Harvard Catalyst Profiles

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Rizwan Romee, M.D.

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2018 - 2019
Dunkin Donuts Breakthrough Grant
2015 - 2018
ASH Scholar Award (faculty)
2015 - 2018
ASCO Career Development Award (faculty)

As a translational physician-scientist my long-term goals are to translate novel aspects of immunology to improve treatments for patients with advanced malignancies. The primary research focus of my lab is gene manipulation of the human NK cells aimed at enhancing anti-tumor function and modulating tumor micro-environment. We are also working on developing novel ways to deliver potent cytokines to the tumor microenvironment and investigating ways to further enhance activity and targeting capabilities of memory-like NK cells.

We described human memory-like NK cells with enhanced anti-tumor activity and in a first in human clinical trial demonstrated safety and promising activity of these cells in relapsed / refractory AML patients. In clinic we are currently testing these memory-like NK cells in combination with novel immunemodulatory agents in patients with advanced malignancies.

I also lead our haploidentical transplant program at Dana Farber Cancer Institute and we are working to potentially use haploidentical donor transplantation as a platform to incorporate NK cell-based immunotherapy approaches for patients with high risk hematologic malignancies undergoing transplantation.

Available: 01/01/21, Expires: 12/31/22

My lab at Dana Farber is developing novel NK cell CAR constructs aimed at enhancing tumor targeting and or tumor microenvironment modulation. The types of cancer we are developing these novel NK cell CAR currently included advanced AML/MDS, multiple myeloma, ovarian cancer and pancreatic cancer.

Students would be expected to have some experience with cell culture and flow cytometry. Their role will include helping with assessing function (using flow cytometry) of these genetically modified NK cells. In addition they will learn basic skills to generate lenti viruses which we use to transduce the NK cells.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. MMRF Innovations in Clinical Accelerator Program (Rizwan Romee) Nov 1, 2020 - Jan 1, 2023
    Multiple Myeloma Research Foundation (MMRF)
    Memory-like NK Cell Immunotherapy Plus CD38 ARM in MRD+ Multiple Myeloma and High Risk Smoldering Myeloma
    Role: Principal Investigator
  2. LLS Scholar Award (Rizwan Romee) Jul 1, 2020 - Jun 30, 2025
    Leukemia and Lymphoma Society
    Cytokine Induced Memory-Like NK Cell Immunotherapy to Target Post Transplant Relapse
    Role Description: The aim of this project is to target post transplant relapse by novel memory-like NK cells which have enhanced anti-tumor activity without causing graft versus host disease (GVHD).
    Role: Principal Investigator
  3. (Rizwan Romee) Jan 30, 2020 - Dec 31, 2022
    Gateway for Cancer Research
    Harnessing Innate Immunity in Solid Tumors: CTLA-4 Inhibition in Combination with Memory-like Natural Killer (NK) Cell Immune Cell Therapy in Advanced Head & Neck Cancer
    Role Description: We are assessing safety and potential efficacy of memory-like NK cells in patients with advanced head and neck cancer in combination with CTLA-4 blockade (aimed at intra-tumoral Treg depletion) and IL-15 super-agonist, N-803.
    Role: PI
  4. BARR Award (Rizwan Romee) Jan 1, 2020 - Dec 31, 2021
    Claudia Adams Barr Program
    Engineering Memory-Like NK Cells with a Novel CAR Construct Targeting a Neo-Epitope Derived from Intracellular Mutated Nucleophosmin-1 (NPM-1c) in Acute Myeloid Leukemia
    Role Description: This supports our research efforts aimed at genetic manipulation of the memory-like NK cells to enhance their ability to target and kill myeloid blasts.
    Role: Principal Investigator
  5. R21CA245413 (Rizwan Romee) Jan 1, 2020 - Dec 31, 2021
    Memory-like NK cells for enhanced immunotherapy of post transplant relapse in patients with myeloid malignancies
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gooptu M, Romee R, St Martin A, Arora M, Al Malki MM, Antin JH, Bredeson CN, Brunstein CG, Chhabra S, Fuchs EJ, Ghosh N, Grunwald MR, Kanakry CG, Kekre N, McGuirk JP, McNiece I, Mehta RS, Mielcarek M, Milano F, Modi D, Reshef R, Solomon SR, Schroeder MA, Waller EK, Inamoto Y, Soiffer RJ, Eapen M. HLA Haploidentical versus Matched Unrelated Donor Transplants with Post-Transplant Cyclophosphamide based prophylaxis. Blood. 2021 Apr 13. PMID: 33851205.
    Citations:    Fields:    
  2. Goldsmith SR, Abid MB, Auletta JJ, Bashey A, Beitinjaneh A, Castillo P, Chemaly RF, Chen M, Ciurea SO, Dandoy CE, Angel Diaz M, Fuchs EJ, Ganguly S, Kanakry CG, Kanakry JA, Kim S, Komanduri K, Krem M, Lazarus HM, Liu H, Ljungman P, Maziarz RT, Mulroney C, Nathan S, Nishihori T, Page KM, Perales MA, Taplitz RA, Romee R, Riches M. Post-Transplant Cyclophosphamide (PTCy) is Associated with Increased Cytomegalovirus Infection: A CIBMTR Analysis. Blood. 2021 Mar 03. PMID: 33657221.
    Citations:    Fields:    
  3. Ali AK, Tarannum M, Romee R. Is Adoptive Cellular Therapy With Non-T-Cell Immune Effectors the Future? Cancer J. 2021 Mar-Apr 01; 27(2):168-175. PMID: 33750077.
