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James Y Chen, M.D., Ph.D.

Title
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Department
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Biography
Stanford University School of Medicine, Stanford, CAMD2018Medicine
Stanford University School of Medicine, Stanford, CAPhD2016Stem Cell Biology and Regenerative Medicine
University of California Los Angeles, Los Angeles, CABS2008Microbiology, Immunology, and Molecular Genetics

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F30HL122096 (CHEN, JAMES Y.) Jan 15, 2014 - Jan 14, 2017
    NIH
    Clonal Evolution and Prospective Isolation of Myelodysplastic Syndrome Initiating
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sakamaki T, Kao KS, Nishi K, Chen JY, Sadaoka K, Fujii M, Takaori-Kondo A, Weissman IL, Miyanishi M. Hoxb5 defines the heterogeneity of self-renewal capacity in the hematopoietic stem cell compartment. Biochem Biophys Res Commun. 2021 02 05; 539:34-41. PMID: 33418191.
    Citations:    Fields:    
  2. Takimoto CH, Chao MP, Gibbs C, McCamish MA, Liu J, Chen JY, Majeti R, Weissman IL. The Macrophage 'Do not eat me' signal, CD47, is a clinically validated cancer immunotherapy target. Ann Oncol. 2019 03 01; 30(3):486-489. PMID: 30689700.
    Citations: 13     Fields:    Translation:HumansCells
  3. Sikic BI, Lakhani N, Patnaik A, Shah SA, Chandana SR, Rasco D, Colevas AD, O'Rourke T, Narayanan S, Papadopoulos K, Fisher GA, Villalobos V, Prohaska SS, Howard M, Beeram M, Chao MP, Agoram B, Chen JY, Huang J, Axt M, Liu J, Volkmer JP, Majeti R, Weissman IL, Takimoto CH, Supan D, Wakelee HA, Aoki R, Pegram MD, Padda SK. First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers. J Clin Oncol. 2019 04 20; 37(12):946-953. PMID: 30811285.
    Citations: 67     Fields:    Translation:HumansCTClinical Trials
  4. Advani R, Flinn I, Popplewell L, Forero A, Bartlett NL, Ghosh N, Kline J, Roschewski M, LaCasce A, Collins GP, Tran T, Lynn J, Chen JY, Volkmer JP, Agoram B, Huang J, Majeti R, Weissman IL, Takimoto CH, Chao MP, Smith SM. CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma. N Engl J Med. 2018 Nov 01; 379(18):1711-1721. PMID: 30380386.
    Citations: 174     Fields:    Translation:HumansCellsCTClinical Trials
  5. Szade K, Gulati GS, Chan CKF, Kao KS, Miyanishi M, Marjon KD, Sinha R, George BM, Chen JY, Weissman IL. Where Hematopoietic Stem Cells Live: The Bone Marrow Niche. Antioxid Redox Signal. 2018 07 10; 29(2):191-204. PMID: 29113449.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  6. Barkal AA, Weiskopf K, Kao KS, Gordon SR, Rosental B, Yiu YY, George BM, Markovic M, Ring NG, Tsai JM, McKenna KM, Ho PY, Cheng RZ, Chen JY, Barkal LJ, Ring AM, Weissman IL, Maute RL. Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy. Nat Immunol. 2018 Jan; 19(1):76-84. PMID: 29180808.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  7. Chen JY, Miyanishi M, Wang SK, Yamazaki S, Sinha R, Kao KS, Seita J, Sahoo D, Nakauchi H, Weissman IL. Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Nature. 2016 Feb 11; 530(7589):223-7. PMID: 26863982.
    Citations: 99     Fields:    Translation:AnimalsCells
  8. Mori Y, Chen JY, Pluvinage JV, Seita J, Weissman IL. Prospective isolation of human erythroid lineage-committed progenitors. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9638-43. PMID: 26195758.
    Citations: 25     Fields:    Translation:HumansCells
  9. Cheah MT, Chen JY, Sahoo D, Contreras-Trujillo H, Volkmer AK, Scheeren FA, Volkmer JP, Weissman IL. CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):4725-30. PMID: 25825750.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  10. Feng M, Chen JY, Weissman-Tsukamoto R, Volkmer JP, Ho PY, McKenna KM, Cheshier S, Zhang M, Guo N, Gip P, Mitra SS, Weissman IL. Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2145-50. PMID: 25646432.
    Citations: 70     Fields:    Translation:HumansCells
  11. Chan CK, Seo EY, Chen JY, Lo D, McArdle A, Sinha R, Tevlin R, Seita J, Vincent-Tompkins J, Wearda T, Lu WJ, Senarath-Yapa K, Chung MT, Marecic O, Tran M, Yan KS, Upton R, Walmsley GG, Lee AS, Sahoo D, Kuo CJ, Weissman IL, Longaker MT. Identification and specification of the mouse skeletal stem cell. Cell. 2015 Jan 15; 160(1-2):285-98. PMID: 25594184.
    Citations: 181     Fields:    Translation:AnimalsCells
  12. Miyanishi M, Mori Y, Seita J, Chen JY, Karten S, Chan CK, Nakauchi H, Weissman IL. Do pluripotent stem cells exist in adult mice as very small embryonic stem cells? Stem Cell Reports. 2013; 1(2):198-208. PMID: 24052953.
    Citations: 33     Fields:    Translation:AnimalsCells
  13. Chan CK, Lindau P, Jiang W, Chen JY, Zhang LF, Chen CC, Seita J, Sahoo D, Kim JB, Lee A, Park S, Nag D, Gong Y, Kulkarni S, Luppen CA, Theologis AA, Wan DC, DeBoer A, Seo EY, Vincent-Tompkins JD, Loh K, Walmsley GG, Kraft DL, Wu JC, Longaker MT, Weissman IL. Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells. Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31):12643-8. PMID: 23858471.
    Citations: 45     Fields:    Translation:AnimalsCells
  14. Guo W, Schubbert S, Chen JY, Valamehr B, Mosessian S, Shi H, Dang NH, Garcia C, Theodoro MF, Varella-Garcia M, Wu H. Suppression of leukemia development caused by PTEN loss. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1409-14. PMID: 21212363.
    Citations: 31     Fields:    Translation:AnimalsCells
  15. Guo W, Lasky JL, Chang CJ, Mosessian S, Lewis X, Xiao Y, Yeh JE, Chen JY, Iruela-Arispe ML, Varella-Garcia M, Wu H. Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature. 2008 May 22; 453(7194):529-33. PMID: 18463637.
    Citations: 112     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.