Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Darlene Ann Dartt, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01EY029789 (DARTT, DARLENE A) Feb 1, 2020 - Jan 31, 2024
    NIH
    Construction of Conjunctival Equivalents Using Molecular Deposition Techniques
    Role: Principal Investigator
  2. R13EY028021 (DARTT, DARLENE A) May 1, 2017 - Apr 30, 2018
    NIH
    Sixth Military Vision Symposium on Ocular and Vision Injury
    Role: Principal Investigator
  3. R01EY022415 (DARTT, DARLENE A) May 1, 2012 - Apr 30, 2017
    NIH
    Conjunctival Goblet Cell NLRP3 Inflammasome in Ocular Surface Bacterial Infection
    Role: Principal Investigator
  4. R21EY020992 (DARTT, DARLENE A) Sep 1, 2010 - Aug 31, 2012
    NIH
    Lacrimal Gland Regeneration:Identification and Isolation of Progenitor Cells
    Role: Principal Investigator
  5. R01EY019470 (DARTT, DARLENE A) May 1, 2009 - Dec 31, 2023
    NIH
    Conjunctival Goblet Cell Mucin Secretion in Inflammation and Its Resolution
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Magno MS, Olafsson J, Beining M, Moschowits E, Lagali N, Wolffsohn JS, Craig JP, Vehof J, Dartt DA, Utheim TP. Risk associated with treatments for meibomian gland dysfunction. Cont Lens Anterior Eye. 2023 Feb 07; 101818. PMID: 36754735.
    Citations:    Fields:    
  2. Yang M, Lennikov A, Chang K, Ashok A, Lee C, Cho KS, Utheim TP, Dartt DA, Chen DF. Transcorneal but not transpalpebral electrical stimulation disrupts mucin homeostasis of the ocular surface. BMC Ophthalmol. 2022 Dec 15; 22(1):490. PMID: 36522696; PMCID: PMC9756492.
    Citations:    Fields:    Translation:AnimalsCells
  3. Schjerven Magno M, Olafsson J, Beining M, Moschowits E, Lagali N, Wolffsohn JS, Craig JP, Vehof J, Dartt DA, Utheim TP. Hot towels: The bedrock of Meibomian gland dysfunction treatment - A review. Cont Lens Anterior Eye. 2022 Oct 28; 101775. PMID: 36715292.
    Citations:    Fields:    
  4. Mauduit O, Delcroix V, Umazume T, de Paiva CS, Dartt DA, Makarenkova HP. Spatial transcriptomics of the lacrimal gland features macrophage activity and epithelium metabolism as key alterations during chronic inflammation. Front Immunol. 2022; 13:1011125. PMID: 36341342; PMCID: PMC9628215.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Yang M, Fjærvoll HK, Fjærvoll KA, Wang NH, Utheim TP, Serhan CN, Dartt DA. Sex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators. Sci Rep. 2022 09 29; 12(1):16305. PMID: 36175572; PMCID: PMC9522727.
    Citations: 1     Fields:    Translation:HumansCells
  6. Vernhardsdottir RR, Magno MS, Hynnekleiv L, Lagali N, Dartt DA, Vehof J, Jackson CJ, Utheim TP. Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis - A review. Ocul Surf. 2022 10; 26:211-221. PMID: 36210626.
    Citations:    Fields:    Translation:Humans
  7. Botten N, Hodges RR, Bair J, Utheim TP, Serhan CN, Yang M, Dartt DA. Resolvin D2 uses multiple Ca2+ -dependent signaling pathways to stimulate mucin secretion in rat and human conjunctival goblet cells. J Cell Physiol. 2022 10; 237(10):3816-3833. PMID: 36066128; PMCID: PMC9560994.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Olsen MV, Lyngstadaas AV, Bair JA, Hodges RR, Utheim TP, Serhan CN, Dartt DA. Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1. Int J Mol Sci. 2022 Jun 02; 23(11). PMID: 35682912; PMCID: PMC9181304.
    Citations:    Fields:    Translation:AnimalsCells
  9. Hynnekleiv L, Magno M, Vernhardsdottir RR, Moschowits E, Tønseth KA, Dartt DA, Vehof J, Utheim TP. Hyaluronic acid in the treatment of dry eye disease. Acta Ophthalmol. 2022 Dec; 100(8):844-860. PMID: 35514082; PMCID: PMC9790727.
    Citations:    Fields:    
  10. Fjaervoll K, Fjaervoll H, Magno M, Nøland ST, Dartt DA, Vehof J, Utheim TP. Review on the possible pathophysiological mechanisms underlying visual display terminal-associated dry eye disease. Acta Ophthalmol. 2022 Dec; 100(8):861-877. PMID: 35441459; PMCID: PMC9790214.
    Citations:    Fields:    
  11. Beining MW, Magnø MS, Moschowits E, Olafsson J, Vehof J, Dartt DA, Utheim TP. In-office thermal systems for the treatment of dry eye disease. Surv Ophthalmol. 2022 Sep-Oct; 67(5):1405-1418. PMID: 35192836.
    Citations:    Fields:    
  12. Yang M, Botten N, Hodges R, Bair J, Utheim TP, Serhan CN, Dartt DA. Resolvin D2 and Resolvin D1 Differentially Activate Protein Kinases to Counter-Regulate Histamine-Induced [Ca2+]i Increase and Mucin Secretion in Conjunctival Goblet Cells. Int J Mol Sci. 2021 Dec 23; 23(1). PMID: 35008563; PMCID: PMC8745650.
    Citations:    Fields:    Translation:HumansAnimalsCells
  13. Müllertz O, Hedengran A, Mouhammad ZA, Freiberg J, Nagymihály R, Jacobsen J, Larsen SW, Bair J, Utheim TP, Dartt DA, Heegaard S, Petrovski G, Kolko M. Impact of benzalkonium chloride-preserved and preservative-free latanoprost eye drops on cultured human conjunctival goblet cells upon acute exposure and differences in physicochemical properties of the eye drops. BMJ Open Ophthalmol. 2021; 6(1):e000892. PMID: 34993350; PMCID: PMC8689192.
    Citations: 1     
  14. Olafsson J, Lai X, Landsend ECS, Olafsson S, Parissi E, Utheim ØA, Raeder S, Badian RA, Lagali N, Dartt DA, Utheim TP. TheraPearl Eye Mask and Blephasteam for the treatment of meibomian gland dysfunction: a randomized, comparative clinical trial. Sci Rep. 2021 11 17; 11(1):22386. PMID: 34789807; PMCID: PMC8599702.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  15. Magno MS, Olafsson J, Beining M, Moschowits E, Lagali N, Wolffsohn JS, Craig JP, Dartt DA, Vehof J, Utheim TP. Chambered warm moist air eyelid warming devices - a review. Acta Ophthalmol. 2022 Aug; 100(5):499-510. PMID: 34750979.
    Citations:    Fields:    Translation:Humans
  16. Gárriz A, Aubry S, Wattiaux Q, Bair J, Mariano M, Hatzipetrou G, Bowman M, Morokuma J, Ortiz G, Hamrah P, Dartt DA, Zoukhri D. Role of the Phospholipase C Pathway and Calcium Mobilization in Oxytocin-Induced Contraction of Lacrimal Gland Myoepithelial Cells. Invest Ophthalmol Vis Sci. 2021 11 01; 62(14):25. PMID: 34812841.