    Citations:    Fields:    
  4. Chen EC, Li S, Eisfeld AK, Luskin MR, Mims A, Jones D, Antin JH, Cutler CS, Koreth J, Ho VT, Gooptu M, Romee R, El-Jawahri A, McAfee SL, DeFilipp Z, Soiffer RJ, Chen YB, Fathi AT. Outcomes for Patients With IDH-Mutated Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation. Transplant Cell Ther. 2021 Feb 25. PMID: 33840625.
  5. Maurer K, Saucier A, Kim HT, Acharya U, Mo CC, Porter J, Albert C, Cutler C, Antin JH, Koreth J, Gooptu M, Romee R, Wu CJ, Soiffer RJ, Nikiforow S, Jacobson C, Ho VT. COVID-19 and hematopoietic stem cell transplantation and immune effector cell therapy: a US cancer center experience. Blood Adv. 2021 02 09; 5(3):861-871. PMID: 33560397.
    Citations: 2     Fields:    Translation:Humans
  6. Rambaldi B, Kim HT, Reynolds C, Chamling Rai S, Arihara Y, Kubo T, Buon L, Gooptu M, Koreth J, Cutler C, Nikiforow S, Ho VT, Alyea EP, Antin JH, Wu CJ, Soiffer RJ, Ritz J, Romee R. Impaired T- and NK-cell reconstitution after haploidentical HCT with posttransplant cyclophosphamide. Blood Adv. 2021 Jan 26; 5(2):352-364. PMID: 33496734.
    Citations:    Fields:    
  7. Huselton E, Rettig MP, Fletcher T, Ritchey J, Gehrs L, McFarland K, Christ S, Eades WC, Trinkaus K, Romee R, Kulkarni S, Ghobadi A, Abboud C, Cashen AF, Stockerl-Goldstein K, Uy GL, Vij R, Westervelt P, DiPersio JF, Schroeder MA. A phase I trial evaluating the effects of plerixafor, G-CSF, and azacitidine for the treatment of myelodysplastic syndromes. Leuk Lymphoma. 2021 Jan 19; 1-14. PMID: 33467957.
    Citations:    Fields:    
  8. Xie G, Ivica NA, Jia B, Li Y, Dong H, Liang Y, Brown D, Romee R, Chen J. Author Correction: CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia. Nat Biomed Eng. 2021 Jan; 5(1):124. PMID: 33328656.
    Citations: 1     Fields:    
  9. Little JS, Romee R. Tweeting from the Bench: Twitter and the Physician-Scientist Benefits and Challenges. Curr Hematol Malig Rep. 2020 Dec; 15(6):419-423. PMID: 33179209.
    Citations:    Fields:    
  10. Xie G, Ivica NA, Jia B, Li Y, Dong H, Liang Y, Brown D, Romee R, Chen J. CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia. Nat Biomed Eng. 2020 Oct 12. PMID: 33046866.
    Citations: 5     Fields:    
  11. Kekre N, Kim HT, Hofer J, Ho VT, Koreth J, Armand P, Nikiforow S, Gooptu M, Romee R, Alyea EP, Nageshwar P, Glotzbecker B, El-Jawahri A, DeFilipp Z, Soiffer RJ, Antin JH, Chen YB, Cutler C. Correction: Phase II trial of natalizumab with corticosteroids as initial treatment of gastrointestinal acute graft-versus-host disease. Bone Marrow Transplant. 2020 Oct 12. PMID: 33041331.
    Citations:    Fields:    
  12. Kim HT, Shaughnessy CJ, Rai SC, Reynolds C, Ho VT, Cutler C, Koreth J, Gooptu M, Romee R, Nikiforow S, Armand P, Alyea EP, Antin JH, Wu CJ, Soiffer RJ, Ritz J, Brown JR. Allogeneic hematopoietic cell transplantation after prior targeted therapy for high-risk chronic lymphocytic leukemia. Blood Adv. 2020 09 08; 4(17):4113-4123. PMID: 32882002.
    Citations:    Fields:    
  13. Kekre N, Kim HT, Hofer J, Ho VT, Koreth J, Armand P, Nikiforow S, Gooptu M, Romee R, Alyea EP, Nageshwar P, Glotzbecker B, El-Jawahri A, DeFilipp Z, Soiffer RJ, Antin JH, Chen YB, Cutler C. Phase II trial of natalizumab with corticosteroids as initial treatment of gastrointestinal acute graft-versus-host disease. Bone Marrow Transplant. 2020 Sep 08. PMID: 32895491.
    Citations: 1     Fields:    
  14. Berrien-Elliott MM, Cashen AF, Cubitt CC, Neal CC, Wong P, Wagner JA, Foster M, Schappe T, Desai S, McClain E, Becker-Hapak M, Foltz JA, Cooper ML, Jaeger N, Srivatsan SN, Gao F, Romee R, Abboud CN, Uy GL, Westervelt P, Jacoby MA, Pusic I, Stockerl-Goldstein KE, Schroeder MA, DiPersio J, Fehniger TA. Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia. Cancer Discov. 2020 Dec; 10(12):1854-1871. PMID: 32826231.
