Harvard Catalyst Profiles

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Yan Kai, Ph.D.



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mehta S, Buyanbat A, Kai Y, Karayel O, Goldman SR, Seruggia D, Zhang K, Fujiwara Y, Donovan KA, Zhu Q, Yang H, Nabet B, Gray NS, Mann M, Fischer ES, Adelman K, Orkin SH. Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells. Cell Chem Biol. 2022 08 18; 29(8):1273-1287.e8. PMID: 35839780; PMCID: PMC9391307.
    Citations:    Fields:    
  2. Ren Q, Li L, Pan H, Wang X, Gao Q, Huan C, Wang J, Zhang W, Jiang L, Gao S, Kai Y, Chen C. Same Dosages of rPRV/XJ5-gI-/gE-/TK- Prototype Vaccine or Bartha-K61 Vaccine Similarly Protects Growing Pigs Against Lethal Challenge of Emerging vPRV/XJ-5 Strain. Front Vet Sci. 2022; 9:896689. PMID: 35847653; PMCID: PMC9284106.
  3. Olsen SN, Godfrey L, Healy JP, Choi YA, Kai Y, Hatton C, Perner F, Haarer EL, Nabet B, Yuan GC, Armstrong SA. MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape. Mol Cell. 2022 03 17; 82(6):1140-1155.e11. PMID: 35245435; PMCID: PMC9044330.
    Citations: 3     Fields:    Translation:HumansCells
  4. Harada T, Heshmati Y, Kalfon J, Perez MW, Xavier Ferrucio J, Ewers J, Hubbell Engler B, Kossenkov A, Ellegast JM, Yi JS, Bowker A, Zhu Q, Eagle K, Liu T, Kai Y, Dempster JM, Kugener G, Wickramasinghe J, Herbert ZT, Li CH, Vrabic Koren J, Weinstock DM, Paralkar VR, Nabet B, Lin CY, Dharia NV, Stegmaier K, Orkin SH, Pimkin M. A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia. Genes Dev. 2022 03 01; 36(5-6):368-389. PMID: 35301220; PMCID: PMC8973843.
    Citations:    Fields:    Translation:Humans
  5. Kai Y, Ying P, Bo Y, Furong Y, Jin C, Juanjuan F, Pingping T, Fasu Z. Red blood cell distribution width-standard deviation but not red blood cell distribution width-coefficient of variation as a potential index for the diagnosis of iron-deficiency anemia in mid-pregnancy women. Open Life Sci. 2021; 16(1):1213-1218. PMID: 34761112.
  6. Cha HJ, Uyan Ö, Kai Y, Liu T, Zhu Q, Tothova Z, Botten GA, Xu J, Yuan GC, Dekker J, Orkin SH. Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture. Nat Commun. 2021 10 29; 12(1):6241. PMID: 34716321; PMCID: PMC8556400.
    Citations: 2     Fields:    Translation:AnimalsCells
  7. Kai Y, Li BE, Zhu M, Li GY, Chen F, Han Y, Cha HJ, Orkin SH, Cai W, Huang J, Yuan GC. Mapping the evolving landscape of super-enhancers during cell differentiation. Genome Biol. 2021 09 15; 22(1):269. PMID: 34526084; PMCID: PMC8442463.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  8. Liu N, Xu S, Yao Q, Zhu Q, Kai Y, Hsu JY, Sakon P, Pinello L, Yuan GC, Bauer DE, Orkin SH. Transcription factor competition at the ?-globin promoters controls hemoglobin switching. Nat Genet. 2021 04; 53(4):511-520. PMID: 33649594; PMCID: PMC8038971.
    Citations: 16     Fields:    Translation:HumansCells
  9. Perkail S, Andricovich J, Kai Y, Tzatsos A. BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Nat Commun. 2020 06 15; 11(1):3018. PMID: 32541668.
    Citations: 4     Fields:    Translation:HumansAnimals
  10. Zhang Y, Wu X, Kai Y, Lee CH, Cheng F, Li Y, Zhuang Y, Ghaemmaghami J, Chuang KH, Liu Z, Meng Y, Keswani M, Gough NR, Wu X, Zhu W, Tzatsos A, Peng W, Seto E, Sotomayor EM, Zheng X. Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer. JCI Insight. 2019 12 19; 4(24). PMID: 31852841.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  11. Kai Y, Andricovich J, Zeng Z, Zhu J, Tzatsos A, Peng W. Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features. Nat Commun. 2018 10 11; 9(1):4221. PMID: 30310060.
    Citations: 16     Fields:    Translation:HumansCells
  12. Sun J, Cai X, Yung MM, Zhou W, Li J, Zhang Y, Li Z, Liu SS, Cheung ANY, Ngan HYS, Li Y, Dai Z, Kai Y, Tzatsos A, Peng W, Chan DW, Zhu W. miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer. Oncogene. 2019 01; 38(4):564-580. PMID: 30166592.
    Citations: 50     Fields:    Translation:HumansCells
  13. Meng Y, Chen CW, Yung MMH, Sun W, Sun J, Li Z, Li J, Li Z, Zhou W, Liu SS, Cheung ANY, Ngan HYS, Braisted JC, Kai Y, Peng W, Tzatsos A, Li Y, Dai Z, Zheng W, Chan DW, Zhu W. DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer. Cancer Lett. 2018 08 01; 428:104-116. PMID: 29704517; PMCID: PMC7474466.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  14. Zhou W, Sun W, Yung MMH, Dai S, Cai Y, Chen CW, Meng Y, Lee JB, Braisted JC, Xu Y, Southall NT, Shinn P, Huang X, Song Z, Chen X, Kai Y, Cai X, Li Z, Hao Q, Cheung ANY, Ngan HYS, Liu SS, Barak S, Hao J, Dai Z, Tzatsos A, Peng W, Pei H, Han Z, Chan DW, Zheng W, Zhu W. Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance. Oncogene. 2018 07; 37(29):3981-3997. PMID: 29662190.
    Citations: 13     Fields:    Translation:HumansCells
  15. Andricovich J, Perkail S, Kai Y, Casasanta N, Peng W, Tzatsos A. Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors. Cancer Cell. 2018 03 12; 33(3):512-526.e8. PMID: 29533787; PMCID: PMC5854186.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  16. Andricovich J, Kai Y, Tzatsos A. Lysine-specific histone demethylases in normal and malignant hematopoiesis. Exp Hematol. 2016 09; 44(9):778-782. PMID: 27208808; PMCID: PMC5100667.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  17. Phan L, Hsu J, Tri LQ, Willi M, Mansour T, Kai Y, Garner J, Lopez J, Busby B. dbVar structural variant cluster set for data analysis and variant comparison. F1000Res. 2016; 5:673. PMID: 28357035.
    Citations: 9     Fields:    
  18. Andricovich J, Kai Y, Peng W, Foudi A, Tzatsos A. Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis. J Clin Invest. 2016 Mar 01; 126(3):905-20. PMID: 26808549; PMCID: PMC4767361.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.