Harvard Catalyst Profiles

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Takahiro Kishikawa, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Suzuki T, Kishikawa T, Sato T, Takeda N, Sugiura Y, Seimiya T, Sekiba K, Ohno M, Iwata T, Ishibashi R, Otsuka M, Koike K. Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells. Cancer Gene Ther. 2021 Apr 08. PMID: 33833413.
    Citations:    Fields:    
  2. Nakatsuka T, Nakagawa H, Hayata Y, Wake T, Yamada T, Nishibatake Kinoshita M, Nakagomi R, Sato M, Minami T, Uchino K, Enooku K, Kudo Y, Tanaka Y, Kishikawa T, Otsuka M, Tateishi R, Koike K. Post-treatment cell-free DNA as a predictive biomarker in molecular-targeted therapy of hepatocellular carcinoma. J Gastroenterol. 2021 May; 56(5):456-469. PMID: 33712873.
    Citations:    Fields:    
  3. Lee YR, Yehia L, Kishikawa T, Ni Y, Leach B, Zhang J, Panch N, Liu J, Wei W, Eng C, Pandolfi PP. WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition. N Engl J Med. 2020 05 28; 382(22):2103-2116. PMID: 32459922.
    Citations: 5     Fields:    Translation:HumansAnimals
  4. Ishibashi R, Yoshida S, Odawara N, Kishikawa T, Kondo R, Nakada A, Hakuta R, Takahara N, Tanaka E, Sekiba K, Seimiya T, Ohnaga T, Otsuka M, Koike K. Detection of circulating colorectal cancer cells by a custom microfluid system before and after endoscopic metallic stent placement. Oncol Lett. 2019 Dec; 18(6):6397-6404. PMID: 31807163.
    Citations: 2     
  5. Tanaka E, Miyakawa Y, Kishikawa T, Seimiya T, Iwata T, Funato K, Odawara N, Sekiba K, Yamagami M, Suzuki T, Ishibashi R, Otsuka M, Koike K. Expression of circular RNA CDR1-AS in colon cancer cells increases cell surface PD-L1 protein levels. Oncol Rep. 2019 Oct; 42(4):1459-1466. PMID: 31322270.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  6. Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Seimiya T, Suzuki T, Tanaka E, Ishibashi R, Funato K, Koike K. Pevonedistat, a Neuronal Precursor Cell-Expressed Developmentally Down-Regulated Protein 8-Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus. Hepatology. 2019 05; 69(5):1903-1915. PMID: 30586159.
    Citations: 6     Fields:    Translation:HumansCells
  7. Yamagami M, Otsuka M, Kishikawa T, Sekiba K, Seimiya T, Tanaka E, Suzuki T, Ishibashi R, Ohno M, Koike K. ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells. NPJ Aging Mech Dis. 2018; 4:11. PMID: 30455980.
  8. Saito K, Isayama H, Nakai Y, Takahara N, Ishigaki K, Takeda T, Hakuta R, Saito T, Uchino R, Kishikawa T, Hamada T, Mizuno S, Sasaki T, Kogure H, Matsubara S, Yamamoto N, Ijichi H, Tateishi K, Tada M, Koike K. A phase II trial of gemcitabine, S-1 and LV combination (GSL) therapy in patients with advanced pancreatic cancer. Invest New Drugs. 2019 04; 37(2):338-344. PMID: 30411217.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  9. Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Suzuki T, Ishibashi R, Seimiya T, Tanaka E, Koike K. Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx-DDB1 Interaction. Cell Mol Gastroenterol Hepatol. 2019; 7(2):297-312. PMID: 30704981.
    Citations: 11     Fields:    Translation:HumansCells
  10. Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Suzuki T, Ishibashi R, Seimiya T, Tanaka E, Koike K. Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA. World J Gastroenterol. 2018 Jun 07; 24(21):2261-2268. PMID: 29881235.
    Citations: 5     Fields:    Translation:HumansCells
  11. Kishikawa T, Otsuka M, Suzuki T, Seimiya T, Sekiba K, Ishibashi R, Tanaka E, Ohno M, Yamagami M, Koike K. Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer. Mol Cancer Res. 2018 08; 16(8):1255-1262. PMID: 29748382.
    Citations: 4     Fields:    Translation:HumansAnimals
  12. Sekiba K, Otsuka M, Ohno M, Kishikawa T, Yamagami M, Suzuki T, Ishibashi R, Seimiya T, Tanaka E, Koike K. DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels. Oncotarget. 2018 Apr 20; 9(30):20953-20964. PMID: 29765512.
    Citations: 6     Fields:    
  13. Takata A, Otsuka M, Kishikawa T, Yamagami M, Ishibashi R, Sekiba K, Suzuki T, Ohno M, Yamashita Y, Abe T, Masuzaki R, Ikenoue T, Koike K. RASAL1 is a potent regulator of hepatic stellate cell activity and liver fibrosis. Oncotarget. 2017 Sep 12; 8(39):64840-64852. PMID: 29029395.
