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Shiaulou Yuan, Ph.D.

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Institution
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Biography
education and training
University of California, Berkeley, CABA05/2004Molecular and Cell Biology
Yale University, New Haven, CTPhD12/2011Genetics
Yale School of Medicine, New Haven, CTPostdoc05/2018Cardiovascular and Developmental Biology

Overview
overview
Dr. Shiaulou Yuan is an Assistant Professor of Medicine at Massachusetts General Hospital and Harvard Medical School. Dr. Yuan received his undergraduate degree in molecular cell biology from University of California, Berkeley in 2004 under Dr. Athanasios Theologis. He completed his Ph.D. in genetics from Yale University in 2011 with Dr. Zhaoxia Sun. Dr. Yuan performed his postdoctoral training in cardiovascular biology and developmental biology with Dr. Martina Brueckner at Yale School of Medicine. He received additional postdoctoral training in light sheet microscopy, laser nanosurgery techniques, and biophysical approaches with Dr. Joe Howard at Yale University and Dr. Scott Fraser at University of Southern California. In 2018, he started his own independent laboratory in the Cardiovascular Research Center at Massachusetts General Hospital and Harvard Medical School. Dr. Yuan’s research focuses on elucidating the cellular and molecular mechanisms that shape the developing heart, and in particular, the function of cilia in this process.
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL165241 (YUAN, SHIAULOU) Jul 1, 2022 - Jun 30, 2027
    NIH
    Optogenetic regulation of intra-ciliary calcium signaling in cardiac situs development
    Role: Principal Investigator
  2. K99HD086274 (YUAN, SHIAULOU) Jul 21, 2016 - Jun 30, 2018
    NIH
    Ciliary Calcium Signaling and Cardiac Left-Right Asymmetry
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li Y, Xu W, Cheng Y, Djenoune L, Zhuang C, Cox AL, Britto CJ, Yuan S, Wang S, Sun Z. Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesis. Proc Natl Acad Sci U S A. 2024 Nov 19; 121(47):e2402818121. PMID: 39541357; PMCID: PMC11588059.
    Citations:
    Fields: SciScienceTranslation:AnimalsCells
  2. Mishra-Gorur K, Barak T, Kaulen LD, Henegariu O, Jin SC, Aguilera SM, Yalbir E, Goles G, Nishimura S, Miyagishima D, Djenoune L, Altinok S, Rai DK, Viviano S, Prendergast A, Zerillo C, Ozcan K, Baran B, Sencar L, Goc N, Yarman Y, Ercan-Encicek AG, Bilguvar K, Lifton RP, Moliterno J, Louvi A, Yuan S, Deniz E, Brueckner M, Gunel M. Reply to Pisan et al.: Pathogenicity of inherited TRAF7 mutations in congenital heart disease. Proc Natl Acad Sci U S A. 2024 Mar 19; 121(12):e2319578121. PMID: 38466853; PMCID: PMC10963000.
    Citations:
    Fields: SciScienceTranslation:Humans
  3. Mishra-Gorur K, Barak T, Kaulen LD, Henegariu O, Jin SC, Aguilera SM, Yalbir E, Goles G, Nishimura S, Miyagishima D, Djenoune L, Altinok S, Rai DK, Viviano S, Prendergast A, Zerillo C, Ozcan K, Baran B, Sencar L, Goc N, Yarman Y, Ercan-Sencicek AG, Bilguvar K, Lifton RP, Moliterno J, Louvi A, Yuan S, Deniz E, Brueckner M, Gunel M. Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease. Proc Natl Acad Sci U S A. 2023 04 18; 120(16):e2214997120. PMID: 37043537; PMCID: PMC10120005.
    Citations: 7
    Fields: SciScienceTranslation:HumansAnimals
  4. Djenoune L, Mahamdeh M, Truong TV, Nguyen CT, Fraser SE, Brueckner M, Howard J, Yuan S. Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry. Science. 2023 01 06; 379(6627):71-78. PMID: 36603098; PMCID: PMC9939240.
