Harvard Catalyst Profiles

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Clare M. Baecher-Allan, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Moreira TG, Matos KTF, De Paula GS, Santana TMM, Da Mata RG, Pansera FC, Cortina AS, Spinola MG, Baecher-Allan CM, Keppeke GD, Jacob J, Palejwala V, Chen K, Izzy S, Healey BC, Rezende RM, Dedivitis RA, Shailubhai K, Weiner HL. Corrigendum: Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study. Front Immunol. 2021; 12:815812. PMID: 35095916.
    Citations:    Fields:    
  2. Moreira TG, Matos KTF, De Paula GS, Santana TMM, Da Mata RG, Pansera FC, Cortina AS, Spinola MG, Baecher-Allan CM, Keppeke GD, Jacob J, Palejwala V, Chen K, Izzy S, Healey BC, Rezende RM, Dedivitis RA, Shailubhai K, Weiner HL. Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study. Front Immunol. 2021; 12:709861. PMID: 34475873.
    Citations:    Fields:    Translation:Humans
  3. Millett CE, Harder J, Locascio JJ, Shanahan M, Santone G, Fichorova RN, Corrigan A, Baecher-Allan C, Burdick KE. TNF-a and its soluble receptors mediate the relationship between prior severe mood episodes and cognitive dysfunction in euthymic bipolar disorder. Brain Behav Immun. 2020 08; 88:403-410. PMID: 32272224.
    Citations: 1     Fields:    Translation:Humans
  4. Greenberg SA, Pinkus JL, Kong SW, Baecher-Allan C, Amato AA, Dorfman DM. Highly differentiated cytotoxic T cells in inclusion body myositis. Brain. 2019 09 01; 142(9):2590-2604. PMID: 31326977.
    Citations: 8     Fields:    Translation:HumansCells
  5. von Glehn F, Dias-Carneiro RPC, Moraes AS, Farias AS, Silva VAPG, Oliveira FTM, Silva CEBG, de Carvalho F, Rahal E, Baecher-Allan C, Santos LMB. Dimethyl fumarate downregulates the immune response through the HCA2/GPR109A pathway: Implications for the treatment of multiple sclerosis. Mult Scler Relat Disord. 2018 Jul; 23:46-50. PMID: 29763776.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  6. Kaskow BJ, Baecher-Allan C. Effector T Cells in Multiple Sclerosis. Cold Spring Harb Perspect Med. 2018 04 02; 8(4). PMID: 29358315.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  7. Baecher-Allan C, Kaskow BJ, Weiner HL. Multiple Sclerosis: Mechanisms and Immunotherapy. Neuron. 2018 02 21; 97(4):742-768. PMID: 29470968.
    Citations: 189     Fields:    Translation:HumansAnimalsCells
  8. Donnelly C, Dykstra B, Mondal N, Huang J, Kaskow BJ, Griffin R, Sackstein R, Baecher-Allan C. Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression. Sci Rep. 2018 01 11; 8(1):420. PMID: 29323143.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  9. Bhela S, Kempsell C, Manohar M, Dominguez-Villar M, Griffin R, Bhatt P, Kivisakk-Webb P, Fuhlbrigge R, Kupper T, Weiner H, Baecher-Allan C. Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6. J Immunol. 2015 Mar 01; 194(5):2180-9. PMID: 25637022.
    Citations: 20     Fields:    Translation:HumansCells
  10. Hu X, Kim H, Raj T, Brennan PJ, Trynka G, Teslovich N, Slowikowski K, Chen WM, Onengut S, Baecher-Allan C, De Jager PL, Rich SS, Stranger BE, Brenner MB, Raychaudhuri S. Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells. PLoS Genet. 2014 Jun; 10(6):e1004404. PMID: 24968232.
    Citations: 26     Fields:    Translation:HumansCells
  11. Hu X, Kim H, Brennan PJ, Han B, Baecher-Allan CM, De Jager PL, Brenner MB, Raychaudhuri S. Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19030-5. PMID: 24191009.
    Citations: 7     Fields:    Translation:HumansCells
  12. Seneschal J, Clark RA, Gehad A, Baecher-Allan CM, Kupper TS. Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity. 2012 May 25; 36(5):873-84. PMID: 22560445.
    Citations: 147     Fields:    Translation:HumansCells
  13. Dominguez-Villar M, Baecher-Allan CM, Hafler DA. Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nat Med. 2011 Jun; 17(6):673-5. PMID: 21540856.
