovsky O, Ohno N, Rietsch AM, Cialic R, Wu PM, Doykan CE, Lin J, Cotleur AC, Kidd G, Zorlu MM, Sun N, Hu W, Liu L, Lee JC, Taylor SE, Uehlein L, Dixon D, Gu J, Floruta CM, Zhu M, Charo IF, Weiner HL, Ransohoff RM. Differential roles of microglia and monocytes in the inflamed central nervous system. J Exp Med. 2014 Jul 28; 211(8):1533-49. PMID: 25002752.
    Citations: 358     Fields:    Translation:HumansAnimalsCells
  57. Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL. Identification of a unique TGF-ß-dependent molecular and functional signature in microglia. Nat Neurosci. 2014 Jan; 17(1):131-43. PMID: 24316888.
    Citations: 1040     Fields:    Translation:HumansAnimalsCells
  58. Butovsky O, Siddiqui S, Gabriely G, Lanser AJ, Dake B, Murugaiyan G, Doykan CE, Wu PM, Gali RR, Iyer LK, Lawson R, Berry J, Krichevsky AM, Cudkowicz ME, Weiner HL. Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest. 2012 Sep; 122(9):3063-87. PMID: 22863620; PMCID: PMC3428086.
    Citations: 240     Fields:    Translation:HumansAnimalsCells
  59. Vaknin I, Kunis G, Miller O, Butovsky O, Bukshpan S, Beers DR, Henkel JS, Yoles E, Appel SH, Schwartz M. Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis. PLoS One. 2011; 6(11):e26921. PMID: 22073221.
    Citations: 34     Fields:    Translation:Animals
  60. Landa G, Butovsky O, Shoshani J, Schwartz M, Pollack A. Weekly vaccination with Copaxone (glatiramer acetate) as a potential therapy for dry age-related macular degeneration. Curr Eye Res. 2008 Nov; 33(11):1011-3. PMID: 19085384.
    Citations: 16     Fields:    Translation:HumansPHPublic Health
  61. Butovsky O, Kunis G, Koronyo-Hamaoui M, Schwartz M. Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model. Eur J Neurosci. 2007 Jul; 26(2):413-6. PMID: 17623022.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  62. Butovsky O, Bukshpan S, Kunis G, Jung S, Schwartz M. Microglia can be induced by IFN-gamma or IL-4 to express neural or dendritic-like markers. Mol Cell Neurosci. 2007 Jul; 35(3):490-500. PMID: 17560122.
    Citations: 41     Fields:    Translation:AnimalsCells
  63. Butovsky O, Koronyo-Hamaoui M, Kunis G, Ophir E, Landa G, Cohen H, Schwartz M. Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11784-9. PMID: 16864778; PMCID: PMC1544247.
    Citations: 145     Fields:    Translation:AnimalsCells
  64. Butovsky O, Landa G, Kunis G, Ziv Y, Avidan H, Greenberg N, Schwartz A, Smirnov I, Pollack A, Jung S, Schwartz M. Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. J Clin Invest. 2006 Apr; 116(4):905-15. PMID: 16557302; PMCID: PMC1409740.
    Citations: 116     Fields:    Translation:AnimalsCells
  65. Schwartz M, Butovsky O, Kipnis J. Does inflammation in an autoimmune disease differ from inflammation in neurodegenerative diseases? Possible implications for therapy. J Neuroimmune Pharmacol. 2006 Mar; 1(1):4-10. PMID: 18040786.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  66. Ziv Y, Ron N, Butovsky O, Landa G, Sudai E, Greenberg N, Cohen H, Kipnis J, Schwartz M. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat Neurosci. 2006 Feb; 9(2):268-75. PMID: 16415867.
    Citations: 448     Fields:    Translation:AnimalsCells
  67. Schwartz M, Butovsky O, Brück W, Hanisch UK. Microglial phenotype: is the commitment reversible? Trends Neurosci. 2006 Feb; 29(2):68-74. PMID: 16406093.
    Citations: 165     Fields:    Translation:HumansAnimalsCells
  68. Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci. 2006 Jan; 31(1):149-60. PMID: 16297637.
    Citations: 378     Fields:    Translation:AnimalsCells
  69. Butovsky O, Talpalar AE, Ben-Yaakov K, Schwartz M. Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective. Mol Cell Neurosci. 2005 Jul; 29(3):381-93. PMID: 15890528.
    Citations: 133     Fields:    Translation:AnimalsCells
  70. Avidan H, Kipnis J, Butovsky O, Caspi RR, Schwartz M. Vaccination with autoantigen protects against aggregated beta-amyloid and glutamate toxicity by controlling microglia: effect of CD4+CD25+ T cells. Eur J Immunol. 2004 Dec; 34(12):3434-45. PMID: 15549735.
    Citations: 22     Fields:    Translation:AnimalsCellsPHPublic Health
  71. Ibarra A, Hauben E, Butovsky O, Schwartz M. The therapeutic window after spinal cord injury can accommodate T cell-based vaccination and methylprednisolone in rats. Eur J Neurosci. 2004 Jun; 19(11):2984-90. PMID: 15182305.
    Citations: 10     Fields:    Translation:AnimalsCells
  72. Hauben E, Gothilf A, Cohen A, Butovsky O, Nevo U, Smirnov I, Yoles E, Akselrod S, Schwartz M. Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury. J Neurosci. 2003 Sep 24; 23(25):8808-19. PMID: 14507981; PMCID: PMC6740409.
    Citations: 24     Fields:    Translation:AnimalsCellsPHPublic Health
  73. Bomstein Y, Marder JB, Vitner K, Smirnov I, Lisaey G, Butovsky O, Fulga V, Yoles E. Features of skin-coincubated macrophages that promote recovery from spinal cord injury. J Neuroimmunol. 2003 Sep; 142(1-2):10-6. PMID: 14512160.
    Citations: 37     Fields:    Translation:AnimalsCells
  74. Butovsky O, Hauben E, Schwartz M. Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7--2 (CD86) and prevention of cyst formation. FASEB J. 2001 Apr; 15(6):1065-7. PMID: 11292669.
    Citations: 35     Fields:    Translation:AnimalsCells
  75. Fisher J, Levkovitch-Verbin H, Schori H, Yoles E, Butovsky O, Kaye JF, Ben-Nun A, Schwartz M. Vaccination for neuroprotection in the mouse optic nerve: implications for optic neuropathies. J Neurosci. 2001 Jan 01; 21(1):136-42. PMID: 11150329; PMCID: PMC6762428.
    Citations: 41     Fields:    Translation:AnimalsCellsPHPublic Health
  76. Hauben E, Butovsky O, Nevo U, Yoles E, Moalem G, Agranov E, Mor F, Leibowitz-Amit R, Pevsner E, Akselrod S, Neeman M, Cohen IR, Schwartz M. Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion. J Neurosci. 2000 Sep 01; 20(17):6421-30. PMID: 10964948; PMCID: PMC6772980.
    Citations: 89     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.