    Citations: 3     Fields:    
  15. Solomon SR, Martin AS, Zhang MJ, Ballen K, Bashey A, Battiwalla M, Baxter-Lowe LA, Brunstein C, Chhabra S, Perez MAD, Fuchs EJ, Ganguly S, Hardy N, Hematti P, McGuirk J, Peres E, Ringden O, Rizzieri D, Romee R, Solh M, Szwajcer D, van der Poel M, Waller E, William BM, Eapen M. Optimal Donor for African Americans with Hematologic Malignancy: HLA-Haploidentical Relative or Umbilical Cord Blood Transplant. Biol Blood Marrow Transplant. 2020 10; 26(10):1930-1936. PMID: 32649981.
    Citations:    Fields:    
  16. Rashid N, Slade M, Abboud R, Gao F, DiPersio JF, Westervelt P, Uy G, Stockerl-Goldstein K, Romee R, Schroeder MA. The effect of donor type on outcomes in adults with acute myeloid leukemia after reduced-intensity hematopoietic peripheral blood cell transplant - a retrospective study. Transpl Int. 2020 09; 33(9):1089-1098. PMID: 32468720.
    Citations:    Fields:    
  17. Im A, Rashidi A, Wang T, Hemmer M, MacMillan ML, Pidala J, Jagasia M, Pavletic S, Majhail NS, Weisdorf D, Abdel-Azim H, Agrawal V, Al-Homsi AS, Aljurf M, Askar M, Auletta JJ, Bashey A, Beitinjaneh A, Bhatt VR, Byrne M, Cahn JY, Cairo M, Castillo P, Cerny J, Chhabra S, Choe H, Ciurea S, Daly A, Perez MAD, Farhadfar N, Gadalla SM, Gale R, Ganguly S, Gergis U, Hanna R, Hematti P, Herzig R, Hildebrandt GC, Lad DP, Lee C, Lehmann L, Lekakis L, Kamble RT, Kharfan-Dabaja MA, Khandelwal P, Martino R, Murthy HS, Nishihori T, O'Brien TA, Olsson RF, Patel SS, Perales MA, Prestidge T, Qayed M, Romee R, Schoemans H, Seo S, Sharma A, Solh M, Strair R, Teshima T, Urbano-Ispizua A, Van der Poel M, Vij R, Wagner JL, William B, Wirk B, Yared JA, Spellman SR, Arora M, Hamilton BK. Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide. Biol Blood Marrow Transplant. 2020 08; 26(8):1459-1468. PMID: 32434056.
    Citations: 2     Fields:    
  18. Espada E, Cheng MP, Kim HT, Woolley AE, Avigan JI, Forcade E, Soares MVD, Lacerda JF, Nikiforow S, Gooptu M, Romee R, Alyea EP, Armand P, Cutler CS, Ho VT, Koreth J, Antin JH, Soiffer RJ, Marty FM, Ritz J. BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation. Blood Adv. 2020 05 12; 4(9):1881-1893. PMID: 32374880.
    Citations: 2     Fields:    
  19. Hickey CL, Romee R, Nikiforow S, Dorfman D, Mazzeo M, Koreth J. A case of Epstein Barr virus-related post-transplant lymphoproliferative disorder after haploidentical allogeneic stem cell transplantation using post-transplantation cyclophosphamide. Haematologica. 2020 07; 105(7):e379-e381. PMID: 32241847.
    Citations:    Fields:    Translation:HumansCells
  20. Baumeister SHC, Rambaldi B, Shapiro RM, Romee R. Key Aspects of the Immunobiology of Haploidentical Hematopoietic Cell Transplantation. Front Immunol. 2020; 11:191. PMID: 32117310.
    Citations: 4     Fields:    Translation:HumansCells
  21. Perales MA, Tomlinson B, Zhang MJ, St Martin A, Beitinjaneh A, Gibson J, Hogan W, Kekre N, Lazarus H, Marks D, McGuirk J, Romee R, Solh M, Wagner JE, Weisdorf DJ, de Lima M, Eapen M. Alternative donor transplantation for acute myeloid leukemia in patients aged =50 years: young HLA-matched unrelated or haploidentical donor? Haematologica. 2020; 105(2):407-413. PMID: 31101756.
    Citations: 6     Fields:    Translation:Humans
  22. Heberton MM, Tripathi S, Slade M, Trinkaus K, Romee R, Anadkat M. Cutaneous graft-versus-host disease incidence is similar in haploidentical and matched unrelated hematopoietic transplant recipients: A retrospective cohort study. J Am Acad Dermatol. 2020 Dec; 83(6):1654-1658. PMID: 31689447.
    Citations: 1     Fields:    Translation:Humans
  23. Lewis C, Kim HT, Roeker LE, Cutler C, Koreth J, Nikiforow S, Armand P, Gootpu M, Romee R, Glotzbecker B, Nageshwar P, Antin JH, Alyea EP, Richardson P, Soiffer RJ, Ho VT. Incidence, Predictors, and Outcomes of Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2020 03; 26(3):529-539. PMID: 31678537.
    Citations:    Fields:    
  24. Krieger E, Sabo R, Moezzi S, Cain C, Roberts C, Kimball P, Chesney A, McCarty J, Keating A, Romee R, Wiedl C, Qayyum R, Toor A. Killer Immunoglobulin-Like Receptor-Ligand Interactions Predict Clinical Outcomes following Unrelated Donor Transplantations. Biol Blood Marrow Transplant. 2020 04; 26(4):672-682. PMID: 31676338.
