Harvard Catalyst Profiles

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Hirofumi Nagao, Ph.D., M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nagao H, Cai W, Brandão BB, Wewer Albrechtsen NJ, Steger M, Gattu AK, Pan H, Dreyfuss JM, Wunderlich FT, Mann M, Kahn CR. Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling. J Clin Invest. 2023 Feb 15; 133(4). PMID: 36548088; PMCID: PMC9927934.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Nagao H, Jayavelu AK, Cai W, Pan H, Dreyfuss JM, Batista TM, Brandão BB, Mann M, Kahn CR. Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis. Nat Commun. 2023 01 04; 14(1):57. PMID: 36599833; PMCID: PMC9812992.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Kawachi Y, Fujishima Y, Nishizawa H, Nakamura T, Akari S, Murase T, Saito T, Miyazaki Y, Nagao H, Fukuda S, Kita S, Katakami N, Doki Y, Maeda N, Shimomura I. Increased plasma XOR activity induced by NAFLD/NASH and its possible involvement in vascular neointimal proliferation. JCI Insight. 2021 09 08; 6(17). PMID: 34494551; PMCID: PMC8492303.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  4. Nagao H, Cai W, Wewer Albrechtsen NJ, Steger M, Batista TM, Pan H, Dreyfuss JM, Mann M, Kahn CR. Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains. Proc Natl Acad Sci U S A. 2021 04 27; 118(17). PMID: 33879610.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  5. Kawachi Y, Fujishima Y, Nishizawa H, Nagao H, Nakamura T, Akari S, Murase T, Taya N, Omori K, Miyake A, Fukuda S, Takahara M, Kita S, Katakami N, Maeda N, Shimomura I. Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment. J Diabetes Investig. 2021 Aug; 12(8):1512-1520. PMID: 33211396; PMCID: PMC8354500.
    Citations: 3     Fields:    Translation:Humans
  6. Tanaka Y, Kita S, Nishizawa H, Fukuda S, Fujishima Y, Obata Y, Nagao H, Masuda S, Nakamura Y, Shimizu Y, Mineo R, Natsukawa T, Funahashi T, Ranscht B, Fukada SI, Maeda N, Shimomura I. Author Correction: Adiponectin promotes muscle regeneration through binding to T-cadherin. Sci Rep. 2020 Jul 17; 10(1):12219. PMID: 32678119; PMCID: PMC7367247.
    Citations:    Fields:    
  7. Tanaka Y, Kita S, Nishizawa H, Fukuda S, Fujishima Y, Obata Y, Nagao H, Masuda S, Nakamura Y, Shimizu Y, Mineo R, Natsukawa T, Funahashi T, Ranscht B, Fukada SI, Maeda N, Shimomura I. Adiponectin promotes muscle regeneration through binding to T-cadherin. Sci Rep. 2019 01 09; 9(1):16. PMID: 30626897.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  8. Masuda S, Fujishima Y, Maeda N, Tsugawa-Shimizu Y, Nakamura Y, Tanaka Y, Obata Y, Fukuda S, Nagao H, Kita S, Nishizawa H, Shimomura I. Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E239-E250. PMID: 30457913.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  9. Murai J, Nishizawa H, Otsuka A, Fukuda S, Tanaka Y, Nagao H, Sakai Y, Suzuki M, Yokota S, Tada H, Doi M, Fujishima Y, Kita S, Funahashi T, Maeda N, Nakamura T, Shimomura I. Low muscle quality in Japanese type 2 diabetic patients with visceral fat accumulation. Cardiovasc Diabetol. 2018 08 04; 17(1):112. PMID: 30077183.
    Citations: 23     Fields:    Translation:Humans
  10. Nagao H, Nishizawa H, Tanaka Y, Fukata T, Mizushima T, Furuno M, Bamba T, Tsushima Y, Fujishima Y, Kita S, Funahashi T, Maeda N, Mori M, Fukusaki E, Shimomura I. Hypoxanthine Secretion from Human Adipose Tissue and its Increase in Hypoxia. Obesity (Silver Spring). 2018 07; 26(7):1168-1178. PMID: 29877616.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  11. Obata Y, Kita S, Koyama Y, Fukuda S, Takeda H, Takahashi M, Fujishima Y, Nagao H, Masuda S, Tanaka Y, Nakamura Y, Nishizawa H, Funahashi T, Ranscht B, Izumi Y, Bamba T, Fukusaki E, Hanayama R, Shimada S, Maeda N, Shimomura I. Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release. JCI Insight. 2018 04 19; 3(8). PMID: 29669945.
