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Nazlee Zebardast, M.D.

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Mentoring
Ophthalmic Data Science [login at prompt]
Available: 04/25/22, Expires: 03/01/24

Multiple projects are available for highly motivated student in the field of ophthalmic epidemiology and data science. Background in statistics and knowledge of statistical and computer programming is helpful. 1. Genomics and disease risk prediction. Using two large biobanks and results from a large ophthalmic clinical trial, these projects aim to understand the influence of polygenic risk on glaucoma disease risk, phenotype, and progression. 2. Machine learning. Using large existing datasets these projects aim to use machine learning for better disease prognostication. Unsupervised and semi supervised deep learning models will be used on large repositories of ophthalmic imaging to understand subtypes of disease and characterize progression. The goal is to define structural and longitudinal endophenotypes that are closely aligned with disease type, severity, and progression. 3. Outcomes and health equity research. Multiple datasets are available for use including a large ophthalmic registry, large EHR database and Medicare datasets. We have previously used these datasets to understand the effectiveness of new surgical procedures in the US and racial healthcare inequities among glaucoma patients. Student role: The primary goal of these projects is for the students to learn how to handle large amounts of healthcare data and perform appropriate statistical analysis. The student will formulate the research question and use existing data to answer these questions. The goal is that the student will take ownership of a project and bring it to fruition by planning and completing at least one manuscript. The student can decide on the question most interesting to them or work with the mentor to join an existing project. Student and mentor will meet at least weekly (and more often as needed) to ensure adequate progress.


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Woreta FA, Gordon LK, Knight OJ, Randolph JD, Zebardast N, Pérez-González CE. Enhancing Diversity in the Ophthalmology Workforce. Ophthalmology. 2022 10; 129(10):e127-e136. PMID: 36058741; PMCID: PMC9509453.
    Citations:    Fields:    Translation:Humans
  2. Randolph JD, Zebardast N, Pérez-González CE. Improving Ophthalmic Workforce Diversity: A Call to Action. Ophthalmology. 2022 10; 129(10):1081-1082. PMID: 36058732.
    Citations:    Fields:    Translation:Humans
  3. Halawa OA, Kolli A, Oh G, Mitchell WG, Glynn RJ, Kim DH, Friedman DS, Zebardast N. Reply. Ophthalmology. 2022 Nov; 129(11):e155-e156. PMID: 36041954.
    Citations:    Fields:    
  4. Ciociola EC, Yang SA, Hall N, Lorch AC, Miller JW, Friedman DS, Boland MV, Elze T, Zebardast N. Effectiveness of Trabeculectomy and Tube Shunt with versus without Concurrent Phacoemulsification: Intelligent Research in Sight Registry Longitudinal Analysis. Ophthalmol Glaucoma. 2022 Jul 14. PMID: 35840047.
    Citations:    Fields:    
  5. Sekimitsu S, Wang J, Elze T, Segrè AV, Wiggs JL, Zebardast N. Interaction of background genetic risk, psychotropic medications, and primary angle closure glaucoma in the UK Biobank. PLoS One. 2022; 17(6):e0270530. PMID: 35763501; PMCID: PMC9239437.
    Citations:    Fields:    Translation:Humans
  6. Sekimitsu S, Elze T, Zebardast N. Impact of the Affordable Care Act on Glaucoma Severity at First Presentation. Ophthalmic Epidemiol. 2022 Jun 20; 1-4. PMID: 35723011.
    Citations:    Fields:    
  7. Halawa OA, Jin Q, Pasquale LR, Kang JH, Lorch AC, Sobrin L, Miller JW, Li Y, Eslami M, Wang M, Zebardast N, Elze T. Race and Ethnicity Differences in Disease Severity and Visual Field Progression Among Glaucoma Patients. Am J Ophthalmol. 2022 10; 242:69-76. PMID: 35654121.
    Citations:    Fields:    
  8. Halawa OA, Sekimitsu S, Boland MV, Zebardast N. Sex-Based Differences in Medicare Reimbursements among Ophthalmologists Persist across Time. Ophthalmology. 2022 09; 129(9):1056-1063. PMID: 35588946.
    Citations:    Fields:    
  9. Halawa OA, Roldan AM, Meshkin RS, Zebardast N, Fenwick EK, Lamoureux EL, Friedman DS. Factors associated with glaucoma-specific quality of life in a US glaucoma clinic in a pilot implementation of an online computerised adaptive test (GlauCAT). Br J Ophthalmol. 2022 May 12. PMID: 35551060.
