Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Barry Steven Shea, M.D.

Title
Institution
Department
Address

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R21AG065602 (SHEA, BARRY S.) Sep 30, 2019 - May 31, 2021
    NIH
    Fibrin-PET Imaging to Detect Aging Associated Lung Injury in Idiopathic Pulmonary Fibrosis
    Role: Principal Investigator
  2. K08HL105656 (SHEA, BARRY S.) Dec 8, 2010 - Nov 30, 2016
    NIH
    The Role of Sphingosine 1-Phosphate in Lung Injury and Fibrosis
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Peljto AL, Blumhagen RZ, Walts AD, Cardwell J, Powers J, Corte TJ, Dickinson JL, Glaspole I, Moodley YP, Vasakova MK, Bendstrup E, Davidsen JR, Borie R, Crestani B, Dieude P, Bonella F, Costabel U, Gudmundsson G, Donnelly SC, Egan J, Henry MT, Keane MP, Kennedy MP, McCarthy C, McElroy AN, Olaniyi JA, O'Reilly KMA, Richeldi L, Leone PM, Poletti V, Puppo F, Tomassetti S, Luzzi V, Kokturk N, Mogulkoc N, Fiddler CA, Hirani N, Jenkins G, Maher TM, Molyneaux PL, Parfrey H, Braybrooke R, Blackwell TS, Jackson PD, Nathan SD, Porteous MK, Brown KK, Christie JD, Collard HR, Eickelberg O, Foster EE, Gibson KF, Glassberg M, Kass D, Kropski JA, Lederer D, Linderholm AL, Loyd J, Mathai SK, Montesi SB, Noth I, Oldham JM, Palmisciano AJ, Reichner CA, Rojas M, Roman J, Schluger N, Shea BS, Swigris JJ, Wolters PJ, Zhang Y, Prele CMA, Enghelmayer JI, Otaola M, Ryerson CJ, Salinas M, Sterclova M, Gebremariam TH, Myllärniemi M, Carbone R, Furusawa H, Hirose M, Inoue Y, Miyazaki Y, Ohta K, Ohta S, Okamoto T, Kim DS, Pardo A, Selman M, Aranda AU, Park MS, Park JS, Song JW, Molina-Molina M, Planas-Cerezales L, Westergren-Thorsson G, Smith AV, Manichaikul AW, Kim JS, Rich SS, Oelsner EC, Barr RG, Rotter JI, Dupuis J, O'Connor G, Vasan RS, Cho MH, Silverman EK, Schwarz MI, Steele MP, Lee JS, Yang IV, Fingerlin TE, Schwartz DA. Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants. Am J Respir Crit Care Med. 2023 Jan 05. PMID: 36602845.
    Citations: 1     Fields:    
  2. Cao Y, Rudrakshala J, Williams R, Rodriguez S, Sorkhdini P, Yang AX, Mundy M, Yang D, Palmisciano A, Walsh T, Delcompare C, Caine T, Tomasi L, Shea BS, Zhou Y. CRTH2 Mediates Profibrotic Macrophage Differentiation and Promotes Lung Fibrosis. Am J Respir Cell Mol Biol. 2022 08; 67(2):201-214. PMID: 35585756; PMCID: PMC9348565.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  3. Axelsson Raja A, Wakimoto H, DeLaughter DM, Reichart D, Gorham J, Conner DA, Lun M, Probst CK, Sakai N, Knipe RS, Montesi SB, Shea B, Adam LP, Leinwand LA, Wan W, Choi ES, Lindberg EL, Patone G, Noseda M, Hübner N, Seidman CE, Tager AM, Seidman JG, Ho CY. Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model. Proc Natl Acad Sci U S A. 2022 07 12; 119(28):e2204174119. PMID: 35787042; PMCID: PMC9282378.
    Citations: 2     Fields:    Translation:AnimalsCells
  4. Knipe RS, Spinney JJ, Abe EA, Probst CK, Franklin A, Logue A, Giacona F, Drummond M, Griffith J, Brazee PL, Hariri LP, Montesi SB, Black KE, Hla T, Kuo A, Cartier A, Engelbrecht E, Christoffersen C, Shea BS, Tager AM, Medoff BD. Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2022 01; 66(1):38-52. PMID: 34343038; PMCID: PMC8803357.
    Citations: 5     Fields:    Translation:AnimalsCells
  5. Misra AK, Wong NL, Healey TT, Lally EV, Shea BS. Interstitial lung disease is a dominant feature in patients with circulating myositis-specific antibodies. BMC Pulm Med. 2021 Nov 14; 21(1):370. PMID: 34775966; PMCID: PMC8591876.
