Harvard Catalyst Profiles

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Daniel Perl, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Benjamini D, Priemer DS, Perl DP, Brody DL, Basser PJ. Mapping astrogliosis in the individual human brain using multidimensional MRI. Brain. 2023 Mar 01; 146(3):1212-1226. PMID: 35953450; PMCID: PMC9976979.
    Citations: 2     Fields:    Translation:HumansCells
  2. Iacono D, Murphy EK, Stimpson CD, Leonessa F, Perl DP. Double Blast Wave Primary Effect on Synaptic, Glymphatic, Myelin, Neuronal and Neurovascular Markers. Brain Sci. 2023 Feb 08; 13(2). PMID: 36831830; PMCID: PMC9954059.
  3. Kelly JP, Priemer DS, Perl DP, Filley CM. Sports Concussion and Chronic Traumatic Encephalopathy: Finding a Path Forward. Ann Neurol. 2023 02; 93(2):222-225. PMID: 36504163.
    Citations:    Fields:    Translation:Humans
  4. Lee MH, Perl DP, Steiner J, Pasternack N, Li W, Maric D, Safavi F, Horkayne-Szakaly I, Jones R, Stram MN, Moncur JT, Hefti M, Folkerth RD, Nath A. Reply: The spectrum of complement pathway activation is integral to the pathogenesis of severe COVID-19. Brain. 2022 11 21; 145(11):e118. PMID: 36327115.
    Citations:    Fields:    Translation:HumansCells
  5. Priemer DS, Rhodes CH, Karlovich E, Perl DP, Goldman JE. Aß Deposits in the Neocortex of Adult and Infant Hypoxic Brains, Including in Cases of COVID-19. J Neuropathol Exp Neurol. 2022 11 16; 81(12):988-995. PMID: 36264253.
    Citations:    Fields:    Translation:Humans
  6. Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB. Aß and tau prions feature in the neuropathogenesis of Down syndrome. Proc Natl Acad Sci U S A. 2022 11 16; 119(46):e2212954119. PMID: 36343257; PMCID: PMC9674250.
    Citations: 1     Fields:    Translation:Humans
  7. Lee MH, Perl DP, Steiner J, Pasternack N, Li W, Maric D, Safavi F, Horkayne-Szakaly I, Jones R, Stram MN, Moncur JT, Hefti M, Folkerth RD, Nath A. Neurovascular injury with complement activation and inflammation in COVID-19. Brain. 2022 07 29; 145(7):2555-2568. PMID: 35788639; PMCID: PMC9278212.
    Citations: 17     Fields:    Translation:HumansCells
  8. Priemer DS, Perl DP. A Commentary on "Delayed-Onset Neuropathological Complications From a Foramen Magnum & Occipital Crest Focused Traumatic Brain Injury of the Vietnam War" Parts I, II, and III. Mil Med. 2022 07 01; 187(7-8):938-940. PMID: 34632520.
    Citations:    Fields:    Translation:Humans
  9. Edlow BL, Bodien YG, Baxter T, Belanger HG, Cali RJ, Deary KB, Fischl B, Foulkes AS, Gilmore N, Greve DN, Hooker JM, Huang SY, Kelemen JN, Kimberly WT, Maffei C, Masood M, Perl DP, Polimeni JR, Rosen BR, Tromly SL, Tseng CJ, Yao EF, Zürcher NR, Mac Donald CL, Dams-O'Connor K. Long-Term Effects of Repeated Blast Exposure in United States Special Operations Forces Personnel: A Pilot Study Protocol. J Neurotrauma. 2022 10; 39(19-20):1391-1407. PMID: 35620901; PMCID: PMC9529318.
    Citations:    Fields:    Translation:Humans
  10. Fernández-Castañeda A, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O'Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R, Yalçin B, Taylor KR, Acosta-Alvarez L, Malacon K, Keough MB, Ni L, Woo PJ, Contreras-Esquivel D, Toland AMS, Gehlhausen JR, Klein J, Takahashi T, Silva J, Israelow B, Lucas C, Mao T, Peña-Hernández MA, Tabachnikova A, Homer RJ, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Vogel H, Hefti MM, Perl DP, Liddelow S, Folkerth R, Putrino D, Nath A, Iwasaki A, Monje M. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell. 2022 07 07; 185(14):2452-2468.e16. PMID: 35768006; PMCID: PMC9189143.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  11. Priemer DS, Iacono D, Rhodes CH, Olsen CH, Perl DP. Chronic Traumatic Encephalopathy in the Brains of Military Personnel. N Engl J Med. 2022 06 09; 386(23):2169-2177. PMID: 35675177.
    Citations: 5     Fields:    Translation:Humans
  12. Iacono D, Murphy EK, Sherman PM, Chapapas H, Cerqueira B, Christensen C, Perl DP, Sladky J. High altitude is associated with pTau deposition, neuroinflammation, and myelin loss. Sci Rep. 2022 04 27; 12(1):6839. PMID: 35477957; PMCID: PMC9046305.
    Citations:    Fields:    Translation:AnimalsCells
  13. Ameen-Ali KE, Bretzin A, Lee EB, Folkerth R, Hazrati LN, Iacono D, Keene CD, Kofler J, Kovacs GG, Nolan A, Perl DP, Priemer DS, Smith DH, Wiebe DJ, Stewart W. Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change. Acta Neuropathol Commun. 2022 04 11; 10(1):50. PMID: 35410438; PMCID: PMC8996534.
    Citations: 4     Fields:    Translation:HumansCells
  14. Fernández-Castañeda A, Lu P, Geraghty AC, Song E, Lee MH, Wood J, Yalçin B, Taylor KR, Dutton S, Acosta-Alvarez L, Ni L, Contreras-Esquivel D, Gehlhausen JR, Klein J, Lucas C, Mao T, Silva J, Peña-Hernández MA, Tabachnikova A, Takahashi T, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Hefti M, Perl D, Folkerth R, Putrino D, Nath A, Iwasaki A, Monje M. Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain. bioRxiv. 2022 Jan 10. PMID: 35043113; PMCID: PMC8764721.
  15. Yuh EL, Jain S, Sun X, Pisica D, Harris MH, Taylor SR, Markowitz AJ, Mukherjee P, Verheyden J, Giacino JT, Levin HS, McCrea M, Stein MB, Temkin NR, Diaz-Arrastia R, Robertson CS, Lingsma HF, Okonkwo DO, Maas AIR, Manley GT, Adeoye O, Badjatia N, Boase K, Bodien Y, Corrigan JD, Crawford K, Dikmen S, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson AR, Foreman B, Gardner R, Gaudette E, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Keene CD, Kramer J, Kreitzer N, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Nelson L, Ngwenya LB, Noel F, Nolan A, Palacios E, Perl D, Rabinowitz M, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Toga A, Valadka A, Vassar M, Zafonte R. Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI. JAMA Neurol. 2021 09 01; 78(9):1137-1148. PMID: 34279565; PMCID: PMC8290344.
