Harvard Catalyst Profiles

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David McClatchy, Ph.D.


Dartmouth College, Hanover, NHAB2013Engineering Sciences
Dartmouth College, Hanover, NHPhD2018Biomedical Engineering/Medical Physics
Harvard Medical Physics Residency Program, Boston, MA2021Therapeutic Medical Physics


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F31CA196308 (MCCLATCHY III, DAVID) May 1, 2016 - Apr 30, 2019
    Structured Light Scatteroscopy for Intraoperative Breast Tumor Margin Assessment
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kamran SC, McClatchy DM, Pursley J, Trofimov AV, Remillard K, Saraf A, Ghosh A, Thabet A, Sutphin P, Miyamoto DT, Efstathiou JA. Characterization of an Iodinated Rectal Spacer for Prostate Photon and Proton Radiation Therapy. Pract Radiat Oncol. 2022 Mar-Apr; 12(2):135-144. PMID: 34619374.
    Citations: 1     Fields:    Translation:Humans
  2. Pardo A, Streeter SS, Maloney BW, Gutierrez-Gutierrez JA, McClatchy DM, Wells WA, Paulsen KD, Lopez-Higuera JM, Pogue BW, Conde OM. Modeling and Synthesis of Breast Cancer Optical Property Signatures With Generative Models. IEEE Trans Med Imaging. 2021 06; 40(6):1687-1701. PMID: 33684035; PMCID: PMC8224479.
    Citations: 3     Fields:    Translation:Humans
  3. McClatchy DM, Willers H, Hata AN, Piotrowska Z, Sequist LV, Paganetti H, Grassberger C. Modeling Resistance and Recurrence Patterns of Combined Targeted-Chemoradiotherapy Predicts Benefit of Shorter Induction Period. Cancer Res. 2020 11 15; 80(22):5121-5133. PMID: 32907839.
    Citations: 2     Fields:    Translation:Humans
  4. McClatchy DM. Quantifying Preexisting Resistant and Persister Populations-Response. Cancer Res. 2019 10 01; 79(19):5122. PMID: 31575630.
    Citations:    Fields:    
  5. Streeter SS, Maloney BW, McClatchy DM, Jermyn M, Pogue BW, Rizzo EJ, Wells WA, Paulsen KD. Structured light imaging for breast-conserving surgery, part II: texture analysis and classification. J Biomed Opt. 2019 09; 24(9):1-12. PMID: 31522486.
    Citations: 6     Fields:    Translation:Humans
  6. Maloney BW, Streeter SS, McClatchy DM, Pogue BW, Rizzo EJ, Wells WA, Paulsen KD. Structured light imaging for breast-conserving surgery, part I: optical scatter and color analysis. J Biomed Opt. 2019 09; 24(9):1-8. PMID: 31512442.
    Citations: 4     Fields:    Translation:Humans
  7. Grassberger C, McClatchy D, Geng C, Kamran SC, Fintelmann F, Maruvka YE, Piotrowska Z, Willers H, Sequist LV, Hata AN, Paganetti H. Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies. Cancer Res. 2019 07 15; 79(14):3776-3788. PMID: 31113818; PMCID: PMC6635042.
    Citations: 13     Fields:    Translation:Humans
  8. Maloney BW, McClatchy DM, Pogue BW, Paulsen KD, Wells WA, Barth RJ. Review of methods for intraoperative margin detection for breast conserving surgery. J Biomed Opt. 2018 10; 23(10):1-19. PMID: 30369108.
    Citations: 30     Fields:    Translation:Humans
  9. McClatchy DM, Zuurbier RA, Wells WA, Paulsen KD, Pogue BW. Micro-computed tomography enables rapid surgical margin assessment during breast conserving surgery (BCS): correlation of whole BCS micro-CT readings to final histopathology. Breast Cancer Res Treat. 2018 Dec; 172(3):587-595. PMID: 30225621; PMCID: PMC6245085.
