Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

profileClare M. Baecher-Allan, PH.D.

TitleAssistant Professor of Neurology
InstitutionBrigham and Women's Hospital
AddressHarvard Institutes of Medicine
77 Avenue Louis Pasteur
Boston MA 02115
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bhela S, Kempsell C, Manohar M, Dominguez-Villar M, Griffin R, Bhatt P, Kivisakk-Webb P, Fuhlbrigge R, Kupper T, Weiner H, Baecher-Allan C. Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6. J Immunol. 2015 Mar 01; 194(5):2180-9. PMID: 25637022; PMCID: PMC4428169.
  2. Hu X, Kim H, Raj T, Brennan PJ, Trynka G, Teslovich N, Slowikowski K, Chen WM, Onengut S, Baecher-Allan C, De Jager PL, Rich SS, Stranger BE, Brenner MB, Raychaudhuri S. Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells. PLoS Genet. 2014 Jun; 10(6):e1004404. PMID: 24968232; PMCID: PMC4072514.
  3. Hu X, Kim H, Brennan PJ, Han B, Baecher-Allan CM, De Jager PL, Brenner MB, Raychaudhuri S. Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19030-5. PMID: 24191009; PMCID: PMC3839720.
  4. Seneschal J, Clark RA, Gehad A, Baecher-Allan CM, Kupper TS. Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity. 2012 May 25; 36(5):873-84. PMID: 22560445; PMCID: PMC3716276.
  5. Dominguez-Villar M, Baecher-Allan CM, Hafler DA. Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nat Med. 2011 Jun; 17(6):673-5. PMID: 21540856; PMCID: PMC3675886.
  6. Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA. CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis. J Immunol. 2011 Mar 15; 186(6):3317-26. PMID: 21300823; PMCID: PMC4467560.
  7. Konry T, Dominguez-Villar M, Baecher-Allan C, Hafler DA, Yarmush ML. Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine. Biosens Bioelectron. 2011 Jan 15; 26(5):2707-10. PMID: 20888750; PMCID: PMC3141325.
  8. Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010 Jul 01; 185(1):46-54. PMID: 20498357; PMCID: PMC2936106.
  9. Ashley CW, Baecher-Allan C. Cutting Edge: Responder T cells regulate human DR+ effector regulatory T cell activity via granzyme B. J Immunol. 2009 Oct 15; 183(8):4843-7. PMID: 19801510; PMCID: PMC2918804.
  10. Pyne S, Hu X, Wang K, Rossin E, Lin TI, Maier LM, Baecher-Allan C, McLachlan GJ, Tamayo P, Hafler DA, De Jager PL, Mesirov JP. Automated high-dimensional flow cytometric data analysis. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8519-24. PMID: 19443687; PMCID: PMC2682540.
  11. De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA. The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5264-9. PMID: 19237575; PMCID: PMC2664005.
  12. Maier LM, Anderson DE, Severson CA, Baecher-Allan C, Healy B, Liu DV, Wittrup KD, De Jager PL, Hafler DA. Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol. 2009 Feb 01; 182(3):1541-7. PMID: 19155502; PMCID: PMC3992946.
  13. Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood. 2009 Apr 30; 113(18):4240-9. PMID: 19171879; PMCID: PMC2676084.
  14. Costantino CM, Baecher-Allan C, Hafler DA. Multiple sclerosis and regulatory T cells. J Clin Immunol. 2008 Nov; 28(6):697-706. PMID: 18763026; PMCID: PMC2752287.
  15. Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 2008 Jul 17; 454(7202):350-2. PMID: 18469800; PMCID: PMC2760130.
  16. Costantino CM, Baecher-Allan CM, Hafler DA. Human regulatory T cells and autoimmunity. Eur J Immunol. 2008 Apr; 38(4):921-4. PMID: 18395861; PMCID: PMC2752283.
  17. Kostianovsky AM, Maier LM, Baecher-Allan C, Anderson AC, Anderson DE. Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression. J Immunol. 2007 May 15; 178(10):6158-63. PMID: 17475842.
    View in: PubMed
  18. Baecher-Allan C, Hafler DA. Human regulatory T cells and their role in autoimmune disease. Immunol Rev. 2006 Aug; 212:203-16. PMID: 16903916.
    View in: PubMed
  19. Baecher-Allan C. Human CD25high Tregs: isolation by beads versus by FACS sorting. Clin Immunol. 2006 Aug; 120(2):234-5. PMID: 16762596.
    View in: PubMed
  20. Baecher-Allan CM, Hafler DA. The purification and functional analysis of human CD4+CD25high regulatory T cells. Curr Protoc Immunol. 2006 May; Chapter 7:Unit 7.4B. PMID: 18432975.
    View in: PubMed
  21. Baecher-Allan C, Wolf E, Hafler DA. MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol. 2006 Apr 15; 176(8):4622-31. PMID: 16585553.
    View in: PubMed
  22. Baecher-Allan C, Anderson DE. Immune regulation in tumor-bearing hosts. Curr Opin Immunol. 2006 Apr; 18(2):214-9. PMID: 16464567.
