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Jeremy Michael Van Raamsdonk, Ph.D.


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  1. R21AG058241 (MOORE, DARREN JOHN) Dec 1, 2017 - Nov 30, 2019
    Developing novel treatments for Parkinson's disease by targeting molecular pathways that have been shown to modulate aging
    Role: Principal Investigator
  2. R01GM121756 (VAN RAAMSDONK, JEREMY MICHAEL) Jan 1, 2017 - Dec 31, 2022
    Molecular mechanisms by which mild elevation of mitochondrial superoxide extends lifespan
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Traa A, Machiela E, Rudich PD, Soo SK, Senchuk MM, Van Raamsdonk JM. Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation. Int J Mol Sci. 2021 Dec 14; 22(24). PMID: 34948242.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Soo SK, Van Raamsdonk JM. High confidence ATFS-1 target genes for quantifying activation of the mitochondrial unfolded protein response. MicroPubl Biol. 2021; 2021. PMID: 34693215.
  3. Campos JC, Wu Z, Rudich PD, Soo SK, Mistry M, Ferreira JC, Blackwell TK, Van Raamsdonk JM. Mild mitochondrial impairment enhances innate immunity and longevity through ATFS-1 and p38 signaling. EMBO Rep. 2021 12 06; 22(12):e52964. PMID: 34617666.
    Citations: 5     Fields:    
  4. Machiela E, Rudich PD, Traa A, Anglas U, Soo SK, Senchuk MM, Van Raamsdonk JM. Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington's Disease. Aging Dis. 2021 Oct; 12(7):1753-1772. PMID: 34631219.
    Citations: 1     
  5. Soo SK, Traa A, Rudich PD, Mistry M, Van Raamsdonk JM. Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors. Life Sci Alliance. 2021 12; 4(12). PMID: 34583931.
    Citations: 2     Fields:    
  6. Shields HJ, Traa A, Van Raamsdonk JM. Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies. Front Cell Dev Biol. 2021; 9:628157. PMID: 33644065.
    Citations: 15     
  7. Senchuk MM, Van Raamsdonk JM, Moore DJ. Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease. Neurobiol Dis. 2021 04; 151:105267. PMID: 33450392.
    Citations:    Fields:    Translation:Animals
  8. Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, Friguet B, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Gut P, Ivanchenko M, Legault V, Lemaître JF, Liontis T, Liu GH, Liu M, Maier AB, Nóbrega OT, Olde Rikkert MGM, Pawelec G, Rheault S, Senior AM, Simm A, Soo S, Traa A, Ukraintseva S, Vanhaelen Q, Van Raamsdonk JM, Witkowski JM, Yashin AI, Ziman R, Fülöp T. Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mech Ageing Dev. 2020 10; 191:111316. PMID: 32693105.
    Citations: 12     Fields:    Translation:Humans
  9. Soo SK, Rudich PD, Traa A, Harris-Gauthier N, Shields HJ, Van Raamsdonk JM. Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders. Mech Ageing Dev. 2020 09; 190:111297. PMID: 32610099.
    Citations: 7     Fields:    Translation:Humans
  10. Machiela E, Liontis T, Dues DJ, Rudich PD, Traa A, Wyman L, Kaufman C, Cooper JF, Lew L, Nadarajan S, Senchuk MM, Van Raamsdonk JM. Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways. FASEB J. 2020 06; 34(6):8475-8492. PMID: 32385951.
    Citations: 6     Fields:    Translation:AnimalsCells
  11. Dues DJ, Andrews EK, Senchuk MM, Van Raamsdonk JM. Resistance to Stress Can Be Experimentally Dissociated From Longevity. J Gerontol A Biol Sci Med Sci. 2019 07 12; 74(8):1206-1214. PMID: 30247515.
    Citations: 12     Fields:    Translation:Animals
  12. Wu Z, Senchuk MM, Dues DJ, Johnson BK, Cooper JF, Lew L, Machiela E, Schaar CE, DeJonge H, Blackwell TK, Van Raamsdonk JM. Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways. BMC Biol. 2018 12 18; 16(1):147. PMID: 30563508.
    Citations: 32     Fields:    Translation:AnimalsCells
  13. Cooper JF, Spielbauer KK, Senchuk MM, Nadarajan S, Colaiácovo MP, Van Raamsdonk JM. a-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease. Exp Neurol. 2018 12; 310:58-69. PMID: 30194957.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  14. Senchuk MM, Dues DJ, Schaar CE, Johnson BK, Madaj ZB, Bowman MJ, Winn ME, Van Raamsdonk JM. Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans. PLoS Genet. 2018 03; 14(3):e1007268. PMID: 29522556.