    Citations: 11     Fields:    Translation:Humans
  10. McClatchy DM, Rizzo EJ, Wells WA, Black CC, Paulsen KD, Kanick SC, Pogue BW. Light scattering measured with spatial frequency domain imaging can predict stromal versus epithelial proportions in surgically resected breast tissue. J Biomed Opt. 2018 09; 24(7):1-11. PMID: 30264552; PMCID: PMC6676039.
    Citations: 8     Fields:    Translation:Humans
  11. McClatchy DM, Rizzo EJ, Meganck J, Kempner J, Vicory J, Wells WA, Paulsen KD, Pogue BW. Calibration and analysis of a multimodal micro-CT and structured light imaging system for the evaluation of excised breast tissue. Phys Med Biol. 2017 Nov 10; 62(23):8983-9000. PMID: 29048330.
    Citations: 12     Fields:    Translation:Humans
  12. Carlson ML, McClatchy DM, Gunn JR, Elliott JT, Paulsen KD, Kanick SC, Pogue BW. Wide-field color imaging of scatter-based tissue contrast using both high spatial frequency illumination and cross-polarization gating. J Biophotonics. 2018 02; 11(2). PMID: 28800205.
    Citations: 1     Fields:    Translation:Animals
  13. McClatchy DM, Hoopes PJ, Pogue BW, Kanick SC. Monochromatic subdiffusive spatial frequency domain imaging provides in-situ sensitivity to intratumoral morphological heterogeneity in a murine model. J Biophotonics. 2017 02; 10(2):211-216. PMID: 27807933.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  14. McClatchy DM, Rizzo EJ, Wells WA, Cheney PP, Hwang JC, Paulsen KD, Pogue BW, Kanick SC. Wide-field quantitative imaging of tissue microstructure using sub-diffuse spatial frequency domain imaging. Optica. 2016 Jun 20; 3(6):613-621. PMID: 27547790; PMCID: PMC4989924.
    Citations: 26     
  15. McClatchy DM, Krishnaswamy V, Kanick SC, Elliott JT, Wells WA, Barth RJ, Paulsen KD, Pogue BW. Molecular dyes used for surgical specimen margin orientation allow for intraoperative optical assessment during breast conserving surgery. J Biomed Opt. 2015 Apr; 20(4):040504. PMID: 25901654.
    Citations: 6     Fields:    Translation:Humans
  16. Kanick SC, McClatchy DM, Krishnaswamy V, Elliott JT, Paulsen KD, Pogue BW. Sub-diffusive scattering parameter maps recovered using wide-field high-frequency structured light imaging. Biomed Opt Express. 2014 Oct 01; 5(10):3376-90. PMID: 25360357; PMCID: PMC4206309.
    Citations: 32     
  17. Krishnaswamy V, Elliott JT, McClatchy DM, Barth RJ, Wells WA, Pogue BW, Paulsen KD. Structured light scatteroscopy. J Biomed Opt. 2014; 19(7):070504. PMID: 25057960.
    Citations: 16     Fields:    Translation:AnimalsCells
  18. Sexton K, Davis SC, McClatchy D, Valdes PA, Kanick SC, Paulsen KD, Roberts DW, Pogue BW. Pulsed-light imaging for fluorescence guided surgery under normal room lighting. Opt Lett. 2013 Sep 01; 38(17):3249-52. PMID: 23988926.
    Citations: 18     Fields:    Translation:Animals
  19. Glaser AK, Davis SC, McClatchy DM, Zhang R, Pogue BW, Gladstone DJ. Projection imaging of photon beams by the Cerenkov effect. Med Phys. 2013 Jan; 40(1):012101. PMID: 23298103.
    Citations: 28     Fields:    
  20. Glaser A, McClatchy D, Davis S, Gladstone D, Pogue B. SU-E-T-11: LINAC Dose Profiling Using Cherenkov Emission Imaging. Med Phys. 2012 Jun; 39(6Part9):3704. PMID: 28519046.
    Citations:    Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.