    Citations:    Fields:    Translation:AnimalsCells
  17. Fjaervoll H, Fjaervoll K, Magno M, Moschowits E, Vehof J, Dartt DA, Utheim TP. The association between visual display terminal use and dry eye: a review. Acta Ophthalmol. 2022 Jun; 100(4):357-375. PMID: 34697901.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  18. Van Acker SI, Van den Bogerd B, Van Acker ZP, Vailionyte A, Haagdorens M, Koppen C, Ní Dhubhghaill S, Dartt DA, Pintelon I. Characterisation of Gel-Forming Mucins Produced In Vivo and In Ex Vivo Conjunctival Explant Cultures. Int J Mol Sci. 2021 Sep 29; 22(19). PMID: 34638869; PMCID: PMC8508887.
    Citations:    Fields:    Translation:HumansCells
  19. Hedengran A, Begun X, Müllertz O, Mouhammad Z, Vohra R, Bair J, Dartt DA, Cvenkel B, Heegaard S, Petrovski G, Kolko M. Benzalkonium Chloride-Preserved Anti-Glaucomatous Eye Drops and Their Effect on Human Conjunctival Goblet Cells in vitro. Biomed Hub. 2021 May-Aug; 6(2):69-75. PMID: 34616748; PMCID: PMC8460924.
    Citations: 3     
  20. Makuloluwa AK, Hamill KJ, Rauz S, Bosworth L, Haneef A, Romano V, Williams RL, Dartt DA, Kaye SB. Biological tissues and components, and synthetic substrates for conjunctival cell transplantation. Ocul Surf. 2021 10; 22:15-26. PMID: 34119712.
    Citations: 1     Fields:    Translation:Cells
  21. Makuloluwa AK, Hamill KJ, Rauz S, Bosworth L, Haneef A, Romano V, Williams RL, Dartt DA, Kaye SB. The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration. Ocul Surf. 2021 Jun 05. PMID: 34102309.
    Citations: 2     Fields:    
  22. Lyngstadaas AV, Olsen MV, Bair JA, Hodges RR, Utheim TP, Serhan CN, Dartt DA. Pro-Resolving Mediator Annexin A1 Regulates Intracellular Ca2+ and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases. Front Immunol. 2021; 12:618653. PMID: 33968020.
    Citations: 2     Fields:    Translation:AnimalsCells
  23. Masli S, Dartt DA. Mouse Models of Sjögren's Syndrome with Ocular Surface Disease. Int J Mol Sci. 2020 Nov 30; 21(23). PMID: 33266081.
    Citations: 4     Fields:    Translation:Animals
  24. Tellefsen Nøland S, Badian RA, Utheim TP, Utheim ØA, Stojanovic A, Tashbayev B, Raeder S, Dartt DA, Chen X. Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients. Ocul Surf. 2021 01; 19:68-73. PMID: 33246035.
    Citations: 2     Fields:    Translation:Humans
  25. Swift W, Bair JA, Chen W, Li M, Lie S, Li D, Yang M, Shatos MA, Hodges RR, Kolko M, Utheim TP, Scott W, Dartt DA. Povidone iodine treatment is deleterious to human ocular surface conjunctival cells in culture. BMJ Open Ophthalmol. 2020; 5(1):e000545. PMID: 32995498; PMCID: PMC7497553.
    Citations: 1     
  26. García-Posadas L, Hodges RR, Utheim TP, Olstad OK, Delcroix V, Makarenkova HP, Dartt DA. Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease. Am J Pathol. 2020 10; 190(10):2067-2079. PMID: 32679229; PMCID: PMC7520664.
    Citations: 7     Fields:    Translation:AnimalsCells
  27. Yang M, Bair JA, Hodges RR, Serhan CN, Dartt DA. Resolvin E1 Reduces Leukotriene B4-Induced Intracellular Calcium Increase and Mucin Secretion in Rat Conjunctival Goblet Cells. Am J Pathol. 2020 09; 190(9):1823-1832. PMID: 32561135; PMCID: PMC7450248.
    Citations: 1     Fields:    Translation:AnimalsCells
  28. Olsen MV, Lyngstadaas AV, Bair JA, Hodges RR, Utheim TP, Serhan CN, Dartt DA. Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca2+ ] and secretion in conjunctival goblet cells. J Cell Physiol. 2021 01; 236(1):340-353. PMID: 32510663.
    Citations: 4     Fields:    Translation:AnimalsCells
  29. Yang M, Lippestad M, Hodges RR, Fjærvoll HK, Fjærvoll KA, Bair JA, Utheim TP, Serhan CN, Dartt DA. RvE1 uses the LTB4 receptor BLT1 to increase [Ca2+]i and stimulate mucin secretion in cultured rat and human conjunctival goblet cells. Ocul Surf. 2020 07; 18(3):470-482. PMID: 32361084.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  30. Tashbayev B, Utheim TP, Utheim ØA, Ræder S, Jensen JL, Yazdani M, Lagali N, Vitelli V, Dartt DA, Chen X. Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease. Sci Rep. 2020 03 26; 10(1):5542. PMID: 32218518.
    Citations: 9     Fields:    Translation:Humans
  31. Jackson CJ, Myklebust Ernø IT, Ringstad H, Tønseth KA, Dartt DA, Utheim TP. Simple limbal epithelial transplantation: Current status and future perspectives. Stem Cells Transl Med. 2020 03; 9(3):316-327. PMID: 31802651.
    Citations: 16     Fields:    Translation:HumansCells
  32. Xiao J, Adil MY, Olafsson J, Chen X, Utheim ØA, Ræder S, Lagali NS, Dartt DA, Utheim TP. Diagnostic Test Efficacy of Meibomian Gland Morphology and Function. Sci Rep. 2019 11 22; 9(1):17345. PMID: 31758085.
    Citations: 3     Fields:    Translation:Humans
  33. Xiao J, Adil MY, Chen X, Utheim ØA, Ræder S, Tønseth KA, Lagali NS, Dartt DA, Utheim TP. Functional and Morphological Evaluation of Meibomian Glands in the Assessment of Meibomian Gland Dysfunction Subtype and Severity. Am J Ophthalmol. 2020 01; 209:160-167. PMID: 31526799.
    Citations: 11     Fields:    Translation:Humans
  34. Yazdani M, Chen X, Tashbayev B, Utheim ØA, Ræder S, Hua Y, Eidet JR, Stojanovic A, Dartt DA, Utheim TP. Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients. Curr Eye Res. 2019 09; 44(9):941-947. PMID: 30955380.
    Citations: 3     Fields:    Translation:Humans
  35. Botten N, Hodges RR, Li D, Bair JA, Shatos MA, Utheim TP, Serhan CN, Dartt DA. Resolvin D2 elevates cAMP to increase intracellular [Ca2+] and stimulate secretion from conjunctival goblet cells. FASEB J. 2019 07; 33(7):8468-8478. PMID: 31013438.
    Citations: 10     Fields:    Translation:AnimalsCells
  36. Tiedemann D, Mouhammad ZA, Utheim TP, Dartt DA, Heegaard S, Petrovski G, Kolko M. Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment. J Glaucoma. 2019 04; 28(4):325-333. PMID: 30585937.
