Harvard Catalyst Profiles

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Hiroto Kikuchi, Ph.D., M.B.,B.S.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shigeta K, Datta M, Hato T, Kitahara S, Chen IX, Matsui A, Kikuchi H, Mamessier E, Aoki S, Ramjiawan RR, Ochiai H, Bardeesy N, Huang P, Cobbold M, Zhu AX, Jain RK, Duda DG. Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma. Hepatology. 2020 Apr; 71(4):1247-1261. PMID: 31378984.
    Citations:    
  2. Takeda M, Sakaguchi T, Hiraide T, Shibasaki Y, Morita Y, Kikuchi H, Ikegami K, Setou M, Konno H, Takeuchi H. Role of caveolin-1 in hepatocellular carcinoma arising from non-alcoholic fatty liver disease. Cancer Sci. 2018 Aug; 109(8):2401-2411. PMID: 29896915.
    Citations: 1     Fields:    Translation:HumansCells
  3. Murakami T, Kikuchi H, Ishimatsu H, Iino I, Hirotsu A, Matsumoto T, Ozaki Y, Kawabata T, Hiramatsu Y, Ohta M, Kamiya K, Fukushima M, Baba S, Kitagawa K, Kitagawa M, Konno H. Tenascin C in colorectal cancer stroma is a predictive marker for liver metastasis and is a potent target of miR-198 as identified by microRNA analysis. Br J Cancer. 2017 Oct 24; 117(9):1360-1370. PMID: 29065427.
    Citations: 1     Fields:    Translation:HumansCells
  4. Hara R, Kikuchi H, Setoguchi T, Miyazaki S, Yamamoto M, Hiramatsu Y, Kamiya K, Ohta M, Baba S, Konno H. Microarray analysis reveals distinct gene set profiles for gastric and intestinal gastrointestinal stromal tumors. Anticancer Res. 2015 Jun; 35(6):3289-98. PMID: 26026088.
    Citations: 2     Fields:    Translation:HumansCells
  5. Uehara T, Kikuchi H, Miyazaki S, Iino I, Setoguchi T, Hiramatsu Y, Ohta M, Kamiya K, Morita Y, Tanaka H, Baba S, Hayasaka T, Setou M, Konno H. Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer. Ann Surg Oncol. 2016 Feb; 23 Suppl 2:S206-13. PMID: 25752890.
    Citations: 11     Fields:    Translation:Humans
  6. Kikuchi H, Kamiya K, Hiramatsu Y, Miyazaki S, Yamamoto M, Ohta M, Baba S, Konno H. Laparoscopic narrow-band imaging for the diagnosis of peritoneal metastasis in gastric cancer. Ann Surg Oncol. 2014 Nov; 21(12):3954-62. PMID: 24859934.
    Citations: 6     Fields:    Translation:Humans
  7. Miyazaki S, Kikuchi H, Iino I, Uehara T, Setoguchi T, Fujita T, Hiramatsu Y, Ohta M, Kamiya K, Kitagawa K, Kitagawa M, Baba S, Konno H. Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts. Int J Cancer. 2014 Jul 15; 135(2):295-307. PMID: 24375080.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  8. Wang L, Gala M, Yamamoto M, Pino MS, Kikuchi H, Shue DS, Shirasawa S, Austin TR, Lynch MP, Rueda BR, Zukerberg LR, Chung DC. Adrenomedullin is a therapeutic target in colorectal cancer. Int J Cancer. 2014 May 01; 134(9):2041-50. PMID: 24519534.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  9. Duerr EM, Mizukami Y, Moriichi K, Gala M, Jo WS, Kikuchi H, Xavier RJ, Chung DC. Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines. Am J Physiol Gastrointest Liver Physiol. 2012 May 15; 302(10):G1223-30. PMID: 22383492.
