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Jie Hu, Ph.D., M.D.

Other Positions

Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaMD06/2011Preventive Medicine
School of Public Health, Huazhong University of Science and Technology, Wuhan, ChinaPhD06/2016Environmental Epidemiology
Department of Epidemiology, Brown University School of Public Health, Providence, RIVisiting Scholar06/2018Epidemiology
Division of Women's Health, Brigham and Women's Hospital, Boston, MAResearch Fellow06/2022Medicine/Women's Health
Trudy Bush Fellowship for Cardiovascular Disease Research in Women’s Health
Semifinalist, Charles J. Epstein Trainee Award for Excellence in Human Genetics Research
Early Investigator Travel Award
Connors-BRI Research Recognition Award
Reviewers’ Choice Abstract

I am a Research Fellow in the Saxena Lab in the Center for Genomic Medicine and Department of Anaesthesia at Massachusetts General Hospital and Harvard Medical School, and the Liang Lab in the Department of Epidemiology at Harvard T.H. Chan School of Public Health. I am an epidemiologist with rich research experience in maternal and child health, women’s health, and environmental health. My long-term career goal is to become an independent researcher in the area of women’s and children’s health and cardiometabolic disease epidemiology, focusing on identifying novel risk factors, investigating the intergenerational link in disease susceptibility and the influencing factors, and examining health disparities and the underlying mechanisms to promote personalized treatment and prevention.

I am interested the etiology of adverse pregnancy outcomes and their long-term impact on cardiometabolic health in women and their children. My current research utilizes large-scale, multi-omics data, under the framework of systems epidemiology, to identify novel risk factors and the underlying mechanisms of adverse pregnancy outcomes and cardiometabolic diseases in women, as well as to examine the (epi)genetic and metabolic bases of the intergenerational link in cardiometabolic disease risk. My research also extends to examining the origin and mechanisms of sex and race differences in cardiometabolic disease risk. I am also leading or participating in multiple consortium metabolomics and (epi)genetics projects in the Trans-Omics for Precision Medicine (TOPMed), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), and COnsortium of METabolomics Studies (COMETS).

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hu J, Yao J, Deng S, Balasubramanian R, Jiménez MC, Li J, Guo X, Cruz DE, Gao Y, Huang T, Zeleznik OA, Ngo D, Liu S, Rosal MC, Nassir R, Paynter NP, Albert CM, Tracy RP, Durda P, Liu Y, Taylor KD, Johnson WC, Sun Q, Rimm EB, Eliassen AH, Rich SS, Rotter JI, Gerszten RE, Clish CB, Rexrode KM. Differences in Metabolomic Profiles Between Black and White Women and Risk of Coronary Heart Disease: an Observational Study of Women From Four US Cohorts. Circ Res. 2022 09 16; 131(7):601-615. PMID: 36052690; PMCID: PMC9473718.
    Citations: 3     Fields:    Translation:Humans
  2. Jaworek T, Xu H, Gaynor BJ, Cole JW, Rannikmae K, Stanne TM, Tomppo L, Abedi V, Amouyel P, Armstrong ND, Attia J, Bell S, Benavente OR, Boncoraglio GB, Butterworth A, Carcel-Marquez J, Chen Z, Chong M, Cruchaga C, Cushman M, Danesh J, Debette S, Duggan DJ, Durda JP, Engstrom G, Enzinger C, Faul JD, Fecteau NS, Fernandez-Cadenas I, Gieger C, Giese AK, Grewal RP, Grittner U, Havulinna AS, Heitsch L, Hochberg MC, Holliday E, Hu J, Ilinca A, Irvin MR, Jackson RD, Jacob MA, Janssen RR, Jimenez-Conde J, Johnson JA, Kamatani Y, Kardia SL, Koido M, Kubo M, Lange L, Lee JM, Lemmens R, Levi CR, Li J, Li L, Lin K, Lopez H, Luke S, Maguire J, McArdle PF, McDonough CW, Meschia JF, Metso T, Muller-Nurasyid M, O'Connor TD, O'Donnell M, Peddareddygari LR, Pera J, Perry JA, Peters A, Putaala J, Ray D, Rexrode K, Ribases M, Rosand J, Rothwell PM, Rundek T, Ryan KA, Sacco RL, Salomaa V, Sanchez-Mora C, Schmidt R, Sharma P, Slowik A, Smith JA, Smith NL, Wassertheil-Smoller S, Soederholm M, Stine OC, Strbian D, Sudlow CL, Tatlisumak T, Terao C, Thijs V, Torres-Aguila NP, Tregouet DA, Tuladhar AM, Veldink JH, Walters RG, Weir DR, Woo D, Worrall BB, Hong CC, Ross O, Zand R, Leeuw FE, Lindgren AG, Pare G, Anderson CD, Markus HS, Jern C, Malik R, Dichgans M, Mitchell BD, Kittner SJ. Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke. Neurology. 2022 Aug 31. PMID: 36240095; PMCID: PMC9620803.
