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Xiao Tian, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 12; 588(7836):124-129. PMID: 33268865; PMCID: PMC7752134.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  2. Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson EK, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang ZD, Gorbunova V, Liu X, Gladyshev VN. Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Cell Rep. 2020 07 28; 32(4):107949. PMID: 32726638; PMCID: PMC9385191.
    Citations: 6     Fields:    Translation:AnimalsCells
  3. Zhao J, Tian X, Zhu Y, Zhang Z, Rydkina E, Yuan Y, Zhang H, Roy B, Cornwell A, Nevo E, Shang X, Huang R, Kristiansen K, Seluanov A, Fang X, Gorbunova V. Reply to: Transformation of naked mole-rat cells. Nature. 2020 07; 583(7814):E8-E13. PMID: 32612220.
    Citations: 2     Fields:    Translation:AnimalsCells
  4. Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y, Gorbunova V, Mao Z. A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Res. 2019 09 19; 47(16):8563-8580. PMID: 31291457.
    Citations: 23     Fields:    Translation:HumansCells
  5. Katagi H, Louis N, Unruh D, Sasaki T, He X, Zhang A, Ma Q, Piunti A, Shimazu Y, Lamano JB, Carcaboso AM, Tian X, Seluanov A, Gorbunova V, Laurie KL, Kondo A, Wadhwani NR, Lulla R, Goldman S, Venneti S, Becher OJ, Zou L, Shilatifard A, Hashizume R. Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma. Clin Cancer Res. 2019 09 15; 25(18):5572-5583. PMID: 31227500; PMCID: PMC6744979.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  6. Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V. SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell. 2019 04 18; 177(3):622-638.e22. PMID: 31002797.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  7. Tian X, Doerig K, Park R, Can Ran Qin A, Hwang C, Neary A, Gilbert M, Seluanov A, Gorbunova V. Evolution of telomere maintenance and tumour suppressor mechanisms across mammals. Philos Trans R Soc Lond B Biol Sci. 2018 03 05; 373(1741). PMID: 29335367; PMCID: PMC5784063.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  8. Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Tian X, Serrano M, de Magalhaes JP, Nevo E, Gladyshev VN, Seluanov A, Gorbunova V. Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1801-1806. PMID: 29432174; PMCID: PMC5828632.
    Citations: 27     Fields:    Translation:AnimalsCells
  9. Tan L, Ke Z, Tombline G, Macoretta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu NV, Yuan ZF, Garcia BA, Shi YG, Shi Y, Seluanov A, Gorbunova V. Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming. Stem Cell Reports. 2017 11 14; 9(5):1721-1734. PMID: 29107597.
    Citations: 28     Fields:    Translation:AnimalsCells
  10. Tian X, Seluanov A, Gorbunova V. Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species. Trends Endocrinol Metab. 2017 10; 28(10):722-734. PMID: 28888702; PMCID: PMC5679293.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  11. Tian X, Seluanov A, Gorbunova V. Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging. Cell Metab. 2017 May 02; 25(5):991-992. PMID: 28467943.
    Citations: 1     Fields:    Translation:HumansAnimals
  12. Patrick A, Seluanov M, Hwang C, Tam J, Khan T, Morgenstern A, Wiener L, Vazquez JM, Zafar H, Wen R, Muratkalyeva M, Doerig K, Zagorulya M, Cole L, Catalano S, Lobo Ladd AA, Coppi AA, Coskun Y, Tian X, Ablaeva J, Nevo E, Gladyshev VN, Zhang ZD, Vijg J, Seluanov A, Gorbunova V. Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. Aging (Albany NY). 2016 05; 8(5):841-7. PMID: 27163160.
    Citations: 6     Fields:    Translation:AnimalsCells
  13. Tian X, Azpurua J, Ke Z, Augereau A, Zhang ZD, Vijg J, Gladyshev VN, Gorbunova V, Seluanov A. INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):1053-8. PMID: 25550505; PMCID: PMC4313802.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  14. Vaidya A, Mao Z, Tian X, Spencer B, Seluanov A, Gorbunova V. Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age. PLoS Genet. 2014 Jul; 10(7):e1004511. PMID: 25033455.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  15. Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, Mao Z, Nevo E, Gorbunova V, Seluanov A. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature. 2013 Jul 18; 499(7458):346-9. PMID: 23783513.
    Citations: 282     Fields:    Translation:HumansAnimalsCells
  16. Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, Seluanov A. Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):19392-6. PMID: 23129611.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  17. Weng L, Tian X, Gao Y, Watashi K, Shimotohno K, Wakita T, Kohara M, Toyoda T. Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro. Biochim Biophys Acta. 2012 Dec; 1820(12):1886-92. PMID: 22954804.
    Citations: 4     Fields:    Translation:HumansCells
  18. Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A. 2012 Jul 17; 109(29):11800-5. PMID: 22753495.
    Citations: 73     Fields:    Translation:HumansCells
  19. Wang Q, Weng L, Tian X, Counor D, Sun J, Mao Y, Deubel V, Okada H, Toyoda T. Effect of the methyltransferase domain of Japanese encephalitis virus NS5 on the polymerase activity. Biochim Biophys Acta. 2012 May; 1819(5):411-8. PMID: 22285573.
    Citations: 6     Fields:    Translation:Cells
  20. Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V. SIRT6 promotes DNA repair under stress by activating PARP1. Science. 2011 Jun 17; 332(6036):1443-6. PMID: 21680843.
    Citations: 346     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.