    Citations:    Fields:    Translation:HumansCells
  10. Kawabata T, Kikuchi H, Okazaki S, Yamamoto M, Hiramatsu Y, Yang J, Baba M, Ohta M, Kamiya K, Tanaka T, Konno H. Near-infrared multichannel Raman spectroscopy with a 1064 nm excitation wavelength for ex vivo diagnosis of gastric cancer. J Surg Res. 2011 Aug; 169(2):e137-43. PMID: 21612793.
    Citations: 4     Fields:    Translation:Humans
  11. Kikuchi H, Setoguchi T, Miyazaki S, Yamamoto M, Ohta M, Kamiya K, Sakaguchi T, Konno H. Surgical intervention for imatinib and sunitinib-resistant gastrointestinal stromal tumors. Int J Clin Oncol. 2011 Dec; 16(6):741-5. PMID: 21394667.
    Citations:    Fields:    Translation:Humans
  12. Setoguchi T, Kikuchi H, Yamamoto M, Baba M, Ohta M, Kamiya K, Tanaka T, Baba S, Goto-Inoue N, Setou M, Sasaki T, Mori H, Sugimura H, Konno H. Microarray analysis identifies versican and CD9 as potent prognostic markers in gastric gastrointestinal stromal tumors. Cancer Sci. 2011 Apr; 102(4):883-9. PMID: 21244575.
    Citations: 10     Fields:    Translation:Humans
  13. Zeng M, Kikuchi H, Pino MS, Chung DC. Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells. PLoS One. 2010 Jun 04; 5(6):e10966. PMID: 20532039.
    Citations: 14     Fields:    Translation:HumansCells
  14. Pino MS, Kikuchi H, Zeng M, Herraiz MT, Sperduti I, Berger D, Park DY, Iafrate AJ, Zukerberg LR, Chung DC. Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability. Gastroenterology. 2010 Apr; 138(4):1406-17. PMID: 20026115.
    Citations: 38     Fields:    Translation:HumansCells
  15. Ohta M, Kawabata T, Yamamoto M, Tanaka T, Kikuchi H, Hiramatsu Y, Kamiya K, Baba M, Konno H. TSU68, an antiangiogenic receptor tyrosine kinase inhibitor, induces tumor vascular normalization in a human cancer xenograft nude mouse model. Surg Today. 2009; 39(12):1046-53. PMID: 19997799.
    Citations: 12     Fields:    Translation:HumansAnimals
  16. Kikuchi H, Pino MS, Zeng M, Shirasawa S, Chung DC. Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer. Cancer Res. 2009 Nov 01; 69(21):8499-506. PMID: 19843849.
    Citations: 33     Fields:    Translation:HumansCells
  17. Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, Xavier RJ. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res. 2009 Aug; 37(14):4587-602. PMID: 19491311.
    Citations: 134     Fields:    Translation:HumansCells
  18. Imamura T, Kikuchi H, Herraiz MT, Park DY, Mizukami Y, Mino-Kenduson M, Lynch MP, Rueda BR, Benita Y, Xavier RJ, Chung DC. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer. 2009 Feb 15; 124(4):763-71. PMID: 19030186.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  19. Yamamoto M, Kikuchi H, Ohta M, Kawabata T, Hiramatsu Y, Kondo K, Baba M, Kamiya K, Tanaka T, Kitagawa M, Konno H. TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche. Cancer Res. 2008 Dec 01; 68(23):9754-62. PMID: 19047154.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  20. Fujiki K, Duerr EM, Kikuchi H, Ng A, Xavier RJ, Mizukami Y, Imamura T, Kulke MH, Chung DC. Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth. Gastroenterology. 2008 Sep; 135(3):907-16, 916.e1-2. PMID: 18655788.
    Citations: 5     Fields:    Translation:HumansCells
  21. Kawabata T, Mizuno T, Okazaki S, Hiramatsu M, Setoguchi T, Kikuchi H, Yamamoto M, Hiramatsu Y, Kondo K, Baba M, Ohta M, Kamiya K, Tanaka T, Suzuki S, Konno H. Optical diagnosis of gastric cancer using near-infrared multichannel Raman spectroscopy with a 1064-nm excitation wavelength. J Gastroenterol. 2008; 43(4):283-90. PMID: 18458844.