    Citations: 1     Fields:    
  14. Sekiba K, Yamagami M, Otsuka M, Suzuki T, Kishikawa T, Ishibashi R, Ohno M, Sato M, Koike K. Transcriptional activation of the MICA gene with an engineered CRISPR-Cas9 system. Biochem Biophys Res Commun. 2017 04 29; 486(2):521-525. PMID: 28322797.
    Citations: 4     Fields:    Translation:HumansCells
  15. Yoshikawa T, Wu J, Otsuka M, Kishikawa T, Suzuki N, Takata A, Ohno M, Ishibashi R, Yamagami M, Nakagawa R, Kato N, Miyazawa M, Han J, Koike K. Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis. Gastroenterology. 2017 02; 152(3):631-643. PMID: 27825961.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  16. Kishikawa T, Otsuka M, Yoshikawa T, Ohno M, Ijichi H, Koike K. Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1. Nat Commun. 2016 Sep 26; 7:13006. PMID: 27667193.
    Citations: 7     Fields:    
  17. Kishikawa T, Otsuka M, Yoshikawa T, Ohno M, Yamamoto K, Yamamoto N, Kotani A, Koike K. Quantitation of circulating satellite RNAs in pancreatic cancer patients. JCI Insight. 2016 06 02; 1(8):e86646. PMID: 27699267.
    Citations: 9     Fields:    Translation:HumansCells
  18. Otsuka M, Kishikawa T, Yoshikawa T, Yamagami M, Ohno M, Takata A, Shibata C, Ishibashi R, Koike K. MicroRNAs and liver disease. J Hum Genet. 2017 Jan; 62(1):75-80. PMID: 27225852.
    Citations: 15     Fields:    Translation:Humans
  19. Takata A, Otsuka M, Ohno M, Kishikawa T, Yoshikawa T, Koike K. Mutual antagonism between hepatitis B viral mRNA and host microRNA let-7. Sci Rep. 2016 Mar 16; 6:23237. PMID: 26979389.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  20. Kishikawa T, Otsuka M, Ohno M, Yoshikawa T, Sato M, Koike K. Development of a screening method to identify regulators of MICA shedding. Biochem Biophys Res Commun. 2015 Oct 02; 465(4):764-8. PMID: 26299929.
    Citations: 2     Fields:    Translation:HumansCells
  21. Tada M, Takagi K, Kawakubo K, Hakuta R, Ishigaki K, Takeda T, Fujiwara H, Umefune G, Saito K, Saito T, Watanabe T, Akiyama D, Uchino R, Kishikawa T, Takahara N, Takahashi R, Yamamoto K, Hamada T, Mizuno S, Miyabayashi K, Mohri D, Matsubara S, Kogure H, Nakai Y, Yamamoto N, Sasaki T, Sasahira N, Hirano K, Ijichi H, Tateishi K, Isayama H, Koike K. [IPMN and pancreatic cyst as high risk of pancreatic cancer]. Nihon Shokakibyo Gakkai Zasshi. 2015 Aug; 112(8):1474-8. PMID: 26250126.
    Citations: 1     Fields:    Translation:Humans
  22. Kishikawa T, Otsuka M, Ohno M, Yoshikawa T, Takata A, Koike K. Circulating RNAs as new biomarkers for detecting pancreatic cancer. World J Gastroenterol. 2015 Jul 28; 21(28):8527-40. PMID: 26229396.
    Citations: 55     Fields:    Translation:Humans
  23. Yoshikawa T, Wu J, Otsuka M, Kishikawa T, Ohno M, Shibata C, Takata A, Han F, Kang YJ, Chen CY, Shyu AB, Han J, Koike K. ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression. Nucleic Acids Res. 2015 Sep 03; 43(15):7577-89. PMID: 26187994.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  24. Ohno M, Otsuka M, Kishikawa T, Yoshikawa T, Takata A, Koike K. Novel therapeutic approaches for hepatitis B virus covalently closed circular DNA. World J Gastroenterol. 2015 Jun 21; 21(23):7084-8. PMID: 26109795.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  25. Kishikawa T, Otsuka M, Tan PS, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, Takehana K, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K. Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine. Oncotarget. 2015 Apr 10; 6(10):8339-52. PMID: 25826076.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  26. Shibata C, Otsuka M, Kishikawa T, Ohno M, Yoshikawa T, Takata A, Koike K. Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma. World J Hepatol. 2015 Jan 27; 7(1):1-6. PMID: 25624991.