    Citations: 2     Fields:    Translation:HumansCells
  37. Utheim OA, Pasovic L, Raeder S, Eidet JR, Fostad IG, Sehic A, Roald B, de la Paz MF, Lyberg T, Dartt DA, Utheim TP. Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells. PLoS One. 2019; 14(3):e0212524. PMID: 30861002; PMCID: PMC6413940.
    Citations: 4     Fields:    Translation:HumansCells
  38. Dartt DA, Hodges RR, Serhan CN. Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface. Adv Exp Med Biol. 2019; 1161:13-25. PMID: 31562618; PMCID: PMC6859005.
    Citations: 8     Fields:    Translation:HumansCells
  39. Adil MY, Xiao J, Olafsson J, Chen X, Lagali NS, Ræder S, Utheim ØA, Dartt DA, Utheim TP. Meibomian Gland Morphology Is a Sensitive Early Indicator of Meibomian Gland Dysfunction. Am J Ophthalmol. 2019 04; 200:16-25. PMID: 30578784.
    Citations: 14     Fields:    Translation:Humans
  40. Kaye R, Botten N, Lippestad M, Li D, Hodges RR, Utheim TP, Serhan CN, Dartt DA. Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells. Exp Eye Res. 2019 03; 180:53-62. PMID: 30513286; PMCID: PMC6389367.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  41. Tatematsu Y, Khan Q, Blanco T, Bair JA, Hodges RR, Masli S, Dartt DA. Thrombospondin-1 Is Necessary for the Development and Repair of Corneal Nerves. Int J Mol Sci. 2018 Oct 16; 19(10). PMID: 30332778.
    Citations: 8     Fields:    Translation:AnimalsCells
  42. Shen J, Xiao R, Bair J, Wang F, Vandenberghe LH, Dartt D, Baranov P, Ng YSE. Novel engineered, membrane-localized variants of vascular endothelial growth factor (VEGF) protect retinal ganglion cells: a proof-of-concept study. Cell Death Dis. 2018 10 03; 9(10):1018. PMID: 30282966.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  43. Saban DR, Hodges RR, Mathew R, Reyes NJ, Yu C, Kaye R, Swift W, Botten N, Serhan CN, Dartt DA. Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model. Mucosal Immunol. 2019 01; 12(1):145-153. PMID: 30279513; PMCID: PMC6301119.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  44. Momtazi L, Dartt DA, Nilsen O, Eidet JR. Molecular layer deposition builds biocompatible substrates for epithelial cells. J Biomed Mater Res A. 2018 12; 106(12):3090-3098. PMID: 30194710.
    Citations: 1     Fields:    Translation:AnimalsCells
  45. Yazdani M, Chen X, Tashbayev B, Utheim ØA, Ræder S, Lagali N, Stojanovic A, Dartt DA, Utheim TP. Tear Production Levels and Dry Eye Disease Severity in a Large Norwegian Cohort. Curr Eye Res. 2018 12; 43(12):1465-1470. PMID: 30183390.
    Citations: 3     Fields:    Translation:Humans
  46. García-Posadas L, Hodges RR, Diebold Y, Dartt DA. Context-Dependent Regulation of Conjunctival Goblet Cell Function by Allergic Mediators. Sci Rep. 2018 08 15; 8(1):12162. PMID: 30111832.
    Citations: 12     Fields:    Translation:AnimalsCells
  47. Utheim OA, Lyberg T, Eidet JR, Raeder S, Sehic A, Roald B, Messelt E, de la Paz MF, Dartt DA, Utheim TP. Effect of Transportation on Cultured Limbal Epithelial Sheets for Worldwide Treatment of Limbal Stem Cell Deficiency. Sci Rep. 2018 Jul 12; 8(1):10502. PMID: 30002380.
    Citations: 1     Fields:    Translation:HumansCells
  48. He M, Lippestad M, Li D, Hodges RR, Utheim TP, Dartt DA. Activation of the EGF Receptor by Histamine Receptor Subtypes Stimulates Mucin Secretion in Conjunctival Goblet Cells. Invest Ophthalmol Vis Sci. 2018 07 02; 59(8):3543-3553. PMID: 30025103; PMCID: PMC6049985.
    Citations: 4     Fields:    Translation:AnimalsCells
  49. Lippestad M, Hodges RR, Utheim TP, Serhan CN, Dartt DA. Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca2+ in cultured rat conjunctival goblet cells. Exp Eye Res. 2018 08; 173:64-72. PMID: 29702100.
    Citations: 12     Fields:    Translation:AnimalsCells
  50. Landsend ECS, Utheim ØA, Pedersen HR, Aass HCD, Lagali N, Dartt DA, Baraas RC, Utheim TP. The Level of Inflammatory Tear Cytokines is Elevated in Congenital Aniridia and Associated with Meibomian Gland Dysfunction. Invest Ophthalmol Vis Sci. 2018 04 01; 59(5):2197-2204. PMID: 29801153.
    Citations: 9     Fields:    Translation:Humans
  51. Landsend ECS, Pedersen HR, Utheim ØA, Xiao J, Adil MY, Tashbayev B, Lagali N, Dartt DA, Baraas RC, Utheim TP. Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia. Br J Ophthalmol. 2019 01; 103(1):119-124. PMID: 29519880.
    Citations: 2     Fields:    Translation:Humans
  52. Bhattacharya S, García-Posadas L, Hodges RR, Makarenkova HP, Masli S, Dartt DA. Alteration in nerves and neurotransmitter stimulation of lacrimal gland secretion in the TSP-1-/- mouse model of aqueous deficiency dry eye. Mucosal Immunol. 2018 07; 11(4):1138-1148. PMID: 29445135; PMCID: PMC6030454.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  53. Li D, Hodges RR, Bispo P, Gilmore MS, Gregory-Ksander M, Dartt DA. Neither non-toxigenic Staphylococcus aureus nor commensal S. epidermidi activates NLRP3 inflammasomes in human conjunctival goblet cells. BMJ Open Ophthalmol. 2017; 2(1):e000101. PMID: 29354725; PMCID: PMC5751869.
    Citations: 5     
  54. Lippestad M, Hodges RR, Utheim TP, Serhan CN, Dartt DA. Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways. Invest Ophthalmol Vis Sci. 2017 09 01; 58(11):4530-4544. PMID: 28892824; PMCID: PMC5595227.
    Citations: 18     Fields:    Translation:AnimalsCells
  55. Jackson CJ, Reppe S, Eidet JR, Eide L, Tønseth KA, Bergersen LH, Dartt DA, Griffith M, Utheim TP. Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets. Sci Rep. 2017 08 15; 7(1):8206. PMID: 28811665.
    Citations: 4     Fields:    Translation:HumansCells
  56. Belmonte C, Nichols JJ, Cox SM, Brock JA, Begley CG, Bereiter DA, Dartt DA, Galor A, Hamrah P, Ivanusic JJ, Jacobs DS, McNamara NA, Rosenblatt MI, Stapleton F, Wolffsohn JS. TFOS DEWS II pain and sensation report. Ocul Surf. 2017 07; 15(3):404-437. PMID: 28736339; PMCID: PMC5706540.
    Citations: 139     Fields:    Translation:AnimalsCells
  57. Islam R, Eidet JR, Badian RA, Lippestad M, Messelt E, Griffith M, Dartt DA, Utheim TP. Tissue Harvesting Site and Culture Medium Affect Attachment, Growth, and Phenotype of Ex Vivo Expanded Oral Mucosal Epithelial Cells. Sci Rep. 2017 04 06; 7(1):674. PMID: 28386069.