    Citations: 39     Fields:    Translation:AnimalsCells
  15. Cooper JF, Van Raamsdonk JM. Modeling Parkinson's Disease in C. elegans. J Parkinsons Dis. 2018; 8(1):17-32. PMID: 29480229.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  16. Cooper JF, Machiela E, Dues DJ, Spielbauer KK, Senchuk MM, Van Raamsdonk JM. Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson's disease models. Sci Rep. 2017 11 27; 7(1):16441. PMID: 29180793.
    Citations: 34     Fields:    Translation:AnimalsCells
  17. Tyson T, Senchuk M, Cooper JF, George S, Van Raamsdonk JM, Brundin P. Novel animal model defines genetic contributions for neuron-to-neuron transfer of a-synuclein. Sci Rep. 2017 08 08; 7(1):7506. PMID: 28790319.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  18. Van Raamsdonk JM. Mechanisms underlying longevity: A genetic switch model of aging. Exp Gerontol. 2018 07 01; 107:136-139. PMID: 28797825.
    Citations: 6     Fields:    Translation:HumansAnimals
  19. Dues DJ, Schaar CE, Johnson BK, Bowman MJ, Winn ME, Senchuk MM, Van Raamsdonk JM. Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans. Free Radic Biol Med. 2017 07; 108:362-373. PMID: 28392283.
    Citations: 25     Fields:    Translation:AnimalsCells
  20. Van Raamsdonk JM, Vega IE, Brundin P. Oxidative stress in neurodegenerative disease: causation or association? Oncotarget. 2017 Feb 14; 8(7):10777-10778. PMID: 28099897.
    Citations: 10     Fields:    Translation:HumansAnimals
  21. Senchuk MM, Dues DJ, Van Raamsdonk JM. Measuring Oxidative Stress in Caenorhabditis elegans: Paraquat and Juglone Sensitivity Assays. Bio Protoc. 2017 Jan 05; 7(1). PMID: 29276721.
    Citations: 17     
  22. Ghosh A, Tyson T, George S, Hildebrandt EN, Steiner JA, Madaj Z, Schulz E, Machiela E, McDonald WG, Escobar Galvis ML, Kordower JH, Van Raamsdonk JM, Colca JR, Brundin P. Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease. Sci Transl Med. 2016 12 07; 8(368):368ra174. PMID: 27928028.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  23. Machiela E, Dues DJ, Senchuk MM, Van Raamsdonk JM. Oxidative stress is increased in C. elegans models of Huntington's disease but does not contribute to polyglutamine toxicity phenotypes. Neurobiol Dis. 2016 Dec; 96:1-11. PMID: 27544481.
    Citations: 23     Fields:    Translation:AnimalsCells
  24. Dues DJ, Andrews EK, Schaar CE, Bergsma AL, Senchuk MM, Van Raamsdonk JM. Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways. Aging (Albany NY). 2016 04; 8(4):777-95. PMID: 27053445.
    Citations: 38     Fields:    Translation:AnimalsCells
  25. Cooper JF, Dues DJ, Spielbauer KK, Machiela E, Senchuk MM, Van Raamsdonk JM. Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models. NPJ Parkinsons Dis. 2015; 1:15022. PMID: 28725688.
    Citations: 38     
  26. Van Raamsdonk JM. Levels and location are crucial in determining the effect of ROS on lifespan. Worm. 2015 Oct-Dec; 4(4):e1094607. PMID: 27123369.
    Citations: 6     
  27. Schaar CE, Dues DJ, Spielbauer KK, Machiela E, Cooper JF, Senchuk M, Hekimi S, Van Raamsdonk JM. Mitochondrial and cytoplasmic ROS have opposing effects on lifespan. PLoS Genet. 2015 Feb; 11(2):e1004972. PMID: 25671321.
    Citations: 82     Fields:    Translation:AnimalsCells
  28. Van Raamsdonk JM, Hekimi S. Superoxide dismutase is dispensable for normal animal lifespan. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5785-90. PMID: 22451939.
    Citations: 131     Fields:    Translation:AnimalsCells
  29. Van Raamsdonk JM, Hekimi S. FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1. Mech Ageing Dev. 2011 Oct; 132(10):519-21. PMID: 21893079.
    Citations: 61     Fields:    Translation:Animals
  30. Van Raamsdonk JM, Hekimi S. Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship? Antioxid Redox Signal. 2010 Dec 15; 13(12):1911-53. PMID: 20568954.