    Citations: 23
    Fields: SciScienceTranslation:AnimalsCells
  5. Kim JJH, Parajuli S, Sinha A, Mahamdeh M, van den Boomen M, Coll-Font J, Chen LS, Fan Y, Eder RA, Phipps K, Yuan S, Nguyen C. Pocket CLARITY enables distortion-mitigated cardiac microstructural tissue characterization of large-scale specimens. Front Cardiovasc Med. 2022; 9:1037500. PMID: 36451924; PMCID: PMC9701703.
    Citations:
  6. Akerberg AA, Trembley M, Butty V, Schwertner A, Zhao L, Beerens M, Liu X, Mahamdeh M, Yuan S, Boyer L, MacRae C, Nguyen C, Pu WT, Burns CE, Burns CG. RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Circ Res. 2022 12 02; 131(12):980-1000. PMID: 36367103; PMCID: PMC9770155.
    Citations: 9
    Fields: CarCardiologyVasVascular Diseases
  7. Djenoune L, Berg K, Brueckner M, Yuan S. A change of heart: new roles for cilia in cardiac development and disease. Nat Rev Cardiol. 2022 Apr; 19(4):211-227. PMID: 34862511; PMCID: PMC10161238.
    Citations: 23
    Fields: CarCardiologyTranslation:HumansCells
  8. Yuan S, Brueckner M. Left-Right Asymmetry: Myosin 1D at the Center. Curr Biol. 2018 05 07; 28(9):R567-R569. PMID: 29738734.
    Citations: 3
    Fields: BioBiologyTranslation:AnimalsCells
  9. Li Y, Zhao L, Yuan S, Zhang J, Sun Z. Axonemal dynein assembly requires the R2TP complex component Pontin. Development. 2017 12 15; 144(24):4684-4693. PMID: 29113992; PMCID: PMC5769618.
    Citations: 24
    Fields: BioBiologyEmbEmbryologyTranslation:AnimalsCells
  10. Xu W, Jin M, Hu R, Wang H, Zhang F, Yuan S, Cao Y. The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. J Am Soc Nephrol. 2017 Jan; 28(1):118-129. PMID: 27401686; PMCID: PMC5198270.
    Citations: 24
    Fields: NepNephrologyTranslation:HumansAnimalsCells
  11. Yuan S, Brueckner M. Visualization and Manipulation of Cilia and Intraciliary Calcium in the Zebrafish Left-Right Organizer. Methods Mol Biol. 2016; 1454:123-47. PMID: 27514920.
    Citations:
    Fields: MolMolecular BiologyTranslation:AnimalsCells
  12. Yuan S, Zhao L, Brueckner M, Sun Z. Intraciliary calcium oscillations initiate vertebrate left-right asymmetry. Curr Biol. 2015 Mar 02; 25(5):556-67. PMID: 25660539; PMCID: PMC4469357.
    Citations: 82
    Fields: BioBiologyTranslation:HumansAnimalsCells
  13. Boskovski MT, Yuan S, Pedersen NB, Goth CK, Makova S, Clausen H, Brueckner M, Khokha MK. The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality. Nature. 2013 Dec 19; 504(7480):456-9. PMID: 24226769; PMCID: PMC3869867.
    Citations: 98
    Fields: SciScienceTranslation:HumansAnimalsCells
  14. Yuan S, Sun Z. Expanding horizons: ciliary proteins reach beyond cilia. Annu Rev Genet. 2013; 47:353-76. PMID: 24016188; PMCID: PMC5703194.
    Citations: 42
    Fields: GenGeneticsTranslation:HumansAnimalsCells
  15. Zhao L, Yuan S, Cao Y, Kallakuri S, Li Y, Kishimoto N, DiBella L, Sun Z. Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility. Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31):12697-702. PMID: 23858445.