    Citations: 2     Fields:    
  25. Solomon SR, St Martin A, Shah NN, Fatobene G, Al Malki MM, Ballen KK, Bashey A, Bejanyan N, Bolaños Meade J, Brunstein CG, DeFilipp Z, Champlin RE, Fuchs EJ, Hamadani M, Hematti P, Kanakry CG, McGuirk JP, McNiece IK, Ciurea SO, Pasquini MC, Rocha V, Romee R, Patel SS, Vasu S, Waller EK, Wingard JR, Zhang MJ, Eapen M. Myeloablative vs reduced intensity T-cell-replete haploidentical transplantation for hematologic malignancy. Blood Adv. 2019 10 08; 3(19):2836-2844. PMID: 31582392.
    Citations: 13     Fields:    Translation:Humans
  26. Rimando J, Slade M, DiPersio JF, Westervelt P, Gao F, Liu C, Romee R. The Predicted Indirectly Recognizable HLA Epitopes (PIRCHE) Score for HLA Class I Graft-versus-Host Disparity Is Associated with Increased Acute Graft-versus-Host Disease in Haploidentical Transplantation with Post-Transplantation Cyclophosphamide. Biol Blood Marrow Transplant. 2020 01; 26(1):123-131. PMID: 31563575.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  27. Dholaria B, Savani BN, Labopin M, Luznik L, Ruggeri A, Mielke S, Al Malki MM, Kongtim P, Fuchs E, Huang XJ, Locatelli F, Aversa F, Castagna L, Bacigalupo A, Martelli M, Blaise D, Ben Soussan P, Arnault Y, Handgretinger R, Roy DC, O'Donnell P, Bashey A, Solomon S, Romee R, Lewalle P, Gayoso J, Maschan M, Lazarus HM, Ballen K, Giebel S, Baron F, Ciceri F, Esteve J, Gorin NC, Spyridonidis A, Schmid C, Ciurea SO, Nagler A, Mohty M. Clinical applications of donor lymphocyte infusion from an HLA-haploidentical donor: consensus recommendations from the Acute Leukemia Working Party of the EBMT. Haematologica. 2020 01; 105(1):47-58. PMID: 31537691.
    Citations: 3     Fields:    Translation:HumansCells
  28. Meybodi MA, Cao W, Luznik L, Bashey A, Zhang X, Romee R, Saber W, Hamadani M, Weisdorf DJ, Chu H, Rashidi A. HLA-haploidentical vs matched-sibling hematopoietic cell transplantation: a systematic review and meta-analysis. Blood Adv. 2019 09 10; 3(17):2581-2585. PMID: 31484635.
    Citations: 2     Fields:    Translation:Humans
  29. Rashidi A, Hamadani M, Zhang MJ, Wang HL, Abdel-Azim H, Aljurf M, Assal A, Bajel A, Bashey A, Battiwalla M, Beitinjaneh AM, Bejanyan N, Bhatt VR, Bolaños-Meade J, Byrne M, Cahn JY, Cairo M, Ciurea S, Copelan E, Cutler C, Daly A, Diaz MA, Farhadfar N, Gale RP, Ganguly S, Grunwald MR, Hahn T, Hashmi S, Hildebrandt GC, Holland HK, Hossain N, Kanakry CG, Kharfan-Dabaja MA, Khera N, Koc Y, Lazarus HM, Lee JW, Maertens J, Martino R, McGuirk J, Munker R, Murthy HS, Nakamura R, Nathan S, Nishihori T, Palmisiano N, Patel S, Pidala J, Olin R, Olsson RF, Oran B, Ringden O, Rizzieri D, Rowe J, Savoie ML, Schultz KR, Seo S, Shaffer BC, Singh A, Solh M, Stockerl-Goldstein K, Verdonck LF, Wagner J, Waller EK, De Lima M, Sandmaier BM, Litzow M, Weisdorf D, Romee R, Saber W. Outcomes of haploidentical vs matched sibling transplantation for acute myeloid leukemia in first complete remission. Blood Adv. 2019 06 25; 3(12):1826-1836. PMID: 31201170.
    Citations: 13     Fields:    Translation:Humans
  30. Ahmed S, Kanakry JA, Ahn KW, Litovich C, Abdel-Azim H, Aljurf M, Bacher VU, Bejanyan N, Cohen JB, Farooq U, Fuchs EJ, Bolaños-Meade J, Ghosh N, Herrera AF, Hossain NM, Inwards D, Kanate AS, Martino R, Munshi PN, Murthy H, Mussetti A, Nieto Y, Perales MA, Romee R, Savani BN, Seo S, Wirk B, Yared JA, Sureda A, Fenske TS, Hamadani M. Lower Graft-versus-Host Disease and Relapse Risk in Post-Transplant Cyclophosphamide-Based Haploidentical versus Matched Sibling Donor Reduced-Intensity Conditioning Transplant for Hodgkin Lymphoma. Biol Blood Marrow Transplant. 2019 09; 25(9):1859-1868. PMID: 31132455.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  31. Rambaldi B, Romee R. Inducing Fat to Feed a Natural Killer of Malignancy. Mol Ther. 2019 05 08; 27(5):898-899. PMID: 30992190.
    Citations:    Fields:    Translation:HumansCells
  32. Ciurea SO, Al Malki MM, Kongtim P, Fuchs EJ, Luznik L, Huang XJ, Ciceri F, Locatelli F, Aversa F, Castagna L, Bacigalupo A, Martelli M, Blaise D, Ben Soussan P, Arnault Y, Handgretinger R, Roy DC, O'Donnell PV, Bashey A, Solomon S, Romee R, Gayoso J, Lazarus HM, Ballen K, Savani BN, Mohty M, Nagler A. The European Society for Blood and Marrow Transplantation (EBMT) consensus recommendations for donor selection in haploidentical hematopoietic cell transplantation. Bone Marrow Transplant. 2020 01; 55(1):12-24. PMID: 30833742.
