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Yasufumi Nagata, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sakaguchi C, Nagata Y, Kikuchi A, Takeshige Y, Minami N. Differences in Levels of Biomarkers of Potential Harm Among Users of a Heat-Not-Burn Tobacco Product, Cigarette Smokers, and Never-Smokers in Japan: A Post-Marketing Observational Study. Nicotine Tob Res. 2021 Jun 08; 23(7):1143-1152. PMID: 33502518.
    Citations:    Fields:    
  2. Levine RA, Nagata Y. Imaging Cardiac Valve Mechanics: A New Frontier. JACC Cardiovasc Imaging. 2021 Apr; 14(4):794-796. PMID: 33832662.
    Citations:    Fields:    
  3. Bertrand PB, Churchill TW, Yucel E, Namasivayam M, Bernard S, Nagata Y, He W, Andrews CT, Picard MH, Weyman AE, Levine RA, Hung J. Prognostic importance of the transmitral pressure gradient in mitral annular calcification with associated mitral valve dysfunction. Eur Heart J. 2020 12 01; 41(45):4321-4328. PMID: 33221855.
    Citations: 1     Fields:    Translation:Humans
  4. Onoue T, Iwataki M, Araki M, Akashi J, Kitano T, Nabeshima Y, Hei S, Nagata Y, Hayashi A, Tsuda Y, Sonoda S, Fujino Y, Levine RA, Otsuji Y. Novel noninvasive estimation of mixed venous oxygen saturation by echocardiography and expired gas analysis. Am J Physiol Heart Circ Physiol. 2020 11 01; 319(5):H1078-H1086. PMID: 32946269.
    Citations:    Fields:    Translation:Humans
  5. Bertrand PB, Nagata Y, Namasivayam M, Levine RA. The Artifact that Tells the Truth: Color Doppler Splay Unmasking Significant Mitral Regurgitation. J Am Soc Echocardiogr. 2020 10; 33(10):1220-1222. PMID: 32855003.
    Citations:    Fields:    Translation:Humans
  6. Nagata Y, Iwataki M, Nabeshima Y, Hei S, Onoue T, Hayashi A, Otani K, Tsuda Y, Araki M, Kim DH, Song JK, Hayashida A, Toki M, Yuasa T, Mizukami N, Nishimura Y, Levine RA, Otsuji Y. Potential mechanism of left ventricular spherical remodeling: association of mitral valve complex-myocardium longitudinal tissue remodeling mismatch. Am J Physiol Heart Circ Physiol. 2020 09 01; 319(3):H694-H704. PMID: 32795182.
    Citations:    Fields:    Translation:Humans
  7. Lakatos BK, Nabeshima Y, Tokodi M, Nagata Y, Tosér Z, Otani K, Kitano T, Fábián A, Ujvári A, Boros AM, Merkely B, Kovács A, Takeuchi M. Importance of Nonlongitudinal Motion Components in Right Ventricular Function: Three-Dimensional Echocardiographic Study in Healthy Volunteers. J Am Soc Echocardiogr. 2020 08; 33(8):995-1005.e1. PMID: 32620323.
    Citations: 3     Fields:    
  8. Muraru D, Badano LP, Nagata Y, Surkova E, Nabeshima Y, Genovese D, Otsuji Y, Guida V, Azzolina D, Palermo C, Takeuchi M. Development and prognostic validation of partition values to grade right ventricular dysfunction severity using 3D echocardiography. Eur Heart J Cardiovasc Imaging. 2020 01 01; 21(1):10-21. PMID: 31539046.
    Citations: 4     Fields:    
  9. Sakaguchi C, Miura N, Ohara H, Nagata Y. Effects of reduced exposure to cigarette smoking on changes in biomarkers of potential harm in adult smokers: results of combined analysis of two clinical studies. Biomarkers. 2019 Jul; 24(5):457-468. PMID: 31084221.