    Citations: 90     Fields:    Translation:Animals
  31. Van Raamsdonk JM, Meng Y, Camp D, Yang W, Jia X, Bénard C, Hekimi S. Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage. Genetics. 2010 Jun; 185(2):559-71. PMID: 20382831.
    Citations: 52     Fields:    Translation:AnimalsCells
  32. Van Raamsdonk JM, Hekimi S. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 2009 Feb; 5(2):e1000361. PMID: 19197346.
    Citations: 217     Fields:    Translation:AnimalsCells
  33. Van Raamsdonk JM, Murphy Z, Selva DM, Hamidizadeh R, Pearson J, Petersén A, Björkqvist M, Muir C, Mackenzie IR, Hammond GL, Vogl AW, Hayden MR, Leavitt BR. Testicular degeneration in Huntington disease. Neurobiol Dis. 2007 Jun; 26(3):512-20. PMID: 17433700.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  34. Van Raamsdonk JM, Metzler M, Slow E, Pearson J, Schwab C, Carroll J, Graham RK, Leavitt BR, Hayden MR. Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain. Neurobiol Dis. 2007 Apr; 26(1):189-200. PMID: 17276692.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  35. Van Raamsdonk JM, Pearson J, Murphy Z, Hayden MR, Leavitt BR. Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease. BMC Neurosci. 2006 Dec 05; 7:80. PMID: 17147801.
    Citations: 24     Fields:    Translation:AnimalsCells
  36. Zhang Y, Leavitt BR, van Raamsdonk JM, Dragatsis I, Goldowitz D, MacDonald ME, Hayden MR, Friedlander RM. Huntingtin inhibits caspase-3 activation. EMBO J. 2006 Dec 13; 25(24):5896-906. PMID: 17124493.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  37. Van Raamsdonk JM, Warby SC, Hayden MR. Selective degeneration in YAC mouse models of Huntington disease. Brain Res Bull. 2007 Apr 30; 72(2-3):124-31. PMID: 17352936.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  38. Van Raamsdonk JM, Gibson WT, Pearson J, Murphy Z, Lu G, Leavitt BR, Hayden MR. Body weight is modulated by levels of full-length huntingtin. Hum Mol Genet. 2006 May 01; 15(9):1513-23. PMID: 16571604.
    Citations: 43     Fields:    Translation:Animals
  39. Leavitt BR, van Raamsdonk JM, Shehadeh J, Fernandes H, Murphy Z, Graham RK, Wellington CL, Raymond LA, Hayden MR. Wild-type huntingtin protects neurons from excitotoxicity. J Neurochem. 2006 Feb; 96(4):1121-9. PMID: 16417581.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  40. Van Raamsdonk JM, Murphy Z, Slow EJ, Leavitt BR, Hayden MR. Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease. Hum Mol Genet. 2005 Dec 15; 14(24):3823-35. PMID: 16278236.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  41. Van Raamsdonk JM, Pearson J, Bailey CD, Rogers DA, Johnson GV, Hayden MR, Leavitt BR. Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease. J Neurochem. 2005 Oct; 95(1):210-20. PMID: 16181425.
    Citations: 33     Fields:    Translation:Animals
  42. Van Raamsdonk JM, Pearson J, Rogers DA, Lu G, Barakauskas VE, Barr AM, Honer WG, Hayden MR, Leavitt BR. Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease. Exp Neurol. 2005 Dec; 196(2):266-72. PMID: 16129433.
    Citations: 16     Fields:    Translation:Animals
  43. Pinto JT, Van Raamsdonk JM, Leavitt BR, Hayden MR, Jeitner TM, Thaler HT, Krasnikov BF, Cooper AJ. Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease. J Neurochem. 2005 Aug; 94(4):1087-101. PMID: 15992377.
    Citations: 23     Fields:    Translation:Animals
  44. Van Raamsdonk JM, Pearson J, Slow EJ, Hossain SM, Leavitt BR, Hayden MR. Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease. J Neurosci. 2005 Apr 20; 25(16):4169-80. PMID: 15843620.
    Citations: 107     Fields:    Translation:Animals
  45. Van Raamsdonk JM, Pearson J, Rogers DA, Bissada N, Vogl AW, Hayden MR, Leavitt BR. Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease. Hum Mol Genet. 2005 May 15; 14(10):1379-92. PMID: 15829505.
    Citations: 51     Fields:    Translation:Animals
  46. Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum Mol Genet. 2003 Jul 01; 12(13):1555-67. PMID: 12812983.
    Citations: 337     Fields:    Translation:HumansAnimalsCells
  47. Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. J Neurosci. 2002 Sep 15; 22(18):7862-72. PMID: 12223539.
    Citations: 118     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.