    Citations: 196     Fields:    Translation:HumansCells
  14. Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA. CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis. J Immunol. 2011 Mar 15; 186(6):3317-26. PMID: 21300823.
    Citations: 27     Fields:    Translation:HumansCells
  15. Konry T, Dominguez-Villar M, Baecher-Allan C, Hafler DA, Yarmush ML. Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine. Biosens Bioelectron. 2011 Jan 15; 26(5):2707-10. PMID: 20888750.
    Citations: 32     Fields:    Translation:HumansCells
  16. Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010 Jul 01; 185(1):46-54. PMID: 20498357.
    Citations: 64     Fields:    Translation:HumansCells
  17. Ashley CW, Baecher-Allan C. Cutting Edge: Responder T cells regulate human DR+ effector regulatory T cell activity via granzyme B. J Immunol. 2009 Oct 15; 183(8):4843-7. PMID: 19801510.
    Citations: 23     Fields:    Translation:HumansCells
  18. Pyne S, Hu X, Wang K, Rossin E, Lin TI, Maier LM, Baecher-Allan C, McLachlan GJ, Tamayo P, Hafler DA, De Jager PL, Mesirov JP. Automated high-dimensional flow cytometric data analysis. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8519-24. PMID: 19443687.
    Citations: 103     Fields:    Translation:Cells
  19. De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA. The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5264-9. PMID: 19237575.
    Citations: 78     Fields:    Translation:HumansCells
  20. Maier LM, Anderson DE, Severson CA, Baecher-Allan C, Healy B, Liu DV, Wittrup KD, De Jager PL, Hafler DA. Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol. 2009 Feb 01; 182(3):1541-7. PMID: 19155502.
    Citations: 58     Fields:    Translation:HumansCells
  21. Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood. 2009 Apr 30; 113(18):4240-9. PMID: 19171879.
    Citations: 193     Fields:    Translation:HumansCells
  22. Costantino CM, Baecher-Allan C, Hafler DA. Multiple sclerosis and regulatory T cells. J Clin Immunol. 2008 Nov; 28(6):697-706. PMID: 18763026.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  23. Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 2008 Jul 17; 454(7202):350-2. PMID: 18469800.
    Citations: 400     Fields:    Translation:HumansCells
  24. Costantino CM, Baecher-Allan CM, Hafler DA. Human regulatory T cells and autoimmunity. Eur J Immunol. 2008 Apr; 38(4):921-4. PMID: 18395861.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  25. Kostianovsky AM, Maier LM, Baecher-Allan C, Anderson AC, Anderson DE. Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression. J Immunol. 2007 May 15; 178(10):6158-63. PMID: 17475842.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  26. Baecher-Allan C, Hafler DA. Human regulatory T cells and their role in autoimmune disease. Immunol Rev. 2006 Aug; 212:203-16. PMID: 16903916.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  27. Baecher-Allan C. Human CD25high Tregs: isolation by beads versus by FACS sorting. Clin Immunol. 2006 Aug; 120(2):234-5. PMID: 16762596.
    Citations: 1     Fields:    Translation:HumansCells
  28. Baecher-Allan CM, Hafler DA. The purification and functional analysis of human CD4+CD25high regulatory T cells. Curr Protoc Immunol. 2006 May; Chapter 7:Unit 7.4B. PMID: 18432975.
    Citations: 7     Fields:    Translation:HumansCells
  29. Baecher-Allan C, Wolf E, Hafler DA. MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol. 2006 Apr 15; 176(8):4622-31. PMID: 16585553.
    Citations: 153     Fields:    Translation:HumansCells
  30. Baecher-Allan C, Anderson DE. Immune regulation in tumor-bearing hosts. Curr Opin Immunol. 2006 Apr; 18(2):214-9. PMID: 16464567.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  31. Baecher-Allan C, Anderson DE. Regulatory cells and human cancer. Semin Cancer Biol. 2006 Apr; 16(2):98-105. PMID: 16378733.
    Citations: 26     Fields:    Translation:HumansCells
  32. Baecher-Allan CM, Hafler DA. Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells. Clin Immunol. 2005 Nov; 117(2):192; discussion 193. PMID: 16214081.
    Citations: 7     Fields:    Translation:HumansCells
  33. Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, Baecher-Allan C. Multiple sclerosis. Immunol Rev. 2005 Apr; 204:208-31. PMID: 15790361.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  34. Baecher-Allan C, Wolf E, Hafler DA. Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells. Clin Immunol. 2005 Apr; 115(1):10-8. PMID: 15870015.