    Citations:    Fields:    
  3. Louca P, Nogal A, Moskal A, Goulding NJ, Shipley MJ, Alkis T, Lindbohm JV, Hu J, Kifer D, Wang N, Chawes B, Rexrode KM, Ben-Shlomo Y, Kivimaki M, Murphy RA, Yu B, Gunter MJ, Suhre K, Lawlor DA, Mangino M, Menni C. Cross-Sectional Blood Metabolite Markers of Hypertension: A Multicohort Analysis of 44,306 Individuals from the COnsortium of METabolomics Studies. Metabolites. 2022 Jun 28; 12(7). PMID: 35888725; PMCID: PMC9324896.
  4. Cruz DE, Tahir UA, Hu J, Ngo D, Chen ZZ, Robbins JM, Katz D, Balasubramanian R, Peterson B, Deng S, Benson MD, Shi X, Dailey L, Gao Y, Correa A, Wang TJ, Clish CB, Rexrode KM, Wilson JG, Gerszten RE. Metabolomic Analysis of Coronary Heart Disease in an African American Cohort From the Jackson Heart Study. JAMA Cardiol. 2022 02 01; 7(2):184-194. PMID: 34851361; PMCID: PMC8637385.
    Citations: 3     Fields:    Translation:Humans
  5. Balasubramanian R, Hu J, Guasch-Ferre M, Li J, Sorond F, Zhao Y, Shutta KH, Salas-Salvado J, Hu F, Clish CB, Rexrode KM. Metabolomic Profiles Associated With Incident Ischemic Stroke. Neurology. 2022 02 01; 98(5):e483-e492. PMID: 34853177; PMCID: PMC8826464.
    Citations: 1     Fields:    Translation:Humans
  6. Qi Q, Li J, Yu B, Moon JY, Chai JC, Merino J, Hu J, Ruiz-Canela M, Rebholz C, Wang Z, Usyk M, Chen GC, Porneala BC, Wang W, Nguyen NQ, Feofanova EV, Grove ML, Wang TJ, Gerszten RE, Dupuis J, Salas-Salvadó J, Bao W, Perkins DL, Daviglus ML, Thyagarajan B, Cai J, Wang T, Manson JE, Martínez-González MA, Selvin E, Rexrode KM, Clish CB, Hu FB, Meigs JB, Knight R, Burk RD, Boerwinkle E, Kaplan RC. Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut. 2022 06; 71(6):1095-1105. PMID: 34127525; PMCID: PMC8697256.
    Citations: 22     Fields:    Translation:HumansCells
  7. Li J, Lee DH, Hu J, Tabung FK, Li Y, Bhupathiraju SN, Rimm EB, Rexrode KM, Manson JE, Willett WC, Giovannucci EL, Hu FB. Dietary Inflammatory Potential and Risk of Cardiovascular Disease Among Men and Women in the U.S. J Am Coll Cardiol. 2020 11 10; 76(19):2181-2193. PMID: 33153576; PMCID: PMC7745775.