    Citations: 1     Fields:    
  10. Saini C, Shen LQ, Pasquale LR, Boland MV, Friedman DS, Zebardast N, Fazli M, Li Y, Eslami M, Elze T, Wang M. Assessing Surface Shapes of the Optic Nerve Head and Peripapillary Retinal Nerve Fiber Layer in Glaucoma with Artificial Intelligence. Ophthalmol Sci. 2022 Sep; 2(3):100161. PMID: 36245761.
    Citations:    
  11. Kolli A, Sekimitsu S, Wang J, Segre A, Friedman D, Elze T, Pasquale LR, Wiggs J, Zebardast N. Background polygenic risk modulates the association between glaucoma and cardiopulmonary diseases and measures: an analysis from the UK Biobank. Br J Ophthalmol. 2022 Mar 31. PMID: 35361574; PMCID: PMC9522920.
    Citations: 1     Fields:    
  12. Zekavat SM, Sekimitsu S, Ye Y, Raghu V, Zhao H, Elze T, Segrè AV, Wiggs JL, Natarajan P, Del Priore L, Zebardast N, Wang JC. Photoreceptor Layer Thinning Is an Early Biomarker for Age-Related Macular Degeneration: Epidemiologic and Genetic Evidence from UK Biobank OCT Data. Ophthalmology. 2022 06; 129(6):694-707. PMID: 35149155; PMCID: PMC9134644.
    Citations:    Fields:    Translation:Humans
  13. Fenwick EK, Roldan AM, Halawa OA, Meshkin RS, Zebardast N, Popov V, Lis P, Friedman DS, Lamoureux EL. Implementation of an Online Glaucoma-Specific Quality of Life Computerized Adaptive Test System in a US Glaucoma Hospital. Transl Vis Sci Technol. 2022 Feb 01; 11(2):24. PMID: 35171226; PMCID: PMC8857615.
    Citations: 1     Fields:    Translation:Humans
  14. Roldan AM, Zebardast N, Pistilli M, Khachatryan N, Payal A, Begum H, Artornsombudh P, Pujari SS, Rosenbaum JT, Sen HN, Suhler EB, Thorne JE, Bhatt NP, Foster CS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Buchanich JM, Kempen JH. Corneal Endothelial Transplantation in Uveitis: Incidence and Risk Factors. Am J Ophthalmol. 2022 04; 236:288-297. PMID: 34780793; PMCID: PMC8957566.
    Citations: 2     Fields:    Translation:Humans
  15. Zekavat SM, Raghu VK, Trinder M, Ye Y, Koyama S, Honigberg MC, Yu Z, Pampana A, Urbut S, Haidermota S, O'Regan DP, Zhao H, Ellinor PT, Segrè AV, Elze T, Wiggs JL, Martone J, Adelman RA, Zebardast N, Del Priore L, Wang JC, Natarajan P. Deep Learning of the Retina Enables Phenome- and Genome-Wide Analyses of the Microvasculature. Circulation. 2022 01 11; 145(2):134-150. PMID: 34743558; PMCID: PMC8746912.
    Citations: 1     Fields:    Translation:Humans
  16. Halawa OA, Kolli A, Oh G, Mitchell WG, Glynn RJ, Kim DH, Friedman DS, Zebardast N. Racial and Socioeconomic Differences in Eye Care Utilization among Medicare Beneficiaries with Glaucoma. Ophthalmology. 2022 04; 129(4):397-405. PMID: 34626697; PMCID: PMC8940630.
    Citations: 2     Fields:    Translation:Humans
  17. Li Y, Mitchell W, Elze T, Zebardast N. Association Between Diabetes, Diabetic Retinopathy, and Glaucoma. Curr Diab Rep. 2021 09 08; 21(10):38. PMID: 34495413.
    Citations:    Fields:    Translation:Humans
  18. Halawa OA, Friedman DS, Roldan AM, Zebardast N. Changing trends in ocular trauma during the COVID-19 pandemic in the USA. Br J Ophthalmol. 2021 Aug 20. PMID: 34417186.
    Citations: 2     Fields:    
  19. Yang SA, Mitchell WG, Hall N, Elze T, Miller JW, Lorch AC, Zebardast N. Usage Patterns of Minimally Invasive Glaucoma Surgery (MIGS) Differ by Glaucoma Type: IRIS Registry Analysis 2013-2018. Ophthalmic Epidemiol. 2022 08; 29(4):443-451. PMID: 34311672.