    Citations: 22     
  27. Ohno M, Otsuka M, Kishikawa T, Shibata C, Yoshikawa T, Takata A, Muroyama R, Kowatari N, Sato M, Kato N, Kuroda S, Koike K. Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA. Oncotarget. 2014 Jul 30; 5(14):5581-90. PMID: 25026299.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  28. Shibata C, Ohno M, Otsuka M, Kishikawa T, Goto K, Muroyama R, Kato N, Yoshikawa T, Takata A, Koike K. The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels. Virology. 2014 Aug; 462-463:42-8. PMID: 25092460.
    Citations: 21     Fields:    Translation:HumansCells
  29. Shibata C, Otsuka M, Kishikawa T, Yoshikawa T, Ohno M, Takata A, Koike K. Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma. Mol Cell Ther. 2013; 1:5. PMID: 26056570.
    Citations: 18     
  30. Otsuka M, Kishikawa T, Yoshikawa T, Ohno M, Takata A, Shibata C, Koike K. The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects. J Gastroenterol. 2014 Feb; 49(2):173-84. PMID: 24258409.
    Citations: 11     Fields:    Translation:Humans
  31. Yoshikawa T, Otsuka M, Kishikawa T, Takata A, Ohno M, Shibata C, Kang YJ, Yoshida H, Koike K. Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model. PLoS One. 2013; 8(9):e71969. PMID: 24023722.
    Citations: 9     Fields:    Translation:Animals
  32. Shibata C, Kishikawa T, Otsuka M, Ohno M, Yoshikawa T, Takata A, Yoshida H, Koike K. Inhibition of microRNA122 decreases SREBP1 expression by modulating suppressor of cytokine signaling 3 expression. Biochem Biophys Res Commun. 2013 Aug 16; 438(1):230-5. PMID: 23891753.
    Citations: 7     Fields:    Translation:HumansCells
  33. Ohno M, Shibata C, Kishikawa T, Yoshikawa T, Takata A, Kojima K, Akanuma M, Kang YJ, Yoshida H, Otsuka M, Koike K. The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice. Sci Rep. 2013; 3:2553. PMID: 23989853.
    Citations: 17     Fields:    Translation:AnimalsCells
  34. Kishikawa T, Otsuka M, Yoshikawa T, Ohno M, Takata A, Shibata C, Kondo Y, Akanuma M, Yoshida H, Koike K. Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs. Sci Rep. 2013; 3:2739. PMID: 24061441.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  35. Takata A, Otsuka M, Yoshikawa T, Kishikawa T, Hikiba Y, Obi S, Goto T, Kang YJ, Maeda S, Yoshida H, Omata M, Asahara H, Koike K. MicroRNA-140 acts as a liver tumor suppressor by controlling NF-?B activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression. Hepatology. 2013 Jan; 57(1):162-70. PMID: 22898998.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  36. Yoshikawa T, Takata A, Otsuka M, Kishikawa T, Kojima K, Yoshida H, Koike K. Silencing of microRNA-122 enhances interferon-a signaling in the liver through regulating SOCS3 promoter methylation. Sci Rep. 2012; 2:637. PMID: 22957141.
    Citations: 41     Fields:    Translation:HumansCells
  37. Minami T, Kishikawa T, Sato M, Tateishi R, Yoshida H, Koike K. Meta-analysis: mortality and serious adverse events of peginterferon plus ribavirin therapy for chronic hepatitis C. J Gastroenterol. 2013 Feb; 48(2):254-68. PMID: 22790350.
    Citations: 6     Fields:    Translation:Humans
  38. Takata A, Otsuka M, Yoshikawa T, Kishikawa T, Kudo Y, Goto T, Yoshida H, Koike K. A miRNA machinery component DDX20 controls NF-?B via microRNA-140 function. Biochem Biophys Res Commun. 2012 Apr 13; 420(3):564-9. PMID: 22445758.
    Citations: 16     Fields:    Translation:HumansCells
  39. Otsuka M, Takata A, Yoshikawa T, Kojima K, Kishikawa T, Shibata C, Takekawa M, Yoshida H, Omata M, Koike K. Receptor for activated protein kinase C: requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma. PLoS One. 2011; 6(9):e24359. PMID: 21935400.
    Citations: 11     Fields:    Translation:HumansCells
  40. Takata A, Otsuka M, Kojima K, Yoshikawa T, Kishikawa T, Yoshida H, Koike K. MicroRNA-22 and microRNA-140 suppress NF-?B activity by regulating the expression of NF-?B coactivators. Biochem Biophys Res Commun. 2011 Aug 12; 411(4):826-31. PMID: 21798241.
    Citations: 33     Fields:    Translation:HumansCells
  41. Kojima K, Takata A, Vadnais C, Otsuka M, Yoshikawa T, Akanuma M, Kondo Y, Kang YJ, Kishikawa T, Kato N, Xie Z, Zhang WJ, Yoshida H, Omata M, Nepveu A, Koike K. MicroRNA122 is a key regulator of a-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma. Nat Commun. 2011 Jun 07; 2:338. PMID: 21654638.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.