    Citations: 3     Fields:    Translation:AnimalsCells
  58. Fostad IG, Eidet JR, Lagali NS, Dartt DA, Ræder S, Messelt EB, Utheim TP. Identification of Objective Morphometric Markers of Xerostomia in the Oral Mucosa Epithelium with In Vivo Confocal Microscopy. Microsc Microanal. 2017 02; 23(1):88-96. PMID: 28162126.
    Citations:    Fields:    Translation:HumansCells
  59. English JT, Norris PC, Hodges RR, Dartt DA, Serhan CN. Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics. Prostaglandins Leukot Essent Fatty Acids. 2017 02; 117:17-27. PMID: 28237084; PMCID: PMC5329889.
    Citations: 58     Fields:    Translation:Humans
  60. Hodges RR, Li D, Shatos MA, Serhan CN, Dartt DA. Lipoxin A4 Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells. Sci Rep. 2016 11 08; 6:36124. PMID: 27824117.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  61. He M, Storr-Paulsen T, Wang AL, Ghezzi CE, Wang S, Fullana M, Karamichos D, Utheim TP, Islam R, Griffith M, Islam MM, Hodges RR, Wnek GE, Kaplan DL, Dartt DA. Artificial Polymeric Scaffolds as Extracellular Matrix Substitutes for Autologous Conjunctival Goblet Cell Expansion. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):6134-6146. PMID: 27832279; PMCID: PMC5104422.
    Citations: 6     Fields:    Translation:HumansCells
  62. Shatos MA, Hodges RR, Morinaga M, McNay DE, Islam R, Bhattacharya S, Li D, Turpie B, Makarenkova HP, Masli S, Utheim TP, Dartt DA. Alteration in cellular turnover and progenitor cell population in lacrimal glands from thrombospondin 1-/- mice, a model of dry eye. Exp Eye Res. 2016 Dec; 153:27-41. PMID: 27697548; PMCID: PMC5121046.
    Citations: 8     Fields:    Translation:AnimalsCells
  63. Gromova A, Voronov DA, Yoshida M, Thotakura S, Meech R, Dartt DA, Makarenkova HP. Lacrimal Gland Repair Using Progenitor Cells. Stem Cells Transl Med. 2016 Aug 15. PMID: 27526700.
    Citations:    
  64. Gromova A, Voronov DA, Yoshida M, Thotakura S, Meech R, Dartt DA, Makarenkova HP. Lacrimal Gland Repair Using Progenitor Cells. Stem Cells Transl Med. 2017 01; 6(1):88-98. PMID: 28170196.
    Citations: 19     Fields:    Translation:AnimalsCells
  65. Ryan DS, Bower KS, Sia RK, Shatos MA, Howard RS, Mines MJ, Stutzman RD, Dartt DA. Goblet cell response after photorefractive keratectomy and laser in situ keratomileusis. J Cataract Refract Surg. 2016 08; 42(8):1181-9. PMID: 27531295.
    Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
  66. Hodges RR, Dartt DA. Signaling Pathways of Purinergic Receptors and Their Interactions with Cholinergic and Adrenergic Pathways in the Lacrimal Gland. J Ocul Pharmacol Ther. 2016 10; 32(8):490-497. PMID: 27463365.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  67. Fostad IG, Eidet JR, Utheim TP, Ræder S, Lagali NS, Messelt EB, Dartt DA. Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility. PLoS One. 2016; 11(5):e0155214. PMID: 27148875.
    Citations: 3     Fields:    Translation:Humans
  68. Hodges RR, Li D, Shatos MA, Bair JA, Lippestad M, Serhan CN, Dartt DA. Lipoxin A4 activates ALX/FPR2 receptor to regulate conjunctival goblet cell secretion. Mucosal Immunol. 2017 01; 10(1):46-57. PMID: 27072607; PMCID: PMC5063650.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  69. Utheim TP, Islam R, Fostad IG, Eidet JR, Sehic A, Olstad OK, Dartt DA, Messelt EB, Griffith M, Pasovic L. Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes. PLoS One. 2016; 11(3):e0152526. PMID: 27023475.
    Citations: 5     Fields:    Translation:HumansCells
  70. García-Posadas L, Contreras-Ruiz L, Soriano-Romaní L, Dartt DA, Diebold Y. Conjunctival Goblet Cell Function: Effect of Contact Lens Wear and Cytokines. Eye Contact Lens. 2016 Mar; 42(2):83-90. PMID: 26067396.
    Citations: 8     Fields:    Translation:HumansCells
  71. Eidet JR, Dartt DA, Utheim TP. Concise Review: Comparison of Culture Membranes Used for Tissue Engineered Conjunctival Epithelial Equivalents. J Funct Biomater. 2015 Dec 11; 6(4):1064-84. PMID: 26690486; PMCID: PMC4695911.
    Citations: 10     
  72. Bower KS, Sia RK, Ryan DS, Mines MJ, Dartt DA. Chronic dry eye in photorefractive keratectomy and laser in situ keratomileusis: Manifestations, incidence, and predictive factors. J Cataract Refract Surg. 2015 Dec; 41(12):2624-34. PMID: 26796443.
    Citations: 25     Fields:    Translation:HumansCTClinical Trials
  73. Makarenkova HP, Dartt DA. Myoepithelial Cells: Their Origin and Function in Lacrimal Gland Morphogenesis, Homeostasis, and Repair. Curr Mol Biol Rep. 2015 Sep 01; 1(3):115-123. PMID: 26688786; PMCID: PMC4683023.
    Citations: 24     
  74. García-Posadas L, Hodges RR, Li D, Shatos MA, Storr-Paulsen T, Diebold Y, Dartt DA. Interaction of IFN-? with cholinergic agonists to modulate rat and human goblet cell function. Mucosal Immunol. 2016 Jan; 9(1):206-17. PMID: 26129651; PMCID: PMC4698109.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  75. Islam R, Jackson C, Eidet JR, Messelt EB, Corraya RM, Lyberg T, Griffith M, Dartt DA, Utheim TP. Effect of Storage Temperature on Structure and Function of Cultured Human Oral Keratinocytes. PLoS One. 2015; 10(6):e0128306. PMID: 26052937.
    Citations: 8     Fields:    Translation:HumansCells
  76. Utheim O, Islam R, Lyberg T, Roald B, Eidet JR, de la Paz MF, Dartt DA, Raeder S, Utheim TP. Serum-free and xenobiotic-free preservation of cultured human limbal epithelial cells. PLoS One. 2015; 10(3):e0118517. PMID: 25734654.
    Citations: 11     Fields:    Translation:HumansCells
  77. Dartt DA, Masli S. Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation. Curr Opin Allergy Clin Immunol. 2014 Oct; 14(5):464-70. PMID: 25061855.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  78. Sanderson J, Dartt DA, Trinkaus-Randall V, Pintor J, Civan MM, Delamere NA, Fletcher EL, Salt TE, Grosche A, Mitchell CH. Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland. Exp Eye Res. 2014 Oct; 127:270-9. PMID: 25151301.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  79. Eidet JR, Utheim ØA, Islam R, Lyberg T, Messelt EB, Dartt DA, Utheim TP. The impact of storage temperature on the morphology, viability, cell number and metabolism of cultured human conjunctival epithelium. Curr Eye Res. 2015 Jan; 40(1):30-9. PMID: 24750037.
