Harvard Catalyst Profiles

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Lucy Hwa-Yue Young, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R29EY010975 (YOUNG, LUCY H) Sep 1, 1994 - Aug 31, 2000
    Role: Principal Investigator
  2. F32EY006145 (YOUNG, LUCY H) Jul 1, 1988
    Role: Principal Investigator
  3. S07RR005485 (JAKOBIEC, FREDERICK A.) Apr 1, 1979 - Sep 29, 1992
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wai KM, Begaj T, Patil S, Chen EM, Miller JB, Kylstra J, Aronow ME, Young LH, Huckfeldt R, Husain D, Kim LA, Vavvas DG, Eliott D, Mukai S, Gragoudas ES, Patel NA, Sobrin L, Miller JW, Parikh R, Wu DM. The Effect of Sample Medication Use on Subsequent Anti-VEGF Agent Selection for Neovascular Age-Related Macular Degeneration. Semin Ophthalmol. 2022 Oct-Nov; 37(7-8):902-908. PMID: 35923110.
    Citations:    Fields:    
  2. Saini C, Chen TC, Young LH, Vavvas DG, Vangel M, Papaliodis GN, Mukai S, Turalba AV, Rhee DJ, Wu DM, Eliott D, Miller JB, Song BJ, Shen LQ, Pasquale LR, Chodosh J. Restoration of Vision in Severe, Cicatricial, Ocular Surface Disease With the Boston Keratoprosthesis Type II. Am J Ophthalmol. 2022 11; 243:42-54. PMID: 35850253.
    Citations:    Fields:    Translation:Humans
  3. Xu C, Chen TC, Chodosh J, Eliott D, Mukai S, Shen LQ, Vavvas DG, Young LH, Lin MM. Endoscopic Cyclophotocoagulation in Boston Keratoprosthesis Type II. Ophthalmol Glaucoma. 2022 Jan-Feb; 5(1):120-123. PMID: 34265498.
    Citations:    Fields:    Translation:Humans
  4. Huckfeldt RM, Grigorian F, Place E, Comander JI, Vavvas D, Young LH, Yang P, Shurygina M, Pierce EA, Pennesi ME. Biallelic RP1-associated retinal dystrophies: Expanding the mutational and clinical spectrum. Mol Vis. 2020; 26:423-433. PMID: 32565670.
    Citations: 5     Fields:    Translation:Humans
  5. Arranz-Solís D, Cordeiro C, Young LH, Dardé ML, Commodaro AG, Grigg ME, Saeij JPJ. Serotyping of Toxoplasma gondii Infection Using Peptide Membrane Arrays. Front Cell Infect Microbiol. 2019; 9:408. PMID: 31850240.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  6. Zantut PRA, Veras MM, Yariwake VY, Takahashi WY, Saldiva PH, Young LH, Damico FM, Fajersztajn L. Effects of cannabis and its components on the retina: a systematic review. Cutan Ocul Toxicol. 2020 Mar; 39(1):1-9. PMID: 31648567.
    Citations: 1     Fields:    Translation:HumansAnimals
  7. Sangaré LO, Yang N, Konstantinou EK, Lu D, Mukhopadhyay D, Young LH, Saeij JPJ. Toxoplasma GRA15 Activates the NF-?B Pathway through Interactions with TNF Receptor-Associated Factors. mBio. 2019 07 16; 10(4). PMID: 31311877.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  8. Lee Kim E, Weiner AJ, Ung C, Roh M, Wang J, Lee IJ, Huang NT, Stem M, Dahrouj M, Eliott D, Vavvas DG, Young LHY, Williams GA, Garretson BR, Kim IK, Hassan TS, Mukai S, Ruby AJ, Faia LJ, Capone A, Comander J, Kim LA, Wu DM, Drenser KA, Woodward MA, Wolfe JD, Yonekawa Y. Characterization of Epiretinal Proliferation in Full-Thickness Macular Holes and Effects on Surgical Outcomes. Ophthalmol Retina. 2019 08; 3(8):694-702. PMID: 31104985; PMCID: PMC6684822.
