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Donghai Wen, M.D.


Guangzhou University of Chinese Medicine, Guangzhou, ChinaMD06/2006Chinese Medicine
Fudan University, Shanghai, ChinaPhD06/2011Internal Medicine
University of Nebraska Medical Center, Omaha, NEPostdoc05/2015Renal Physiology
University of Texas Southwestern Medical Center, Dallas, TXResidency06/2018Internal Medicine
BWH/MGH, Harvard Medical School, Boston, MAFellow06/2021Nephrology
Honored Graduate
Postdoctoral Excellence in Research Award Finalist
Campbell Fellow in Kidney Week

Physician scientist and nephrologist at Massachusetts General Hospital and Harvard Medical School.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhang Q, Jiang X, Wen D, Zhang Y, Mao J, Ni L, Chen J. Vitamin D Receptor/Vitamin D Response Element Directly Modulate Nestin Transcription to Ameliorate PAN-Induced Podocyte Morphological Changes. Nephron. 2022 May 06; 1-13. PMID: 35526529.
    Citations:    Fields:    
  2. Wang M, Wen D, Zhang W, Chen W, Tao Y, Fan C, Huang B, Chen J, Wang H, Zhang M. Effects of Cinacalcet and Parathyroidectomy on Blood Pressure in Maintenance Hemodialysis Patients with Secondary Hyperparathyroidism. Iran J Kidney Dis. 2022 03; 16(2):135-146. PMID: 35489082.
    Citations:    Fields:    Translation:Humans
  3. Mao J, Wang M, Ni L, Gong W, Jiang X, Zhang Q, Zhang M, Wen D, Chen J. Local NF-?B Activation Promotes Parathyroid Hormone Synthesis and Secretion in Uremic Patients. Endocrinology. 2021 07 01; 162(7). PMID: 33912936.
    Citations: 1     Fields:    Translation:HumansCells
  4. Ngo D, Wen D, Gao Y, Keyes MJ, Drury ER, Katz DH, Benson MD, Sinha S, Shen D, Farrell LA, Peterson BD, Friedman DJ, Elmariah S, Young BA, Smith JG, Yang Q, Vasan RS, Larson MG, Correa A, Humphreys BD, Wang TJ, Pollak MR, Wilson JG, Gerszten RE, Rhee EP. Circulating testican-2 is a podocyte-derived marker of kidney health. Proc Natl Acad Sci U S A. 2020 10 06; 117(40):25026-25035. PMID: 32958645; PMCID: PMC7547280.
    Citations: 8     Fields:    Translation:HumansCells
  5. Li XJ, Wen R, Wen DY, Lin P, Pan DH, Zhang LJ, He Y, Shi L, Qin YY, Lai YH, Lai JN, Yang JL, Lai QQ, Wang J, Ma J, Yang H, Pang YY. Downregulation of miR-193a-3p via targeting cyclin D1 in thyroid cancer. Mol Med Rep. 2020 09; 22(3):2199-2218. PMID: 32705210; PMCID: PMC7411362.
    Citations: 2     Fields:    Translation:Humans
  6. Xie ZC, Huang JC, Zhang LJ, Gan BL, Wen DY, Chen G, Li SH, Yan HB. Exploration of the diagnostic value and molecular mechanism of miR-1 in prostate cancer: A study based on meta-analyses and bioinformatics. Mol Med Rep. 2018 Dec; 18(6):5630-5646. PMID: 30365107; PMCID: PMC6236292.
    Citations: 7     Fields:    Translation:Humans
  7. Wang B, Wen D, Li H, Wang-France J, Sansom SC. Net K+ secretion in the thick ascending limb of mice on a low-Na, high-K diet. Kidney Int. 2017 10; 92(4):864-875. PMID: 28688582; PMCID: PMC5610618.
    Citations: 4     Fields:    Translation:HumansAnimals
  8. Wen D, Sansom SC. Physiological role of NBCe2 in the regulation of electrolyte transport in the distal nephron. Am J Physiol Renal Physiol. 2015 Sep 15; 309(6):F489-91. PMID: 26136555; PMCID: PMC6189740.