    Citations: 13     Fields:    
  33. Epperla N, Ahn KW, Litovich C, Ahmed S, Battiwalla M, Cohen JB, Dahi P, Farhadfar N, Farooq U, Freytes CO, Ghosh N, Haverkos B, Herrera A, Hertzberg M, Hildebrandt G, Inwards D, Kharfan-Dabaja MA, Khimani F, Lazarus H, Lazaryan A, Lekakis L, Murthy H, Nathan S, Nishihori T, Pawarode A, Prestidge T, Ramakrishnan P, Rezvani AR, Romee R, Shah NN, Sureda A, Fenske TS, Hamadani M. Allogeneic hematopoietic cell transplantation provides effective salvage despite refractory disease or failed prior autologous transplant in angioimmunoblastic T-cell lymphoma: a CIBMTR analysis. J Hematol Oncol. 2019 01 10; 12(1):6. PMID: 30630534.
    Citations: 7     Fields:    Translation:Humans
  34. Rimando J, Slade M, DiPersio JF, Westervelt P, Gao F, Liu C, Romee R. HLA epitope mismatch in haploidentical transplantation is associated with decreased relapse and delayed engraftment. Blood Adv. 2018 12 26; 2(24):3590-3601. PMID: 30563883.
    Citations: 6     Fields:    Translation:Humans
  35. How J, Vij KR, Ebadi M, DeFor TE, Romee R, Dolan MM, Ustun C, Weisdorf DJ, Linden MA, Rashidi A. Prognostic value of prior consolidation in acute myeloid leukemia patients undergoing hematopoietic cell transplantation in minimal residual disease-negative first complete remission. Am J Hematol. 2018 12; 93(12):E381-E383. PMID: 30144151.
    Citations: 1     Fields:    Translation:Humans
  36. Robinson TM, Fuchs EJ, Zhang MJ, St Martin A, Labopin M, Keesler DA, Blaise D, Bashey A, Bourhis JH, Ciceri F, Ciurea SO, Devine SM, Mohty M, McCurdy SR, Milpied N, McNiece IK, Rocha V, Romee R, Socie G, Yakoub-Agha I, Soiffer RJ, Eapen M, Nagler A. Related donor transplants: has posttransplantation cyclophosphamide nullified the detrimental effect of HLA mismatch? Blood Adv. 2018 06 12; 2(11):1180-1186. PMID: 29794073.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  37. Huselton E, Slade M, Trinkaus KM, DiPersio JF, Westervelt P, Romee R. Propensity Score Analysis of Conditioning Intensity in Peripheral Blood Haploidentical Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2018 10; 24(10):2047-2055. PMID: 29803753.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  38. Romee R, Cooley S, Berrien-Elliott MM, Westervelt P, Verneris MR, Wagner JE, Weisdorf DJ, Blazar BR, Ustun C, DeFor TE, Vivek S, Peck L, DiPersio JF, Cashen AF, Kyllo R, Musiek A, Schaffer A, Anadkat MJ, Rosman I, Miller D, Egan JO, Jeng EK, Rock A, Wong HC, Fehniger TA, Miller JS. First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation. Blood. 2018 06 07; 131(23):2515-2527. PMID: 29463563.
    Citations: 74     Fields:    Translation:HumansCellsCTClinical Trials
  39. McCurdy SR, Zhang MJ, St Martin A, Al Malki MM, Bashey A, Gaballa S, Keesler DA, Hamadani M, Norkin M, Perales MA, Reshef R, Rocha V, Romee R, Solh M, Urbano-Ispizua A, Waller EK, Fuchs EJ, Eapen M. Effect of donor characteristics on haploidentical transplantation with posttransplantation cyclophosphamide. Blood Adv. 2018 02 13; 2(3):299-307. PMID: 29440002.
    Citations: 16     Fields:    Translation:Humans
  40. Ali AM, Weisel D, Gao F, Uy GL, Cashen AF, Jacoby MA, Wartman LD, Ghobadi A, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Schroeder MA, Westervelt P, DiPersio JF, Welch JS. Patterns of infectious complications in acute myeloid leukemia and myelodysplastic syndromes patients treated with 10-day decitabine regimen. Cancer Med. 2017 Dec; 6(12):2814-2821. PMID: 29058375.
    Citations: 3     Fields:    Translation:Humans
  41. Goldsmith SR, Slade M, DiPersio JF, Westervelt P, Schroeder MA, Gao F, Romee R. Donor-lymphocyte infusion following haploidentical hematopoietic cell transplantation with peripheral blood stem cell grafts and PTCy. Bone Marrow Transplant. 2017 Dec; 52(12):1623-1628. PMID: 29035393.