    Citations: 7     Fields:    Translation:Humans
  9. Jorge A, Ung C, Young LH, Melles RB, Choi HK. Hydroxychloroquine retinopathy - implications of research advances for rheumatology care. Nat Rev Rheumatol. 2018 12; 14(12):693-703. PMID: 30401979.
    Citations: 68     Fields:    Translation:Humans
  10. Prasad S, Young LH, Bouffard M, Gupta R. Case 37-2018: A 23-Year-Old Woman with Vision Loss. N Engl J Med. 2018 Nov 29; 379(22):2152-2159. PMID: 30485774.
    Citations:    Fields:    Translation:Humans
  11. Jorge AM, Melles RB, Zhang Y, Lu N, Rai SK, Young LH, Costenbader KH, Ramsey-Goldman R, Lim SS, Esdaile JM, Clarke AE, Urowitz MB, Askanase A, Aranow C, Petri M, Choi H. Hydroxychloroquine prescription trends and predictors for excess dosing per recent ophthalmology guidelines. Arthritis Res Ther. 2018 07 05; 20(1):133. PMID: 29976231; PMCID: PMC6034317.
    Citations: 10     Fields:    Translation:Humans
  12. Chung EJ, Efstathiou NE, Konstantinou EK, Maidana DE, Miller JW, Young LH, Vavvas DG. AICAR suppresses TNF-a-induced complement factor B in RPE cells. Sci Rep. 2017 12 15; 7(1):17651. PMID: 29247196.
    Citations: 5     Fields:    Translation:HumansCells
  13. Konstantinou EK, Notomi S, Kosmidou C, Brodowska K, Al-Moujahed A, Nicolaou F, Tsoka P, Gragoudas E, Miller JW, Young LH, Vavvas DG. Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity. Sci Rep. 2017 04 21; 7:46581. PMID: 28429726; PMCID: PMC5399488.
    Citations: 34     Fields:    Translation:HumansCells
  14. Krishnamurthy S, Konstantinou EK, Young LH, Gold DA, Saeij JP. The human immune response to Toxoplasma: Autophagy versus cell death. PLoS Pathog. 2017 03; 13(3):e1006176. PMID: 28278184; PMCID: PMC5344534.
    Citations: 18     Fields:    Translation:HumansAnimals
  15. Cordeiro CA, Vieira ELM, Castro VM, Dutra WO, Costa RA, Orefice JL, Campos WR, Orefice F, Young LH, Teixeira AL. T cell immunoregulation in active ocular toxoplasmosis. Immunol Lett. 2017 04; 184:84-91. PMID: 28214536.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  16. Ung C, Borkar DS, Young LH. Current and Emerging Treatment for Diabetic Macular Edema. Int Ophthalmol Clin. 2017; 57(4):165-177. PMID: 28885255.
    Citations: 2     Fields:    Translation:Humans
  17. Stryjewski TP, Scott NL, Barshak MB, Tobin EH, Mali JO, Young LH, Foster CS, Kim IK, Durand ML. Treatment of Refractory Acute Retinal Necrosis with Intravenous Foscarnet or Cidofovir. Ocul Immunol Inflamm. 2018; 26(2):199-203. PMID: 27598973.
    Citations: 3     Fields:    Translation:HumansCells
  18. Finn AP, Eliott D, Kim LA, Husain D, Wu DM, Young LH, Kim IK, Andreoli C, Skondra D, Vavvas DG, Miller JB. Characteristics and Outcomes of Simultaneous Bilateral Rhegmatogenous Retinal Detachments. Ophthalmic Surg Lasers Imaging Retina. 2016 09 01; 47(9):840-5. PMID: 27631480.