    Citations: 11     Fields:    Translation:HumansCells
  80. Contreras-Ruiz L, Ryan DS, Sia RK, Bower KS, Dartt DA, Masli S. Polymorphism in THBS1 gene is associated with post-refractive surgery chronic ocular surface inflammation. Ophthalmology. 2014 Jul; 121(7):1389-97. PMID: 24679443.
    Citations: 18     Fields:    Translation:HumansCells
  81. Contreras-Ruiz L, Ghosh-Mitra A, Shatos MA, Dartt DA, Masli S. Modulation of conjunctival goblet cell function by inflammatory cytokines. Mediators Inflamm. 2013; 2013:636812. PMID: 24453426.
    Citations: 41     Fields:    Translation:AnimalsCells
  82. Dartt DA, Willcox MD. Complexity of the tear film: importance in homeostasis and dysfunction during disease. Exp Eye Res. 2013 Dec; 117:1-3. PMID: 24280033.
    Citations: 37     Fields:    Translation:Humans
  83. Stapleton F, Marfurt C, Golebiowski B, Rosenblatt M, Bereiter D, Begley C, Dartt D, Gallar J, Belmonte C, Hamrah P, Willcox M. The TFOS International Workshop on Contact Lens Discomfort: report of the subcommittee on neurobiology. Invest Ophthalmol Vis Sci. 2013 Oct 18; 54(11):TFOS71-97. PMID: 24058137.
    Citations: 29     Fields:    Translation:Humans
  84. McGilligan VE, Gregory-Ksander MS, Li D, Moore JE, Hodges RR, Gilmore MS, Moore TC, Dartt DA. Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells. PLoS One. 2013; 8(9):e74010. PMID: 24040145; PMCID: PMC3769353.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  85. Li D, Shatos MA, Hodges RR, Dartt DA. Role of PKCa activation of Src, PI-3K/AKT, and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2013 Aug 21; 54(8):5661-74. PMID: 23882690.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  86. Hodges RR, Dartt DA. Tear film mucins: front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins. Exp Eye Res. 2013 Dec; 117:62-78. PMID: 23954166.
    Citations: 44     Fields:    Translation:Humans
  87. Engelsvold DH, Utheim TP, Olstad OK, Gonzalez P, Eidet JR, Lyberg T, Trøseid AM, Dartt DA, Raeder S. miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. Exp Eye Res. 2013 Oct; 115:189-98. PMID: 23872359.
    Citations: 30     Fields:    Translation:Humans
  88. Li D, Jiao J, Shatos MA, Hodges RR, Dartt DA. Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2013 Apr 23; 54(4):2872-84. PMID: 23518767.
    Citations: 20     Fields:    Translation:AnimalsCells
  89. Li D, Hodges RR, Jiao J, Carozza RB, Shatos MA, Chiang N, Serhan CN, Dartt DA. Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. Mucosal Immunol. 2013 Nov; 6(6):1119-30. PMID: 23462912; PMCID: PMC3742576.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  90. Saban DR, Calder V, Kuo CH, Reyes NJ, Dartt DA, Ono SJ, Niederkorn JY. New twists to an old story: novel concepts in the pathogenesis of allergic eye disease. Curr Eye Res. 2013 Mar; 38(3):317-30. PMID: 23281793.
    Citations: 15     Fields:    Translation:HumansCells
  91. Li D, Carozza RB, Shatos MA, Hodges RR, Dartt DA. Effect of histamine on Ca(2+)-dependent signaling pathways in rat conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2012 Oct 05; 53(11):6928-38. PMID: 22956601.
    Citations: 19     Fields:    Translation:AnimalsCells
  92. Fostad IG, Eidet JR, Shatos MA, Utheim TP, Utheim OA, Raeder S, Dartt DA. Biopsy harvesting site and distance from the explant affect conjunctival epithelial phenotype ex vivo. Exp Eye Res. 2012 Nov; 104:15-25. PMID: 23022405.
    Citations: 4     Fields:    Translation:AnimalsCells
  93. Hodges RR, Bair JA, Carozza RB, Li D, Shatos MA, Dartt DA. Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion. Exp Eye Res. 2012 Oct; 103:99-113. PMID: 22975404.
    Citations: 30     Fields:    Translation:AnimalsCells
  94. Hayashi D, Li D, Hayashi C, Shatos M, Hodges RR, Dartt DA. Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion. Invest Ophthalmol Vis Sci. 2012 May 17; 53(6):2993-3003. PMID: 22467574.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  95. Eidet JR, Fostad IG, Shatos MA, Utheim TP, Utheim ØA, Raeder S, Dartt DA. Effect of biopsy location and size on proliferative capacity of ex vivo expanded conjunctival tissue. Invest Ophthalmol Vis Sci. 2012 May 14; 53(6):2897-903. PMID: 22491407.
    Citations: 9     Fields:    Translation:AnimalsCells
  96. Shatos MA, Haugaard-Kedstrom L, Hodges RR, Dartt DA. Isolation and characterization of progenitor cells in uninjured, adult rat lacrimal gland. Invest Ophthalmol Vis Sci. 2012 May 14; 53(6):2749-59. PMID: 22427571.
    Citations: 27     Fields:    Translation:AnimalsCells
  97. Ohtomo K, Shatos MA, Vrouvlianis J, Li D, Hodges RR, Dartt DA. Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells. Invest Ophthalmol Vis Sci. 2011 Dec 16; 52(13):9503-15. PMID: 22039237.
    Citations: 20     Fields:    Translation:AnimalsCells
  98. Eidet JR, Utheim OA, Raeder S, Dartt DA, Lyberg T, Carreras E, Huynh TT, Messelt EB, Louch WE, Roald B, Utheim TP. Effects of serum-free storage on morphology, phenotype, and viability of ex vivo cultured human conjunctival epithelium. Exp Eye Res. 2012 Jan; 94(1):109-16. PMID: 22154551.
    Citations: 18     Fields:    Translation:HumansCells
  99. Moore JE, Vasey GT, Dartt DA, McGilligan VE, Atkinson SD, Grills C, Lamey PJ, Leccisotti A, Frazer DG, Moore TC. Effect of tear hyperosmolarity and signs of clinical ocular surface pathology upon conjunctival goblet cell function in the human ocular surface. Invest Ophthalmol Vis Sci. 2011 Aug 03; 52(9):6174-80. PMID: 21519030.
    Citations: 14     Fields:    Translation:HumansCells
  100. Dartt DA, Hodges RR. Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion. Invest Ophthalmol Vis Sci. 2011 Jul 29; 52(8):5720-9. PMID: 21685341.
    Citations: 7     Fields:    Translation:AnimalsCells
  101. Dartt DA. Tear lipocalin: structure and function. Ocul Surf. 2011 Jul; 9(3):126-38. PMID: 21791187.
    Citations: 38     Fields:    Translation:HumansCells
  102. Hodges RR, Vrouvlianis J, Scott R, Dartt DA. Identification of P2X3 and P2X7 purinergic receptors activated by ATP in rat lacrimal gland. Invest Ophthalmol Vis Sci. 2011 May 17; 52(6):3254-63. PMID: 21421865.