    Citations: 39     Fields:    Translation:Humans
  8. Li J, Guasch-Ferré M, Chung W, Ruiz-Canela M, Toledo E, Corella D, Bhupathiraju SN, Tobias DK, Tabung FK, Hu J, Zhao T, Turman C, Feng YA, Clish CB, Mucci L, Eliassen AH, Costenbader KH, Karlson EW, Wolpin BM, Ascherio A, Rimm EB, Manson JE, Qi L, Martínez-González MÁ, Salas-Salvadó J, Hu FB, Liang L. The Mediterranean diet, plasma metabolome, and cardiovascular disease risk. Eur Heart J. 2020 07 21; 41(28):2645-2656. PMID: 32406924; PMCID: PMC7377580.
    Citations: 54     Fields:    Translation:Humans
  9. Hu J, Lin JH, Jiménez MC, Manson JE, Hankinson SE, Rexrode KM. Plasma Estradiol and Testosterone Levels and Ischemic Stroke in Postmenopausal Women. Stroke. 2020 04; 51(4):1297-1300. PMID: 32078496.
    Citations: 5     Fields:    Translation:Humans
  10. Hu J, Li Y, Rexrode KM, Xu S. Response by Hu et al to Letter Regarding Article, "Impact of the 2017 ACC/AHA Guideline for High Blood Pressure on Evaluating Gestational Hypertension-Associated Risks for Newborns and Mothers: A Retrospective Birth Cohort Study". Circ Res. 2020 01 03; 126(1):e5-e6. PMID: 31895664.
    Citations:    Fields:    Translation:Humans
  11. Hu J, Li Y, Rexrode KM, Xu S. Response by Hu et al to Letter Regarding Article, "Impact of the 2017 ACC/AHA Guideline for High Blood Pressure on Evaluating Gestational Hypertension-Associated Risks for Newborns and Mothers: A Retrospective Birth Cohort Study". Circ Res. 2019 11 08; 125(11):e96-e97. PMID: 31697632.
    Citations:    Fields:    Translation:Humans
  12. Ding M, Zeleznik OA, Guasch-Ferre M, Hu J, Lasky-Su J, Lee IM, Jackson RD, Shadyab AH, LaMonte MJ, Clish C, Eliassen AH, Sacks F, Willett WC, Hu FB, Rexrode KM, Kraft P. Metabolome-Wide Association Study of the Relationship Between Habitual Physical Activity and Plasma Metabolite Levels. Am J Epidemiol. 2019 11 01; 188(11):1932-1943. PMID: 31364705.
    Citations: 14     Fields:    Translation:Humans
  13. Hu J, Zhao H, Braun JM, Zheng T, Zhang B, Xia W, Zhang W, Li J, Zhou Y, Li H, Li J, Zhou A, Zhang Y, Buka SL, Liu S, Peng Y, Wu C, Jiang M, Huo W, Zhu Y, Shi K, Li Y, Cai Z, Xu S. Associations of Trimester-Specific Exposure to Bisphenols with Size at Birth: A Chinese Prenatal Cohort Study. Environ Health Perspect. 2019 10; 127(10):107001. PMID: 31573832; PMCID: PMC6867404.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  14. Li J, Liu W, Xia W, Zhao H, Zhou Y, Li Y, Wu C, Liu H, Zhang B, Zhu Y, Hu J, Wang X, Ye D, Xu S, Cai Z. Variations, Determinants, and Coexposure Patterns of Personal Care Product Chemicals among Chinese Pregnant Women: A Longitudinal Study. Environ Sci Technol. 2019 06 04; 53(11):6546-6555. PMID: 31081626.
    Citations: 3     Fields:    Translation:Humans
  15. Hu J, Li Y, Zhang B, Zheng T, Li J, Peng Y, Zhou A, Buka SL, Liu S, Zhang Y, Shi K, Xia W, Rexrode KM, Xu S. Impact of the 2017 ACC/AHA Guideline for High Blood Pressure on Evaluating Gestational Hypertension-Associated Risks for Newborns and Mothers. Circ Res. 2019 07 05; 125(2):184-194. PMID: 31104583.