    Citations: 13     Fields:    Translation:Humans
  16. McCrea MA, Giacino JT, Barber J, Temkin NR, Nelson LD, Levin HS, Dikmen S, Stein M, Bodien YG, Boase K, Taylor SR, Vassar M, Mukherjee P, Robertson C, Diaz-Arrastia R, Okonkwo DO, Markowitz AJ, Manley GT, Adeoye O, Badjatia N, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson AR, Foreman B, Gardner R, Gaudette E, Goldman D, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Keene CD, Korley FK, Kramer J, Kreitzer N, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Ngwenya LB, Noel F, Nolan A, Palacios E, Perl D, Puccio A, Rabinowitz M, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Sherer M, Toga A, Valadka A, Wang K, Yue JK, Yuh E, Zafonte R. Functional Outcomes Over the First Year After Moderate to Severe Traumatic Brain Injury in the Prospective, Longitudinal TRACK-TBI Study. JAMA Neurol. 2021 08 01; 78(8):982-992. PMID: 34228047; PMCID: PMC8261688.
    Citations: 14     Fields:    Translation:Humans
  17. Shively SB, Priemer DS, Stein MB, Perl DP. Pathophysiology of Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Neuropsychiatric Clinical Expression. Psychiatr Clin North Am. 2021 09; 44(3):443-458. PMID: 34373000.
    Citations: 5     Fields:    Translation:Humans
  18. Iacono D, Raiciulescu S, Olsen C, Perl DP. Traumatic Brain Injury Exposure Lowers Age of Cognitive Decline in AD and Non-AD Conditions. Front Neurol. 2021; 12:573401. PMID: 34054681.
    Citations: 5     
  19. Benjamini D, Iacono D, Komlosh ME, Perl DP, Brody DL, Basser PJ. Diffuse axonal injury has a characteristic multidimensional MRI signature in the human brain. Brain. 2021 04 12; 144(3):800-816. PMID: 33739417; PMCID: PMC8041044.
    Citations: 16     Fields:    Translation:Humans
  20. Smith DH, Dollé JP, Ameen-Ali KE, Bretzin A, Cortes E, Crary JF, Dams-O'Connor K, Diaz-Arrastia R, Edlow BL, Folkerth R, Hazrati LN, Hinds SR, Iacono D, Johnson VE, Keene CD, Kofler J, Kovacs GG, Lee EB, Manley G, Meaney D, Montine T, Okonkwo DO, Perl DP, Trojanowski JQ, Wiebe DJ, Yaffe K, McCabe T, Stewart W. COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI). Acta Neuropathol Commun. 2021 03 01; 9(1):32. PMID: 33648593; PMCID: PMC7919306.
    Citations: 6     Fields:    Translation:Humans
  21. Bieniek KF, Cairns NJ, Crary JF, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Vonsattel JP, Stewart W, Dams-O'Connor K, Gordon WA, Tripodis Y, Alvarez VE, Mez J, Alosco ML, McKee AC. The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol. 2021 02 22; 80(3):210-219. PMID: 33611507; PMCID: PMC7899277.
    Citations: 43     Fields:    Translation:Humans
  22. Nolan AL, Petersen C, Iacono D, Mac Donald CL, Mukherjee P, van der Kouwe A, Jain S, Stevens A, Diamond BR, Wang R, Markowitz AJ, Fischl B, Perl DP, Manley GT, Keene CD, Diaz-Arrastia R, Edlow BL. Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study. J Neurotrauma. 2021 06 15; 38(12):1620-1631. PMID: 33412995; PMCID: PMC8165468.
    Citations: 6     Fields:    Translation:Humans
  23. Iacono D, Murphy EK, Avantsa SS, Perl DP, Day RM. Reduction of pTau and APP levels in mammalian brain after low-dose radiation. Sci Rep. 2021 01 26; 11(1):2215. PMID: 33500491; PMCID: PMC7838187.
    Citations: 3     Fields:    Translation:AnimalsCells
  24. Schwerin SC, Chatterjee M, Hutchinson EB, Djankpa FT, Armstrong RC, McCabe JT, Perl DP, Juliano SL. Expression of GFAP and Tau Following Blast Exposure in the Cerebral Cortex of Ferrets. J Neuropathol Exp Neurol. 2021 01 20; 80(2):112-128. PMID: 33421075.
    Citations: 8     Fields:    Translation:Animals
  25. Lee MH, Perl DP, Nair G, Li W, Maric D, Murray H, Dodd SJ, Koretsky AP, Watts JA, Cheung V, Masliah E, Horkayne-Szakaly I, Jones R, Stram MN, Moncur J, Hefti M, Folkerth RD, Nath A. Microvascular Injury in the Brains of Patients with Covid-19. N Engl J Med. 2021 02 04; 384(5):481-483. PMID: 33378608; PMCID: PMC7787217.
    Citations: 208     Fields:    Translation:HumansCells
  26. Murphy EK, Iacono D, Pan H, Grimes JB, Parks S, Raiciulescu S, Leonessa F, Perl DP. Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences. Sci Rep. 2020 10 15; 10(1):17446. PMID: 33060648; PMCID: PMC7566442.
    Citations: 4     Fields:    Translation:AnimalsCells
  27. Meabon JS, Cook DG, Yagi M, Terry GE, Cross DJ, Muzi M, Pagulayan KF, Logsdon AF, Schindler AG, Ghai V, Wang K, Fallen S, Zhou Y, Kim TK, Lee I, Banks WA, Carlson ES, Mayer C, Hendrickson RC, Raskind MA, Marshall DA, Perl DP, Keene CD, Peskind ER. Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure. J Neurol Sci. 2020 Oct 15; 417:117049. PMID: 32758764; PMCID: PMC7492467.
    Citations: 2     Fields:    Translation:Humans
  28. Kovacs GG, Robinson JL, Perl DP, Lee VM, Trojanowski JQ. Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex. Acta Neuropathol. 2020 10; 140(4):591-593. PMID: 32662040; PMCID: PMC7986993.
    Citations: 1     Fields:    Translation:HumansCells
  29. Logsdon AF, Schindler AG, Meabon JS, Yagi M, Herbert MJ, Banks WA, Raskind MA, Marshall DA, Keene CD, Perl DP, Peskind ER, Cook DG. Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury. Sci Rep. 2020 06 10; 10(1):9420. PMID: 32523011; PMCID: PMC7287110.
    Citations: 13     Fields:    Translation:AnimalsCells
  30. Pas K, Komlosh ME, Perl DP, Basser PJ, Benjamini D. Retaining information from multidimensional correlation MRI using a spectral regions of interest generator. Sci Rep. 2020 02 24; 10(1):3246. PMID: 32094400.