    Citations: 2     Fields:    Translation:Humans
  19. Miller JB, Yonekawa Y, Eliott D, Kim IK, Kim LA, Loewenstein JI, Sobrin L, Young LH, Mukai S, Vavvas DG. Long-term Follow-up and Outcomes in Traumatic Macular Holes. Am J Ophthalmol. 2016 06; 166:206-207. PMID: 27084591.
    Citations: 2     Fields:    Translation:Humans
  20. Vavvas DG, Daniels AB, Kapsala ZG, Goldfarb JW, Ganotakis E, Loewenstein JI, Young LH, Gragoudas ES, Eliott D, Kim IK, Tsilimbaris MK, Miller JW. Regression of Some High-risk Features of Age-related Macular Degeneration (AMD) in Patients Receiving Intensive Statin Treatment. EBioMedicine. 2016 Mar; 5:198-203. PMID: 27077128.
    Citations: 65     Fields:    Translation:HumansCTClinical Trials
  21. Brader HS, Young LH. Subthreshold Diode Micropulse Laser: A Review. Semin Ophthalmol. 2016; 31(1-2):30-9. PMID: 26959127.
    Citations: 14     Fields:    Translation:Humans
  22. Roh M, Yasa C, Cho H, Nicholson L, Uchiyama E, Young LH, Lobo AM, Papaliodis GN, Durand ML, Sobrin L. The role of serological titres in the diagnosis of ocular toxoplasmosis. Acta Ophthalmol. 2016 Aug; 94(5):521-2. PMID: 26426456.
    Citations: 4     Fields:    Translation:HumansAnimals
  23. Miller JB, Yonekawa Y, Eliott D, Kim IK, Kim LA, Loewenstein JI, Sobrin L, Young LH, Mukai S, Vavvas DG. Long-term Follow-up and Outcomes in Traumatic Macular Holes. Am J Ophthalmol. 2015 Dec; 160(6):1255-1258.e1. PMID: 26393438.
    Citations: 16     Fields:    Translation:Humans
  24. Taniguchi EV, Young LH, Shen LQ. Optic nerve pit and associated macular detachment. JAMA Ophthalmol. 2015 Jan; 133(1):e141775. PMID: 25569314.
    Citations:    Fields:    Translation:Humans
  25. Thanos A, Papakostas TD, Young LH. Scleral Buckle: Does it Still Have a Role in Retinal Detachment Repair? Int Ophthalmol Clin. 2015; 55(4):147-56. PMID: 26322434.
    Citations: 2     Fields:    Translation:Humans
  26. Patel AV, Barb SM, Young LH. Finding the Optimal Treatment Plan for Exudative AMD: A review of Current Anti-VEGF Dosing Regimens. Int Ophthalmol Clin. 2015; 55(4):103-12. PMID: 26322430.
    Citations:    Fields:    Translation:Humans
  27. Barb SM, Patel AV, Young LH. Toxoplasmic Retinitis: To Treat or Not to Treat and With What Drug? Int Ophthalmol Clin. 2015; 55(4):137-45. PMID: 26322433.
    Citations: 1     Fields:    Translation:Humans
  28. Chen X, Modjtahedi BS, Young LH. Management of Diabetic Macular Edema: Is It Time to Say Goodbye to Macular Laser? Int Ophthalmol Clin. 2015; 55(4):113-22. PMID: 26322431.
    Citations: 1     Fields:    Translation:Humans
  29. Qian CX, Young LH. The impact of cataract surgery on AMD development and progression. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):301-11. PMID: 25325855.
    Citations: 4     Fields:    Translation:Humans
  30. Ramsey DJ, Haddock LJ, Young LH, Eliott D. Complications of subspecialty ophthalmic care: systemic complications from the intravitreal administration of agents that target the vascular endothelial growth factor pathway. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):263-75. PMID: 25325852.
    Citations: 3     Fields:    Translation:Humans
  31. Haddock LJ, Ramsey DJ, Young LH. Complications of subspecialty ophthalmic care: endophthalmitis after intravitreal injections of anti-vascular endothelial growth factor medications. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):257-62. PMID: 25325851.