    Citations: 1     Fields:    Translation:HumansAnimals
  10. Onoue T, Iwataki M, Araki M, Itoh H, Isotani A, Umeda H, Fukuda S, Nagata Y, Tsuda Y, Fujino Y, Hanyu M, Ando K, Shirai S, Takeuchi M, Saeki S, Levine RA, Otsuji Y. Insights into the mechanism of paradoxical low-flow, low-pressure gradient severe aortic stenosis: association with reduced O2 consumption by the whole body. . 2019 04 01; 316(4):H840-H848. PMID: 30681367.
    Citations: 2     Translation:Humans
  11. Levine RA, Nagata Y, Dal-Bianco JP. Left Ventricular Dyssynchrony and the Mitral Valve Apparatus: An Orchestra That Needs to Play in Sync. JACC Cardiovasc Imaging. 2019 09; 12(9):1738-1740. PMID: 30660517.
    Citations: 1     Fields:    Translation:Humans
  12. Namisaki H, Nagata Y, Seo Y, Ishizu T, Izumo M, Akashi YJ, Yamashita E, Otsuji Y, Takeuchi M. Symptomatic paradoxical low gradient severe aortic stenosis: A possible link to heart failure with preserved ejection fraction. J Cardiol. 2019 06; 73(6):536-543. PMID: 30617000.
    Citations:    Fields:    Translation:Humans
  13. Nagata Y, Takeuchi M, Otani K, Sonoda S, Otsuji Y. Usefulness of Cibenzoline Stress Echocardiography to Determine Severity of Aortic Stenosis in a Patient with Combined Left Ventricular Outflow Tract Obstruction and Aortic Stenosis. J UOEH. 2019; 41(3):343-349. PMID: 31548489.
    Citations:    Fields:    Translation:Humans
  14. Hei S, Iwataki M, Jang JY, Kuwaki H, Mahara K, Fukuda S, Kim YJ, Nabeshima Y, Onoue T, Nagata Y, Nishino S, Watanabe N, Takeuchi M, Nishimura Y, Song JK, Levine RA, Otsuji Y. Possible mechanism of late systolic mitral valve prolapse: systolic superior shift of leaflets secondary to annular dilatation that causes papillary muscle traction. . 2019 03 01; 316(3):H629-H638. PMID: 30575434.
    Citations: 4     Translation:Humans
  15. Nabeshima Y, Nagata Y, Negishi K, Seo Y, Ishizu T, Sato K, Aonuma K, Koto D, Izumo M, Akashi YJ, Yamashita E, Oshima S, Otsuji Y, Takeuchi M. Direct Comparison of Severity Grading Assessed by Two-Dimensional, Three-Dimensional, and Doppler Echocardiography for Predicting Prognosis in Asymptomatic Aortic Stenosis. J Am Soc Echocardiogr. 2018 10; 31(10):1080-1090.e3. PMID: 30061016.
    Citations:    Fields:    Translation:Humans
  16. Wu VC, Takeuchi M, Nagata Y, Izumo M, Akashi YJ, Lin FC, Otsuji Y. Prognostic value of area of calcified aortic valve by 2-dimensional echocardiography in asymptomatic severe aortic stenosis patients with preserved left ventricular ejection fraction. Medicine (Baltimore). 2018 Mar; 97(12):e0246. PMID: 29561453.
    Citations:    Fields:    Translation:Humans
  17. Nagata Y, Kado Y, Onoue T, Otani K, Nakazono A, Otsuji Y, Takeuchi M. Impact of image quality on reliability of the measurements of left ventricular systolic function and global longitudinal strain in 2D echocardiography. Echo Res Pract. 2018 Mar; 5(1):27-39. PMID: 29432198.
    Citations: 5     
  18. Onoue T, Fukuda S, Hayashi A, Hei S, Kado Y, Nagata Y, Iwataki M, Kohno R, Otani K, Miyamoto T, Oginosawa Y, Araki M, Sonoda S, Takeuchi M, Abe H, Otsuji Y. Müller Maneuver as a Tool for Stress Echocardiography: Evaluation of Exercise Capacity in Patients With Dilated Cardiomyopathy. JACC Cardiovasc Imaging. 2018 07; 11(7):1031-1032. PMID: 29248644.
