Harvard Catalyst Profiles

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David Pieter Hoytema van Konijnenburg, Ph.D., M.D.

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Biography
awards and honors
2008 - 2010
BSc Honors Program in Medicine
2011 - 2014
MSc Honors Program in Medicine
2013
Student Research Award, Dutch Digestive Foundation
2015
Travel Grant, Federation of Clinical Immunology Societies (FOCIS)
2015
Talma Eykman Thesis Award in Medicine, Biomedical Sciences or Health Sciences
2015
National Prize for medical student, The Professor Chris Gips Foundation for Young Scientific Talent
2018
PhD Thesis Award, Pediatrics Association of the Netherlands (NVK), Section on Infection & Immunity
2020
House Staff Development Award, Medical Staff Organization
2020
Fred Lovejoy Resident Research Award
2020
Trainee Travel Award for Excellence, Alumni Association
2021
Chrysalis Project participant, American Academy of Allergy, Asthma & Immunology (AAAAI)
2022
Bravo! Way to Shine Star Award
2022
Fellow Teaching Honor Roll

Overview
overview
MD PhD, completed PhD work in Immunology at Utrecht University, Van Wijk lab and The Rockefeller University, Mucida lab. My research focused on intestinal T cells using a combination of techniques including live imaging. Completed pediatrics residency at Boston Childrens Hospital and Harvard Medical School concurrent with research at Harvard Medical School, Kirchhausen lab, Zon lab, where I studied the development and function of tissue-resident immune cells whilst completing the Integrated Research Pathway.
Current Allergy and Immunology Fellow at Boston Children's Hospital and Harvard Medical School, working in Nigrovic lab and Zanoni lab on tissue-resident immune cells in the lung. Clinically especially passionate about providing care for patients with immune dysregulation syndromes or immunodeficiency, with a focus on immunogenetics and research-based clinical care for patients with rare diseases of the immune system. Part of MIDAS Immune Dysregulation program and Interstitial Lung Diseases program at Boston Children's Hospital.
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Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Silva HM, Báfica A, Rodrigues-Luiz GF, Chi J, Santos PDA, Reis BS, Hoytema van Konijnenburg DP, Crane A, Arifa RDN, Martin P, Mendes DAGB, Mansur DS, Torres VJ, Cadwell K, Cohen P, Mucida D, Lafaille JJ. Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges. J Exp Med. 2019 04 01; 216(4):786-806. PMID: 30862706.
    Citations: 43     Fields:    Translation:AnimalsCells
  2. Lutter L, Hoytema van Konijnenburg DP, Brand EC, Oldenburg B, van Wijk F. The elusive case of human intraepithelial T cells in gut homeostasis and inflammation. Nat Rev Gastroenterol Hepatol. 2018 10; 15(10):637-649. PMID: 29973676.
    Citations: 20     Fields:    Translation:HumansCells
  3. Petrelli A, Mijnheer G, Hoytema van Konijnenburg DP, van der Wal MM, Giovannone B, Mocholi E, Vazirpanah N, Broen JC, Hijnen D, Oldenburg B, Coffer PJ, Vastert SJ, Prakken BJ, Spierings E, Pandit A, Mokry M, van Wijk F. PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation. J Clin Invest. 2018 10 01; 128(10):4669-4681. PMID: 30198907; PMCID: PMC6159979.
    Citations: 40     Fields:    Translation:HumansCellsCTClinical Trials
  4. Hoytema van Konijnenburg DP, Reis BS, Pedicord VA, Farache J, Victora GD, Mucida D. Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection. Cell. 2017 Nov 02; 171(4):783-794.e13. PMID: 28942917.
    Citations: 97     Fields:    Translation:AnimalsCells
  5. Hoytema van Konijnenburg DP, Mucida D. Intraepithelial lymphocytes. Curr Biol. 2017 Aug 07; 27(15):R737-R739. PMID: 28787597.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  6. Sujino T, London M, Hoytema van Konijnenburg DP, Rendon T, Buch T, Silva HM, Lafaille JJ, Reis BS, Mucida D. Tissue adaptation of regulatory and intraepithelial CD4? T cells controls gut inflammation. Science. 2016 Jun 24; 352(6293):1581-6. PMID: 27256884.
    Citations: 92     Fields:    Translation:AnimalsCells
  7. Reis BS, Hoytema van Konijnenburg DP, Grivennikov SI, Mucida D. Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity. 2014 Aug 21; 41(2):244-56. PMID: 25148025.
    Citations: 60     Fields:    Translation:AnimalsCells
  8. van de Ven AA, Hoytema van Konijnenburg DP, Wensing AM, van Montfrans JM. The role of prolonged viral gastrointestinal infections in the development of immunodeficiency-related enteropathy. Clin Rev Allergy Immunol. 2012 Feb; 42(1):79-91. PMID: 22116710.
    Citations: 5     Fields:    Translation:HumansAnimals
  9. van de Ven AA, de Jong PA, Hoytema van Konijnenburg DP, Kessels OA, Boes M, Sanders EA, Terheggen-Lagro SW, van Montfrans JM. Airway and interstitial lung disease are distinct entities in paediatric common variable immunodeficiency. Clin Exp Immunol. 2011 Aug; 165(2):235-42. PMID: 21635229.
    Citations: 13     Fields:    Translation:HumansCells
  10. van de Ven AA, van Montfrans JM, Terheggen-Lagro SW, Beek FJ, Hoytema van Konijnenburg DP, Kessels OA, de Jong PA. A CT scan score for the assessment of lung disease in children with common variable immunodeficiency disorders. Chest. 2010 Aug; 138(2):371-9. PMID: 20299624.
    Citations: 12     Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.