    Citations: 7     Fields:    Translation:Humans
  31. Iacono D, Lee P, Edlow BL, Gray N, Fischl B, Kenney K, Lew HL, Lozanoff S, Liacouras P, Lichtenberger J, Dams-O'Connor K, Cifu D, Hinds SR, Perl DP. Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity. J Neuropathol Exp Neurol. 2020 02 01; 79(2):144-162. PMID: 31851313.
    Citations: 9     Fields:    Translation:Humans
  32. Perl D, Waljee AK, Bishu S, Higgins PDR, Wasnik AP, Stidham RW. Imaging Features Associated With Failure of Nonoperative Management of Intraabdominal Abscesses in Crohn Disease. Inflamm Bowel Dis. 2019 11 14; 25(12):1939-1944. PMID: 31294779.
    Citations: 3     Fields:    Translation:Humans
  33. Sharma R, Cramer NP, Perry B, Adahman Z, Murphy EK, Xu X, Dardzinski BJ, Galdzicki Z, Perl DP, Dickstein DL, Iacono D. Chronic Exposure to High Altitude: Synaptic, Astroglial and Memory Changes. Sci Rep. 2019 11 11; 9(1):16406. PMID: 31712561.
    Citations: 6     Fields:    Translation:AnimalsCellsPHPublic Health
  34. Griffin AD, Turtzo LC, Parikh GY, Tolpygo A, Lodato Z, Moses AD, Nair G, Perl DP, Edwards NA, Dardzinski BJ, Armstrong RC, Ray-Chaudhury A, Mitra PP, Latour LL. Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury. Brain. 2019 11 01; 142(11):3550-3564. PMID: 31608359; PMCID: PMC6821371.
    Citations: 39     Fields:    Translation:HumansCells
  35. Nelson LD, Temkin NR, Dikmen S, Barber J, Giacino JT, Yuh E, Levin HS, McCrea MA, Stein MB, Mukherjee P, Okonkwo DO, Robertson CS, Diaz-Arrastia R, Manley GT, Adeoye O, Badjatia N, Boase K, Bodien Y, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson A, Foreman B, Gardner R, Gaudette E, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Korley F, Kramer J, Kreitzer N, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Noel F, Palacios E, Perl D, Puccio A, Rabinowitz M, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Sherer M, Taylor S, Toga A, Valadka A, Vassar MJ, Vespa P, Wang K, Yue JK, Zafonte R. Recovery After Mild Traumatic Brain Injury in Patients Presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study. JAMA Neurol. 2019 Sep 01; 76(9):1049-1059. PMID: 31157856; PMCID: PMC6547159.
    Citations: 82     Fields:    
  36. Stein MB, Jain S, Giacino JT, Levin H, Dikmen S, Nelson LD, Vassar MJ, Okonkwo DO, Diaz-Arrastia R, Robertson CS, Mukherjee P, McCrea M, Mac Donald CL, Yue JK, Yuh E, Sun X, Campbell-Sills L, Temkin N, Manley GT, Adeoye O, Badjatia N, Boase K, Bodien Y, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Diaz-Arrastia R, Dikmen S, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson A, Foreman B, Gardner R, Gaudette E, Giacino JT, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Korley F, Kramer J, Kreitzer N, Levin H, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, McCrea M, Merchant R, Mukherjee P, Nelson LD, Noel F, Okonkwo DO, Palacios E, Perl D, Puccio A, Rabinowitz M, Robertson CS, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Sherer M, Stein MB, Taylor S, Toga A, Temkin N, Valadka A, Vassar MJ, Vespa P, Wang K, Yue JK, Yuh E, Zafonte R. Risk of Posttraumatic Stress Disorder and Major Depression in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study. JAMA Psychiatry. 2019 03 01; 76(3):249-258. PMID: 30698636; PMCID: PMC6439818.
    Citations: 69     Fields:    Translation:Humans
  37. Munger EL, Edler MK, Hopkins WD, Ely JJ, Erwin JM, Perl DP, Mufson EJ, Hof PR, Sherwood CC, Raghanti MA. Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees. J Comp Neurol. 2019 05 01; 527(7):1179-1195. PMID: 30578640; PMCID: PMC6401278.
    Citations: 19     Fields:    Translation:AnimalsCells
  38. Edler MK, Sherwood CC, Meindl RS, Munger EL, Hopkins WD, Ely JJ, Erwin JM, Perl DP, Mufson EJ, Hof PR, Raghanti MA. Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees. J Comp Neurol. 2018 12 15; 526(18):2921-2936. PMID: 30069930; PMCID: PMC6283685.
    Citations: 16     Fields:    Translation:AnimalsCells
  39. Snyder HM, Carare RO, DeKosky ST, de Leon MJ, Dykxhoorn D, Gan L, Gardner R, Hinds SR, Jaffee M, Lamb BT, Landau S, Manley G, McKee A, Perl D, Schneider JA, Weiner M, Wellington C, Yaffe K, Bain L, Pacifico AM, Carrillo MC. Military-related risk factors for dementia. Alzheimers Dement. 2018 12; 14(12):1651-1662. PMID: 30415806.
    Citations: 3     Fields:    Translation:HumansAnimals
  40. Iacono D, Lee P, Hallett M, Perl D. Possible Post-Traumatic Focal Dystonia Associated with Tau Pathology Localized to Putamen-Globus Pallidus. Mov Disord Clin Pract. 2018 Sep-Oct; 5(5):492-498. PMID: 30637269; PMCID: PMC6207110.
    Citations: 2     
  41. Seabury SA, Gaudette É, Goldman DP, Markowitz AJ, Brooks J, McCrea MA, Okonkwo DO, Manley GT, Adeoye O, Badjatia N, Boase K, Bodien Y, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Diaz-Arrastia R, Dikmen S, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson A, Foreman B, Gardner R, Giacino J, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Korley F, Kramer J, Kreitzer N, Levin H, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Mukherjee P, Nelson L, Noel F, Palacios E, Perl D, Puccio A, Rabinowitz M, Robertson C, Rosand J, Sander A, Satris G, Schnyer D, Sherer M, Stein M, Taylor S, Temkin N, Toga A, Valadka A, Vassar M, Vespa P, Wang K, Yue J, Yuh E, Zafonte R. Assessment of Follow-up Care After Emergency Department Presentation for Mild Traumatic Brain Injury and Concussion: Results From the TRACK-TBI Study. JAMA Netw Open. 2018 05 18; 1(1):e180210. PMID: 30646055; PMCID: PMC6324305.