    Citations: 3     Fields:    Translation:Humans
  42. Wagner JA, Rosario M, Romee R, Berrien-Elliott MM, Schneider SE, Leong JW, Sullivan RP, Jewell BA, Becker-Hapak M, Schappe T, Abdel-Latif S, Ireland AR, Jaishankar D, King JA, Vij R, Clement D, Goodridge J, Malmberg KJ, Wong HC, Fehniger TA. CD56bright NK cells exhibit potent antitumor responses following IL-15 priming. J Clin Invest. 2017 Nov 01; 127(11):4042-4058. PMID: 28972539.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  43. Rashidi A, Ali AM, Vij KR, Shanley R, Romee R, Cooley SA, Westervelt P, DiPersio JF, Miller JS, Weisdorf DJ, Ustun C. Allogeneic hematopoietic cell transplantation in morphologic leukemia-free aplastic state. Am J Hematol. 2017 Sep; 92(9):E549-E552. PMID: 28568483.
    Citations:    Fields:    Translation:Humans
  44. Slade M, DiPersio JF, Westervelt P, Vij R, Schroeder MA, Romee R. Haploidentical Hematopoietic Cell Transplant with Post-Transplant Cyclophosphamide and Peripheral Blood Stem Cell Grafts in Older Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome. Biol Blood Marrow Transplant. 2017 Oct; 23(10):1736-1743. PMID: 28688919.
    Citations: 9     Fields:    Translation:Humans
  45. Bashey A, Zhang MJ, McCurdy SR, St Martin A, Argall T, Anasetti C, Ciurea SO, Fasan O, Gaballa S, Hamadani M, Munshi P, Al Malki MM, Nakamura R, O'Donnell PV, Perales MA, Raj K, Romee R, Rowley S, Rocha V, Salit RB, Solh M, Soiffer RJ, Fuchs EJ, Eapen M. Mobilized Peripheral Blood Stem Cells Versus Unstimulated Bone Marrow As a Graft Source for T-Cell-Replete Haploidentical Donor Transplantation Using Post-Transplant Cyclophosphamide. J Clin Oncol. 2017 Sep 10; 35(26):3002-3009. PMID: 28644773.
    Citations: 49     Fields:    Translation:HumansCells
  46. Hamilton BK, Rybicki L, Abounader D, Adekola K, Advani A, Aldoss I, Bachanova V, Bashey A, Brown S, DeLima M, Devine S, Flowers CR, Ganguly S, Jagasia M, Kennedy VE, Kim DDH, McGuirk J, Pullarkat V, Romee R, Sandhu K, Smith M, Ueda M, Viswabandya A, Vu K, Wall S, Zeichner SB, Perales MA, Majhail NS. Allogeneic Hematopoietic Cell Transplantation for Adult T Cell Acute Lymphoblastic Leukemia. Biol Blood Marrow Transplant. 2017 Jul; 23(7):1117-1121. PMID: 28396160.
    Citations: 2     Fields:    Translation:Humans
  47. Lin CJ, Vader JM, Slade M, DiPersio JF, Westervelt P, Romee R. Cardiomyopathy in patients after posttransplant cyclophosphamide-based hematopoietic cell transplantation. Cancer. 2017 05 15; 123(10):1800-1809. PMID: 28262921.
    Citations: 3     Fields:    Translation:Humans
  48. Pande A, Non LR, Romee R, Santos CA. Pseudozyma and other non-Candida opportunistic yeast bloodstream infections in a large stem cell transplant center. Transpl Infect Dis. 2017 Apr; 19(2). PMID: 28099778.
    Citations: 8     Fields:    Translation:HumansAnimals
  49. Ali AM, Jacoby M, Romee R. Virescent tongue. Ann Hematol. 2017 May; 96(5):883-884. PMID: 28243694.
    Citations:    Fields:    Translation:Humans
  50. Zou J, Romee R, Slade M, Phelan D, Keller J, Mohanakumar T, Grossman BJ. Untreated donor specific antibodies against HLA are associated with poor outcomes in peripheral blood haploidentical hematopoietic cell transplantation. Bone Marrow Transplant. 2017 06; 52(6):898-901. PMID: 28218756.
    Citations: 1     Fields:    Translation:Humans
  51. How J, Slade M, Vu K, DiPersio JF, Westervelt P, Uy GL, Abboud CN, Vij R, Schroeder MA, Fehniger TA, Romee R. T Cell-Replete Peripheral Blood Haploidentical Hematopoietic Cell Transplantation with Post-Transplantation Cyclophosphamide Results in Outcomes Similar to Transplantation from Traditionally Matched Donors in Active Disease Acute Myeloid Leukemia. Biol Blood Marrow Transplant. 2017 Apr; 23(4):648-653. PMID: 28087457.
    Citations: 9     Fields:    Translation:HumansCells
  52. Huselton E, Slade M, DiPersio JF, Westervelt P, Vij R, Uy GL, Fehniger TA, Abboud CN, Gao F, Schroeder MA, Romee R. Single institution experience with G-CSF mobilized T-cell replete haploidentical hematopoietic cell transplantation. Bone Marrow Transplant. 2017 05; 52(5):769-771. PMID: 28067881.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  53. Slade M, Goldsmith S, Romee R, DiPersio JF, Dubberke ER, Westervelt P, Uy GL, Lawrence SJ. Epidemiology of infections following haploidentical peripheral blood hematopoietic cell transplantation. Transpl Infect Dis. 2017 Feb; 19(1). PMID: 28030755.
    Citations: 9     Fields:    Translation:Humans
  54. Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ. TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes. N Engl J Med. 2016 11 24; 375(21):2023-2036. PMID: 27959731.
