Harvard Catalyst Profiles

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Seth Rakoff-Nahoum, Ph.D., M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. DP2GM136652 (RAKOFF-NAHOUM, SETH) Sep 30, 2019 - May 31, 2024
    Positive Selection as a Host Mechanism to Control the Microbiome
    Role: Principal Investigator
  2. K08AI130392 (RAKOFF-NAHOUM, SETH) Feb 2, 2017 - Jan 31, 2022
    Carbohydrate Public Good Interactions in Healthy and Dysbiotic Bacteroidales Communities
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kuziel GA, Rakoff-Nahoum S. The gut microbiome. Curr Biol. 2022 03 28; 32(6):R257-R264. PMID: 35349808.
    Citations:    Fields:    
  2. Park SY, Rao C, Coyte KZ, Kuziel GA, Zhang Y, Huang W, Franzosa EA, Weng JK, Huttenhower C, Rakoff-Nahoum S. Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite. Cell. 2022 02 03; 185(3):513-529.e21. PMID: 35120663.
    Citations:    Fields:    Translation:Cells
  3. Rao C, Coyte KZ, Bainter W, Geha RS, Martin CR, Rakoff-Nahoum S. Multi-kingdom ecological drivers of microbiota assembly in preterm infants. Nature. 2021 03; 591(7851):633-638. PMID: 33627867.
    Citations: 17     Fields:    Translation:Humans
  4. Coyte KZ, Rao C, Rakoff-Nahoum S, Foster KR. Ecological rules for the assembly of microbiome communities. PLoS Biol. 2021 02; 19(2):e3001116. PMID: 33606675.
    Citations: 5     Fields:    Translation:Humans
  5. Bainter W, Platt CD, Park SY, Stafstrom K, Wallace JG, Peters ZT, Massaad MJ, Becuwe M, Salinas SA, Jones J, Beaussant-Cohen S, Jaber F, Yang JS, Walther TC, Orange JS, Rao C, Rakoff-Nahoum S, Tsokos M, Naseem SUR, Al-Tamemi S, Chou J, Hsu VW, Geha RS. Combined immunodeficiency due to a mutation in the ?1 subunit of the coat protein I complex. J Clin Invest. 2021 02 01; 131(3). PMID: 33529166.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Mills KI, Albert BD, Bechard LJ, Duggan CP, Kaza A, Rakoff-Nahoum S, Vlamakis H, Sleeper LA, Newburger JW, Priebe GP, Mehta NM. Stress ulcer prophylaxis versus placebo-a blinded randomized control trial to evaluate the safety of two strategies in critically ill infants with congenital heart disease (SUPPRESS-CHD). Trials. 2020 Jun 29; 21(1):590. PMID: 32600393.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  7. Ordovas-Montanes J, Beyaz S, Rakoff-Nahoum S, Shalek AK. Distribution and storage of inflammatory memory in barrier tissues. Nat Rev Immunol. 2020 05; 20(5):308-320. PMID: 32015472.
    Citations: 10     Fields:    Translation:HumansCells
  8. Coyte KZ, Rakoff-Nahoum S. Understanding Competition and Cooperation within the Mammalian Gut Microbiome. Curr Biol. 2019 06 03; 29(11):R538-R544. PMID: 31163167.
    Citations: 31     Fields:    Translation:Animals
  9. Mead BE, Ordovas-Montanes J, Braun AP, Levy LE, Bhargava P, Szucs MJ, Ammendolia DA, MacMullan MA, Yin X, Hughes TK, Wadsworth MH, Ahmad R, Rakoff-Nahoum S, Carr SA, Langer R, Collins JJ, Shalek AK, Karp JM. Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types. BMC Biol. 2018 06 05; 16(1):62. PMID: 29871632.
    Citations: 15     Fields:    Translation:HumansCells
  10. Foster KR, Schluter J, Coyte KZ, Rakoff-Nahoum S. The evolution of the host microbiome as an ecosystem on a leash. Nature. 2017 08 02; 548(7665):43-51. PMID: 28770836.
    Citations: 182     Fields:    Translation:HumansAnimals
  11. Sasabe J, Miyoshi Y, Rakoff-Nahoum S, Zhang T, Mita M, Davis BM, Hamase K, Waldor MK. Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota. Nat Microbiol. 2016 07 25; 1(10):16125. PMID: 27670111.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  12. Rakoff-Nahoum S, Foster KR, Comstock LE. The evolution of cooperation within the gut microbiota. Nature. 2016 05 12; 533(7602):255-9. PMID: 27111508.
    Citations: 162     Fields:    Translation:HumansAnimalsCells
  13. Rakoff-Nahoum S. Another Reason to Thank Mom: Gestational Effects of Microbiota Metabolites. Cell Host Microbe. 2016 Apr 13; 19(4):425-7. PMID: 27078061.
    Citations: 1     Fields:    Translation:Animals
  14. McLoughlin K, Schluter J, Rakoff-Nahoum S, Smith AL, Foster KR. Host Selection of Microbiota via Differential Adhesion. Cell Host Microbe. 2016 Apr 13; 19(4):550-9. PMID: 27053168.
