Harvard Catalyst Profiles

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Jeffrey R Moffitt, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Moffitt JR, Lundberg E, Heyn H. The emerging landscape of spatial profiling technologies. Nat Rev Genet. 2022 12; 23(12):741-759. PMID: 35859028.
    Citations:    Fields:    
  2. Petukhov V, Xu RJ, Soldatov RA, Cadinu P, Khodosevich K, Moffitt JR, Kharchenko PV. Cell segmentation in imaging-based spatial transcriptomics. Nat Biotechnol. 2022 03; 40(3):345-354. PMID: 34650268.
    Citations: 4     Fields:    Translation:Cells
  3. Kagan J, Moritz RL, Mazurchuk R, Lee JH, Kharchenko PV, Rozenblatt-Rosen O, Ruppin E, Edfors F, Ginty F, Goltsev Y, Wells JA, LaCava J, Riesterer JL, Germain RN, Shi T, Chee MS, Budnik BA, Yates JR, Chait BT, Moffitt JR, Smith RD, Srivastava S. National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions. J Proteome Res. 2020 05 01; 19(5):1900-1912. PMID: 32163288.
    Citations: 3     Fields:    
  4. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ. MAFG-driven astrocytes promote CNS inflammation. Nature. 2020 02; 578(7796):593-599. PMID: 32051591; PMCID: PMC8049843.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  5. Xia C, Babcock HP, Moffitt JR, Zhuang X. Multiplexed detection of RNA using MERFISH and branched DNA amplification. Sci Rep. 2019 05 22; 9(1):7721. PMID: 31118500.
    Citations: 31     Fields:    Translation:HumansCells
  6. Moffitt JR, Bambah-Mukku D, Eichhorn SW, Vaughn E, Shekhar K, Perez JD, Rubinstein ND, Hao J, Regev A, Dulac C, Zhuang X. Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region. Science. 2018 11 16; 362(6416). PMID: 30385464; PMCID: PMC6482113.
    Citations: 260     Fields:    Translation:AnimalsCells
  7. Wang G, Moffitt JR, Zhuang X. Author Correction: Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy. Sci Rep. 2018 Apr 19; 8(1):6487. PMID: 29670197.
    Citations: 2     Fields:    
  8. Wang G, Moffitt JR, Zhuang X. Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy. Sci Rep. 2018 03 19; 8(1):4847. PMID: 29555914.
    Citations: 54     Fields:    
  9. Emanuel G, Moffitt JR, Zhuang X. High-throughput, image-based screening of pooled genetic-variant libraries. Nat Methods. 2017 Dec; 14(12):1159-1162. PMID: 29083401; PMCID: PMC5958624.
    Citations: 18     Fields:    Translation:Cells
  10. Moffitt JR, Hao J, Bambah-Mukku D, Lu T, Dulac C, Zhuang X. High-performance multiplexed fluorescence in situ hybridization in culture and tissue with matrix imprinting and clearing. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):14456-14461. PMID: 27911841.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  11. Moffitt JR, Hao J, Wang G, Chen KH, Babcock HP, Zhuang X. High-throughput single-cell gene-expression profiling with multiplexed error-robust fluorescence in situ hybridization. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):11046-51. PMID: 27625426; PMCID: PMC5047202.
    Citations: 137     Fields:    Translation:HumansCells
  12. Wang S, Su JH, Beliveau BJ, Bintu B, Moffitt JR, Wu CT, Zhuang X. Spatial organization of chromatin domains and compartments in single chromosomes. Science. 2016 Aug 05; 353(6299):598-602. PMID: 27445307.
    Citations: 214     Fields:    Translation:HumansCells
  13. Moffitt JR, Pandey S, Boettiger AN, Wang S, Zhuang X. Spatial organization shapes the turnover of a bacterial transcriptome. Elife. 2016 05 20; 5. PMID: 27198188; PMCID: PMC4874777.