    Citations: 15     Fields:    Translation:Animals
  103. Dartt DA, Hodges RR. Cholinergic agonists activate P2X7 receptors to stimulate protein secretion by the rat lacrimal gland. Invest Ophthalmol Vis Sci. 2011 May 01; 52(6):3381-90. PMID: 21421880.
    Citations: 17     Fields:    Translation:AnimalsCells
  104. Hodges RR, Guilbert E, Shatos MA, Natarajan V, Dartt DA. Phospholipase D1, but not D2, regulates protein secretion via Rho/ROCK in a Ras/Raf-independent, MEK-dependent manner in rat lacrimal gland. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2199-210. PMID: 21212180.
    Citations: 6     Fields:    Translation:Animals
  105. Dartt DA, Hodges RR, Li D, Shatos MA, Lashkari K, Serhan CN. Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. J Immunol. 2011 Apr 01; 186(7):4455-66. PMID: 21357260; PMCID: PMC3532815.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  106. Funaki C, Hodges RR, Dartt DA. Identification of the Raf-1 signaling pathway used by cAMP to inhibit p42/p44 MAPK in rat lacrimal gland acini: role in potentiation of protein secretion. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12):6321-8. PMID: 20671279.
    Citations: 10     Fields:    Translation:AnimalsCells
  107. Turpie B, Yoshimura T, Gulati A, Rios JD, Dartt DA, Masli S. Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice. Am J Pathol. 2009 Sep; 175(3):1136-47. PMID: 19700744; PMCID: PMC2731132.
    Citations: 64     Fields:    Translation:AnimalsCells
  108. Hodges RR, Vrouvlianis J, Shatos MA, Dartt DA. Characterization of P2X7 purinergic receptors and their function in rat lacrimal gland. Invest Ophthalmol Vis Sci. 2009 Dec; 50(12):5681-9. PMID: 19608535.
    Citations: 16     Fields:    Translation:AnimalsCells
  109. Dartt DA. Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases. Prog Retin Eye Res. 2009 May; 28(3):155-77. PMID: 19376264.
    Citations: 143     Fields:    Translation:HumansAnimalsCells
  110. Shatos MA, Hodges RR, Bair JA, Lashkari K, Dartt DA. Stimulatory role of PKCalpha in extracellular regulated kinase 1/2 pathway in conjunctival goblet cell proliferation. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1619-25. PMID: 19074803.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  111. Rocha EM, Alves M, Rios JD, Dartt DA. The aging lacrimal gland: changes in structure and function. Ocul Surf. 2008 Oct; 6(4):162-74. PMID: 18827949.
    Citations: 39     Fields:    Translation:Humans
  112. Shatos MA, Hodges RR, Oshi Y, Bair JA, Zoukhri D, Kublin C, Lashkari K, Dartt DA. Role of cPKCalpha and nPKCepsilon in EGF-stimulated goblet cell proliferation. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):614-20. PMID: 18824739; PMCID: PMC2692670.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  113. Moore JE, Graham JE, Goodall EA, Dartt DA, Leccisotti A, McGilligan VE, Moore TC. Concordance between common dry eye diagnostic tests. Br J Ophthalmol. 2009 Jan; 93(1):66-72. PMID: 18782801.
    Citations: 15     Fields:    Translation:Humans
  114. Shatos MA, Gu J, Hodges RR, Lashkari K, Dartt DA. ERK/p44p42 mitogen-activated protein kinase mediates EGF-stimulated proliferation of conjunctival goblet cells in culture. Invest Ophthalmol Vis Sci. 2008 Aug; 49(8):3351-9. PMID: 18421078.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  115. Ríos JD, Shatos MA, Urashima H, Dartt DA. Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells. Exp Eye Res. 2008 Apr; 86(4):629-36. PMID: 18295205.
    Citations: 14     Fields:    Translation:AnimalsCells
  116. Konomi K, Chen LL, Tarko RS, Scally A, Schaumberg DA, Azar D, Dartt DA. Preoperative characteristics and a potential mechanism of chronic dry eye after LASIK. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):168-74. PMID: 18172089.
    Citations: 27     Fields:    Translation:HumansCells
  117. Graham JE, Moore JE, Jiru X, Moore JE, Goodall EA, Dooley JS, Hayes VE, Dartt DA, Downes CS, Moore TC. Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5616-23. PMID: 18055811.
    Citations: 103     Fields:    Translation:HumansCells
  118. Gu J, Chen L, Shatos MA, Rios JD, Gulati A, Hodges RR, Dartt DA. Presence of EGF growth factor ligands and their effects on cultured rat conjunctival goblet cell proliferation. Exp Eye Res. 2008 Feb; 86(2):322-34. PMID: 18155194; PMCID: PMC2547492.
    Citations: 19     Fields:    Translation:AnimalsCells
  119. Hodges RR, Horikawa Y, Rios JD, Shatos MA, Dartt DA. Effect of protein kinase C and Ca(2+) on p42/p44 MAPK, Pyk2, and Src activation in rat conjunctival goblet cells. Exp Eye Res. 2007 Dec; 85(6):836-44. PMID: 17919561.
    Citations: 14     Fields:    Translation:AnimalsCells
  120. Funaki C, Hodges RR, Dartt DA. Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland. Am J Physiol Cell Physiol. 2007 Nov; 293(5):C1551-60. PMID: 17687004.
    Citations: 10     Fields:    Translation:AnimalsCells
  121. Collins JF, Dartt DA, Dana R. Mist delivery of eye medication to the anterior segment. Am J Ophthalmol. 2007 Jul; 144(1):137-9. PMID: 17601439.
    Citations: 1     Fields:    Translation:Humans
  122. Ríos JD, Ghinelli E, Gu J, Hodges RR, Dartt DA. Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation. Invest Ophthalmol Vis Sci. 2007 Apr; 48(4):1543-51. PMID: 17389483.
    Citations: 11     Fields:    Translation:AnimalsCells
  123. Diebold Y, Chen LL, Tepavcevic V, Ferdman D, Hodges RR, Dartt DA. Lymphocytic infiltration and goblet cell marker alteration in the conjunctiva of the MRL/MpJ-Fas(lpr) mouse model of Sjögren's syndrome. Exp Eye Res. 2007 Mar; 84(3):500-12. PMID: 17208228.
    Citations: 8     Fields:    Translation:AnimalsCells
  124. Hodges RR, Rios JD, Vrouvlianis J, Ota I, Zoukhri D, Dartt DA. Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK. Invest Ophthalmol Vis Sci. 2006 Aug; 47(8):3352-9. PMID: 16877402.
    Citations: 8     Fields:    Translation:AnimalsCells
  125. Chen L, Hodges RR, Funaki C, Zoukhri D, Gaivin RJ, Perez DM, Dartt DA. Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells. Am J Physiol Cell Physiol. 2006 Nov; 291(5):C946-56. PMID: 16760267; PMCID: PMC2151204.
    Citations: 20     Fields:    Translation:AnimalsCells
  126. Ríos JD, Shatos M, Urashima H, Tran H, Dartt DA. OPC-12759 increases proliferation of cultured rat conjunctival goblet cells. Cornea. 2006 Jun; 25(5):573-81. PMID: 16783146.