    Citations: 59     Fields:    Translation:Humans
  15. Ordovas-Montanes J, Rakoff-Nahoum S, Huang S, Riol-Blanco L, Barreiro O, von Andrian UH. The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease. Trends Immunol. 2015 Oct; 36(10):578-604. PMID: 26431937.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  16. Rakoff-Nahoum S, Kong Y, Kleinstein SH, Subramanian S, Ahern PP, Gordon JI, Medzhitov R. Analysis of gene-environment interactions in postnatal development of the mammalian intestine. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):1929-36. PMID: 25691701.
    Citations: 41     Fields:    Translation:Animals
  17. Rakoff-Nahoum S, Comstock LE. Immunology: Starve a fever, feed the microbiota. Nature. 2014 Oct 30; 514(7524):576-7. PMID: 25274298.
    Citations: 1     Fields:    Translation:Animals
  18. Rakoff-Nahoum S, Coyne MJ, Comstock LE. An ecological network of polysaccharide utilization among human intestinal symbionts. Curr Biol. 2014 Jan 06; 24(1):40-49. PMID: 24332541.
    Citations: 129     Fields:    Translation:HumansCells
  19. Rakoff-Nahoum S, Bousvaros A. Innate and adaptive immune connections in inflammatory bowel diseases. Curr Opin Gastroenterol. 2010 Nov; 26(6):572-7. PMID: 20871398.
    Citations: 12     Fields:    Translation:HumansAnimals
  20. Rakoff-Nahoum S, Medzhitov R. Toll-like receptors and cancer. Nat Rev Cancer. 2009 Jan; 9(1):57-63. PMID: 19052556.
    Citations: 367     Fields:    Translation:HumansAnimalsCells
  21. Rakoff-Nahoum S, Medzhitov R. Innate immune recognition of the indigenous microbial flora. Mucosal Immunol. 2008 Nov; 1 Suppl 1:S10-4. PMID: 19079220.
    Citations: 39     Fields:    Translation:HumansAnimals
  22. Rakoff-Nahoum S, Medzhitov R. Role of toll-like receptors in tissue repair and tumorigenesis. Biochemistry (Mosc). 2008 May; 73(5):555-61. PMID: 18605980.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  23. Garrison KE, Jones RB, Meiklejohn DA, Anwar N, Ndhlovu LC, Chapman JM, Erickson AL, Agrawal A, Spotts G, Hecht FM, Rakoff-Nahoum S, Lenz J, Ostrowski MA, Nixon DF. T cell responses to human endogenous retroviruses in HIV-1 infection. PLoS Pathog. 2007 Nov; 3(11):e165. PMID: 17997601.
    Citations: 75     Fields:    Translation:HumansCells
  24. Rakoff-Nahoum S, Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science. 2007 Jul 06; 317(5834):124-7. PMID: 17615359.
    Citations: 248     Fields:    Translation:AnimalsCells
  25. Rakoff-Nahoum S, Medzhitov R. Prostaglandin-secreting cells: a portable first aid kit for tissue repair. J Clin Invest. 2007 Jan; 117(1):83-6. PMID: 17200710.
    Citations: 3     Fields:    Translation:HumansCells
  26. Rakoff-Nahoum S. Why cancer and inflammation? Yale J Biol Med. 2006 Dec; 79(3-4):123-30. PMID: 17940622.
    Citations: 139     Fields:    Translation:HumansAnimals
  27. Rakoff-Nahoum S, Chen H, Kraus T, George I, Oei E, Tyorkin M, Salik E, Beuria P, Sperber K. Retraction: Regulation of class II expression in monocytic cells after HIV-1 infection. J Immunol. 2006 Nov 01; 177(9):6561. PMID: 17056589.
    Citations:    Fields:    
  28. Rakoff-Nahoum S, Hao L, Medzhitov R. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity. 2006 Aug; 25(2):319-29. PMID: 16879997.
    Citations: 165     Fields:    Translation:AnimalsCells
  29. Rakoff-Nahoum S, Kuebler PJ, Heymann JJ, E Sheehy M, Ortiz GM, S Ogg G, Barbour JD, Lenz J, Steinfeld AD, Nixon DF. Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma. AIDS Res Hum Retroviruses. 2006 Jan; 22(1):52-6. PMID: 16438646.
    Citations: 29     Fields:    Translation:HumansCells
  30. Rakoff-Nahoum S, Medzhitov R. Role of the innate immune system and host-commensal mutualism. Curr Top Microbiol Immunol. 2006; 308:1-18. PMID: 16922084.
    Citations: 27     Fields:    Translation:HumansAnimals
  31. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004 Jul 23; 118(2):229-41. PMID: 15260992.
    Citations: 1597     Fields:    Translation:AnimalsCells
  32. Rakoff-Nahoum S, Chen H, Kraus T, George I, Oei E, Tyorkin M, Salik E, Beuria P, Sperber K. Regulation of class II expression in monocytic cells after HIV-1 infection. J Immunol. 2001 Aug 15; 167(4):2331-42. PMID: 11490022.
    Citations: 2     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.