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Yanmin Zhu, Ph.D.

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Overview
My current research focuses on the utilization and outcomes of both the commonly used and newly marketed medical products in pregnant women and their offspring. I have a special interest in linking large existing databases to obtain rich information across multiple real-world data sources (e.g., claims databases, electronic health records, and state birth certificates), and establishing advanced methods (e.g., machine learning-based gestational age prediction and non-live birth identification algorithms), to generate evidence on the use of medical products during pregnancy for clinical practice and post-marketing surveillance.

Mentoring
Available: 12/01/22, Expires: 03/31/23

Project overview: Given the challenges of including pregnant individuals in clinical trials due to ethical considerations and the relatively small sample size when they do, researchers are increasingly using healthcare utilization data to evaluate the magnitude of potential safety concerns related to medication exposure in pregnancy. While knowing the start of pregnancy or the gestational age at birth is essential to determine when during pregnancy the medication exposure occurs, this information is generally not recorded in healthcare utilization databases. International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) coding-based algorithms to estimate gestational age have been developed. Since the US switched to ICD-10-CM codes in October 2015, a new set of gestational age-related ICD-10-CM codes are available, which provides the opportunity to modify the current ICD-9-CM based algorithms, or develop new ICD-10-CM based algorithm for more accurate estimation of gestational age, for both live birth and non-live birth in healthcare utilization databases. Using the Medicaid claims database, we aim to develop ICD-10-CM based gestational age algorithms, and compare the estimated gestational age to the ICD-9-CM based algorithms that have been converted into ICD-10 coding for both live and non-live birth. We will further identify a subset of pregnancies in the Mass General Brigham Research Patient Data Registry (MGB RPDR) system using a previously established linkage between the Medicaid data and the MGB RPDR for patients receiving care within the MGB system. Based on the gestational age extracted from the medical records, we will estimate the differences between the algorithm estimated gestational age and the gold standard. Expected student role: Under the guidance of the faculty mentor and by working with the research team (including other investigators, research scientists and programmers under the H4P research group), the student will be responsible for (1) developing the study protocol to estimate gestational age using ICD 10 codes, and (2) working with chart reviewers to extract gestational age from the medical records. Dependent on the involvement and availability of the student, the student may also be responsible for conference abstract and/or manuscript drafting.

Available: 12/01/22, Expires: 02/28/23

Project overview: Healthcare utilization databases have been routinely used to evaluate medication safety in pregnant and pediatric populations. While algorithms for identification of some neonatal outcomes have been well established (i.e., cardiac malformations, neural tube defects, oral clefts, and clubfoot), algorithms for many other clinically important neonatal outcomes have not been previously developed or validated, including the ones that have been reported to be associated with antibiotics and other medications that are frequently used in pregnancy. Using the linked Medicaid claims database and Mass General Brigham Research Patient Data Registry (MGB RPDR), we aim to develop and validate claims-based algorithms for neonatal outcomes, including urinary tract, genital, gastrointestinal (including pyloric stenosis) and musculoskeletal malformations, and hyperbilirubinemia/ neonatal jaundice. First, we will develop diagnosis and procedure code-based algorithms to identify select neonatal outcomes in Medicaid claims data. As the next step, we will further identify the subset of potential cases in the MGB RPDR system using a previously established linkage between the Medicaid data and the MGB RPDR for patients receiving care within the MGB system. Based on the medical records and standardized clinical criteria, trained chart reviewers will determine the presence or absence of the outcomes. The positive predictive values and their confidence intervals for all outcomes will be estimated. Expected student role: Under the guidance of the faculty mentor and via working with the research team (including clinicians, research scientist and programmers), the student will be responsible for (1) developing the study protocol to identify neonatal outcomes using claims data, and (2) working with chart reviewers to determine the presence or absence of the outcomes. Depending on the involvement and availability of the student in the project, the student has the opportunity to be responsible for drafting conference abstract, and/or the manuscript.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HD107759 (ZHU, YANMIN) Sep 2, 2022 - May 31, 2027
    NIH
    Comparative Safety of Antibiotics for Common Bacterial Infections During Pregnancy
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhu Y, Bateman BT, Hernandez-Diaz S, Gray KJ, Straub L, Reimers RM, Manning-Geist B, Yoselevsky E, Taylor LG, Ouellet-Hellstrom R, Ma Y, Qiang Y, Hua W, Huybrechts KF. Validation of Claims-based Algorithms to Identify Non-Live Birth Outcomes. Pharmacoepidemiol Drug Saf. 2022 Nov 24. PMID: 36420643.