    Citations: 15     Fields:    Translation:AnimalsCells
  127. Hodges RR, Shatos MA, Tarko RS, Vrouvlianis J, Gu J, Dartt DA. Nitric oxide and cGMP mediate alpha1D-adrenergic receptor-Stimulated protein secretion and p42/p44 MAPK activation in rat lacrimal gland. Invest Ophthalmol Vis Sci. 2005 Aug; 46(8):2781-9. PMID: 16043851; PMCID: PMC1373785.
    Citations: 15     Fields:    Translation:AnimalsCells
  128. Jerdeva GV, Yarber FA, Trousdale MD, Rhodes CJ, Okamoto CT, Dartt DA, Hamm-Alvarez SF. Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68. PMID: 15930141; PMCID: PMC1414898.
    Citations: 13     Fields:    Translation:Animals
  129. Ríos JD, Horikawa Y, Chen LL, Kublin CL, Hodges RR, Dartt DA, Zoukhri D. Age-dependent alterations in mouse exorbital lacrimal gland structure, innervation and secretory response. Exp Eye Res. 2005 Apr; 80(4):477-91. PMID: 15781275; PMCID: PMC3243076.
    Citations: 41     Fields:    Translation:AnimalsCells
  130. Chen LL, Johansson JK, Hodges RR, Zoukhri D, Ghinelli E, Rios JD, Dartt DA. Differential effects of the EGF family of growth factors on protein secretion, MAPK activation, and intracellular calcium concentration in rat lacrimal gland. Exp Eye Res. 2005 Mar; 80(3):379-89. PMID: 15721620.
    Citations: 7     Fields:    Translation:Animals
  131. Jiao J, Huang X, Feit-Leithman RA, Neve RL, Snider W, Dartt DA, Chen DF. Bcl-2 enhances Ca(2+) signaling to support the intrinsic regenerative capacity of CNS axons. EMBO J. 2005 Mar 09; 24(5):1068-78. PMID: 15719013; PMCID: PMC554135.
    Citations: 46     Fields:    Translation:AnimalsCells
  132. Hodges RR, Raddassi I, Zoukhri D, Toker A, Kazlauskas A, Dartt DA. Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):3974-81. PMID: 15505044.
    Citations: 9     Fields:    Translation:AnimalsCells
  133. Dartt DA. Dysfunctional neural regulation of lacrimal gland secretion and its role in the pathogenesis of dry eye syndromes. Ocul Surf. 2004 Apr; 2(2):76-91. PMID: 17216081.
    Citations: 25     Fields:    
  134. Dartt DA. Interaction of EGF family growth factors and neurotransmitters in regulating lacrimal gland secretion. Exp Eye Res. 2004 Mar; 78(3):337-45. PMID: 15106911.
    Citations: 14     Fields:    Translation:HumansCells
  135. Usui T, Ishida S, Yamashiro K, Kaji Y, Poulaki V, Moore J, Moore T, Amano S, Horikawa Y, Dartt D, Golding M, Shima DT, Adamis AP. VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2. Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):368-74. PMID: 14744874.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  136. Dartt DA. Control of mucin production by ocular surface epithelial cells. Exp Eye Res. 2004 Feb; 78(2):173-85. PMID: 14729350.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  137. Sohn UD, Park JH, Lee TS, Shin CY, Jeong JH, Kim JH, Je HD, Dartt DA, Zoukhri D, Choi HC, Lee KY. Differential regulation by Ca(2+) of calmodulin- and PKC-dependent contractile pathways in cat lower oesophageal sphincter. Auton Autacoid Pharmacol. 2003 Oct-Dec; 23(5-6):307-17. PMID: 15255815.
    Citations: 1     Fields:    Translation:AnimalsCells
  138. Lee-Kwon W, Kim JH, Choi JW, Kawano K, Cha B, Dartt DA, Zoukhri D, Donowitz M. Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes. Am J Physiol Cell Physiol. 2003 Dec; 285(6):C1527-36. PMID: 12954600.
    Citations: 47     Fields:    Translation:AnimalsCells
  139. Ghinelli E, Johansson J, Ríos JD, Chen LL, Zoukhri D, Hodges RR, Dartt DA. Presence and localization of neurotrophins and neurotrophin receptors in rat lacrimal gland. Invest Ophthalmol Vis Sci. 2003 Aug; 44(8):3352-7. PMID: 12882781.
    Citations: 14     Fields:    Translation:Animals
  140. Shatos MA, Ríos JD, Horikawa Y, Hodges RR, Chang EL, Bernardino CR, Rubin PA, Dartt DA. Isolation and characterization of cultured human conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2477-86. PMID: 12766046.
    Citations: 42     Fields:    Translation:HumansCells
  141. Horikawa Y, Shatos MA, Hodges RR, Zoukhri D, Rios JD, Chang EL, Bernardino CR, Rubin PA, Dartt DA. Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2535-44. PMID: 12766054.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  142. Tepavcevic V, Hodges RR, Zoukhri D, Dartt DA. Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland. Invest Ophthalmol Vis Sci. 2003 Mar; 44(3):1075-81. PMID: 12601032.
    Citations: 9     Fields:    Translation:AnimalsCells
  143. Joussen AM, Poulaki V, Mitsiades N, Stechschulte SU, Kirchhof B, Dartt DA, Fong GH, Rudge J, Wiegand SJ, Yancopoulos GD, Adamis AP. VEGF-dependent conjunctivalization of the corneal surface. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):117-23. PMID: 12506063.
    Citations: 23     Fields:    Translation:AnimalsCells
  144. Hodges RR, Dartt DA. Regulatory pathways in lacrimal gland epithelium. Int Rev Cytol. 2003; 231:129-96. PMID: 14713005.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  145. Kanno H, Horikawa Y, Hodges RR, Zoukhri D, Shatos MA, Rios JD, Dartt DA. Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C988-98. PMID: 12620895.
    Citations: 39     Fields:    Translation:AnimalsCells
  146. Xu KP, Dartt DA, Yu FS. EGF-induced ERK phosphorylation independent of PKC isozymes in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2002 Dec; 43(12):3673-9. PMID: 12454035.
    Citations: 10     Fields:    Translation:HumansCells
  147. Dartt DA. Regulation of mucin and fluid secretion by conjunctival epithelial cells. Prog Retin Eye Res. 2002 Nov; 21(6):555-76. PMID: 12433377.
    Citations: 47     Fields:    Translation:AnimalsCells
  148. Ota I, Zoukhri D, Hodges RR, Rios JD, Tepavcevic V, Raddassi I, Chen LL, Dartt DA. Alpha 1-adrenergic and cholinergic agonists activate MAPK by separate mechanisms to inhibit secretion in lacrimal gland. Am J Physiol Cell Physiol. 2003 Jan; 284(1):C168-78. PMID: 12388118.
    Citations: 17     Fields:    Translation:AnimalsCells
  149. Hodges RR, Kazlauskas A, Toker A, Dartt DA. Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion. Adv Exp Med Biol. 2002; 506(Pt A):237-41. PMID: 12613914.
    Citations: 1     Fields:    Translation:AnimalsCells
  150. Dartt DA, Kanno H, Rios J, Zoukhri D. Role of mitogen-activated protein kinase in cholinergic stimulation of conjunctival goblet cell secretion. Adv Exp Med Biol. 2002; 506(Pt A):297-300. PMID: 12613923.