    Citations: 11     Fields:    Translation:Humans
  16. Zhang W, Xia W, Liu W, Li X, Hu J, Zhang B, Xu S, Zhou Y, Li J, Cai Z, Li Y. Exposure to Bisphenol a Substitutes and Gestational Diabetes Mellitus: A Prospective Cohort Study in China. Front Endocrinol (Lausanne). 2019; 10:262. PMID: 31114544; PMCID: PMC6503732.
    Citations: 14     Fields:    
  17. Li Y, Xu S, Li Y, Zhang B, Huo W, Zhu Y, Wan Y, Zheng T, Zhou A, Chen Z, Huang Z, Hu J, Zhang W, Wang X, Ye D, Xia W. Association between urinary parabens and gestational diabetes mellitus across prepregnancy body mass index categories. Environ Res. 2019 03; 170:151-159. PMID: 30579989.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  18. Wu C, Xia W, Li Y, Li J, Zhang B, Zheng T, Zhou A, Zhao H, Huo W, Hu J, Jiang M, Hu C, Liao J, Chen X, Xu B, Lu S, Cai Z, Xu S. Repeated Measurements of Paraben Exposure during Pregnancy in Relation to Fetal and Early Childhood Growth. Environ Sci Technol. 2019 01 02; 53(1):422-433. PMID: 30427191.
    Citations: 8     Fields:    Translation:Humans
  19. Hu J, Wu C, Zheng T, Zhang B, Xia W, Peng Y, Liu W, Jiang M, Liu S, Buka SL, Zhou A, Zhang Y, Jiang Y, Hu C, Chen X, Zeng Q, Chen X, Xu B, Zhang X, Truong A, Shi K, Qian Z, Li Y, Xu S. Critical Windows for Associations between Manganese Exposure during Pregnancy and Size at Birth: A Longitudinal Cohort Study in Wuhan, China. Environ Health Perspect. 2018 12; 126(12):127006. PMID: 30675808; PMCID: PMC6371690.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  20. Hu J, Peng Y, Zheng T, Zhang B, Liu W, Wu C, Jiang M, Braun JM, Liu S, Buka SL, Zhou A, Wise JP, Zhang Y, Jiang Y, Hu C, Chen X, Huang Z, Zheng D, Shi K, Zhang X, Truong A, Qian Z, Xia W, Li Y, Xu S. Effects of trimester-specific exposure to vanadium on ultrasound measures of fetal growth and birth size: a longitudinal prospective prenatal cohort study. Lancet Planet Health. 2018 10; 2(10):e427-e437. PMID: 30318100.
    Citations: 11     Fields:    Translation:HumansPHPublic Health
  21. Peng Y, Hu J, Li Y, Zhang B, Liu W, Li H, Zhang H, Hu C, Chen X, Xia W, Lu S, Xu S. Exposure to chromium during pregnancy and longitudinally assessed fetal growth: Findings from a prospective cohort. Environ Int. 2018 12; 121(Pt 1):375-382. PMID: 30245360.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  22. Wu C, Li J, Xia W, Li Y, Zhang B, Zhou A, Hu J, Li C, Zhao H, Jiang M, Hu C, Liao J, Huo W, Chen X, Xu B, Lu S, Cai Z, Xu S. The association of repeated measurements of prenatal exposure to triclosan with fetal and early-childhood growth. Environ Int. 2018 11; 120:54-62. PMID: 30064055.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  23. Jiang M, Li Y, Zhang B, Zhou A, Zhu Y, Li J, Zhao H, Chen L, Hu J, Wu C, Peng Y, Liao J, Xia Z, Cai Z, Chen X, Xu B, Xia W, Xu S. Urinary concentrations of phthalate metabolites associated with changes in clinical hemostatic and hematologic parameters in pregnant women. Environ Int. 2018 11; 120:34-42. PMID: 30059848.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  24. Li J, Zhu X, Yu K, Jiang H, Zhang Y, Wang B, Liu X, Deng S, Hu J, Deng Q, Sun H, Guo H, Zhang X, Chen W, Yuan J, He M, Bai Y, Han X, Liu B, Liu C, Guo Y, Zhang B, Zhang Z, Hu FB, Gao W, Li L, Lathrop M, Laprise C, Liang L, Wu T. Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging. Environ Health Perspect. 2018 06; 126(6):067005. PMID: 29906262; PMCID: PMC6108582.