    Citations: 10     Fields:    Translation:Humans
  32. Melo MB, Nguyen QP, Cordeiro C, Hassan MA, Yang N, McKell R, Rosowski EE, Julien L, Butty V, Dardé ML, Ajzenberg D, Fitzgerald K, Young LH, Saeij JP. Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways. PLoS Pathog. 2013; 9(12):e1003779. PMID: 24367253.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  33. Cordeiro CA, Moreira PR, Bessa TF, Costa GC, Dutra WO, Campos WR, Oréfice F, Young LH, Teixeira AL. Interleukin-6 gene polymorphism (-174 G/C) is associated with toxoplasmic retinochoroiditis. Acta Ophthalmol. 2013 Jun; 91(4):e311-4. PMID: 23336844.
    Citations: 9     Fields:    Translation:HumansAnimals
  34. Sandhu HS, Young LH. Ocular siderosis. Int Ophthalmol Clin. 2013; 53(4):177-84. PMID: 24088944.
    Citations: 11     Fields:    Translation:Humans
  35. Yiu G, Young LH. Choroidal osteomas. JAMA Ophthalmol. 2013 Jan; 131(1):124. PMID: 23307230.
    Citations:    Fields:    Translation:Humans
  36. Bessa TF, Cordeiro CA, Gonçalves RM, Young LH, Campos WR, Oréfice F, Teixeira AL. Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic retinochoroiditis. Braz J Infect Dis. 2012 Nov-Dec; 16(6):540-4. PMID: 23141990.
    Citations: 1     Fields:    Translation:Humans
  37. Yiu G, Young LH. Progressive outer retinal necrosis presenting as cherry red spot. Ocul Immunol Inflamm. 2012 Oct; 20(5):384-6. PMID: 22957726.
    Citations:    Fields:    Translation:Humans
  38. Thanos A, Vavvas D, Young LH, Foster CS. Choroidal neovascular membrane formation and retinochoroidopathy in a patient with systemic langerhans cell histiocytosis: a case report and review of the literature. Case Rep Ophthalmol. 2012 Jan; 3(1):128-35. PMID: 23002392.
  39. Thanos A, Morizane Y, Murakami Y, Giani A, Mantopoulos D, Kayama M, Roh MI, Michaud N, Pawlyk B, Sandberg M, Young LH, Miller JW, Vavvas DG. Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse. Am J Pathol. 2012 May; 180(5):1917-27. PMID: 22429967; PMCID: PMC3349832.
    Citations: 23     Fields:    Translation:AnimalsCells
  40. Chang GC, Young LH. Sympathetic ophthalmia. Semin Ophthalmol. 2011 Jul-Sep; 26(4-5):316-20. PMID: 21958181.
    Citations: 12     Fields:    Translation:Humans
  41. Daniels AB, Kohanim S, Huynh N, Durand ML, Young LH. Antiviral chemoprophylaxis for ocular viral infections in hematopoietic stem cell and bone marrow transplant patients. Int Ophthalmol Clin. 2011; 51(4):53-66. PMID: 21897140.
    Citations:    Fields:    Translation:Humans
  42. Englander M, Young LH. Ocular toxoplasmosis: advances in detection and treatment. Int Ophthalmol Clin. 2011; 51(4):13-23. PMID: 21897136.
    Citations: 1     Fields:    Translation:HumansAnimals
  43. Huynh N, Daniels AB, Kohanim S, Young LH. Medical treatment for cytomegalovirus retinitis. Int Ophthalmol Clin. 2011; 51(4):93-103. PMID: 21897143.
    Citations: 1     Fields:    Translation:Humans
  44. Young LH, Bazari H, Durand ML, Branda JA. Case records of the Massachusetts General Hospital. Case 33-2010. A 22-year-old woman with blurred vision and renal failure. N Engl J Med. 2010 Oct 28; 363(18):1749-58. PMID: 20979476.