    Citations: 3     Fields:    Translation:HumansAnimals
  9. Wen D, Yuan Y, Cornelius RJ, Li H, Warner PC, Wang B, Wang-France J, Boettger T, Sansom SC. Deficient acid handling with distal RTA in the NBCe2 knockout mouse. Am J Physiol Renal Physiol. 2015 Sep 15; 309(6):F523-30. PMID: 26109087; PMCID: PMC4572397.
    Citations: 7     Fields:    Translation:AnimalsCells
  10. Wen D, Yuan Y, Warner PC, Wang B, Cornelius RJ, Wang-France J, Li H, Boettger T, Sansom SC. Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency. Hypertension. 2015 Jul; 66(1):68-74. PMID: 25941340.
    Citations: 13     Fields:    Translation:Animals
  11. Cornelius RJ, Wen D, Li H, Yuan Y, Wang-France J, Warner PC, Sansom SC. Low Na, high K diet and the role of aldosterone in BK-mediated K excretion. PLoS One. 2015; 10(1):e0115515. PMID: 25607984.
    Citations: 13     Fields:    Translation:Animals
  12. Huang XZ, Wen D, Zhang M, Xie Q, Ma L, Guan Y, Ren Y, Chen J, Hao CM. Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-ß/Smad3 pathway. J Cell Biochem. 2014 May; 115(5):996-1005. PMID: 24356887.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  13. Wen D, Cornelius RJ, Rivero-Hernandez D, Yuan Y, Li H, Weinstein AM, Sansom SC. Relation between BK-a/ß4-mediated potassium secretion and ENaC-mediated sodium reabsorption. Kidney Int. 2014 Jul; 86(1):139-45. PMID: 24573316.
    Citations: 16     Fields:    Translation:Animals
  14. Wen D, Cornelius RJ, Sansom SC. Interacting influence of diuretics and diet on BK channel-regulated K homeostasis. Curr Opin Pharmacol. 2014 Apr; 15:28-32. PMID: 24721651.
    Citations: 11     Fields:    Translation:Animals
  15. Wen D, Huang X, Zhang M, Zhang L, Chen J, Gu Y, Hao CM. Resveratrol attenuates diabetic nephropathy via modulating angiogenesis. PLoS One. 2013; 8(12):e82336. PMID: 24312656.
    Citations: 42     Fields:    Translation:Animals
  16. Wen D, Cornelius RJ, Yuan Y, Sansom SC. Regulation of BK-a expression in the distal nephron by aldosterone and urine pH. Am J Physiol Renal Physiol. 2013 Aug 15; 305(4):F463-76. PMID: 23761673.
    Citations: 24     Fields:    Translation:Animals
  17. Bugaj V, Sansom SC, Wen D, Hatcher LI, Stockand JD, Mironova E. Flow-sensitive K+-coupled ATP secretion modulates activity of the epithelial Na+ channel in the distal nephron. J Biol Chem. 2012 Nov 09; 287(46):38552-8. PMID: 23002235.
    Citations: 7     Fields:    Translation:Animals
  18. Cornelius RJ, Wen D, Hatcher LI, Sansom SC. Bicarbonate promotes BK-a/ß4-mediated K excretion in the renal distal nephron. Am J Physiol Renal Physiol. 2012 Dec 01; 303(11):F1563-71. PMID: 22993067.
    Citations: 9     Fields:    Translation:Animals
  19. Wen D, Ni L, You L, Zhang L, Gu Y, Hao CM, Chen J. Upregulation of nestin in proximal tubules may participate in cell migration during renal repair. Am J Physiol Renal Physiol. 2012 Dec 01; 303(11):F1534-44. PMID: 22993065.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  20. Wen D, You L, Zhang Q, Zhang L, Gu Y, Hao CM, Chen J. Upregulation of nestin protects podocytes from apoptosis induced by puromycin aminonucleoside. Am J Nephrol. 2011; 34(5):423-34. PMID: 21952051.
    Citations: 6     Fields:    Translation:AnimalsCells
  21. Oquendo P, Alberta J, Wen DZ, Graycar JL, Derynck R, Stiles CD. The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. J Biol Chem. 1989 Mar 05; 264(7):4133-7. PMID: 2917992.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.