    Citations: 40
    Fields: SciScienceTranslation:AnimalsCells
  16. Yuan S, Zaidi S, Brueckner M. Congenital heart disease: emerging themes linking genetics and development. Curr Opin Genet Dev. 2013 Jun; 23(3):352-9. PMID: 23790954; PMCID: PMC4154700.
    Citations: 35
    Fields: GenGeneticsTranslation:HumansCells
  17. Paavola J, Schliffke S, Rossetti S, Kuo IY, Yuan S, Sun Z, Harris PC, Torres VE, Ehrlich BE. Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. J Mol Cell Cardiol. 2013 May; 58:199-208. PMID: 23376035; PMCID: PMC3636149.
    Citations: 41
    Fields: CarCardiologyCelCell BiologyMolMolecular BiologyTranslation:HumansAnimalsCells
  18. Yuan S, Zhao L, Sun Z. Dissecting the functional interplay between the TOR pathway and the cilium in zebrafish. Methods Enzymol. 2013; 525:159-89. PMID: 23522470.
    Citations: 2
    Fields: BioBiochemistryTranslation:AnimalsCells
  19. Yuan S, Sun Z. TORC1-mediated protein synthesis regulates cilia size and function: implications for organelle size control by diverse signaling cascades. Cell Cycle. 2012 May 01; 11(9):1750-2. PMID: 22517434.
    Citations: 3
    Fields: CelCell BiologyTranslation:AnimalsCells
  20. Yuan S, Li J, Diener DR, Choma MA, Rosenbaum JL, Sun Z. Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):2021-6. PMID: 22308353.
    Citations: 55
    Fields: SciScienceTranslation:HumansAnimalsCells
  21. Malicki J, Avanesov A, Li J, Yuan S, Sun Z. Analysis of cilia structure and function in zebrafish. Methods Cell Biol. 2011; 101:39-74. PMID: 21550439.
    Citations: 33
    Fields: CelCell BiologyTranslation:HumansAnimalsCells
  22. Yuan S, Sun Z. Microinjection of mRNA and morpholino antisense oligonucleotides in zebrafish embryos. J Vis Exp. 2009 May 07; (27). PMID: 19488022.
    Citations: 48
    Fields: BioBiologyMedMedicine (General)Translation:Animals
  23. Armstrong JI, Yuan S, Dale JM, Tanner VN, Theologis A. Identification of inhibitors of auxin transcriptional activation by means of chemical genetics in Arabidopsis. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14978-83. PMID: 15466695; PMCID: PMC522024.
    Citations: 46
    Fields: SciScienceTranslation:Animals
  24. Yamada K, Lim J, Dale JM, Chen H, Shinn P, Palm CJ, Southwick AM, Wu HC, Kim C, Nguyen M, Pham P, Cheuk R, Karlin-Newmann G, Liu SX, Lam B, Sakano H, Wu T, Yu G, Miranda M, Quach HL, Tripp M, Chang CH, Lee JM, Toriumi M, Chan MM, Tang CC, Onodera CS, Deng JM, Akiyama K, Ansari Y, Arakawa T, Banh J, Banno F, Bowser L, Brooks S, Carninci P, Chao Q, Choy N, Enju A, Goldsmith AD, Gurjal M, Hansen NF, Hayashizaki Y, Johnson-Hopson C, Hsuan VW, Iida K, Karnes M, Khan S, Koesema E, Ishida J, Jiang PX, Jones T, Kawai J, Kamiya A, Meyers C, Nakajima M, Narusaka M, Seki M, Sakurai T, Satou M, Tamse R, Vaysberg M, Wallender EK, Wong C, Yamamura Y, Yuan S, Shinozaki K, Davis RW, Theologis A, Ecker JR. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science. 2003 Oct 31; 302(5646):842-6. PMID: 14593172.
    Citations: 369
    Fields: SciScienceTranslation:AnimalsCells
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