    Citations: 62     Fields:    Translation:AnimalsCells
  12. Sato F, Maeda N, Yamada T, Namazui H, Fukuda S, Natsukawa T, Nagao H, Murai J, Masuda S, Tanaka Y, Obata Y, Fujishima Y, Nishizawa H, Funahashi T, Shimomura I. Association of Epicardial, Visceral, and Subcutaneous Fat With Cardiometabolic Diseases. Circ J. 2018 01 25; 82(2):502-508. PMID: 28954947.
    Citations: 25     Fields:    Translation:Humans
  13. Fukuda S, Hirata A, Nishizawa H, Nagao H, Kimura T, Fujishima Y, Yamaoka M, Kozawa J, Imagawa A, Funahashi T, Maeda N, Shimomura I. Characteristics of sleep-wake cycle and sleep duration in Japanese type 2 diabetes patients with visceral fat accumulation. J Diabetes Investig. 2018 Jan; 9(1):63-68. PMID: 28178395; PMCID: PMC5754525.
    Citations: 3     Fields:    Translation:Humans
  14. Fukuda S, Kita S, Obata Y, Fujishima Y, Nagao H, Masuda S, Tanaka Y, Nishizawa H, Funahashi T, Takagi J, Maeda N, Shimomura I. The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2. J Biol Chem. 2017 05 12; 292(19):7840-7849. PMID: 28325833.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  15. Nagao H, Nishizawa H, Bamba T, Nakayama Y, Isozumi N, Nagamori S, Kanai Y, Tanaka Y, Kita S, Fukuda S, Funahashi T, Maeda N, Fukusaki E, Shimomura I. Increased Dynamics of Tricarboxylic Acid Cycle and Glutamate Synthesis in Obese Adipose Tissue: IN VIVO METABOLIC TURNOVER ANALYSIS. J Biol Chem. 2017 03 17; 292(11):4469-4483. PMID: 28119455.
    Citations: 18     Fields:    Translation:AnimalsCells
  16. Natsukawa T, Maeda N, Fukuda S, Yamaoka M, Fujishima Y, Nagao H, Sato F, Nishizawa H, Sawano H, Hayashi Y, Funahashi T, Kai T, Shimomura I. Significant Association of Serum Adiponectin and Creatine Kinase-MB Levels in ST-Segment Elevation Myocardial Infarction. J Atheroscler Thromb. 2017 Aug 01; 24(8):793-803. PMID: 28100880; PMCID: PMC5556187.
    Citations: 11     Fields:    Translation:Humans
  17. Obata Y, Maeda N, Yamada Y, Yamamoto K, Nakamura S, Yamaoka M, Tanaka Y, Masuda S, Nagao H, Fukuda S, Fujishima Y, Kita S, Nishizawa H, Funahashi T, Matsubara KI, Matsuzawa Y, Shimomura I. Impact of visceral fat on gene expression profile in peripheral blood cells in obese Japanese subjects. Cardiovasc Diabetol. 2016 11 29; 15(1):159. PMID: 27899146; PMCID: PMC5129204.
    Citations: 7     Fields:    Translation:Humans
  18. Fukuda S, Hirata A, Nishizawa H, Nagao H, Kashine S, Kimura T, Inoue K, Fujishima Y, Yamaoka M, Kozawa J, Kitamura T, Yasuda T, Maeda N, Imagawa A, Funahashi T, Shimomura I. Systemic arteriosclerosis and eating behavior in Japanese type 2 diabetic patients with visceral fat accumulation. Cardiovasc Diabetol. 2015 Jan 16; 14:8. PMID: 25592402; PMCID: PMC4301666.
    Citations: 12     Fields:    Translation:Humans
  19. Inoue K, Maeda N, Fujishima Y, Fukuda S, Nagao H, Yamaoka M, Hirata A, Nishizawa H, Funahashi T, Shimomura I. Long-term impact of liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, on body weight and glycemic control in Japanese type 2 diabetes: an observational study. Diabetol Metab Syndr. 2014; 6(1):95. PMID: 25237400.
    Citations: 18     
  20. Nagao H, Miki S, Toyoda M. Development of a miniaturized multi-turn time-of-flight mass spectrometer with a pulsed fast atom bombardment ion source. Eur J Mass Spectrom (Chichester). 2014; 20(3):215-20. PMID: 24892292.