    Citations: 39     Fields:    Translation:Humans
  42. Edlow BL, Keene CD, Perl DP, Iacono D, Folkerth RD, Stewart W, Mac Donald CL, Augustinack J, Diaz-Arrastia R, Estrada C, Flannery E, Gordon WA, Grabowski TJ, Hansen K, Hoffman J, Kroenke C, Larson EB, Lee P, Mareyam A, McNab JA, McPhee J, Moreau AL, Renz A, Richmire K, Stevens A, Tang CY, Tirrell LS, Trittschuh EH, van der Kouwe A, Varjabedian A, Wald LL, Wu O, Yendiki A, Young L, Zöllei L, Fischl B, Crane PK, Dams-O'Connor K. Multimodal Characterization of the Late Effects of Traumatic Brain Injury: A Methodological Overview of the Late Effects of Traumatic Brain Injury Project. J Neurotrauma. 2018 07 15; 35(14):1604-1619. PMID: 29421973.
    Citations: 15     Fields:    Translation:Humans
  43. Kenney K, Iacono D, Edlow BL, Katz DI, Diaz-Arrastia R, Dams-O'Connor K, Daneshvar DH, Stevens A, Moreau AL, Tirrell LS, Varjabedian A, Yendiki A, van der Kouwe A, Mareyam A, McNab JA, Gordon WA, Fischl B, McKee AC, Perl DP. Dementia After Moderate-Severe Traumatic Brain Injury: Coexistence of Multiple Proteinopathies. J Neuropathol Exp Neurol. 2018 Jan 01; 77(1):50-63. PMID: 29155947; PMCID: PMC5939622.
    Citations: 43     Fields:    Translation:HumansCells
  44. Dugger BN, Perl DP, Carlson GA. Neurodegenerative Disease Transmission and Transgenesis in Mice. Cold Spring Harb Perspect Biol. 2017 Nov 01; 9(11). PMID: 28193724; PMCID: PMC5666636.
    Citations: 8     Fields:    Translation:Animals
  45. Sours C, Hinds SR, McKee AC, Perl DP, Leggieri MJ. Brain Banks and Tissue Repositories for Blast-Related Chronic Traumatic Encephalopathy Research. J Neurotrauma. 2017 09; 34(S1):S4-S5. PMID: 28937954.
    Citations: 1     Fields:    Translation:Humans
  46. Agoston D, Arun P, Bellgowan P, Broglio S, Cantu R, Cook D, da Silva UO, Dickstein D, Elder G, Fudge E, Gandy S, Gill J, Glenn JF, Gupta RK, Hinds S, Hoffman S, Lattimore T, Lin A, Lu KP, Maroon J, Okonkwo D, Perl D, Robinson M, Rosen C, Smith D. Military Blast Injury and Chronic Neurodegeneration: Research Presentations from the 2015 International State-of-the-Science Meeting. J Neurotrauma. 2017 09; 34(S1):S6-S17. PMID: 28937955; PMCID: PMC5695753.
    Citations: 5     Fields:    Translation:Humans
  47. Schindler AG, Meabon JS, Pagulayan KF, Hendrickson RC, Meeker KD, Cline M, Li G, Sikkema C, Wilkinson CW, Perl DP, Raskind MR, Peskind ER, Clark JJ, Cook DG. Blast-related disinhibition and risk seeking in mice and combat Veterans: Potential role for dysfunctional phasic dopamine release. Neurobiol Dis. 2017 Oct; 106:23-34. PMID: 28619545.
    Citations: 13     Fields:    Translation:HumansAnimalsPHPublic Health
  48. Iacono D, Shively SB, Edlow BL, Perl DP. Chronic Traumatic Encephalopathy: Known Causes, Unknown Effects. Phys Med Rehabil Clin N Am. 2017 05; 28(2):301-321. PMID: 28390515.
    Citations: 4     Fields:    Translation:Humans
  49. Shively SB, Perl DP. Astroglial scarring after blast exposure: unproven causality - Authors' reply. Lancet Neurol. 2017 01; 16(1):27. PMID: 27979349.
    Citations:    Fields:    Translation:HumansCells
  50. Shively SB, Perl DP. Viewing the Invisible Wound: Novel Lesions Identified in Postmortem Brains of U.S. Service Members With Military Blast Exposure. Mil Med. 2017 01; 182(1):1461-1463. PMID: 28051958.
    Citations: 2     Fields:    Translation:Humans
  51. Shively SB, Edgerton SL, Iacono D, Purohit DP, Qu BX, Haroutunian V, Davis KL, Diaz-Arrastia R, Perl DP. Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain. Acta Neuropathol. 2017 03; 133(3):353-366. PMID: 27885490; PMCID: PMC5325841.
    Citations: 16     Fields:    Translation:HumansCells
  52. Shively SB, Horkayne-Szakaly I, Jones RV, Kelly JP, Armstrong RC, Perl DP. Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series. Lancet Neurol. 2016 08; 15(9):944-953. PMID: 27291520.
    Citations: 66     Fields:    Translation:HumansCells
  53. Perl D, Leddin D, Bizos D, Veitch A, N'Dow J, Bush-Goddard S, Njie R, Lemoine M, Anderson ST, Igoe J, Anandasabapathy S, Shah B. Endoscopic capacity in West Africa. Afr Health Sci. 2016 Mar; 16(1):329-38. PMID: 27358650; PMCID: PMC4915418.
    Citations: 5     Fields:    Translation:Humans
  54. Logue OC, Cramer NP, Xu X, Perl DP, Galdzicki Z. Alterations of functional properties of hippocampal networks following repetitive closed-head injury. Exp Neurol. 2016 Mar; 277:227-243. PMID: 26730521.
    Citations: 15     Fields:    Translation:AnimalsCells
  55. McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Vonsattel JP, Stewart W, Tripodis Y, Crary JF, Bieniek KF, Dams-O'Connor K, Alvarez VE, Gordon WA. The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathol. 2016 Jan; 131(1):75-86. PMID: 26667418; PMCID: PMC4698281.
    Citations: 324     Fields:    Translation:HumansCells
  56. Parikh ND, Perl D, Lee MH, Chang SS, Polydorides AD, Moshier E, Godbold J, Zhou E, Mitcham J, Richards-Kortum R, Anandasabapathy S. In vivo classification of colorectal neoplasia using high-resolution microendoscopy: Improvement with experience. J Gastroenterol Hepatol. 2015 Jul; 30(7):1155-60. PMID: 25753782; PMCID: PMC4504008.
    Citations: 6     Fields:    Translation:Humans
  57. Hollyer JA, McGuinness E, Bowers LC, Didier ES, Giudice C, Perl DP, Fogarty U. Encephalitozoon cuniculi-Associated Equine Encephalitis: A Case Report. J Equine Vet Sci. 2014 Nov-Dec; 34(11-12):1348-1351. PMID: 33727764.
    Citations:    Fields:    
  58. Perl DP, Parikh N, Chang S, Peng P, Thekkek N, Lee MH, Polydorides AD, Mitcham J, Richards-Kortum R, Anandasabapathy S. Diagnosis of neoplasia in Barrett's esophagus using vital-dye enhanced fluorescence imaging. J Vis Exp. 2014 May 11; (87). PMID: 24893592.