    Citations: 42     Fields:    Translation:HumansCells
  35. Baecher-Allan C, Hafler DA. Suppressor T cells in human diseases. J Exp Med. 2004 Aug 02; 200(3):273-6. PMID: 15280423.
    Citations: 39     Fields:    Translation:HumansCells
  36. Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med. 2004 Apr 05; 199(7):971-9. PMID: 15067033.
    Citations: 550     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  37. Baecher-Allan C, Viglietta V, Hafler DA. Human CD4+CD25+ regulatory T cells. Semin Immunol. 2004 Apr; 16(2):89-98. PMID: 15036232.
    Citations: 118     Fields:    Translation:HumansCells
  38. Cao D, Malmström V, Baecher-Allan C, Hafler D, Klareskog L, Trollmo C. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol. 2003 Jan; 33(1):215-23. PMID: 12594850.
    Citations: 128     Fields:    Translation:HumansCells
  39. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Found Symp. 2003; 252:67-88; discussion 88-91, 106-14. PMID: 14609213.
    Citations: 35     Fields:    Translation:HumansCells
  40. Baecher-Allan C, Viglietta V, Hafler DA. Inhibition of human CD4(+)CD25(+high) regulatory T cell function. J Immunol. 2002 Dec 01; 169(11):6210-7. PMID: 12444126.
    Citations: 76     Fields:    Translation:HumansCells
  41. Barth RK, Hanchett LA, Baecher-Allan CM. Mapping susceptibility genes for the induction of pulmonary fibrosis in mice. Chest. 2002 Mar; 121(3 Suppl):21S. PMID: 11893659.
    Citations: 4     Fields:    Translation:Animals
  42. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25high regulatory cells in human peripheral blood. J Immunol. 2001 Aug 01; 167(3):1245-53. PMID: 11466340.
    Citations: 555     Fields:    Translation:HumansCells
  43. Sharon J, Sarantopoulos S, Den W, Kao CY, Baecher-Allan CM, Santora KE, Sompuram SR, Petersen-Mahrt S, Williams BR. Recombinant polyclonal antibody libraries. Comb Chem High Throughput Screen. 2000 Jun; 3(3):185-96. PMID: 10903378.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  44. Yao J, Baecher-Allan CM, Sharon J. Serpins identified as cell growth inhibitors in human plasma. Mol Cell Biol Res Commun. 2000 Feb; 3(2):76-81. PMID: 10775503.
    Citations: 1     Fields:    Translation:HumansCells
  45. Baecher-Allan CM, Santora K, Sarantopoulos S, Den W, Sompuram SR, Sharon J, Cevallos AM, Bhat N, Ward H. Generation of a polyclonal Fab phage display library to the protozoan parasite Cryptosporidium parvum. Comb Chem High Throughput Screen. 1999 Dec; 2(6):319-25. PMID: 10644857.
    Citations:    Fields:    Translation:HumansAnimalsCells
  46. Daly HE, Baecher-Allan CM, Paxhia AT, Ryan RM, Barth RK, Finkelstein JN. Cell-specific gene expression reveals changes in epithelial cell populations after bleomycin treatment. Lab Invest. 1998 Apr; 78(4):393-400. PMID: 9564884.
    Citations: 7     Fields:    Translation:AnimalsCells
  47. O'Brien DP, Baecher-Allan CM, Burns RP, Shastri N, Barth RK. Elimination of T-cell-receptor beta-chain diversity in transgenic mice restricts antigen-specific but not alloreactive responses. Immunology. 1997 Jul; 91(3):375-82. PMID: 9301526.
    Citations: 2     Fields:    Translation:AnimalsCells
  48. Daly HE, Baecher-Allan CM, Barth RK, D'Angio CT, Finkelstein JN. Bleomycin induces strain-dependent alterations in the pattern of epithelial cell-specific marker expression in mouse lung. Toxicol Appl Pharmacol. 1997 Feb; 142(2):303-10. PMID: 9070353.
    Citations: 12     Fields:    Translation:AnimalsCells
  49. Baecher-Allan CM, Barth RK. PCR analysis of cytokine induction profiles associated with mouse strain variation in susceptibility to pulmonary fibrosis. Reg Immunol. 1993 May-Aug; 5(3-4):207-17. PMID: 7694632.
    Citations: 11     Fields:    Translation:AnimalsCells
  50. Baecher-Allan CM, Kemp JD, Dorfman KS, Barth RK, Frelinger JG. Differential epitope expression of Ly-48 (mouse leukosialin). Immunogenetics. 1993; 37(3):183-92. PMID: 7678405.
    Citations: 6     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.