    Citations:    Fields:    
  2. Kim S, Hernández-Díaz S, Zhu Y, Wyszynski D, Huybrechts KF. Association between SARS-CoV-2 infection during pregnancy and postpartum depressive and anxiety symptoms: finding from the International Registry of Coronavirus Exposure in Pregnancy (IRCEP) study. Arch Womens Ment Health. 2022 Oct 27. PMID: 36301380; PMCID: PMC9610338.
    Citations:    Fields:    
  3. Zhu Y, Thai TN, Hernandez-Diaz S, Bateman BT, Winterstein AG, Straub L, Franklin JM, Gray KJ, Wyss R, Mogun H, Vine S, Taylor LG, Ouellet-Hellstrom R, Ma Y, Qiang Y, Hua W, Huybrechts KF. Development and Validation of Algorithms to Estimate Live Birth Gestational Age in Medicaid Analytic eXtract Data. Epidemiology. 2023 Jan 01; 34(1):69-79. PMID: 36455247.
    Citations:    
  4. Suarez EA, Bateman BT, Hernández-Díaz S, Straub L, Wisner KL, Gray KJ, Pennell PB, Lester B, McDougle CJ, Zhu Y, Mogun H, Huybrechts KF. Association of Antidepressant Use During Pregnancy With Risk of Neurodevelopmental Disorders in Children. JAMA Intern Med. 2022 Oct 03. PMID: 36190722; PMCID: PMC9531086.
    Citations:    Fields:    
  5. Straub L, Hernández-Díaz S, Bateman BT, Wisner KL, Gray KJ, Pennell PB, Lester B, McDougle CJ, Suarez EA, Zhu Y, Zakoul H, Mogun H, Huybrechts KF. Association of Antipsychotic Drug Exposure in Pregnancy With Risk of Neurodevelopmental Disorders: A National Birth Cohort Study. JAMA Intern Med. 2022 05 01; 182(5):522-533. PMID: 35343998; PMCID: PMC8961398.
    Citations:    Fields:    Translation:Humans
  6. Straub L, Bateman BT, Hernandez-Diaz S, York C, Lester B, Wisner KL, McDougle CJ, Pennell PB, Gray KJ, Zhu Y, Suarez EA, Mogun H, Huybrechts KF. Neurodevelopmental Disorders Among Publicly or Privately Insured Children in the United States. JAMA Psychiatry. 2022 Mar 01; 79(3):232-242. PMID: 34985527; PMCID: PMC8733868.
    Citations: 1     Fields:    Translation:Humans
  7. Straub L, Huybrechts KF, Hernández-Díaz S, Zhu Y, Vine S, Desai RJ, Gray KJ, Bateman BT. Trajectories of Prescription Opioid Utilization During Pregnancy Among Prepregnancy Chronic Users and Risk of Neonatal Opioid Withdrawal Syndrome. Am J Epidemiol. 2022 01 01; 191(1):208-219. PMID: 34643225; PMCID: PMC8897996.
    Citations:    Fields:    Translation:Humans
  8. Hernández-Díaz S, Bateman BT, Straub L, Zhu Y, Mogun H, Fischer M, Huybrechts KF. Safety of Tenofovir Disoproxil Fumarate for Pregnant Women Facing the Coronavirus Disease 2019 Pandemic. Am J Epidemiol. 2021 11 02; 190(11):2339-2349. PMID: 33847737.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  9. Wood ME, Chen ST, Huybrechts KF, Bateman BT, Gray KJ, Seely EW, Zhu Y, Mogun H, Patorno E, Hernández-Díaz S. Validation of a Claims-based Algorithm to Identify Pregestational Diabetes Among Pregnant Women in the United States. Epidemiology. 2021 11 01; 32(6):855-859. PMID: 34183529; PMCID: PMC8478806.