    Citations: 183     Fields:    Translation:HumansCTClinical Trials
  55. Srour SA, Milton DR, Bashey A, Karduss-Urueta A, Al Malki MM, Romee R, Solomon S, Nademanee A, Brown S, Slade M, Perez R, Rondon G, Forman SJ, Champlin RE, Kebriaei P, Ciurea SO. Haploidentical Transplantation with Post-Transplantation Cyclophosphamide for High-Risk Acute Lymphoblastic Leukemia. Biol Blood Marrow Transplant. 2017 Feb; 23(2):318-324. PMID: 27856368.
    Citations: 10     Fields:    Translation:Humans
  56. Romee R, Rosario M, Berrien-Elliott MM, Wagner JA, Jewell BA, Schappe T, Leong JW, Abdel-Latif S, Schneider SE, Willey S, Neal CC, Yu L, Oh ST, Lee YS, Mulder A, Claas F, Cooper MA, Fehniger TA. Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia. Sci Transl Med. 2016 09 21; 8(357):357ra123. PMID: 27655849.
    Citations: 182     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  57. Rashidi A, Slade M, DiPersio JF, Westervelt P, Vij R, Romee R. Post-transplant high-dose cyclophosphamide after HLA-matched vs haploidentical hematopoietic cell transplantation for AML. Bone Marrow Transplant. 2016 Dec; 51(12):1561-1564. PMID: 27526282.
    Citations: 9     Fields:    Translation:Humans
  58. Slade M, Fakhri B, Savani BN, Romee R. Halfway there: the past, present and future of haploidentical transplantation. Bone Marrow Transplant. 2017 Jan; 52(1):1-6. PMID: 27454072.
    Citations: 5     Fields:    Translation:Humans
  59. Goldsmith SR, Slade M, DiPersio JF, Westervelt P, Lawrence SJ, Uy GL, Abboud CN, Vij R, Schroeder MA, Fehniger TA, Dubberke ER, Trinkaus K, Romee R. Cytomegalovirus viremia, disease, and impact on relapse in T-cell replete peripheral blood haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide. Haematologica. 2016 11; 101(11):e465-e468. PMID: 27443287.
    Citations: 5     Fields:    Translation:HumansCells
  60. Abboud R, Keller J, Slade M, DiPersio JF, Westervelt P, Rettig MP, Meier S, Fehniger TA, Abboud CN, Uy GL, Vij R, Trinkaus KM, Schroeder MA, Romee R. Severe Cytokine-Release Syndrome after T Cell-Replete Peripheral Blood Haploidentical Donor Transplantation Is Associated with Poor Survival and Anti-IL-6 Therapy Is Safe and Well Tolerated. Biol Blood Marrow Transplant. 2016 10; 22(10):1851-1860. PMID: 27318038.
    Citations: 27     Fields:    Translation:HumansCells
  61. Rashidi A, DiPersio JF, Westervelt P, Vij R, Abboud CN, Romee R. Do adults aged 70 years or older with acute myeloid leukemia benefit from allogeneic hematopoietic cell transplantation? Leukemia. 2016 08; 30(8):1797-9. PMID: 27230239.
    Citations: 2     Fields:    Translation:Humans
  62. Rashidi A, DiPersio JF, Westervelt P, Vij R, Schroeder MA, Cashen AF, Fehniger TA, Romee R. Comparison of Outcomes after Peripheral Blood Haploidentical versus Matched Unrelated Donor Allogeneic Hematopoietic Cell Transplantation in Patients with Acute Myeloid Leukemia: A Retrospective Single-Center Review. Biol Blood Marrow Transplant. 2016 09; 22(9):1696-1701. PMID: 27223108.
    Citations: 20     Fields:    Translation:Humans
  63. Rashidi A, DiPersio JF, Westervelt P, Abboud CN, Schroeder MA, Pusic I, Cashen AF, Fehniger TA, Romee R. HLA disparity is not inconsequential in peripheral blood T-replete haploidentical hematopoietic stem cell transplantation. Bone Marrow Transplant. 2016 09; 51(9):1275-8. PMID: 27159170.
    Citations: 2     Fields:    Translation:HumansCells
  64. Rashidi A, DiPersio JF, Westervelt P, Abboud CN, Schroeder MA, Cashen AF, Pusic I, Romee R. Peritransplant Serum Albumin Decline Predicts Subsequent Severe Acute Graft-versus-Host Disease after Mucotoxic Myeloablative Conditioning. Biol Blood Marrow Transplant. 2016 06; 22(6):1137-1141. PMID: 26988741.
    Citations: 3     Fields:    Translation:Humans
  65. Rashidi A, Romee R. Graft-versus-host disease after liver transplantation: the effect of recipient-donor age difference. Clin Transplant. 2016 Mar; 30(3):335-6. PMID: 26786185.
    Citations:    Fields:    Translation:Humans
  66. Berrien-Elliott MM, Romee R, Fehniger TA. Improving natural killer cell cancer immunotherapy. Curr Opin Organ Transplant. 2015 Dec; 20(6):671-80. PMID: 26414502.
    Citations: 19     Fields:    Translation:HumansCells
  67. Rashidi A, DiPersio JF, Westervelt P, Abboud CN, Romee R. Acute myeloid leukemia presenting with extensive bone marrow necrosis, leukemia cutis and testicular involvement: successful treatment with allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2016 Mar; 51(3):454-5. PMID: 26551781.