    Citations:    Fields:    Translation:Humans
  59. Parikh ND, Perl D, Lee MH, Shah B, Young Y, Chang SS, Shukla R, Polydorides AD, Moshier E, Godbold J, Zhou E, Mitcham J, Richards-Kortum R, Anandasabapathy S. In vivo diagnostic accuracy of high-resolution microendoscopy in differentiating neoplastic from non-neoplastic colorectal polyps: a prospective study. Am J Gastroenterol. 2014 Jan; 109(1):68-75. PMID: 24296752.
    Citations: 18     Fields:    Translation:Humans
  60. Diaz-Arrastia R, Perl D. Cognitive dysfunction and contact sports. JAMA Neurol. 2013 Mar 01; 70(3):301-2. PMID: 23303238.
    Citations: 1     Fields:    Translation:Humans
  61. Qu BX, Gong Y, Sinclair D, Fu M, Perl D, Diaz-Arrastia R. cPLA2a knockout mice exhibit abnormalities in the architecture and synapses of cortical neurons. Brain Res. 2013 Feb 25; 1497:101-5. PMID: 23266724.
    Citations: 6     Fields:    Translation:AnimalsCells
  62. Shively S, Scher AI, Perl DP, Diaz-Arrastia R. Dementia resulting from traumatic brain injury: what is the pathology? Arch Neurol. 2012 Oct; 69(10):1245-51. PMID: 22776913; PMCID: PMC3716376.
    Citations: 89     Fields:    Translation:Humans
  63. Perl DP, Daoud AI, Lieberman DE. Effects of footwear and strike type on running economy. Med Sci Sports Exerc. 2012 Jul; 44(7):1335-43. PMID: 22217565.
    Citations: 69     Fields:    Translation:Humans
  64. Nair G, Van Dyk K, Shah U, Purohit DP, Pinto C, Shah AB, Grossman H, Perl D, Ganwir V, Shanker S, Sano M. Characterizing cognitive deficits and dementia in an aging urban population in India. Int J Alzheimers Dis. 2012; 2012:673849. PMID: 22792507.
    Citations: 5     
  65. Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N, Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach T, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Crane PK, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dombroski BA, Duara R, Ellis WD, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch M, Galasko DR, Gallins PJ, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JS, Kaye JA, Kennedy N, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lieberman AP, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Myers AJ, Naj AC, Nowotny P, Parisi JE, Perl DP, Peskind E, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8. PMID: 22722634; PMCID: PMC3398432.
    Citations: 81     Fields:    Translation:Humans
  66. Shively SB, Perl DP. Traumatic brain injury, shell shock, and posttraumatic stress disorder in the military--past, present, and future. J Head Trauma Rehabil. 2012 May-Jun; 27(3):234-9. PMID: 22573042.
    Citations: 37     Fields:    Translation:Humans
  67. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. PMID: 21460841; PMCID: PMC3090745.
    Citations: 987     Fields:    Translation:Humans
  68. Beeri MS, Schmeidler J, Lesser GT, Maroukian M, West R, Leung S, Wysocki M, Perl DP, Purohit DP, Haroutunian V. Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology. Neurobiol Aging. 2012 Jul; 33(7):1258-64. PMID: 21458888.
    Citations: 16     Fields:    Translation:HumansCells
  69. Purohit DP, Batheja NO, Sano M, Jashnani KD, Kalaria RN, Karunamurthy A, Kaur S, Shenoy AS, Van Dyk K, Schmeidler J, Perl DP. Profiles of Alzheimer's disease-related pathology in an aging urban population sample in India. J Alzheimers Dis. 2011; 24(1):187-96. PMID: 21187583.
    Citations: 7     Fields:    Translation:HumansCells
  70. McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee HS, Kubilus CA, Daneshvar DH, Wulff M, Budson AE. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2010 Sep; 69(9):918-29. PMID: 20720505.
    Citations: 256     Fields:    Translation:Humans
  71. Takahashi H, Brasnjevic I, Rutten BP, Van Der Kolk N, Perl DP, Bouras C, Steinbusch HW, Schmitz C, Hof PR, Dickstein DL. Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease. Brain Struct Funct. 2010 Mar; 214(2-3):145-60. PMID: 20213270.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  72. Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, Lopez de Munain A, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9. PMID: 20154673; PMCID: PMC2828525.
    Citations: 259     Fields:    Translation:HumansCells
  73. Perl DP. Neuropathology of Alzheimer's disease. Mt Sinai J Med. 2010 Jan-Feb; 77(1):32-42. PMID: 20101720.
    Citations: 232     Fields:    Translation:HumansCells
  74. Libow LS, Frisina PG, Haroutunian V, Perl DP, Purohit DP. Parkinson's disease dementia: a diminished role for the Lewy body. Parkinsonism Relat Disord. 2009 Sep; 15(8):572-5. PMID: 19346154.
    Citations: 6     Fields:    Translation:HumansCells
  75. Haroutunian V, Schnaider-Beeri M, Schmeidler J, Wysocki M, Purohit DP, Perl DP, Libow LS, Lesser GT, Maroukian M, Grossman HT. Role of the neuropathology of Alzheimer disease in dementia in the oldest-old. Arch Neurol. 2008 Sep; 65(9):1211-7. PMID: 18779425; PMCID: PMC3071251.
    Citations: 79     Fields:    Translation:HumansCells
  76. Agashiwala RM, Louis ED, Hof PR, Perl DP. A novel approach to non-biased systematic random sampling: a stereologic estimate of Purkinje cells in the human cerebellum. Brain Res. 2008 Oct 21; 1236:73-8. PMID: 18725208.
    Citations: 7     Fields:    Translation:HumansCells
  77. Schnaider Beeri M, Silverman JM, Schmeidler J, Wysocki M, Grossman HZ, Purohit DP, Perl DP, Haroutunian V. Clinical dementia rating performed several years prior to death predicts regional Alzheimer's neuropathology. Dement Geriatr Cogn Disord. 2008; 25(5):392-8. PMID: 18367838.
    Citations: 5     Fields:    Translation:HumansCells
  78. Rapp MA, Schnaider-Beeri M, Purohit DP, Perl DP, Haroutunian V, Sano M. Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression. Am J Geriatr Psychiatry. 2008 Feb; 16(2):168-74. PMID: 18239198.
    Citations: 70     Fields:    Translation:HumansCells
  79. Beeri MS, Rapp M, Schmeidler J, Reichenberg A, Purohit DP, Perl DP, Grossman HT, Prohovnik I, Haroutunian V, Silverman JM. Number of children is associated with neuropathology of Alzheimer's disease in women. Neurobiol Aging. 2009 Aug; 30(8):1184-91. PMID: 18079025.