    Citations:    Fields:    
  20. Halawa OA, Zebardast N, Kolli A, Foster PJ, He M, Aung T, Friedman DS. Population-Based Utility of van Herick Grading for Angle-Closure Detection. Ophthalmology. 2021 12; 128(12):1779-1782. PMID: 34129876.
    Citations:    Fields:    Translation:Humans
  21. Ciociola EC, Kavitha S, Sengupta S, Wiggs JL, Kader MA, Raman GV, Rajendrababu S, Ramulu PY, Venkatesh R, Zebardast N. The Heritability of Primary Angle Closure Anatomic Traits and Predictors of Angle Closure in South Indian Siblings. Am J Ophthalmol. 2021 10; 230:188-199. PMID: 33992616.
    Citations:    Fields:    Translation:Humans
  22. Nagda D, Mitchell W, Zebardast N. The functional burden of diabetic retinopathy in the United States. Graefes Arch Clin Exp Ophthalmol. 2021 Oct; 259(10):2977-2986. PMID: 33914161.
    Citations: 2     Fields:    Translation:Humans
  23. Halawa O, Mitchell W, Zebardast N. Fall-Related Eye Injury Among Older Adults in the United States. Am J Ophthalmol. 2021 09; 229:82-89. PMID: 33848534.
    Citations:    Fields:    Translation:Humans
  24. Sekimitsu S, Zebardast N. Glaucoma and Machine Learning: A Call for Increased Diversity in Data. Ophthalmol Glaucoma. 2021 Jul-Aug; 4(4):339-342. PMID: 33879422; PMCID: PMC9166811.
    Citations: 1     Fields:    Translation:Humans
  25. Yang SA, Mitchell W, Hall N, Elze T, Lorch AC, Miller JW, Zebardast N. Trends and Usage Patterns of Minimally Invasive Glaucoma Surgery in the United States: IRIS® Registry Analysis 2013-2018. Ophthalmol Glaucoma. 2021 Nov-Dec; 4(6):558-568. PMID: 33831643.
    Citations: 3     Fields:    Translation:Humans
  26. Zebardast N, Sekimitsu S, Wang J, Elze T, Gharahkhani P, Cole BS, Lin MM, Segrè AV, Wiggs JL. Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank. Ophthalmology. 2021 09; 128(9):1300-1311. PMID: 33713785; PMCID: PMC9134646.
    Citations: 4     Fields:    Translation:HumansCells
  27. Mitchell W, Marmamula S, Zebardast N, Ng W, Locascio JJ, Kumbam T, Brahmanandam S, Barrenkala NR. Psychometric validation techniques applied to the IND-VFQ-33 visual function questionnaire: the Hyderabad ocular morbidity in the elderly study (HOMES). BMC Med Res Methodol. 2021 02 05; 21(1):26. PMID: 33546603.
    Citations:    Fields:    Translation:HumansCells
  28. Mitchell W, Resnick H, Zebardast N. Age-Related Macular Degeneration and Visual and Physical Disability in a Nationally Representative Sample from the United States. Transl Vis Sci Technol. 2020 12; 9(13):42. PMID: 33442496.
    Citations: 1     Fields:    Translation:Humans
  29. Marmamula S, Mitchell W, Zebardast N, Locascio J, Barrenkala NR, Kumbham TR, Modepalli SB, Khanna RC, Friedman DS. Impact of Vision Loss on Visual Function Among Elderly Residents in the "Home for the Aged" in India: The Hyderabad Ocular Morbidity in Elderly Study. Transl Vis Sci Technol. 2020 12; 9(13):11. PMID: 33344055.
    Citations:    Fields:    Translation:Humans
  30. Harris JM, Han IC, Sachdeva MM, Zhang AY, Zebardast N. Post-operative intracranial gas migration with optic nerve infiltration and atrophy following retinal detachment repair. Am J Ophthalmol Case Rep. 2020 Dec; 20:100920. PMID: 32984655; PMCID: PMC7494461.
    Citations:    
  31. Mitchell W, Tom L, Durai I, Rajagopal S, Vimalanathan M, Rengaraj V, Srinivasan K, Zebardast N. The Effectiveness of Intracameral Moxifloxacin Endophthalmitis Prophylaxis for Trabeculectomy. Ophthalmol Glaucoma. 2021 Jan-Feb; 4(1):11-19. PMID: 32738509.