    Citations: 2     Fields:    Translation:Humans
  68. Shanavas M, Popat U, Michaelis LC, Fauble V, McLornan D, Klisovic R, Mascarenhas J, Tamari R, Arcasoy MO, Davies J, Gergis U, Ukaegbu OC, Kamble RT, Storring JM, Majhail NS, Romee R, Verstovsek S, Pagliuca A, Vasu S, Ernst B, Atenafu EG, Hanif A, Champlin R, Hari P, Gupta V. Outcomes of Allogeneic Hematopoietic Cell Transplantation in Patients with Myelofibrosis with Prior Exposure to Janus Kinase 1/2 Inhibitors. Biol Blood Marrow Transplant. 2016 Mar; 22(3):432-40. PMID: 26493563.
    Citations: 27     Fields:    Translation:HumansCTClinical Trials
  69. Rosario M, Liu B, Kong L, Collins LI, Schneider SE, Chen X, Han K, Jeng EK, Rhode PR, Leong JW, Schappe T, Jewell BA, Keppel CR, Shah K, Hess B, Romee R, Piwnica-Worms DR, Cashen AF, Bartlett NL, Wong HC, Fehniger TA. The IL-15-Based ALT-803 Complex Enhances Fc?RIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas. Clin Cancer Res. 2016 Feb 01; 22(3):596-608. PMID: 26423796.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  70. Romee R, Miller JS. ADAM17 and CD56low CD16low NK cells. Haematologica. 2015 Aug; 100(8):e331. PMID: 26314083.
    Citations:    Fields:    Translation:HumansCells
  71. Vu K, Manjappa S, DiPersio JF, Gao F, Westervelt P, Vij R, Stockerl-Goldstein KE, Uy GL, Abboud CN, Schroeder MA, Fehniger TA, Cashen AF, Romee R. Hematologic Recovery after Pretransplant Chemotherapy Does Not Influence Survival after Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia Patients. Biol Blood Marrow Transplant. 2015 Aug; 21(8):1425-30. PMID: 25840336.
    Citations: 1     Fields:    Translation:Humans
  72. Romee R, DiPersio JF. CMV prophylaxis in hematopoietic-cell transplantation. N Engl J Med. 2014 08 07; 371(6):576. PMID: 25099586.
    Citations: 1     Fields:    Translation:Humans
  73. Romee R, Leong JW, Fehniger TA. Utilizing cytokines to function-enable human NK cells for the immunotherapy of cancer. Scientifica (Cairo). 2014; 2014:205796. PMID: 25054077.
    Citations: 43     
  74. Bhamidipati PK, DiPersio JF, Stokerl-Goldstein K, Rashidi A, Gao F, Uy GL, Westervelt P, Vij R, Schroeder MA, Abboud CN, Keller JW, Fehniger TA, Romee R. Haploidentical transplantation using G-CSF-mobilized T-cell replete PBSCs and post-transplantation CY after non-myeloablative conditioning is safe and is associated with favorable outcomes. Bone Marrow Transplant. 2014 Aug; 49(8):1124-6. PMID: 24842528.
    Citations: 8     Fields:    Translation:Humans
  75. Leong JW, Chase JM, Romee R, Schneider SE, Sullivan RP, Cooper MA, Fehniger TA. Preactivation with IL-12, IL-15, and IL-18 induces CD25 and a functional high-affinity IL-2 receptor on human cytokine-induced memory-like natural killer cells. Biol Blood Marrow Transplant. 2014 Apr; 20(4):463-73. PMID: 24434782.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  76. Sullivan RP, Fogel LA, Leong JW, Schneider SE, Wong R, Romee R, Thai TH, Sexl V, Matkovich SJ, Dorn GW, French AR, Fehniger TA. MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways. J Immunol. 2013 Dec 15; 191(12):5904-13. PMID: 24227772.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  77. Manjappa S, Bhamidipati PK, Stokerl-Goldstein KE, DiPersio JF, Uy GL, Westervelt P, Liu J, Schroeder MA, Vij R, Abboud CN, Fehniger TA, Cashen AF, Pusic I, Jacoby M, Meera SJ, Romee R. Protective effect of cytomegalovirus reactivation on relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia patients is influenced by conditioning regimen. Biol Blood Marrow Transplant. 2014 Jan; 20(1):46-52. PMID: 24120526.
    Citations: 27     Fields:    Translation:HumansCellsPHPublic Health
  78. Romee R, Foley B, Lenvik T, Wang Y, Zhang B, Ankarlo D, Luo X, Cooley S, Verneris M, Walcheck B, Miller J. NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17). Blood. 2013 May 02; 121(18):3599-608. PMID: 23487023.
    Citations: 150     Fields:    Translation:HumansCells
  79. Romee R, Weisdorf DJ, Brunstein C, Wagner JE, Cao Q, Blazar BR, Majhail NS, Vercellotti GM, Miller JS, Arora M. Impact of ABO-mismatch on risk of GVHD after umbilical cord blood transplantation. Bone Marrow Transplant. 2013 Aug; 48(8):1046-9. PMID: 23419434.
    Citations: 5     Fields:    Translation:Humans
  80. Romee R, Schneider SE, Leong JW, Chase JM, Keppel CR, Sullivan RP, Cooper MA, Fehniger TA. Cytokine activation induces human memory-like NK cells. Blood. 2012 Dec 06; 120(24):4751-60. PMID: 22983442.
    Citations: 182     Fields:    Translation:HumansCells
  81. Romee R, Brunstein CG, Weisdorf DJ, Majhail NS. Herpes simplex virus encephalitis after allogeneic transplantation: an instructive case. Bone Marrow Transplant. 2010 Apr; 45(4):776-8. PMID: 19701251.
    Citations: 5     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.