    Citations: 28     Fields:    Translation:HumansCells
  80. Geser F, Winton MJ, Kwong LK, Xu Y, Xie SX, Igaz LM, Garruto RM, Perl DP, Galasko D, Lee VM, Trojanowski JQ. Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Acta Neuropathol. 2008 Jan; 115(1):133-45. PMID: 17713769.
    Citations: 75     Fields:    Translation:HumansCells
  81. Yang W, Woltjer RL, Sokal I, Pan C, Wang Y, Brodey M, Peskind ER, Leverenz JB, Zhang J, Perl DP, Galasko DR, Montine TJ. Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy. Am J Pathol. 2007 Sep; 171(3):993-1002. PMID: 17675576; PMCID: PMC1959487.
    Citations: 18     Fields:    Translation:Humans
  82. Perl DP, Olanow CW. The neuropathology of manganese-induced Parkinsonism. J Neuropathol Exp Neurol. 2007 Aug; 66(8):675-82. PMID: 17882011.
    Citations: 117     Fields:    Translation:HumansAnimalsCells
  83. Akram A, Christoffel D, Rocher AB, Bouras C, Kövari E, Perl DP, Morrison JH, Herrmann FR, Haroutunian V, Giannakopoulos P, Hof PR. Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease. Neurobiol Aging. 2008 Sep; 29(9):1296-307. PMID: 17420070; PMCID: PMC2569870.
    Citations: 42     Fields:    Translation:HumansCells
  84. Perl DP. The role of the pathologist in translational and personalized medicine. Mt Sinai J Med. 2007 Apr; 74(1):22-6. PMID: 17516563.
    Citations:    Fields:    Translation:HumansAnimals
  85. Perl DP. The neuropathology of parkinsonism. Handb Clin Neurol. 2007; 83:205-15. PMID: 18808915.
    Citations: 1     Fields:    
  86. Beeri MS, Rapp M, Silverman JM, Schmeidler J, Grossman HT, Fallon JT, Purohit DP, Perl DP, Siddiqui A, Lesser G, Rosendorff C, Haroutunian V. Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers. Neurology. 2006 May 09; 66(9):1399-404. PMID: 16682673; PMCID: PMC3163092.
    Citations: 44     Fields:    Translation:HumansCells
  87. Perl DP. Exposure to aluminium and the subsequent development of a disorder with features of Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2006 Jul; 77(7):811. PMID: 16627536.
    Citations: 5     Fields:    Translation:Humans
  88. Winton MJ, Joyce S, Zhukareva V, Practico D, Perl DP, Galasko D, Craig U, Trojanowski JQ, Lee VM. Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex. Acta Neuropathol. 2006 May; 111(5):401-12. PMID: 16609851.
    Citations: 14     Fields:    Translation:HumansCells
  89. Rapp MA, Schnaider-Beeri M, Grossman HT, Sano M, Perl DP, Purohit DP, Gorman JM, Haroutunian V. Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Arch Gen Psychiatry. 2006 Feb; 63(2):161-7. PMID: 16461859.
    Citations: 131     Fields:    Translation:HumansCells
  90. Prohovnik I, Perl DP, Davis KL, Libow L, Lesser G, Haroutunian V. Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease. Neurology. 2006 Jan 10; 66(1):49-55. PMID: 16401845.
    Citations: 50     Fields:    Translation:HumansCells
  91. Perl DP, Moalem S. Aluminum and Alzheimer's disease, a personal perspective after 25 years. J Alzheimers Dis. 2006; 9(3 Suppl):291-300. PMID: 17004365.
    Citations: 13     Fields:    Translation:HumansCells
  92. Montine TJ, Li K, Perl DP, Galasko D. Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC. Neurology. 2005 Sep 13; 65(5):768-9. PMID: 16157919.
    Citations: 23     Fields:    Translation:HumansPHPublic Health
  93. Shu W, Cho JY, Jiang Y, Zhang M, Weisz D, Elder GA, Schmeidler J, De Gasperi R, Sosa MA, Rabidou D, Santucci AC, Perl D, Morrisey E, Buxbaum JD. Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9643-8. PMID: 15983371; PMCID: PMC1160518.
    Citations: 167     Fields:    Translation:AnimalsCells
  94. Beeri MS, Silverman JM, Davis KL, Marin D, Grossman HZ, Schmeidler J, Purohit DP, Perl DP, Davidson M, Mohs RC, Haroutunian V. Type 2 diabetes is negatively associated with Alzheimer's disease neuropathology. J Gerontol A Biol Sci Med Sci. 2005 Apr; 60(4):471-5. PMID: 15933386; PMCID: PMC3163091.
    Citations: 82     Fields:    Translation:HumansCells
  95. Moalem S, Storey KB, Percy ME, Peros MC, Perl DP. The sweet thing about Type 1 diabetes: a cryoprotective evolutionary adaptation. Med Hypotheses. 2005; 65(1):8-16. PMID: 15893109.
    Citations: 6     Fields:    Translation:HumansAnimals
  96. Good PF, Alapat D, Hsu A, Chu C, Perl D, Wen X, Burstein DE, Kohtz DS. A role for semaphorin 3A signaling in the degeneration of hippocampal neurons during Alzheimer's disease. J Neurochem. 2004 Nov; 91(3):716-36. PMID: 15485501.
    Citations: 57     Fields:    Translation:HumansCells
  97. Perl DP, Fogarty U, Harpaz N, Sachar DB. Bacterial-metal interactions: the potential role of aluminum and other trace elements in the etiology of Crohn's disease. Inflamm Bowel Dis. 2004 Nov; 10(6):881-3. PMID: 15626906.
    Citations: 5     Fields:    Translation:Humans
  98. McNaught KS, Kapustin A, Jackson T, Jengelley TA, Jnobaptiste R, Shashidharan P, Perl DP, Pasik P, Olanow CW. Brainstem pathology in DYT1 primary torsion dystonia. Ann Neurol. 2004 Oct; 56(4):540-7. PMID: 15455404.
    Citations: 57     Fields:    Translation:Humans
  99. Olanow CW, Perl DP, DeMartino GN, McNaught KS. Lewy-body formation is an aggresome-related process: a hypothesis. Lancet Neurol. 2004 Aug; 3(8):496-503. PMID: 15261611.
    Citations: 82     Fields:    Translation:HumansCells
  100. McNaught KS, Perl DP, Brownell AL, Olanow CW. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul; 56(1):149-62. PMID: 15236415.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  101. Sebeo J, Hof PR, Perl DP. Occurrence of alpha-synuclein pathology in the cerebellum of Guamanian patients with parkinsonism-dementia complex. Acta Neuropathol. 2004 Jun; 107(6):497-503. PMID: 15024581.