    Citations:    Fields:    Translation:Humans
  19. Nagata Y, Wu VC, Otsuji Y, Takeuchi M. Normal range of myocardial layer-specific strain using two-dimensional speckle tracking echocardiography. PLoS One. 2017; 12(6):e0180584. PMID: 28662186.
    Citations: 15     Fields:    Translation:Humans
  20. Yang LT, Kado Y, Nagata Y, Otani K, Otsuji Y, Takeuchi M. Timing on echocardiography and blood laboratory test is important for future outcome association in hospitalized heart failure patients. J Cardiol. 2018 Jan; 71(1):71-80. PMID: 28546016.
    Citations: 1     Fields:    Translation:Humans
  21. Nagata Y, Wu VC, Kado Y, Otani K, Lin FC, Otsuji Y, Negishi K, Takeuchi M. Prognostic Value of Right Ventricular Ejection Fraction Assessed by Transthoracic 3D Echocardiography. Circ Cardiovasc Imaging. 2017 Feb; 10(2). PMID: 28174197.
    Citations: 22     Fields:    Translation:Humans
  22. Yang LT, Kado Y, Nagata Y, Otani K, Otsuji Y, Takeuchi M. Strain Imaging with a Bull's-Eye Map for Detecting Significant Coronary Stenosis during Dobutamine Stress Echocardiography. J Am Soc Echocardiogr. 2017 02; 30(2):159-167.e1. PMID: 27916236.
    Citations: 3     Fields:    Translation:Humans
  23. Hayashi A, Fukuda S, Mahara K, Hei S, Onoue T, Kado Y, Nagata Y, Iwataki M, Otani K, Miyamoto T, Oginosawa Y, Sonoda S, Eto M, Nishimura Y, Takanashi S, Levine RA, Otsuji Y. Left Atrial Remodeling in Segmental vs. Global Mitral Valve Prolapse - Three-Dimensional Echocardiography. Circ J. 2016 Nov 25; 80(12):2533-2540. PMID: 27829586.
    Citations:    Fields:    Translation:Humans
  24. Obokata M, Nagata Y, Kado Y, Kurabayashi M, Otsuji Y, Takeuchi M. Ventricular-Arterial Coupling and Exercise-Induced Pulmonary Hypertension During Low-Level Exercise in Heart Failure With Preserved or Reduced Ejection Fraction. J Card Fail. 2017 Mar; 23(3):216-220. PMID: 27737768.
    Citations: 2     Fields:    Translation:Humans
  25. Kado Y, Obokata M, Nagata Y, Ishizu T, Addetia K, Aonuma K, Kurabayashi M, Lang RM, Takeuchi M, Otsuji Y. Cumulative Burden of Myocardial Dysfunction in Cardiac Amyloidosis Assessed Using Four-Chamber Cardiac Strain. J Am Soc Echocardiogr. 2016 11; 29(11):1092-1099.e2. PMID: 27614542.
    Citations: 5     Fields:    Translation:Humans
  26. Yang LT, Yamashita E, Nagata Y, Kado Y, Oshima S, Otsuji Y, Takeuchi M. Prognostic value of biventricular mechanical parameters assessed using cardiac magnetic resonance feature-tracking analysis to predict future cardiac events. J Magn Reson Imaging. 2017 04; 45(4):1034-1045. PMID: 27531830.
    Citations: 5     Fields:    Translation:Humans
  27. Yang LT, Nagata Y, Otani K, Kado Y, Otsuji Y, Takeuchi M. Feasibility of One-Beat Real-Time Full-Volume Three-Dimensional Echocardiography for Assessing Left Ventricular Volumes and Deformation Parameters. J Am Soc Echocardiogr. 2016 09; 29(9):853-860.e2. PMID: 27302414.
    Citations: 3     Fields:    Translation:Humans
  28. Ishikawa S, Kanemaru Y, Nara H, Erami K, Nagata Y. Assessing the mutagenic activities of smoke from different cigarettes in direct exposure experiments using the modified Ames Salmonella assay. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jun; 803-804:13-21. PMID: 27265375.