    Citations: 22     Fields:    Translation:HumansCellsPHPublic Health
  25. Wan Y, Huo W, Xu S, Zheng T, Zhang B, Li Y, Zhou A, Zhang Y, Hu J, Zhu Y, Chen Z, Lu S, Wu C, Jiang M, Jiang Y, Liu H, Yang X, Xia W. Relationship between maternal exposure to bisphenol S and pregnancy duration. Environ Pollut. 2018 Jul; 238:717-724. PMID: 29621731.
    Citations: 22     Fields:    Translation:HumansPHPublic Health
  26. Huo W, Xia W, Wu C, Zhu Y, Zhang B, Wan Y, Zhou A, Qian Z, Chen Z, Jiang Y, Liu H, Hu J, Xu B, Xu S, Li Y. Urinary level of triclosan in a population of Chinese pregnant women and its association with birth outcomes. Environ Pollut. 2018 Feb; 233:872-879. PMID: 28987566.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  27. Hu J, Xia W, Pan X, Zheng T, Zhang B, Zhou A, Buka SL, Bassig BA, Liu W, Wu C, Peng Y, Li J, Zhang C, Liu H, Jiang M, Wang Y, Zhang J, Huang Z, Zheng D, Shi K, Qian Z, Li Y, Xu S. Association of adverse birth outcomes with prenatal exposure to vanadium: a population-based cohort study. Lancet Planet Health. 2017 09; 1(6):e230-e241. PMID: 29851608.
    Citations: 12     Fields:    Translation:HumansPHPublic Health
  28. Pan X, Hu J, Xia W, Zhang B, Liu W, Zhang C, Yang J, Hu C, Zhou A, Chen Z, Cao J, Zhang Y, Wang Y, Huang Z, Lv B, Song R, Zhang J, Xu S, Li Y. Prenatal chromium exposure and risk of preterm birth: a cohort study in Hubei, China. Sci Rep. 2017 06 08; 7(1):3048. PMID: 28596517; PMCID: PMC5465100.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  29. Zhou A, Chang H, Huo W, Zhang B, Hu J, Xia W, Chen Z, Xiong C, Zhang Y, Wang Y, Xu S, Li Y. Prenatal exposure to bisphenol A and risk of allergic diseases in early life. Pediatr Res. 2017 Jun; 81(6):851-856. PMID: 28141789.
    Citations: 12     Fields:    Translation:Humans
  30. Cheng L, Zhang B, Zheng T, Hu J, Zhou A, Bassig BA, Xia W, Savitz DA, Buka S, Xiong C, Braun JM, Zhang Y, Zhou Y, Pan X, Wu C, Wang Y, Qian Z, Yang A, Romano ME, Shi K, Xu S, Li Y. Critical Windows of Prenatal Exposure to Cadmium and Size at Birth. Int J Environ Res Public Health. 2017 01 09; 14(1). PMID: 28075368.
    Citations: 15     Fields:    Translation:HumansPHPublic Health
  31. Wu C, Huo W, Li Y, Zhang B, Wan Y, Zheng T, Zhou A, Chen Z, Qian M, Zhu Y, Jiang Y, Liu H, Hu J, Chen X, Xu B, Xia W, Xu S. Maternal urinary paraben levels and offspring size at birth from a Chinese birth cohort. Chemosphere. 2017 Apr; 172:29-36. PMID: 28061343.