    Citations: 10     Fields:    Translation:HumansCells
  102. Olanow CW, Goetz CG, Kordower JH, Stoessl AJ, Sossi V, Brin MF, Shannon KM, Nauert GM, Perl DP, Godbold J, Freeman TB. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol. 2003 Sep; 54(3):403-14. PMID: 12953276.
    Citations: 383     Fields:    Translation:HumansCellsCTClinical Trials
  103. Bussière T, Giannakopoulos P, Bouras C, Perl DP, Morrison JH, Hof PR. Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: stereologic analysis of prefrontal cortex area 9. J Comp Neurol. 2003 Aug 25; 463(3):281-302. PMID: 12820162.
    Citations: 72     Fields:    Translation:HumansCells
  104. Hof PR, Haroutunian V, Friedrich VL, Byne W, Buitron C, Perl DP, Davis KL. Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia. Biol Psychiatry. 2003 Jun 15; 53(12):1075-85. PMID: 12814859.
    Citations: 127     Fields:    Translation:HumansCells
  105. Giannakopoulos P, Herrmann FR, Bussière T, Bouras C, Kövari E, Perl DP, Morrison JH, Gold G, Hof PR. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology. 2003 May 13; 60(9):1495-500. PMID: 12743238.
    Citations: 429     Fields:    Translation:HumansCells
  106. Perl DP, Hof PR, Purohit DP, Loerzel AJ, Kakulas BA. Hippocampal and entorhinal cortex neurofibrillary tangle formation in Guamanian Chamorros free of overt neurologic dysfunction. J Neuropathol Exp Neurol. 2003 Apr; 62(4):381-8. PMID: 12722830.
    Citations: 7     Fields:    Translation:HumansCells
  107. Bussière T, Gold G, Kövari E, Giannakopoulos P, Bouras C, Perl DP, Morrison JH, Hof PR. Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease. Neuroscience. 2003; 117(3):577-92. PMID: 12617964.
    Citations: 43     Fields:    Translation:HumansCells
  108. Hof PR, Bussière T, Gold G, Kövari E, Giannakopoulos P, Bouras C, Perl DP, Morrison JH. Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease. J Neuropathol Exp Neurol. 2003 Jan; 62(1):55-67. PMID: 12528818.
    Citations: 28     Fields:    Translation:HumansCells
  109. McNaught KS, Shashidharan P, Perl DP, Jenner P, Olanow CW. Aggresome-related biogenesis of Lewy bodies. Eur J Neurosci. 2002 Dec; 16(11):2136-48. PMID: 12473081.
    Citations: 77     Fields:    Translation:HumansCells
  110. Hof PR, Perl DP. Neurofibrillary tangles in the primary motor cortex in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex. Neurosci Lett. 2002 Aug 16; 328(3):294-8. PMID: 12147329.
    Citations: 2     Fields:    Translation:HumansCells
  111. Forman MS, Schmidt ML, Kasturi S, Perl DP, Lee VM, Trojanowski JQ. Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam. Am J Pathol. 2002 May; 160(5):1725-31. PMID: 12000724; PMCID: PMC1850878.
    Citations: 37     Fields:    Translation:HumansCells
  112. Evers MM, Purohit D, Perl D, Khan K, Marin DB. Palliative and aggressive end-of-life care for patients with dementia. Psychiatr Serv. 2002 May; 53(5):609-13. PMID: 11986512.
    Citations: 16     Fields:    Translation:Humans
  113. Walker RH, Purohit DP, Good PF, Perl DP, Brin MF. Severe generalized dystonia due to primary putaminal degeneration: case report and review of the literature. Mov Disord. 2002 May; 17(3):576-84. PMID: 12112210.
    Citations: 1     Fields:    Translation:Humans
  114. Bussière T, Friend PD, Sadeghi N, Wicinski B, Lin GI, Bouras C, Giannakopoulos P, Robakis NK, Morrison JH, Perl DP, Hof PR. Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease. Neuroscience. 2002; 112(1):75-91. PMID: 12044473.
    Citations: 38     Fields:    Translation:Humans
  115. Masliah E, Alford M, Galasko D, Salmon D, Hansen LA, Good PF, Perl DP, Thal L. Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of Guam. Neuroreport. 2001 Dec 21; 12(18):3901-3. PMID: 11742207.
    Citations: 1     Fields:    Translation:HumansCells
  116. Schmidt ML, Zhukareva V, Perl DP, Sheridan SK, Schuck T, Lee VM, Trojanowski JQ. Spinal cord neurofibrillary pathology in Alzheimer disease and Guam Parkinsonism-dementia complex. J Neuropathol Exp Neurol. 2001 Nov; 60(11):1075-86. PMID: 11706937.
    Citations: 20     Fields:    Translation:HumansCells
  117. Poorkaj P, Tsuang D, Wijsman E, Steinbart E, Garruto RM, Craig UK, Chapman NH, Anderson L, Bird TD, Plato CC, Perl DP, Weiderholt W, Galasko D, Schellenberg GD. TAU as a susceptibility gene for amyotropic lateral sclerosis-parkinsonism dementia complex of Guam. Arch Neurol. 2001 Nov; 58(11):1871-8. PMID: 11708997.
    Citations: 14     Fields:    Translation:Humans
  118. Vogt BA, Vogt LJ, Perl DP, Hof PR. Cytology of human caudomedial cingulate, retrosplenial, and caudal parahippocampal cortices. J Comp Neurol. 2001 Sep 24; 438(3):353-76. PMID: 11550177.
    Citations: 27     Fields:    Translation:HumansCells
  119. Hof PR, Nimchinsky EA, Perl DP, Erwin JM. An unusual population of pyramidal neurons in the anterior cingulate cortex of hominids contains the calcium-binding protein calretinin. Neurosci Lett. 2001 Jul 20; 307(3):139-42. PMID: 11438383.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  120. Schmitz C, Korr H, Perl DP, Hof PR. Advanced use of 3-D methods for counting neurons. Trends Neurosci. 2001 Jul; 24(7):377-80. PMID: 11467289.
    Citations: 2     Fields:    Translation:Cells
  121. Kaufmann H, Hague K, Perl D. Accumulation of alpha-synuclein in autonomic nerves in pure autonomic failure. Neurology. 2001 Apr 10; 56(7):980-1. PMID: 11294945.
    Citations: 40     Fields:    Translation:Humans
  122. Perl DP. Barney Sachs and the history of the neuropathologic description of Tay-Sachs disease. Adv Genet. 2001; 44:11-23. PMID: 11596977.
    Citations:    Fields:    Translation:Humans
  123. Perl DP. Neuropathology of Alzheimer's disease and related disorders. Neurol Clin. 2000 Nov; 18(4):847-64. PMID: 11072264.
    Citations: 10     Fields:    Translation:HumansCells
  124. Perl DP, Good PF, Bussière T, Morrison JH, Erwin JM, Hof PR. Practical approaches to stereology in the setting of aging- and disease-related brain banks. J Chem Neuroanat. 2000 Oct; 20(1):7-19. PMID: 11074340.