    View in: PubMed
  23. Baecher-Allan C, Anderson DE. Regulatory cells and human cancer. Semin Cancer Biol. 2006 Apr; 16(2):98-105. PMID: 16378733.
    View in: PubMed
  24. Baecher-Allan CM, Hafler DA. Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells. Clin Immunol. 2005 Nov; 117(2):192; discussion 193. PMID: 16214081.
    View in: PubMed
  25. Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, Baecher-Allan C. Multiple sclerosis. Immunol Rev. 2005 Apr; 204:208-31. PMID: 15790361.
    View in: PubMed
  26. Baecher-Allan C, Wolf E, Hafler DA. Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells. Clin Immunol. 2005 Apr; 115(1):10-8. PMID: 15870015.
    View in: PubMed
  27. Baecher-Allan C, Hafler DA. Suppressor T cells in human diseases. J Exp Med. 2004 Aug 02; 200(3):273-6. PMID: 15280423; PMCID: PMC2211973.
  28. Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med. 2004 Apr 05; 199(7):971-9. PMID: 15067033; PMCID: PMC2211881.
  29. Baecher-Allan C, Viglietta V, Hafler DA. Human CD4+CD25+ regulatory T cells. Semin Immunol. 2004 Apr; 16(2):89-98. PMID: 15036232.
    View in: PubMed
  30. Cao D, Malmström V, Baecher-Allan C, Hafler D, Klareskog L, Trollmo C. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol. 2003 Jan; 33(1):215-23. PMID: 12594850.
    View in: PubMed
  31. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Found Symp. 2003; 252:67-88; discussion 88-91, 106-14. PMID: 14609213.
    View in: PubMed
  32. Baecher-Allan C, Viglietta V, Hafler DA. Inhibition of human CD4(+)CD25(+high) regulatory T cell function. J Immunol. 2002 Dec 01; 169(11):6210-7. PMID: 12444126.
    View in: PubMed
  33. Barth RK, Hanchett LA, Baecher-Allan CM. Mapping susceptibility genes for the induction of pulmonary fibrosis in mice. Chest. 2002 Mar; 121(3 Suppl):21S. PMID: 11893659.
    View in: PubMed
  34. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25high regulatory cells in human peripheral blood. J Immunol. 2001 Aug 01; 167(3):1245-53. PMID: 11466340.
    View in: PubMed
  35. Sharon J, Sarantopoulos S, Den W, Kao CY, Baecher-Allan CM, Santora KE, Sompuram SR, Petersen-Mahrt S, Williams BR. Recombinant polyclonal antibody libraries. Comb Chem High Throughput Screen. 2000 Jun; 3(3):185-96. PMID: 10903378.
    View in: PubMed
  36. Yao J, Baecher-Allan CM, Sharon J. Serpins identified as cell growth inhibitors in human plasma. Mol Cell Biol Res Commun. 2000 Feb; 3(2):76-81. PMID: 10775503.
    View in: PubMed
  37. Baecher-Allan CM, Santora K, Sarantopoulos S, Den W, Sompuram SR, Sharon J, Cevallos AM, Bhat N, Ward H. Generation of a polyclonal Fab phage display library to the protozoan parasite Cryptosporidium parvum. Comb Chem High Throughput Screen. 1999 Dec; 2(6):319-25. PMID: 10644857.
    View in: PubMed
  38. Daly HE, Baecher-Allan CM, Paxhia AT, Ryan RM, Barth RK, Finkelstein JN. Cell-specific gene expression reveals changes in epithelial cell populations after bleomycin treatment. Lab Invest. 1998 Apr; 78(4):393-400. PMID: 9564884.
    View in: PubMed
  39. O'Brien DP, Baecher-Allan CM, Burns RP, Shastri N, Barth RK. Elimination of T-cell-receptor beta-chain diversity in transgenic mice restricts antigen-specific but not alloreactive responses. Immunology. 1997 Jul; 91(3):375-82. PMID: 9301526; PMCID: PMC1364006.
  40. Daly HE, Baecher-Allan CM, Barth RK, D'Angio CT, Finkelstein JN. Bleomycin induces strain-dependent alterations in the pattern of epithelial cell-specific marker expression in mouse lung. Toxicol Appl Pharmacol. 1997 Feb; 142(2):303-10. PMID: 9070353.
    View in: PubMed
  41. Baecher-Allan CM, Barth RK. PCR analysis of cytokine induction profiles associated with mouse strain variation in susceptibility to pulmonary fibrosis. Reg Immunol. 1993 May-Aug; 5(3-4):207-17. PMID: 7694632.
    View in: PubMed
  42. Baecher-Allan CM, Kemp JD, Dorfman KS, Barth RK, Frelinger JG. Differential epitope expression of Ly-48 (mouse leukosialin). Immunogenetics. 1993; 37(3):183-92. PMID: 7678405.
    View in: PubMed
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