    Citations:    Fields:    Translation:Humans
  32. Mitchell W, Bhatia R, Zebardast N. Retrospective cross-sectional analysis of the changes in marijuana use in the USA, 2005-2018. BMJ Open. 2020 07 28; 10(7):e037905. PMID: 32723745.
    Citations: 7     Fields:    Translation:Humans
  33. Velis G, Kavitha S, Zebardast N, Sengupta S, Venkatesh R. Comparison of the corrected intraocular pressure by tonopachy with that of Goldmann applanation tonometry in normal and glaucomatous patients. Indian J Ophthalmol. 2020 04; 68(4):620-626. PMID: 32174582.
    Citations: 1     Fields:    Translation:Humans
  34. Zebardast N, Zheng C, Jampel HD. Effect of a Schlemm's Canal Microstent on Early Postoperative Intraocular Pressure after Cataract Surgery: An Analysis of the HORIZON Randomized Controlled Trial. Ophthalmology. 2020 10; 127(10):1303-1310. PMID: 32143828.
    Citations:    Fields:    Translation:Humans
  35. Tom LM, Kavitha S, Varadaraj V, Palaniswamy K, Raman G, Ramulu PY, Venkatesh R, Zebardast N. Corneal Endothelium Changes 6 Months after Laser Peripheral Iridotomy: Prospective Study. Ophthalmol Glaucoma. 2020 May - Jun; 3(3):220-221. PMID: 32672621.
    Citations:    Fields:    Translation:Humans
  36. Kempen JH, Pistilli M, Begum H, Fitzgerald TD, Liesegang TL, Payal A, Zebardast N, Bhatt NP, Foster CS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Sen HN, Suhler EB, Thorne JE. Remission of Non-Infectious Anterior Scleritis: Incidence and Predictive Factors. Am J Ophthalmol. 2021 03; 223:377-395. PMID: 30951689.
    Citations: 5     Fields:    Translation:Humans
  37. Zebardast N, Kavitha S, Palaniswamy K, Kader MA, Raman G, Rajendrababu S, Ramulu PY, Rengaraj V. Predictors of Short-Term Intraocular Pressure Change after Laser Peripheral Iridotomy: A Prospective Randomized Study. Ophthalmol Glaucoma. 2018 Nov - Dec; 1(3):197-205. PMID: 32672653.
    Citations:    Fields:    Translation:Humans
  38. Kavitha S, Ramulu PY, Venkatesh R, Palaniswamy K, Kader MA, Raman GV, Rajendrababu S, Zebardast N. Resolution of Visual Dysphotopsias after Laser Iridotomy: Six-Month Follow-up. Ophthalmology. 2019 03; 126(3):469-471.e1. PMID: 30315902.
    Citations: 1     Fields:    Translation:Humans
  39. Mudie LI, Varadaraj V, Gajwani P, Munoz B, Ramulu P, Lin FR, Swenor BK, Friedman DS, Zebardast N. Dual sensory impairment: The association between glaucomatous vision loss and hearing impairment and function. PLoS One. 2018; 13(7):e0199889. PMID: 29979753.
    Citations: 5     Fields:    Translation:Humans
  40. Srinivasan K, Zebardast N, Venkatesh R, Ramulu PY. Reply. Ophthalmology. 2018 05; 125(5):e36-e37. PMID: 29681307.
    Citations:    Fields:    
  41. Srinivasan K, Zebardast N, Krishnamurthy P, Abdul Kader M, Raman GV, Rajendrababu S, Venkatesh R, Ramulu PY. Comparison of New Visual Disturbances after Superior versus Nasal/Temporal Laser Peripheral Iridotomy: A Prospective Randomized Trial. Ophthalmology. 2018 03; 125(3):345-351. PMID: 29096997.
    Citations: 4     Fields:    Translation:Humans
  42. Zebardast N, Friedman DS, Vitale S. The Prevalence and Demographic Associations of Presenting Near-Vision Impairment Among Adults Living in the United States. Am J Ophthalmol. 2017 Feb; 174:134-144. PMID: 27865728; PMCID: PMC5253305.
    Citations: 15     Fields:    Translation:Humans
  43. Zebardast N, Kavitha S, Krishnamurthy P, Friedman DS, Nongpiur ME, Aung T, Quigley HA, Ramulu PY, Venkatesh R. Changes in Anterior Segment Morphology and Predictors of Angle Widening after Laser Iridotomy in South Indian Eyes. Ophthalmology. 2016 12; 123(12):2519-2526. PMID: 27726963.