    Citations: 17     Fields:    Translation:HumansAnimals
  125. Shashidharan P, Good PF, Hsu A, Perl DP, Brin MF, Olanow CW. TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease. Brain Res. 2000 Sep 22; 877(2):379-81. PMID: 10986355.
    Citations: 21     Fields:    Translation:HumansCells
  126. Haroutunian V, Serby M, Purohit DP, Perl DP, Marin D, Lantz M, Mohs RC, Davis KL. Contribution of Lewy body inclusions to dementia in patients with and without Alzheimer disease neuropathological conditions. Arch Neurol. 2000 Aug; 57(8):1145-50. PMID: 10927794.
    Citations: 18     Fields:    Translation:HumansCells
  127. Tagliati M, Perl DP, Drayer B, Olanow CW. Progressive dementia and gait disorder in a 78 year old woman. J Neurol Neurosurg Psychiatry. 2000 Apr; 68(4):526-31. PMID: 10727496; PMCID: PMC1736868.
    Citations:    Fields:    Translation:Humans
  128. Jankovic J, Rajput AH, McDermott MP, Perl DP. The evolution of diagnosis in early Parkinson disease. Parkinson Study Group. Arch Neurol. 2000 Mar; 57(3):369-72. PMID: 10714663.
    Citations: 58     Fields:    Translation:HumansCTClinical Trials
  129. Oyanagi K, Chen KM, Craig UK, Yamazaki M, Perl DP. Parkinsonism, dementia and vertical gaze palsy in a Guamanian with atypical neuroglial degeneration. Acta Neuropathol. 2000 Jan; 99(1):73-80. PMID: 10651031.
    Citations: 2     Fields:    Translation:HumansCells
  130. Davis KL, Mohs RC, Marin DB, Purohit DP, Perl DP, Lantz M, Austin G, Haroutunian V. Neuropeptide abnormalities in patients with early Alzheimer disease. Arch Gen Psychiatry. 1999 Nov; 56(11):981-7. PMID: 10565496.
    Citations: 20     Fields:    Translation:Humans
  131. Haroutunian V, Purohit DP, Perl DP, Marin D, Khan K, Lantz M, Davis KL, Mohs RC. Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease. Arch Neurol. 1999 Jun; 56(6):713-8. PMID: 10369312.
    Citations: 89     Fields:    Translation:HumansCells
  132. Nimchinsky EA, Gilissen E, Allman JM, Perl DP, Erwin JM, Hof PR. A neuronal morphologic type unique to humans and great apes. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):5268-73. PMID: 10220455; PMCID: PMC21853.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  133. Davis KL, Mohs RC, Marin D, Purohit DP, Perl DP, Lantz M, Austin G, Haroutunian V. Cholinergic markers in elderly patients with early signs of Alzheimer disease. JAMA. 1999 Apr 21; 281(15):1401-6. PMID: 10217056.
    Citations: 120     Fields:    Translation:HumansCells
  134. Bussière T, Hof PR, Mailliot C, Brown CD, Caillet-Boudin ML, Perl DP, Buée L, Delacourte A. Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration. Acta Neuropathol. 1999 Mar; 97(3):221-30. PMID: 10090668.
    Citations: 35     Fields:    Translation:HumansCells
  135. Fogarty U, Perl D, Good P, Ensley S, Seawright A, Noonan J. A cluster of equine granulomatous enteritis cases: the link with aluminium. Vet Hum Toxicol. 1998 Oct; 40(5):297-305. PMID: 9778770.
    Citations: 2     Fields:    Translation:Animals
  136. Tatton NA, Maclean-Fraser A, Tatton WG, Perl DP, Olanow CW. A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease. Ann Neurol. 1998 Sep; 44(3 Suppl 1):S142-8. PMID: 9749586.
    Citations: 35     Fields:    Translation:HumansCells
  137. Haroutunian V, Perl DP, Purohit DP, Marin D, Khan K, Lantz M, Davis KL, Mohs RC. Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease. Arch Neurol. 1998 Sep; 55(9):1185-91. PMID: 9740112.
    Citations: 98     Fields:    Translation:Humans
  138. Perl DP, Olanow CW, Calne D. Alzheimer's disease and Parkinson's disease: distinct entities or extremes of a spectrum of neurodegeneration? Ann Neurol. 1998 Sep; 44(3 Suppl 1):S19-31. PMID: 9749570.
    Citations: 21     Fields:    Translation:HumansCells
  139. Good PF, Hsu A, Werner P, Perl DP, Olanow CW. Protein nitration in Parkinson's disease. J Neuropathol Exp Neurol. 1998 Apr; 57(4):338-42. PMID: 9600227.
    Citations: 132     Fields:    Translation:HumansCells
  140. Purohit DP, Perl DP, Haroutunian V, Powchik P, Davidson M, Davis KL. Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia: a postmortem neuropathologic study of 100 cases. Arch Gen Psychiatry. 1998 Mar; 55(3):205-11. PMID: 9510214.
    Citations: 52     Fields:    Translation:HumansCells
  141. Schmidt ML, Lee VM, Saido T, Perl D, Schuck T, Iwatsubo T, Trojanowski JQ. Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging. Acta Neuropathol. 1998 Feb; 95(2):117-22. PMID: 9498044.
    Citations: 10     Fields:    Translation:Humans
  142. Powchik P, Davidson M, Haroutunian V, Gabriel SM, Purohit DP, Perl DP, Harvey PD, Davis KL. Postmortem studies in schizophrenia. Schizophr Bull. 1998; 24(3):325-41. PMID: 9718627.
    Citations: 58     Fields:    Translation:HumansCells
  143. Buée-Scherrer V, Buée L, Leveugle B, Perl DP, Vermersch P, Hof PR, Delacourte A. Pathological tau proteins in postencephalitic parkinsonism: comparison with Alzheimer's disease and other neurodegenerative disorders. Ann Neurol. 1997 Sep; 42(3):356-9. PMID: 9307257.
    Citations: 8     Fields:    Translation:HumansCells
  144. Powchik P, Friedman J, Haroutunian V, Greenberg D, Altsteil L, Purohit D, Perl D, Davidson M. Apolipoprotein E4 in schizophrenia: a study of one hundred sixteen cases with concomitant neuropathological examination. Biol Psychiatry. 1997 Aug 15; 42(4):296-8. PMID: 9270908.
    Citations: 3     Fields:    Translation:Humans
  145. Perl DP, Purohit DP. Proposal to revise the morphologic criteria for the diagnosis of Alzheimer's disease. Neurobiol Aging. 1997 Jul-Aug; 18(4 Suppl):S81-4. PMID: 9330991.
    Citations:    Fields:    Translation:HumansCells