    Citations: 6     Fields:    Translation:Humans
  22. Duerr EM, Mizukami Y, Ng A, Xavier RJ, Kikuchi H, Deshpande V, Warshaw AL, Glickman J, Kulke MH, Chung DC. Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis. Endocr Relat Cancer. 2008 Mar; 15(1):243-56. PMID: 18310291.
    Citations: 24     Fields:    Translation:Humans
  23. Hattori T, Isobe T, Abe K, Kikuchi H, Kitagawa K, Oda T, Uchida C, Kitagawa M. Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1. Cancer Res. 2007 Nov 15; 67(22):10789-95. PMID: 18006823.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  24. Kikuchi H, Yamamoto M, Hiramatsu Y, Baba M, Ohta M, Kamiya K, Tanaka T, Suzuki S, Sugimura H, Kitagawa M, Kanai T, Kitayama Y, Kanda T, Nishikura K, Konno H. Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. Cancer Sci. 2007 Nov; 98(11):1734-9. PMID: 17894554.
    Citations: 5     Fields:    Translation:HumansCells
  25. Kikuchi H, Uchida C, Hattori T, Isobe T, Hiramatsu Y, Kitagawa K, Oda T, Konno H, Kitagawa M. ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells. Carcinogenesis. 2007 Aug; 28(8):1752-8. PMID: 17510080.
    Citations: 4     Fields:    Translation:HumansCells
  26. Gao Y, Kitagawa K, Hiramatsu Y, Kikuchi H, Isobe T, Shimada M, Uchida C, Hattori T, Oda T, Nakayama K, Nakayama KI, Tanaka T, Konno H, Kitagawa M. Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res. 2006 Dec 15; 66(24):11623-31. PMID: 17178856.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  27. Hiramatsu Y, Kitagawa K, Suzuki T, Uchida C, Hattori T, Kikuchi H, Oda T, Hatakeyama S, Nakayama KI, Yamamoto T, Konno H, Kitagawa M. Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination. Cancer Res. 2006 Sep 01; 66(17):8477-83. PMID: 16951159.
    Citations: 19     Fields:    Translation:HumansCells
  28. Kikuchi H, Yamamoto M, Hiramatsu Y, Baba M, Ohta M, Kamiya K, Tanaka T, Suzuki S, Sugimura H, Konno H. [Manifestation of liver metastasis 13 years after gastrectomy for gastric GIST]. Nihon Shokakibyo Gakkai Zasshi. 2006 Sep; 103(9):1055-60. PMID: 16953103.
    Citations:    Fields:    Translation:Humans
  29. Kikuchi H, Yamashita K, Kawabata T, Yamamoto M, Hiramatsu Y, Kondo K, Baba M, Ohta M, Kamiya K, Tanaka T, Suzuki S, Kitagawa K, Kitagawa M, Sugimura H, Konno H. Immunohistochemical and genetic features of gastric and metastatic liver gastrointestinal stromal tumors: sequential analyses. Cancer Sci. 2006 Feb; 97(2):127-32. PMID: 16441423.
    Citations: 5     Fields:    Translation:HumansCells
  30. Kikuchi H, Konn H, Kamiya K, Baba M, Ohta M, Kondo K, Hiramatsu Y, Yamamoto M, Tanaka T, Sugimura H, Ohashi M, Kanda T, Nakamura S. [Two cases of postoperative recurrence of gastric GIST treated by imatinib]. Gan To Kagaku Ryoho. 2004 Oct; 31(10):1569-73. PMID: 15508453.
    Citations:    Fields:    Translation:Humans
  31. Hiramatsu Y, Konno H, Kamiya K, Baba M, Ohta M, Kondo K, Yamamoto M, Kikuchi H, Tanaka T, Sugimura H, Nakamura S. [A case of gastric GIST treated preoperatively by imatinib mesylate]. Gan To Kagaku Ryoho. 2004 Aug; 31(8):1219-23. PMID: 15332547.
    Citations:    Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.