    Citations: 3     Fields:    Translation:Cells
  29. Addetia K, Takeuchi M, Maffessanti F, Nagata Y, Hamilton J, Mor-Avi V, Lang RM. Simultaneous Longitudinal Strain in All 4 Cardiac Chambers: A Novel Method for Comprehensive Functional Assessment of the Heart. Circ Cardiovasc Imaging. 2016 Mar; 9(3):e003895. PMID: 26926268.
    Citations: 2     Fields:    Translation:Humans
  30. Mizukoshi K, Takeuchi M, Nagata Y, Addetia K, Lang RM, Akashi YJ, Otsuji Y. Normal Values of Left Ventricular Mass Index Assessed by Transthoracic Three-Dimensional Echocardiography. J Am Soc Echocardiogr. 2016 Jan; 29(1):51-61. PMID: 26601701.
    Citations: 11     Fields:    Translation:Humans
  31. Obokata M, Nagata Y, Wu VC, Kado Y, Kurabayashi M, Otsuji Y, Takeuchi M. Direct comparison of cardiac magnetic resonance feature tracking and 2D/3D echocardiography speckle tracking for evaluation of global left ventricular strain. Eur Heart J Cardiovasc Imaging. 2016 May; 17(5):525-32. PMID: 26377901.
    Citations: 32     Fields:    Translation:Humans
  32. Toida R, Watanabe N, Obase K, Nagata Y, Yoshimura Y, Masuyarna H, Fukunaga T, Fukuda T, Toida T, Ishikawa T, Takeuchi M, Kitamura K, Yoshida K. Prognostic Implication of Three-Dimensional Mitral Valve Tenting Geometry in Dilated Cardiomyopathy. J Heart Valve Dis. 2015 Sep; 24(5):577-85. PMID: 26897836.
    Citations: 3     Fields:    Translation:Humans
  33. Nagata Y, Takeuchi M, Mizukoshi K, Wu VC, Lin FC, Negishi K, Nakatani S, Otsuji Y. Intervendor variability of two-dimensional strain using vendor-specific and vendor-independent software. J Am Soc Echocardiogr. 2015 Jun; 28(6):630-41. PMID: 25747915.
    Citations: 28     Fields:    Translation:Humans
  34. Nagata Y, Takeuchi M, Wu VC, Izumo M, Suzuki K, Sato K, Seo Y, Akashi YJ, Aonuma K, Otsuji Y. Prognostic value of LV deformation parameters using 2D and 3D speckle-tracking echocardiography in asymptomatic patients with severe aortic stenosis and preserved LV ejection fraction. JACC Cardiovasc Imaging. 2015 Mar; 8(3):235-245. PMID: 25682511.
    Citations: 24     Fields:    Translation:Humans
  35. Kuwaki H, Takeuchi M, Chien-Chia Wu V, Otani K, Nagata Y, Hayashi A, Iwataki M, Fukuda S, Yoshitani H, Abe H, Otsuji Y. Redefining diastolic dysfunction grading: combination of E/A =0.75 and deceleration time >140 ms and E/e' =10. JACC Cardiovasc Imaging. 2014 Aug; 7(8):749-58. PMID: 25051944.
    Citations: 9     Fields:    Translation:Humans
  36. Wu VC, Takeuchi M, Kuwaki H, Iwataki M, Nagata Y, Otani K, Haruki N, Yoshitani H, Tamura M, Abe H, Negishi K, Lin FC, Otsuji Y. Prognostic value of LA volumes assessed by transthoracic 3D echocardiography: comparison with 2D echocardiography. JACC Cardiovasc Imaging. 2013 Oct; 6(10):1025-1035. PMID: 24011776.