    Citations: 63     Fields:    Translation:Cells
  14. Moffitt JR, Zhuang X. RNA Imaging with Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH). Methods Enzymol. 2016; 572:1-49. PMID: 27241748; PMCID: PMC5023431.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  15. Boettiger AN, Bintu B, Moffitt JR, Wang S, Beliveau BJ, Fudenberg G, Imakaev M, Mirny LA, Wu CT, Zhuang X. Super-resolution imaging reveals distinct chromatin folding for different epigenetic states. Nature. 2016 Jan 21; 529(7586):418-22. PMID: 26760202.
    Citations: 311     Fields:    Translation:AnimalsCells
  16. Chen KH, Boettiger AN, Moffitt JR, Wang S, Zhuang X. RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells. Science. 2015 Apr 24; 348(6233):aaa6090. PMID: 25858977.
    Citations: 549     Fields:    Translation:HumansCells
  17. Wang S, Moffitt JR, Dempsey GT, Xie XS, Zhuang X. Characterization and development of photoactivatable fluorescent proteins for single-molecule-based superresolution imaging. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8452-7. PMID: 24912163.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  18. Osseforth C, Moffitt JR, Schermelleh L, Michaelis J. Simultaneous dual-color 3D STED microscopy. Opt Express. 2014 Mar 24; 22(6):7028-39. PMID: 24664051.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  19. Babcock HP, Moffitt JR, Cao Y, Zhuang X. Fast compressed sensing analysis for super-resolution imaging using L1-homotopy. Opt Express. 2013 Nov 18; 21(23):28583-96. PMID: 24514370.
    Citations: 17     Fields:    Translation:Humans
  20. Moffitt JR, Bustamante C. Extracting signal from noise: kinetic mechanisms from a Michaelis-Menten-like expression for enzymatic fluctuations. FEBS J. 2014 Jan; 281(2):498-517. PMID: 24428386.
    Citations: 13     Fields:    Translation:Cells
  21. Glaser JI, Zamft BM, Marblestone AH, Moffitt JR, Tyo K, Boyden ES, Church G, Kording KP. Statistical analysis of molecular signal recording. PLoS Comput Biol. 2013; 9(7):e1003145. PMID: 23874187.
    Citations: 13     Fields:    
  22. Teng SW, Mukherji S, Moffitt JR, de Buyl S, O'Shea EK. Robust circadian oscillations in growing cyanobacteria require transcriptional feedback. Science. 2013 May 10; 340(6133):737-40. PMID: 23661759.
    Citations: 58     Fields:    Translation:Cells
  23. Chistol G, Liu S, Hetherington CL, Moffitt JR, Grimes S, Jardine PJ, Bustamante C. High degree of coordination and division of labor among subunits in a homomeric ring ATPase. Cell. 2012 Nov 21; 151(5):1017-28. PMID: 23178121.
    Citations: 65     Fields:    Translation:Cells
  24. Moffitt JR, Lee JB, Cluzel P. The single-cell chemostat: an agarose-based, microfluidic device for high-throughput, single-cell studies of bacteria and bacterial communities. Lab Chip. 2012 Apr 21; 12(8):1487-94. PMID: 22395180.
    Citations: 59     Fields:    Translation:Cells
  25. Cheng W, Arunajadai SG, Moffitt JR, Tinoco I, Bustamante C. Single-base pair unwinding and asynchronous RNA release by the hepatitis C virus NS3 helicase. Science. 2011 Sep 23; 333(6050):1746-9. PMID: 21940894.
    Citations: 64     Fields:    Translation:Cells
  26. Moffitt JR, Osseforth C, Michaelis J. Time-gating improves the spatial resolution of STED microscopy. Opt Express. 2011 Feb 28; 19(5):4242-54. PMID: 21369254.
    Citations: 30     Fields:    
  27. Moffitt JR, Chemla YR, Bustamante C. Mechanistic constraints from the substrate concentration dependence of enzymatic fluctuations. Proc Natl Acad Sci U S A. 2010 Sep 07; 107(36):15739-44. PMID: 20729471.
    Citations: 10     Fields:    Translation:Cells
  28. Yu J, Moffitt J, Hetherington CL, Bustamante C, Oster G. Mechanochemistry of a viral DNA packaging motor. J Mol Biol. 2010 Jul 09; 400(2):186-203. PMID: 20452360.