    Citations: 2     Fields:    Translation:HumansAnimals
  45. Tibbetts MD, Shah CP, Young LH, Duker JS, Maguire JI, Morley MG. Treatment of acute retinal necrosis. Ophthalmology. 2010 Apr; 117(4):818-24. PMID: 20079537.
    Citations: 45     Fields:    Translation:Humans
  46. Rashid S, Young LH. Progression of diabetic retinopathy and maculopathy after phacoemulsification surgery. Int Ophthalmol Clin. 2010; 50(1):155-66. PMID: 20057304.
    Citations: 2     Fields:    Translation:Humans
  47. Pachydaki SI, Young LH. Genetics of hereditary vitreoretinal degenerations. Semin Ophthalmol. 2007 Oct-Dec; 22(4):219-27. PMID: 18097985.
    Citations: 1     Fields:    Translation:Humans
  48. Maison SF, Parker LL, Young L, Adelman JP, Zuo J, Liberman MC. Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance. J Neurophysiol. 2007 Apr; 97(4):2930-6. PMID: 17267753; PMCID: PMC1850627.
    Citations: 13     Fields:    Translation:AnimalsCellsPHPublic Health
  49. Waheed NK, Young LH. Intraocular foreign body related endophthalmitis. Int Ophthalmol Clin. 2007; 47(2):165-71. PMID: 17450016.
    Citations:    Fields:    Translation:Humans
  50. Chang S, Young LH. Acute retinal necrosis: an overview. Int Ophthalmol Clin. 2007; 47(2):145-54. PMID: 17450014.
    Citations: 7     Fields:    Translation:Humans
  51. Ament CS, Zacks DN, Lane AM, Krzystolik M, D'Amico DJ, Mukai S, Young LH, Loewenstein J, Arroyo J, Miller JW. Predictors of visual outcome and choroidal neovascular membrane formation after traumatic choroidal rupture. Arch Ophthalmol. 2006 Jul; 124(7):957-66. PMID: 16832018.
    Citations: 16     Fields:    Translation:Humans
  52. Yu SY, Damico FM, Viola F, D'Amico DJ, Young LH. Retinal toxicity of intravitreal triamcinolone acetonide: a morphological study. Retina. 2006 May-Jun; 26(5):531-6. PMID: 16770259.
    Citations: 21     Fields:    Translation:Animals
  53. Mandava N, Bartlett H, Young LH, Brooks HL. Diagnostic and therapeutic challenges. Retina. 2006 Feb; 26(2):214-8. PMID: 16467681.
    Citations:    Fields:    Translation:Humans
  54. Kim RY, Gragroudas ES, Young LH. Future laser approaches in melanoma treatment. Int Ophthalmol Clin. 2006; 46(1):27-39. PMID: 16365553.
    Citations:    Fields:    Translation:HumansAnimals
  55. Koo L, Young LH. Management of ocular toxoplasmosis. Int Ophthalmol Clin. 2006; 46(2):183-93. PMID: 16770162.
    Citations: 1     Fields:    Translation:Humans
  56. Ament CS, Young LH. Ocular manifestations of helminthic infections: onchocersiasis, cysticercosis, toxocariasis, and diffuse unilateral subacute neuroretinitis. Int Ophthalmol Clin. 2006; 46(2):1-10. PMID: 16770150.
    Citations: 6     Fields:    Translation:Humans
  57. Singh RP, Young LH. Diagnostic tests for posterior segment inflammation. Int Ophthalmol Clin. 2006; 46(2):195-208. PMID: 16770163.
    Citations:    Fields:    Translation:Humans
  58. Wiegand TW, Young LH. Cytomegalovirus retinitis. Int Ophthalmol Clin. 2006; 46(2):91-110. PMID: 16770157.
    Citations: 13     Fields:    Translation:Humans
  59. Paul Chan RV, Young LH. Treatment options for metastatic tumors to the choroid. Semin Ophthalmol. 2005 Oct-Dec; 20(4):207-16. PMID: 16361217.