    Citations: 1     Fields:    Translation:Humans
  6. Hariri LP, Roden AC, Chung JH, Danoff SK, Gomez Manjarres DC, Hartwig M, Kheir F, King C, Kreider M, Lynch DA, Mooney J, Muniappan A, Myers JL, Paoletti L, Raj R, Safdar Z, Suliman S, Thavarajah K, Lederer DJ, Rudell FL, Bianchi P, Shea BS, Ley B. The Role of Surgical Lung Biopsy in the Diagnosis of Fibrotic Interstitial Lung Disease: Perspective from the Pulmonary Fibrosis Foundation. Ann Am Thorac Soc. 2021 10; 18(10):1601-1609. PMID: 34004127.
    Citations: 2     Fields:    Translation:Humans
  7. Munchel JK, Shea BS. Diagnosis and Management of Idiopathic Pulmonary Fibrosis. R I Med J (2013). 2021 Sep 01; 104(7):26-29. PMID: 34437662.
    Citations: 1     Fields:    Translation:Humans
  8. Nahar R, Jain S, Carino G, Shea BS. A Case of Interstitial Pneumonia with Features of Autoimmunity. R I Med J (2013). 2020 Dec 01; 103(10):32-34. PMID: 33261231.
    Citations:    Fields:    Translation:Humans
  9. Mitchell KR, Bomm A, Shea BS, Shemin D, Bayliss G. Inpatient Dialysis Planning During the COVID-19 Pandemic: A Single-Center Experience and Review of the Literature. Int J Nephrol Renovasc Dis. 2020; 13:253-259. PMID: 33116756; PMCID: PMC7585817.
    Citations: 3     
  10. Probst CK, Montesi SB, Medoff BD, Shea BS, Knipe RS. Vascular permeability in the fibrotic lung. Eur Respir J. 2020 07; 56(1). PMID: 32265308; PMCID: PMC9977144.
    Citations: 26     Fields:    Translation:Humans
  11. Moore C, Blumhagen RZ, Yang IV, Walts A, Powers J, Walker T, Bishop M, Russell P, Vestal B, Cardwell J, Markin CR, Mathai SK, Schwarz MI, Steele MP, Lee J, Brown KK, Loyd JE, Crapo JD, Silverman EK, Cho MH, James JA, Guthridge JM, Cogan JD, Kropski JA, Swigris JJ, Bair C, Kim DS, Ji W, Kim H, Song JW, Maier LA, Pacheco KA, Hirani N, Poon AS, Li F, Jenkins RG, Braybrooke R, Saini G, Maher TM, Molyneaux PL, Saunders P, Zhang Y, Gibson KF, Kass DJ, Rojas M, Sembrat J, Wolters PJ, Collard HR, Sundy JS, O'Riordan T, Strek ME, Noth I, Ma SF, Porteous MK, Kreider ME, Patel NB, Inoue Y, Hirose M, Arai T, Akagawa S, Eickelberg O, Fernandez IE, Behr J, Mogulkoc N, Corte TJ, Glaspole I, Tomassetti S, Ravaglia C, Poletti V, Crestani B, Borie R, Kannengiesser C, Parfrey H, Fiddler C, Rassl D, Molina-Molina M, Machahua C, Worboys AM, Gudmundsson G, Isaksson HJ, Lederer DJ, Podolanczuk AJ, Montesi SB, Bendstrup E, Danchel V, Selman M, Pardo A, Henry MT, Keane MP, Doran P, Vašáková M, Sterclova M, Ryerson CJ, Wilcox PG, Okamoto T, Furusawa H, Miyazaki Y, Laurent G, Baltic S, Prele C, Moodley Y, Shea BS, Ohta K, Suzukawa M, Narumoto O, Nathan SD, Venuto DC, Woldehanna ML, Kokturk N, de Andrade JA, Luckhardt T, Kulkarni T, Bonella F, Donnelly SC, McElroy A, Armstong ME, Aranda A, Carbone RG, Puppo F, Beckman KB, Nickerson DA, Fingerlin TE, Schwartz DA. Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 07 15; 200(2):199-208. PMID: 31034279; PMCID: PMC6635791.
    Citations: 49     Fields:    Translation:HumansCells
  12. Montesi SB, Rao R, Liang LL, Goulart HE, Sharma A, Sharma A, Digumarthy SR, Shea BS, Seethamraju RT, Caravan P, Tager AM. Gadofosveset-enhanced lung magnetic resonance imaging to detect ongoing vascular leak in pulmonary fibrosis. Eur Respir J. 2018 05; 51(5). PMID: 29622569; PMCID: PMC6516082.
    Citations: 15     Fields:    Translation:Humans
  13. Knipe RS, Probst CK, Lagares D, Franklin A, Spinney JJ, Brazee PL, Grasberger P, Zhang L, Black KE, Sakai N, Shea BS, Liao JK, Medoff BD, Tager AM. The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 04; 58(4):471-481. PMID: 29211497; PMCID: PMC5894496.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  14. Zhou Y, He CH, Yang DS, Nguyen T, Cao Y, Kamle S, Lee CM, Gochuico BR, Gahl WA, Shea BS, Lee CG, Elias JA. Galectin-3 Interacts with the CHI3L1 Axis and Contributes to Hermansky-Pudlak Syndrome Lung Disease. J Immunol. 2018 03 15; 200(6):2140-2153. PMID: 29427412; PMCID: PMC5839999.