    Citations: 2     Fields:    Translation:Humans
  10. Straub L, Bateman BT, Hernandez-Diaz S, York C, Zhu Y, Suarez EA, Lester B, Gonzalez L, Hanson R, Hildebrandt C, Homsi J, Kang D, Lee KWK, Lee Z, Li L, Longacre M, Shah N, Tukan N, Wallace F, Williams C, Zerriny S, Mogun H, Huybrechts KF. Validity of claims-based algorithms to identify neurodevelopmental disorders in children. Pharmacoepidemiol Drug Saf. 2021 12; 30(12):1635-1642. PMID: 34623720; PMCID: PMC8578450.
    Citations: 1     Fields:    Translation:Humans
  11. Bateman BT, Hernandez-Diaz S, Straub L, Zhu Y, Gray KJ, Desai RJ, Mogun H, Gautam N, Huybrechts KF. Association of first trimester prescription opioid use with congenital malformations in the offspring: population based cohort study. BMJ. 2021 02 10; 372:n102. PMID: 33568363; PMCID: PMC7873721.
    Citations: 5     Fields:    Translation:Humans
  12. Straub L, Huybrechts KF, Hernandez-Diaz S, Zhu Y, Vine S, Desai RJ, Gray KJ, Bateman BT. Chronic prescription opioid use in pregnancy in the United States. Pharmacoepidemiol Drug Saf. 2021 04; 30(4):504-513. PMID: 33428239.
    Citations: 3     Fields:    Translation:Humans
  13. Zhu Y, Huybrechts KF, Desai RJ, Franklin JM, Hernandez-Diaz S, Krumme A, Straub L, Neuman M, Wunsch H, Levin R, Mogun H, Bateman BT. Prescription opioid use after vaginal delivery and subsequent persistent opioid use and misuse. Am J Obstet Gynecol MFM. 2021 03; 3(2):100304. PMID: 33383232; PMCID: PMC9631715.
    Citations: 1     Fields:    Translation:Humans
  14. Huybrechts KF, Bateman BT, Zhu Y, Straub L, Mogun H, Kim SC, Desai RJ, Hernandez-Diaz S. Hydroxychloroquine early in pregnancy and risk of birth defects. Am J Obstet Gynecol. 2021 03; 224(3):290.e1-290.e22. PMID: 32961123; PMCID: PMC7501839.
    Citations: 8     Fields:    Translation:HumansCells
  15. Zhu Y, Hampp C, Wang X, Albogami Y, Wei YJ, Brumback BA, Roussos-Ross D, Winterstein AG. Validation of algorithms to estimate gestational age at birth in the Medicaid Analytic eXtract-Quantifying the misclassification of maternal drug exposure during pregnancy. Pharmacoepidemiol Drug Saf. 2020 11; 29(11):1414-1422. PMID: 32909348.
    Citations: 2     Fields:    Translation:Humans
  16. Zhu Y, Bateman BT, Gray KJ, Hernandez-Diaz S, Mogun H, Straub L, Huybrechts KF. Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study. BMJ. 2020 May 20; 369:m1494. PMID: 32434758; PMCID: PMC7237981.
    Citations: 5     Fields:    Translation:Humans
  17. Huybrechts KF, Hernandez-Diaz S, Straub L, Gray KJ, Zhu Y, Mogun H, Bateman BT. Intravenous Ondansetron in Pregnancy and Risk of Congenital Malformations. JAMA. 2020 01 28; 323(4):372-374. PMID: 31730152; PMCID: PMC6865841.
    Citations: 3     Fields:    Translation:Humans
  18. Choi Y, Park H, Hampp C, Brumback B, Meissner HC, Li Y, Roussos-Ross D, Zhu Y, Henriksen C, Winterstein AG. Usability of encounter data for Medicaid comprehensive managed care vs traditional Medicaid fee-for-service claims among pregnant women. Pharmacoepidemiol Drug Saf. 2020 01; 29(1):30-38. PMID: 31737976.
    Citations: 1     Fields:    Translation:Humans
  19. Dave CV, Goodin A, Zhu Y, Winterstein A, Wang X, Alrwisan A, Hartzema A. Prevalence of Maternal-Risk Factors Related to Neonatal Abstinence Syndrome in a Commercial Claims Database: 2011-2015. Pharmacotherapy. 2019 10; 39(10):1005-1011. PMID: 31361913.