    Citations: 1     Fields:    
  21. Tsushima Y, Nishizawa H, Tochino Y, Nakatsuji H, Sekimoto R, Nagao H, Shirakura T, Kato K, Imaizumi K, Takahashi H, Tamura M, Maeda N, Funahashi T, Shimomura I. Uric acid secretion from adipose tissue and its increase in obesity. J Biol Chem. 2013 Sep 20; 288(38):27138-27149. PMID: 23913681.
    Citations: 119     Fields:    Translation:AnimalsCells
  22. Nagao H, Kashine S, Nishizawa H, Okada T, Kimura T, Hirata A, Fukuda S, Kozawa J, Maeda N, Kitamura T, Yasuda T, Okita K, Hibuse T, Tsugawa M, Imagawa A, Funahashi T, Shimomura I. Vascular complications and changes in body mass index in Japanese type 2 diabetic patients with abdominal obesity. Cardiovasc Diabetol. 2013 Jun 18; 12:88. PMID: 23773268; PMCID: PMC3698109.
    Citations: 7     Fields:    Translation:Humans
  23. Hazama H, Yoshimura H, Aoki J, Nagao H, Toyoda M, Masuda K, Fujii K, Tashima T, Naito Y, Awazu K. Development of a stigmatic mass microscope using laser desorption/ionization and a multi-turn time-of-flight mass spectrometer. J Biomed Opt. 2011 Apr; 16(4):046007. PMID: 21529076.
    Citations: 3     Fields:    Translation:Animals
  24. Shimma S, Nagao H, Aoki J, Takahashi K, Miki S, Toyoda M. Miniaturized high-resolution time-of-flight mass spectrometer MULTUM-S II with an infinite flight path. Anal Chem. 2010 Oct 15; 82(20):8456-63. PMID: 20860354.
    Citations: 12     Fields:    
  25. Nagao H, Shimma S, Hayakawa S, Awazu K, Toyoda M. Development of a tandem time-of-flight mass spectrometer with an electrospray ionization ion source. J Mass Spectrom. 2010 Aug; 45(8):937-43. PMID: 20641007.
    Citations: 1     Fields:    
  26. Hayakawa S, Matsumoto S, Hashimoto M, Iwamoto K, Nagao H, Toyoda M, Shigeri Y, Tajiri M, Wada Y. High-energy electron transfer dissociation (HE-ETD) using alkali metal targets for sequence analysis of post-translational peptides. J Am Soc Mass Spectrom. 2010 Sep; 21(9):1482-9. PMID: 20598903.
    Citations: 3     Fields:    Translation:Cells
  27. Iwamoto K, Nagao H, Toyoda M. Development of an ion trap/multi-turn time-of-flight mass spectrometer with potential- lift. Eur J Mass Spectrom (Chichester). 2009; 15(2):249-60. PMID: 19423910.
    Citations:    Fields:    
  28. Nagao H, Toyoda M, Hayakawa S, Iwamoto K, Ichihara T, Kawamura K, Awazu K. Unimolecular and collision-induced dissociation of singly-charged mono-bromide silver clusters Ag(x)Br(+) (x = 2, 4, 6, 8, 10). Eur J Mass Spectrom (Chichester). 2009; 15(4):459-69. PMID: 19661554.
    Citations:    Fields:    
  29. Hazama H, Nagao H, Suzuki R, Toyoda M, Masuda K, Naito Y, Awazu K. Comparison of mass spectra of peptides in different matrices using matrix-assisted laser desorption/ionization and a multi-turn time-of-flight mass spectrometer, MULTUM-IMG. Rapid Commun Mass Spectrom. 2008 May; 22(10):1461-6. PMID: 18404623.
    Citations: 1     Fields:    
  30. Shimma S, Nagao H, Giannakopulos AE, Hayakawa S, Awazu K, Toyoda M. High-energy collision-induced dissociation of phosphopeptides using a multi-turn tandem time-of-flight mass spectrometer 'MULTUM-TOF/TOF'. J Mass Spectrom. 2008 Apr; 43(4):535-7. PMID: 18069747.
    Citations: 3     Fields:    
  31. Hayakawa S, Hashimoto M, Nagao H, Awazu K, Toyoda M, Ichihara T, Shigeri Y. Study of the dissociation of a charge-reduced phosphopeptide formed by electron transfer from an alkali metal target. Rapid Commun Mass Spectrom. 2008; 22(4):567-72. PMID: 18229886.
    Citations: 5     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.