Harvard Catalyst Profiles

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Zachary Reath Schoepflin, M.D.

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  1. F30AR066506 (SCHOEPFLIN, ZACHARY REATH) Apr 1, 2015 - Mar 31, 2018
    NIH
    Disruption of HIF-PHD system promotes intervertebral disc degeneration
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Choi H, Chaiyamongkol W, Doolittle AC, Johnson ZI, Gogate SS, Schoepflin ZR, Shapiro IM, Risbud MV. COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells. J Biol Chem. 2018 06 08; 293(23):8969-8981. PMID: 29700115.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  2. Silagi ES, Schoepflin ZR, Seifert EL, Merceron C, Schipani E, Shapiro IM, Risbud MV. Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells. J Bone Miner Res. 2018 02; 33(2):338-355. PMID: 28940640.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  3. Schoepflin ZR, Silagi ES, Shapiro IM, Risbud MV. PHD3 is a transcriptional coactivator of HIF-1a in nucleus pulposus cells independent of the PKM2-JMJD5 axis. FASEB J. 2017 09; 31(9):3831-3847. PMID: 28495754.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  4. Schoepflin ZR, Shapiro IM, Risbud MV. Class I and IIa HDACs Mediate HIF-1a Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1a Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc. J Bone Miner Res. 2016 06; 31(6):1287-99. PMID: 26765925.
    Citations: 18     Fields:    Translation:AnimalsCells
  5. Johnson ZI, Schoepflin ZR, Choi H, Shapiro IM, Risbud MV. Disc in flames: Roles of TNF-a and IL-1ß in intervertebral disc degeneration. Eur Cell Mater. 2015 Sep 21; 30:104-16; discussion 116-7. PMID: 26388614.
    Citations: 102     Fields:    Translation:HumansAnimals
  6. Risbud MV, Schoepflin ZR, Mwale F, Kandel RA, Grad S, Iatridis JC, Sakai D, Hoyland JA. Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting. J Orthop Res. 2015 Mar; 33(3):283-93. PMID: 25411088.
    Citations: 95     Fields:    Translation:HumansAnimals
  7. Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. J Biol Chem. 2014 Jul 25; 289(30):20594-605. PMID: 24867948.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  8. Tran CM, Schoepflin ZR, Markova DZ, Kepler CK, Anderson DG, Shapiro IM, Risbud MV. CCN2 suppresses catabolic effects of interleukin-1ß through a5ß1 and aVß3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration. J Biol Chem. 2014 Mar 14; 289(11):7374-87. PMID: 24464580.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  9. Schoepflin ZR, Chen X, Ragonesi CB, Galloway JC, Agrawal SK. Design of a novel mobility device controlled by the feet motion of a standing child: a feasibility study. Med Biol Eng Comput. 2011 Oct; 49(10):1225-31. PMID: 21850470.
    Citations: 3     Fields:    Translation:Humans
  10. Schoepflin ZR, Chen X, Ragonesi CB, Galloway JC, Agrawal SK. Design of a novel mobility device controlled by the feet motion of a standing child. IEEE Int Conf Rehabil Robot. 2011; 2011:5975355. PMID: 22275559.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.