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Richard Michael Walsh Jr., Ph.D.

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University of Texas Southwestern Medical Center, DallasPh.D.2018Molecular Biophysics

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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rawson S, Walsh RM, Velez B, Schnell HM, Jiao F, Blickling M, Ang J, Bhanu MK, Huang L, Hanna J. Yeast PI31 inhibits the proteasome by a direct multisite mechanism. Nat Struct Mol Biol. 2022 08; 29(8):791-800. PMID: 35927584; PMCID: PMC9399903.
    Citations: 1     Fields:    Translation:AnimalsCells
  2. Schnell HM, Ang J, Rawson S, Walsh RM, Micoogullari Y, Hanna J. Mechanism of proteasome gate modulation by assembly chaperones Pba1 and Pba2. J Biol Chem. 2022 05; 298(5):101906. PMID: 35398095; PMCID: PMC9065996.
    Citations:    Fields:    Translation:AnimalsCells
  3. Zhang J, Xiao T, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Walsh RM, Rits-Volloch S, Wesemann DR, Yang W, Seaman MS, Lu J, Chen B. Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. Science. 2021 Dec 10; 374(6573):1353-1360. PMID: 34698504.
    Citations: 127     Fields:    Translation:HumansCells
  4. Cai Y, Zhang J, Xiao T, Lavine CL, Rawson S, Peng H, Zhu H, Anand K, Tong P, Gautam A, Lu S, Sterling SM, Walsh RM, Rits-Volloch S, Lu J, Wesemann DR, Yang W, Seaman MS, Chen B. Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. Science. 2021 08 06; 373(6555):642-648. PMID: 34168070; PMCID: PMC9245151.
    Citations: 108     Fields:    Translation:HumansCells
  5. Schnell HM, Walsh RM, Rawson S, Kaur M, Bhanu MK, Tian G, Prado MA, Guerra-Moreno A, Paulo JA, Gygi SP, Roelofs J, Finley D, Hanna J. Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis. Nat Struct Mol Biol. 2021 05; 28(5):418-425. PMID: 33846632.
    Citations: 8     Fields:    Translation:AnimalsCells
  6. Zhang J, Cai Y, Xiao T, Lu J, Peng H, Sterling SM, Walsh RM, Rits-Volloch S, Zhu H, Woosley AN, Yang W, Sliz P, Chen B. Structural impact on SARS-CoV-2 spike protein by D614G substitution. Science. 2021 04 30; 372(6541):525-530. PMID: 33727252.
    Citations: 169     Fields:    Translation:HumansCells
  7. Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM, Lindahl E, Hibbs RE. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature. 2020 09; 585(7824):303-308. PMID: 32879488; PMCID: PMC7486282.
    Citations: 59     Fields:    Translation:HumansCells
  8. Cai Y, Zhang J, Xiao T, Peng H, Sterling SM, Walsh RM, Rawson S, Rits-Volloch S, Chen B. Distinct conformational states of SARS-CoV-2 spike protein. Science. 2020 09 25; 369(6511):1586-1592. PMID: 32694201.
    Citations: 484     Fields:    Translation:HumansCells
  9. Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE. Agonist Selectivity and Ion Permeation in the a3ß4 Ganglionic Nicotinic Receptor. Neuron. 2019 11 06; 104(3):501-511.e6. PMID: 31488329.
    Citations: 46     Fields:    Translation:HumansCells
  10. Zhu S, Noviello CM, Teng J, Walsh RM, Kim JJ, Hibbs RE. Structure of a human synaptic GABAA receptor. Nature. 2018 07; 559(7712):67-72. PMID: 29950725.
    Citations: 145     Fields:    Translation:HumansCells
  11. Walsh RM, Roh SH, Gharpure A, Morales-Perez CL, Teng J, Hibbs RE. Structural principles of distinct assemblies of the human a4ß2 nicotinic receptor. Nature. 2018 05; 557(7704):261-265. PMID: 29720657.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  12. Sanchez JE, Gross PG, Goetze RW, Walsh RM, Peeples WB, Wood ZA. Evidence of Kinetic Cooperativity in Dimeric Ketopantoate Reductase from Staphylococcus aureus. Biochemistry. 2015 Jun 02; 54(21):3360-3369. PMID: 25946571.
    Citations: 5     Fields:    Translation:HumansCells
  13. Walsh RM, Polizzi SJ, Kadirvelraj R, Howard WW, Wood ZA. Man o' war mutation in UDP-a-D-xylose synthase favors the abortive catalytic cycle and uncovers a latent potential for hexamer formation. Biochemistry. 2015 Jan 27; 54(3):807-19. PMID: 25521717.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  14. Kadirvelraj R, Custer GS, Keul ND, Sennett NC, Sidlo AM, Walsh RM, Wood ZA. Hysteresis in human UDP-glucose dehydrogenase is due to a restrained hexameric structure that favors feedback inhibition. Biochemistry. 2014 Dec 30; 53(51):8043-51. PMID: 25478983.
    Citations: 8     Fields:    Translation:HumansCells
  15. Polizzi SJ, Walsh RM, Le Magueres P, Criswell AR, Wood ZA. Human UDP-a-d-xylose synthase forms a catalytically important tetramer that has not been observed in crystal structures. Biochemistry. 2013 Jun 04; 52(22):3888-98. PMID: 23656592.
    Citations: 2     Fields:    Translation:HumansCells
  16. Polizzi SJ, Walsh RM, Peeples WB, Lim JM, Wells L, Wood ZA. Human UDP-a-D-xylose synthase and Escherichia coli ArnA conserve a conformational shunt that controls whether xylose or 4-keto-xylose is produced. Biochemistry. 2012 Nov 06; 51(44):8844-55. PMID: 23072385.
    Citations: 10     Fields:    Translation:HumansCells
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