    Citations: 2     Fields:    Translation:Humans
  60. Young LH, Gross JG, Lai JC, Shakin JL, Thompson JT. Diagnostic and therapeutic challenges. Retina. 2005 Oct-Nov; 25(7):930-5. PMID: 16205574.
    Citations:    Fields:    Translation:Humans
  61. Chen TC, Young LH. Sturge-Weber syndrome (choroidal hemangioma and glaucoma). J Pediatr Ophthalmol Strabismus. 2005 Sep-Oct; 42(5):320. PMID: 16250225.
    Citations:    Fields:    Translation:Humans
  62. Damico FM, Kiss S, Young LH. Sympathetic ophthalmia. Semin Ophthalmol. 2005 Jul-Sep; 20(3):191-7. PMID: 16282154.
    Citations: 29     Fields:    Translation:Humans
  63. Damico FM, Kiss S, Young LH. Vogt-Koyanagi-Harada disease. Semin Ophthalmol. 2005 Jul-Sep; 20(3):183-90. PMID: 16282153.
    Citations: 21     Fields:    Translation:Humans
  64. Kiss S, Damico FM, Young LH. Ocular manifestations and treatment of syphilis. Semin Ophthalmol. 2005 Jul-Sep; 20(3):161-7. PMID: 16282150.
    Citations: 59     Fields:    Translation:Humans
  65. Krause MH, Kwong KK, Gragoudas ES, Young LH. MRI of blood volume with superparamagnetic iron in choroidal melanoma treated with thermotherapy. Magn Reson Imaging. 2004 Jul; 22(6):779-87. PMID: 15234446.
    Citations: 2     Fields:    Translation:Animals
  66. Acharya N, Young L. Sustained-release drug implants for the treatment of intraocular disease. Int Ophthalmol Clin. 2004; 44(3):33-9. PMID: 15211175.
    Citations: 6     Fields:    Translation:Humans
  67. Krause MH, Kwong KK, Xiong J, Gragoudas ES, Young LH. MRI of blood volume with MS 325 in experimental choroidal melanoma. Magn Reson Imaging. 2003 Sep; 21(7):725-32. PMID: 14559336.
    Citations: 4     Fields:    Translation:Animals
  68. Krause MH, Xiong J, Gragoudas ES, Young LH. Treatment of experimental choroidal melanoma with an Nd:yttrium-lanthanum-fluoride laser at 1047 nm. Arch Ophthalmol. 2003 Mar; 121(3):357-63. PMID: 12617706.
    Citations: 2     Fields:    Translation:Animals
  69. Hu L, Wu X, Song Y, Young LH, Gragoudas ES. [Photodynamic therapy of pigmented choroidal melanomas in rabbits]. Zhonghua Yan Ke Za Zhi. 2002 Aug; 38(8):491-4. PMID: 12410990.
    Citations: 2     Fields:    Translation:AnimalsCells
  70. Krause M, Kwong KK, Xiong J, Gragoudas ES, Young LH. MRI of blood volume and cellular uptake of superparamagnetic iron in an animal model of choroidal melanoma. Ophthalmic Res. 2002 Jul-Aug; 34(4):241-50. PMID: 12297697.
    Citations: 9     Fields:    Translation:AnimalsCells
  71. Youssri AI, Young LH. Closed-globe contusion injuries of the posterior segment. Int Ophthalmol Clin. 2002; 42(3):79-86. PMID: 12131585.
    Citations: 4     Fields:    Translation:HumansAnimals
  72. Zacks DN, Hart L, Young LH. Ultrasonography in the traumatized eye: intraocular foreign body versus artifact. Int Ophthalmol Clin. 2002; 42(3):121-8. PMID: 12131589.
    Citations: 1     Fields:    Translation:Humans
  73. Lit ES, Young LH. Anterior and posterior segment intraocular foreign bodies. Int Ophthalmol Clin. 2002; 42(3):107-20. PMID: 12131588.
    Citations: 14     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.