Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jordan Binin Jastrab, M.D., Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F30AI110067 (JASTRAB, JORDAN B) Sep 1, 2014 - Aug 31, 2018
    Characterization of a novel cofactor of the M. tuberculosis proteasome
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Becker SH, Jastrab JB, Dhabaria A, Chaton CT, Rush JS, Korotkov KV, Ueberheide B, Darwin KH. The Mycobacterium tuberculosis Pup-proteasome system regulates nitrate metabolism through an essential protein quality control pathway. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3202-3210. PMID: 30723150.
    Citations: 8     Fields:    Translation:HumansCells
  2. Hu K, Jastrab JB, Zhang S, Kovach A, Zhao G, Darwin KH, Li H. Proteasome substrate capture and gate opening by the accessory factor PafE from Mycobacterium tuberculosis. J Biol Chem. 2018 03 30; 293(13):4713-4723. PMID: 29414791.
    Citations: 11     Fields:    Translation:Cells
  3. Wu Y, Hu K, Li D, Bai L, Yang S, Jastrab JB, Xiao S, Hu Y, Zhang S, Darwin KH, Wang T, Li H. Mycobacterium tuberculosis proteasomal ATPase Mpa has a ß-grasp domain that hinders docking with the proteasome core protease. Mol Microbiol. 2017 Jul; 105(2):227-241. PMID: 28419599; PMCID: PMC5575984.
    Citations: 12     Fields:    Translation:Cells
  4. Bai L, Jastrab JB, Isasa M, Hu K, Yu H, Gygi SP, Darwin KH, Li H. Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2). J Bacteriol. 2017 05 01; 199(9). PMID: 28193903; PMCID: PMC5388811.
    Citations: 3     Fields:    Translation:AnimalsCells
  5. Jastrab JB, Samanovic MI, Copin R, Shopsin B, Darwin KH. Loss-of-Function Mutations in HspR Rescue the Growth Defect of a Mycobacterium tuberculosis Proteasome Accessory Factor E (pafE) Mutant. J Bacteriol. 2017 04 01; 199(7). PMID: 28096448; PMCID: PMC5350283.
    Citations: 6     Fields:    Translation:Cells
  6. Bai L, Hu K, Wang T, Jastrab JB, Darwin KH, Li H. Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):E1983-92. PMID: 27001842; PMCID: PMC4833279.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  7. Jastrab JB, Wang T, Murphy JP, Bai L, Hu K, Merkx R, Huang J, Chatterjee C, Ovaa H, Gygi SP, Li H, Darwin KH. An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):E1763-72. PMID: 25831519; PMCID: PMC4394314.
    Citations: 23     Fields:    Translation:AnimalsCells
  8. Jastrab JB, Darwin KH. Bacterial Proteasomes. Annu Rev Microbiol. 2015; 69:109-27. PMID: 26488274; PMCID: PMC4702487.
    Citations: 21     Fields:    Translation:Cells
  9. Kasahara DI, Kim HY, Williams AS, Verbout NG, Tran J, Si H, Wurmbrand AP, Jastrab J, Hug C, Umetsu DT, Shore SA. Pulmonary inflammation induced by subacute ozone is augmented in adiponectin-deficient mice: role of IL-17A. J Immunol. 2012 May 01; 188(9):4558-67. PMID: 22474022; PMCID: PMC3345205.
    Citations: 40     Fields:    Translation:AnimalsCells
  10. Zhu M, Hug C, Kasahara DI, Johnston RA, Williams AS, Verbout NG, Si H, Jastrab J, Srivastava A, Williams ES, Ranscht B, Shore SA. Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice. Am J Respir Cell Mol Biol. 2010 Oct; 43(4):487-97. PMID: 19915153.
    Citations: 24     Fields:    Translation:AnimalsPHPublic Health
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Jastrab's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (71)
Co-Authors (2)
Similar People (60)
Same Department 
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.