    Citations: 12     Fields:    Translation:HumansPHPublic Health
  32. Jiang M, Li Y, Zhang B, Zhou A, Zheng T, Qian Z, Du X, Zhou Y, Pan X, Hu J, Wu C, Peng Y, Liu W, Zhang C, Xia W, Xu S. A nested case-control study of prenatal vanadium exposure and low birthweight. Hum Reprod. 2016 09; 31(9):2135-41. PMID: 27381766.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  33. Xia W, Zhou Y, Zheng T, Zhang B, Bassig BA, Li Y, Wise JP, Zhou A, Wan Y, Wang Y, Xiong C, Zhao J, Li Z, Yao Y, Hu J, Pan X, Xu S. Maternal urinary manganese and risk of low birth weight: a case-control study. BMC Public Health. 2016 Feb 12; 16:142. PMID: 26869268.
    Citations: 13     Fields:    Translation:Humans
  34. Zhu X, Li J, Deng S, Yu K, Liu X, Deng Q, Sun H, Zhang X, He M, Guo H, Chen W, Yuan J, Zhang B, Kuang D, He X, Bai Y, Han X, Liu B, Li X, Yang L, Jiang H, Zhang Y, Hu J, Cheng L, Luo X, Mei W, Zhou Z, Sun S, Zhang L, Liu C, Guo Y, Zhang Z, Hu FB, Liang L, Wu T. Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population. Environ Health Perspect. 2016 07; 124(7):966-73. PMID: 26756918; PMCID: PMC4937856.
    Citations: 46     Fields:    Translation:HumansCells
  35. Zhu Y, Wan Y, Li Y, Zhang B, Zhou A, Cai Z, Qian Z, Zhang C, Huo W, Huang K, Hu J, Cheng L, Chang H, Huang Z, Xu B, Xia W, Xu S. Free and total urinary phthalate metabolite concentrations among pregnant women from the Healthy Baby Cohort (HBC), China. Environ Int. 2016 Mar; 88:67-73. PMID: 26722670.
    Citations: 11     Fields:    Translation:Humans
  36. Xia W, Hu J, Zhang B, Li Y, Wise JP, Bassig BA, Zhou A, Savitz DA, Xiong C, Zhao J, du X, Zhou Y, Pan X, Yang J, Wu C, Jiang M, Peng Y, Qian Z, Zheng T, Xu S. A case-control study of maternal exposure to chromium and infant low birth weight in China. Chemosphere. 2016 Feb; 144:1484-9. PMID: 26498095.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  37. Huo W, Xia W, Wan Y, Zhang B, Zhou A, Zhang Y, Huang K, Zhu Y, Wu C, Peng Y, Jiang M, Hu J, Chang H, Xu B, Li Y, Xu S. Maternal urinary bisphenol A levels and infant low birth weight: A nested case-control study of the Health Baby Cohort in China. Environ Int. 2015 Dec; 85:96-103. PMID: 26382648.
    Citations: 30     Fields:    Translation:HumansPHPublic Health
  38. Zhang B, Xia W, Li Y, Bassig BA, Zhou A, Wang Y, Li Z, Yao Y, Hu J, Du X, Zhou Y, Liu J, Xue W, Ma Y, Pan X, Peng Y, Zheng T, Xu S. Prenatal exposure to lead in relation to risk of preterm low birth weight: A matched case-control study in China. Reprod Toxicol. 2015 Nov; 57:190-195. PMID: 26122562; PMCID: PMC4843791.
    Citations: 19     Fields:    Translation:Humans
  39. Xia W, Du X, Zheng T, Zhang B, Li Y, Bassig BA, Zhou A, Wang Y, Xiong C, Li Z, Yao Y, Hu J, Zhou Y, Liu J, Xue W, Ma Y, Pan X, Peng Y, Xu S. A Case-Control Study of Prenatal Thallium Exposure and Low Birth Weight in China. Environ Health Perspect. 2016 Jan; 124(1):164-9. PMID: 26009470; PMCID: PMC4710601.
    Citations: 20     Fields:    Translation:HumansPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.