    Citations: 20     Fields:    Translation:AnimalsCells
  15. Marshall DC, Salciccioli JD, Shea BS, Akuthota P. Trends in mortality from idiopathic pulmonary fibrosis in the European Union: an observational study of the WHO mortality database from 2001-2013. Eur Respir J. 2018 01; 51(1). PMID: 29348182.
    Citations: 32     Fields:    Translation:Humans
  16. Shea BS, Opal SM. The Role of S1PR3 in Protection from Bacterial Sepsis. Am J Respir Crit Care Med. 2017 12 15; 196(12):1500-1502. PMID: 28910137.
    Citations: 3     Fields:    Translation:HumansCells
  17. Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel-Pelletier J, Tager AM, Kapoor M. Corrigendum: ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis. Nat Med. 2017 12 07; 23(12):1499. PMID: 29216045.
    Citations: 2     Fields:    
  18. Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel-Pelletier J, Tager AM, Kapoor M. ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis. Nat Med. 2017 Dec; 23(12):1405-1415. PMID: 29058717; PMCID: PMC5720906.
    Citations: 54     Fields:    Translation:AnimalsCells
  19. Shea BS, Probst CK, Brazee PL, Rotile NJ, Blasi F, Weinreb PH, Black KE, Sosnovik DE, Van Cott EM, Violette SM, Caravan P, Tager AM. Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis. JCI Insight. 2017 May 04; 2(9). PMID: 28469072.
    Citations: 31     Fields:    
  20. Black KE, Berdyshev E, Bain G, Castelino FV, Shea BS, Probst CK, Fontaine BA, Bronova I, Goulet L, Lagares D, Ahluwalia N, Knipe RS, Natarajan V, Tager AM. Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis. FASEB J. 2016 06; 30(6):2435-50. PMID: 27006447; PMCID: PMC4871797.
    Citations: 16     Fields:    Translation:Animals
  21. Shea BS, Sharma A, Mark EJ. Case records of the Massachusetts General Hospital. Case 14-2015. A 58-year-old woman with shortness of breath. N Engl J Med. 2015 Apr 30; 372(18):1749-58. PMID: 25923555.
    Citations: 2     Fields:    Translation:Humans
  22. Ahluwalia N, Shea BS, Tager AM. New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses. Am J Respir Crit Care Med. 2014 Oct 15; 190(8):867-78. PMID: 25090037; PMCID: PMC4299574.
    Citations: 102     Fields:    Translation:Humans
  23. Montesi SB, Mathai SK, Brenner LN, Gorshkova IA, Berdyshev EV, Tager AM, Shea BS. Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis. BMC Pulm Med. 2014 Jan 27; 14:5. PMID: 24468008.
    Citations: 22     Fields:    Translation:Humans
  24. Shea BS, Tager AM. Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis. Proc Am Thorac Soc. 2012 Jul; 9(3):102-10. PMID: 22802282.
    Citations: 43     Fields:    Translation:HumansCells
  25. Shea BS, Tager AM. Sphingolipid regulation of tissue fibrosis. Open Rheumatol J. 2012; 6:123-9. PMID: 22802910.
    Citations: 28     
  26. Lagares D, Busnadiego O, García-Fernández RA, Kapoor M, Liu S, Carter DE, Abraham D, Shi-Wen X, Carreira P, Fontaine BA, Shea BS, Tager AM, Leask A, Lamas S, Rodríguez-Pascual F. Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis Rheum. 2012 May; 64(5):1653-64. PMID: 22492165; PMCID: PMC3338902.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  27. Hariri LP, Mino-Kenudson M, Shea B, Digumarthy S, Onozato M, Yagi Y, Fraire AE, Matsubara O, Mark EJ. Distinct histopathology of acute onset or abrupt exacerbation of hypersensitivity pneumonitis. Hum Pathol. 2012 May; 43(5):660-8. PMID: 21855112.
    Citations: 13     Fields:    Translation:Humans
  28. Liu F, Mih JD, Shea BS, Kho AT, Sharif AS, Tager AM, Tschumperlin DJ. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol. 2010 Aug 23; 190(4):693-706. PMID: 20733059.
    Citations: 360     Fields:    Translation:HumansAnimalsCells
  29. Shea BS, Brooks SF, Fontaine BA, Chun J, Luster AD, Tager AM. Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. Am J Respir Cell Mol Biol. 2010 Dec; 43(6):662-73. PMID: 20081052.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  30. Tager AM, LaCamera P, Shea BS, Campanella GS, Selman M, Zhao Z, Polosukhin V, Wain J, Karimi-Shah BA, Kim ND, Hart WK, Pardo A, Blackwell TS, Xu Y, Chun J, Luster AD. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med. 2008 Jan; 14(1):45-54. PMID: 18066075.
    Citations: 317     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Shea's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (148)
Explore
_
Co-Authors (31)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
© 2023 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.