    Citations: 44     Fields:    Translation:Cells
  29. Moffitt JR, Chemla YR, Bustamante C. Methods in statistical kinetics. Methods Enzymol. 2010; 475:221-57. PMID: 20627160.
    Citations: 22     Fields:    Translation:Cells
  30. Michaelis J, Muschielok A, Andrecka J, Kügel W, Moffitt JR. DNA based molecular motors. Phys Life Rev. 2009 Dec; 6(4):250-66. PMID: 20416848.
    Citations: 7     Fields:    
  31. Bustamante C, Chemla YR, Moffitt JR. High-resolution dual-trap optical tweezers with differential detection: an introduction. Cold Spring Harb Protoc. 2009 Oct; 2009(10):pdb.top60. PMID: 20147062.
    Citations: 6     Fields:    
  32. Aathavan K, Politzer AT, Kaplan A, Moffitt JR, Chemla YR, Grimes S, Jardine PJ, Anderson DL, Bustamante C. Substrate interactions and promiscuity in a viral DNA packaging motor. Nature. 2009 Oct 01; 461(7264):669-73. PMID: 19794496.
    Citations: 67     Fields:    Translation:Cells
  33. Bustamante C, Chemla YR, Moffitt JR. High-resolution dual-trap optical tweezers with differential detection: alignment of instrument components. Cold Spring Harb Protoc. 2009 Oct; 2009(10):pdb.ip76. PMID: 20147041.
    Citations: 1     Fields:    
  34. Bustamante C, Chemla YR, Moffitt JR. High-resolution dual-trap optical tweezers with differential detection: minimizing the influence of measurement noise. Cold Spring Harb Protoc. 2009 Oct; 2009(10):pdb.ip75. PMID: 20147040.
    Citations:    Fields:    
  35. Bustamante C, Chemla YR, Moffitt JR. High-resolution dual-trap optical tweezers with differential detection: data collection and instrument calibration. Cold Spring Harb Protoc. 2009 Oct; 2009(10):pdb.ip74. PMID: 20147039.
    Citations: 1     Fields:    
  36. Bustamante C, Chemla YR, Moffitt JR. High-resolution dual-trap optical tweezers with differential detection: managing environmental noise. Cold Spring Harb Protoc. 2009 Oct; 2009(10):pdb.ip72. PMID: 20147037.
    Citations: 1     Fields:    
  37. Bustamante C, Chemla YR, Moffitt JR. High-resolution dual-trap optical tweezers with differential detection: instrument design. Cold Spring Harb Protoc. 2009 Oct; 2009(10):pdb.ip73. PMID: 20147038.
    Citations: 6     Fields:    
  38. Moffitt JR, Chemla YR, Aathavan K, Grimes S, Jardine PJ, Anderson DL, Bustamante C. Intersubunit coordination in a homomeric ring ATPase. Nature. 2009 Jan 22; 457(7228):446-50. PMID: 19129763.
    Citations: 144     Fields:    Translation:Cells
  39. Chemla YR, Moffitt JR, Bustamante C. Exact solutions for kinetic models of macromolecular dynamics. J Phys Chem B. 2008 May 15; 112(19):6025-44. PMID: 18373360.
    Citations: 21     Fields:    Translation:Cells
  40. Moffitt JR, Chemla YR, Smith SB, Bustamante C. Recent advances in optical tweezers. Annu Rev Biochem. 2008; 77:205-28. PMID: 18307407.
    Citations: 222     Fields:    Translation:HumansAnimals
  41. Moffitt JR, Chemla YR, Izhaky D, Bustamante C. Differential detection of dual traps improves the spatial resolution of optical tweezers. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9006-11. PMID: 16751267; PMCID: PMC1482556.
    Citations: 108     Fields:    
  42. Moffitt JR, Macdonald P, Lindner JF. Self-erasing perturbations of Abelian sandpiles. Phys Rev E Stat Nonlin Soft Matter Phys. 2004; 70(1 Pt 2):016203. PMID: 15324148.
    Citations:    Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.