    Citations: 2     Fields:    Translation:Humans
  20. Knox CA, Hampp C, Palmsten K, Zhu Y, Setoguchi S, Brumback B, Segal R, Winterstein AG. Validation of mother-infant linkage using Medicaid Case ID variable within the Medicaid Analytic eXtract (MAX) database. Pharmacoepidemiol Drug Saf. 2019 09; 28(9):1222-1230. PMID: 31286606; PMCID: PMC8756527.
    Citations: 2     Fields:    Translation:Humans
  21. Huybrechts KF, Hernández-Díaz S, Straub L, Gray KJ, Zhu Y, Patorno E, Desai RJ, Mogun H, Bateman BT. Association of Maternal First-Trimester Ondansetron Use With Cardiac Malformations and Oral Clefts in Offspring. JAMA. 2018 12 18; 320(23):2429-2437. PMID: 30561479; PMCID: PMC6669077.
    Citations: 21     Fields:    Translation:Humans
  22. Wang X, Winterstein AG, Li Y, Zhu Y, Antonelli PJ. Use of Systemic Antibiotics for Acute Otitis Externa: Impact of a Clinical Practice Guideline. Otol Neurotol. 2018 10; 39(9):1088-1094. PMID: 30124617.
    Citations:    Fields:    Translation:Humans
  23. Wei YJ, Zhu Y, Liu W, Bussing R, Winterstein AG. Prevalence of and Factors Associated With Long-term Concurrent Use of Stimulants and Opioids Among Adults With Attention-Deficit/Hyperactivity Disorder. JAMA Netw Open. 2018 08 03; 1(4):e181152. PMID: 30646105; PMCID: PMC6324259.
    Citations: 10     Fields:    Translation:Humans
  24. Zhu Y, Coyle DT, Mohamoud M, Zhou E, Eworuke E, Dormitzer C, Staffa J. Concomitant use of buprenorphine for medication-assisted treatment of opioid use disorder and benzodiazepines: Using the prescription behavior surveillance system. Drug Alcohol Depend. 2018 06 01; 187:221-226. PMID: 29680678; PMCID: PMC8978454.
    Citations: 7     Fields:    Translation:Humans
  25. Li Y, Zhu Y, Chen C, Wang X, Choi Y, Henriksen C, Winterstein AG. Internal validation of Medicaid Analytic eXtract (MAX) data capture for comprehensive managed care plan enrollees from 2007 to 2010. Pharmacoepidemiol Drug Saf. 2018 10; 27(10):1067-1076. PMID: 29210142.
    Citations: 5     Fields:    Translation:Humans
  26. Goodin A, Delcher C, Valenzuela C, Wang X, Zhu Y, Roussos-Ross D, Brown JD. The Power and Pitfalls of Big Data Research in Obstetrics and Gynecology: A Consumer's Guide. Obstet Gynecol Surv. 2017 Nov; 72(11):669-682. PMID: 29164265; PMCID: PMC5704657.
    Citations: 3     Fields:    Translation:Humans
  27. Li Y, Liu W, Zhu Y, Liu X, Winterstein AG. Determinants of Pharmacological Treatment Initiation and Persistence in Publicly Insured Adults With Attention-Deficit/Hyperactivity Disorder. J Clin Psychopharmacol. 2017 Oct; 37(5):546-554. PMID: 28787373.
    Citations:    Fields:    Translation:Humans
  28. Liu X, Hatton RC, Zhu Y, Hincapie-Castillo JM, Bussing R, Barnicoat M, Winterstein AG. Consistency of psychotropic drug-drug interactions listed in drug monographs. J Am Pharm Assoc (2003). 2017 Nov - Dec; 57(6):698-703.e2. PMID: 28844584.
    Citations: 2     Fields:    Translation:Humans
  29. Wang X, Zhu Y, Dave CV, Alrwisan AA, Voils SA, Winterstein AG. Trends of Neonatal Abstinence Syndrome Epidemic and Maternal Risk Factors in Florida. Pharmacotherapy. 2017 Jul; 37(7):806-813. PMID: 28500694.
    Citations: 7     Fields:    Translation:Humans
  30. Zhu Y, Liu W, Li Y, Wang X, Winterstein AG. Prevalence of ADHD in Publicly Insured Adults. J Atten Disord. 2018 Jan; 22(2):182-190. PMID: 28363250.
    Citations: 4     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.