    Citations: 12     Fields:    Translation:Humans
  44. Zebardast N, Kavitha S, Palaniswamy K, Sengupta S, Kader MA, Raman G, Reddy S, Ramulu PY, Venkatesh R. Angle Closure Phenotypes in Siblings of Patients at Different Stages of Angle Closure. Ophthalmology. 2016 07; 123(7):1622-4. PMID: 27102011.
    Citations:    Fields:    Translation:Humans
  45. Zebardast N, Solus JF, Quigley HA, Srikumaran D, Ramulu PY. Comparison of resident and glaucoma faculty practice patterns in the care of open-angle glaucoma. BMC Ophthalmol. 2015 Apr 14; 15:41. PMID: 25879212.
    Citations: 4     Fields:    Translation:Humans
  46. Zebardast N, Swenor BK, van Landingham SW, Massof RW, Munoz B, West SK, Ramulu PY. Comparing the Impact of Refractive and Nonrefractive Vision Loss on Functioning and Disability: The Salisbury Eye Evaluation. Ophthalmology. 2015 Jun; 122(6):1102-10. PMID: 25813453.
    Citations: 14     Fields:    Translation:Humans
  47. Kavitha S, Zebardast N, Palaniswamy K, Wojciechowski R, Chan ES, Friedman DS, Venkatesh R, Ramulu PY. Family history is a strong risk factor for prevalent angle closure in a South Indian population. Ophthalmology. 2014 Nov; 121(11):2091-7. PMID: 24974379.
    Citations: 7     Fields:    Translation:Humans
  48. Loprinzi PD, Zebardast N, Ramulu PY. Cardiorespiratory fitness and vision loss among young and middle-age U.S. adults. Am J Health Promot. 2015 Mar-Apr; 29(4):226-9. PMID: 24717068.
    Citations: 1     Fields:    Translation:Humans
  49. Hall LB, Zebardast N, Huang JJ, Adelman RA. Aflibercept in the treatment of neovascular age-related macular degeneration in previously treated patients. J Ocul Pharmacol Ther. 2014 May; 30(4):346-52. PMID: 24552305.
    Citations: 9     Fields:    Translation:Humans
  50. Zebardast N, Crowley MJ, Bloch MH, Mayes LC, Wyk BV, Leckman JF, Pelphrey KA, Swain JE. Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: initial findings. Psychiatry Res. 2013 Oct 30; 214(1):33-41. PMID: 23916249.
    Citations: 26     Fields:    Translation:Humans
  51. Grippo TM, Liu JH, Zebardast N, Arnold TB, Moore GH, Weinreb RN. Twenty-four-hour pattern of intraocular pressure in untreated patients with ocular hypertension. Invest Ophthalmol Vis Sci. 2013 Jan 17; 54(1):512-7. PMID: 23211815.
    Citations: 22     Fields:    Translation:Humans
  52. Judson BL, Prasad M, Zebardast N. Pathology quiz case 1. Ceruminous gland adenocarcinoma. Arch Otolaryngol Head Neck Surg. 2012 Sep; 138(9):871-2. PMID: 22986727.
    Citations: 1     Fields:    Translation:Humans
  53. Zebardast N, Adelman RA. Intravitreal ranibizumab for treatment of choroidal neovascularization secondary to angioid streaks in pseudoxanthoma elasticum: five-year follow-up. Semin Ophthalmol. 2012 May-Jul; 27(3-4):61-4. PMID: 22784267.
    Citations: 5     Fields:    Translation:Humans
  54. Nowak RJ, Dicapua DB, Zebardast N, Goldstein JM. Response of patients with refractory myasthenia gravis to rituximab: a retrospective study. Ther Adv Neurol Disord. 2011 Sep; 4(5):259-66. PMID: 22010039.
    Citations: 51     
  55. Zebardast N, Lickorish D, Davies JE. Human umbilical cord perivascular cells (HUCPVC): A mesenchymal cell source for dermal wound healing. Organogenesis. 2010 Oct-Dec; 6(4):197-203. PMID: 21220956.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  56. Zebardast N, Patwa HS, Novella SP, Goldstein JM. Rituximab in the management of refractory myasthenia gravis. Muscle Nerve. 2010 Mar; 41(3):375-8. PMID: 19852027.
    Citations: 25     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.