    Citations: 18     Fields:    Translation:Humans
  37. Eiki J, Nagata Y, Futamura M, Sasaki-Yamamoto K, Iino T, Nishimura T, Chiba M, Ohyama S, Yoshida-Yoshimioto R, Fujii K, Hosaka H, Goto-Shimazaki H, Kadotani A, Ohe T, Lin S, Langdon RB, Berger JP. Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs. Mol Pharmacol. 2011 Dec; 80(6):1156-65. PMID: 21937665.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  38. Iino T, Sasaki Y, Bamba M, Mitsuya M, Ohno A, Kamata K, Hosaka H, Maruki H, Futamura M, Yoshimoto R, Ohyama S, Sasaki K, Chiba M, Ohtake N, Nagata Y, Eiki J, Nishimura T. Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators. Bioorg Med Chem Lett. 2009 Oct 01; 19(19):5531-8. PMID: 19726182.
    Citations: 4     Fields:    Translation:Animals
  39. Takahashi K, Hashimoto N, Nakama C, Kamata K, Sasaki K, Yoshimoto R, Ohyama S, Hosaka H, Maruki H, Nagata Y, Eiki J, Nishimura T. The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg Med Chem. 2009 Oct 01; 17(19):7042-51. PMID: 19736020.
    Citations: 6     Fields:    Translation:AnimalsCells
  40. Ishikawa M, Nonoshita K, Ogino Y, Nagae Y, Tsukahara D, Hosaka H, Maruki H, Ohyama S, Yoshimoto R, Sasaki K, Nagata Y, Eiki J, Nishimura T. Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators. Bioorg Med Chem Lett. 2009 Aug 01; 19(15):4450-4. PMID: 19540111.
    Citations: 4     Fields:    Translation:AnimalsCells
  41. Iino T, Hashimoto N, Sasaki K, Ohyama S, Yoshimoto R, Hosaka H, Hasegawa T, Chiba M, Nagata Y, Eiki J, Nishimura T. Structure-activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy. Bioorg Med Chem. 2009 Jun 01; 17(11):3800-9. PMID: 19427223.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  42. Mitsuya M, Kamata K, Bamba M, Watanabe H, Sasaki Y, Sasaki K, Ohyama S, Hosaka H, Nagata Y, Eiki J, Nishimura T. Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators. Bioorg Med Chem Lett. 2009 May 15; 19(10):2718-21. PMID: 19362831.
    Citations: 6     Fields:    Translation:Animals
  43. Iino T, Tsukahara D, Kamata K, Sasaki K, Ohyama S, Hosaka H, Hasegawa T, Chiba M, Nagata Y, Eiki J, Nishimura T. Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators. Bioorg Med Chem. 2009 Apr 01; 17(7):2733-43. PMID: 19282189.
    Citations: 5     Fields:    Translation:AnimalsCells
  44. Nishimura T, Iino T, Mitsuya M, Bamba M, Watanabe H, Tsukahara D, Kamata K, Sasaki K, Ohyama S, Hosaka H, Futamura M, Nagata Y, Eiki J. Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators. Bioorg Med Chem Lett. 2009 Mar 01; 19(5):1357-60. PMID: 19188063.
    Citations: 6     Fields:    Translation:AnimalsCells
  45. Kadotani A, Fujimura M, Nakamura T, Ohyama S, Harada N, Maruki H, Tamai Y, Kanatani A, Eiki J, Nagata Y. Metabolic impact of overexpression of liver glycogen synthase with serine-to-alanine substitutions in rat primary hepatocytes. Arch Biochem Biophys. 2007 Oct 15; 466(2):283-9. PMID: 17880910.
    Citations: 3     Fields:    Translation:AnimalsCells
  46. Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, Nishimura T, Eiki J, Nagata Y. An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism. J Biol Chem. 2006 Dec 08; 281(49):37668-74. PMID: 17028192.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  47. Kang L, Dunn-Meynell AA, Routh VH, Gaspers LD, Nagata Y, Nishimura T, Eiki J, Zhang BB, Levin BE. Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing. Diabetes. 2006 Feb; 55(2):412-20. PMID: 16443775.
    Citations: 92     Fields:    Translation:AnimalsCells
  48. Kamata K, Mitsuya M, Nishimura T, Eiki J, Nagata Y. Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. Structure. 2004 Mar; 12(3):429-38. PMID: 15016359.
    Citations: 124     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.