    Citations: 1     Fields:    Translation:AnimalsCells
  151. Shatos MA, Kano H, Rubin P, Garza G, Dartt DA. Isolation and characterization of human goblet cells in vitro: regulation of proliferation and activation of mitogen-activated protein kinase by EGF and carbachol. Adv Exp Med Biol. 2002; 506(Pt A):301-5. PMID: 12613924.
    Citations: 2     Fields:    Translation:HumansCells
  152. Ríos JD, Ferdman D, Tepavcevic V, Hodges R, Zoukhri D, Dartt DA. Role of Ca2+ and protein kinase C in cholinergic, and alpha1-adrenergic agonists and EGF stimulated mitogen-activated protein kinase activity in lacrimal gland. Adv Exp Med Biol. 2002; 506(Pt A):185-90. PMID: 12613906.
    Citations:    Fields:    Translation:AnimalsCells
  153. Dartt DA. Regulation of lacrimal gland secretion by neurotransmitters and the EGF family of growth factors. Exp Eye Res. 2001 Dec; 73(6):741-52. PMID: 11846506.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  154. Diebold Y, Ríos JD, Hodges RR, Rawe I, Dartt DA. Presence of nerves and their receptors in mouse and human conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2001 Sep; 42(10):2270-82. PMID: 11527940.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  155. Xu KP, Zoukhri D, Zieske JD, Dartt DA, Sergheraert C, Loing E, Yu FS. A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C603-14. PMID: 11443060.
    Citations: 8     Fields:    Translation:HumansCells
  156. Ang RT, Dartt DA, Tsubota K. Dry eye after refractive surgery. Curr Opin Ophthalmol. 2001 Aug; 12(4):318-22. PMID: 11507347.
    Citations: 36     Fields:    Translation:Humans
  157. Shatos MA, Rios JD, Tepavcevic V, Kano H, Hodges R, Dartt DA. Isolation, characterization, and propagation of rat conjunctival goblet cells in vitro. Invest Ophthalmol Vis Sci. 2001 Jun; 42(7):1455-64. PMID: 11381047.
    Citations: 40     Fields:    Translation:AnimalsCells
  158. Dartt DA, Rios JD, Kanno H, Rawe IM, Zieske JD, Ralda N, Hodges RR, Zoukhri D, Rios JR. Regulation of conjunctival goblet cell secretion by Ca(2+)and protein kinase C. Exp Eye Res. 2000 Dec; 71(6):619-28. PMID: 11095914.
    Citations: 14     Fields:    Translation:AnimalsCells
  159. Graham MA, Rawe I, Dartt DA, Joyce NC. Protein kinase C regulation of corneal endothelial cell proliferation and cell cycle. Invest Ophthalmol Vis Sci. 2000 Dec; 41(13):4124-32. PMID: 11095605.
    Citations: 6     Fields:    Translation:AnimalsCells
  160. Ríos JD, Forde K, Diebold Y, Lightman J, Zieske JD, Dartt DA. Development of conjunctival goblet cells and their neuroreceptor subtype expression. Invest Ophthalmol Vis Sci. 2000 Jul; 41(8):2127-37. PMID: 10892854.
    Citations: 10     Fields:    Translation:AnimalsCells
  161. Zoukhri D, Hodges RR, Sergheraert C, Dartt DA. Cholinergic-induced Ca2+ elevation in rat lacrimal gland acini is negatively modulated by PKCdelta and PKCepsilon. Invest Ophthalmol Vis Sci. 2000 Feb; 41(2):386-92. PMID: 10670466.
    Citations: 7     Fields:    Translation:AnimalsCells
  162. Thiam K, Loing E, Zoukhri D, Rommens C, Hodges R, Dartt D, Verwaerde C, Auriault C, Gras-Masse H, Sergheraert C. Direct evidence of cytoplasmic delivery of PKC-alpha, -epsilon and -zeta pseudosubstrate lipopeptides: study of their implication in the induction of apoptosis. FEBS Lett. 1999 Oct 15; 459(3):285-90. PMID: 10526151.
    Citations: 3     Fields:    Translation:HumansCells
  163. Ríos JD, Zoukhri D, Rawe IM, Hodges RR, Zieske JD, Dartt DA. Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulating goblet cell secretion. Invest Ophthalmol Vis Sci. 1999 May; 40(6):1102-11. PMID: 10235543.
    Citations: 34     Fields:    Translation:AnimalsCells
  164. Zoukhri D, Hodges RR, Dartt DA. Lacrimal gland innervation is not altered with the onset and progression of disease in a murine model of Sjögren's syndrome. Clin Immunol Immunopathol. 1998 Nov; 89(2):126-33. PMID: 9787114.
    Citations: 13     Fields:    Translation:AnimalsCells
  165. Zoukhri D, Hodges RR, Rawe IM, Dartt DA. Ca2+ signaling by cholinergic and alpha1-adrenergic agonists is up-regulated in lacrimal and submandibular glands in a murine model of Sjögren's syndrome. Clin Immunol Immunopathol. 1998 Nov; 89(2):134-40. PMID: 9787115.
    Citations: 12     Fields:    Translation:AnimalsCells
  166. Zoukhri D, Hodges RR, Sergheraert C, Dartt DA. Lacrimal gland functions are differentially controlled by protein kinase C isoforms. Ann N Y Acad Sci. 1998 Apr 15; 842:217-20. PMID: 9599315.
    Citations: 1     Fields:    Translation:Animals
  167. Zoukhri D, Hodges RR, Sergheraert C, Dartt DA. Protein kinase C isoforms differentially control lacrimal gland functions. Adv Exp Med Biol. 1998; 438:181-6. PMID: 9634884.
    Citations: 3     Fields:    Translation:Animals
  168. Dartt DA, Hodges RR, Zoukhri D. Signal transduction pathways activated by cholinergic and alpha 1-adrenergic agonists in the lacrimal gland. Adv Exp Med Biol. 1998; 438:113-21. PMID: 9634873.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  169. Hodges RR, Zoukhri D, Lightman JP, Dartt DA. Identification and cellular localization of the components of the VIP signaling pathway in the lacrimal gland. Adv Exp Med Biol. 1998; 438:169-76. PMID: 9634882.
    Citations: 4     Fields:    Translation:AnimalsCells
  170. Zoukhri D, Hodges RR, Willert S, Dartt DA. Immunolocalization of lacrimal gland PKC isoforms. Effect of phorbol esters and cholinergic agonists on their cellular distribution. J Membr Biol. 1997 May 15; 157(2):169-75. PMID: 9151658.
    Citations: 9     Fields:    Translation:Animals
  171. Sohn UD, Zoukhri D, Dartt D, Sergheraert C, Harnett KM, Behar J, Biancani P. Different protein kinase C isozymes mediate lower esophageal sphincter tone and phasic contraction of esophageal circular smooth muscle. Mol Pharmacol. 1997 Mar; 51(3):462-70. PMID: 9058601.
    Citations: 8     Fields:    Translation:Animals
  172. Hodges RR, Zoukhri D, Sergheraert C, Zieske JD, Dartt DA. Identification of vasoactive intestinal peptide receptor subtypes in the lacrimal gland and their signal-transducing components. Invest Ophthalmol Vis Sci. 1997 Mar; 38(3):610-9. PMID: 9071214.
    Citations: 18     Fields:    Translation:AnimalsCells