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Souvarish Sarkar, Ph.D.


Iowa State University, Ames, IAPhD03/2018Molecular Biology, Toxicology
2020 - 2021
Society of Toxicology, Colgate Palmolive Post Doctoral Fellowship
2022 - 2027
K99/R00 Career Transition Grant, NIH

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sarkar S. Microglial ion channels: Key players in non-cell autonomous neurodegeneration. Neurobiol Dis. 2022 Nov; 174:105861. PMID: 36115552; PMCID: PMC9617777.
    Citations:    Fields:    Translation:HumansCells
  2. Langley MR, Rangaraju S, Dey A, Sarkar S. Editorial: Environmental Effect on Neuroinflammation and Neurodegeneration. Front Cell Neurosci. 2022; 16:935190. PMID: 35800133; PMCID: PMC9253752.
  3. Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR, Carr SA, Lindquist S, De Jager PL, Bartel DP, Myers CL, Greenamyre JT, Feany MB, Sunyaev SR, Chung CY, Khurana V. The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability. Cell. 2022 06 09; 185(12):2035-2056.e33. PMID: 35688132; PMCID: PMC9394447.
    Citations:    Fields:    Translation:HumansCells
  4. Palanisamy BN, Sarkar S, Malovic E, Samidurai M, Charli A, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Environmental neurotoxic pesticide exposure induces gut inflammation and enteric neuronal degeneration by impairing enteric glial mitochondrial function in pesticide models of Parkinson's disease: Potential relevance to gut-brain axis inflammation in Parkinson's disease pathogenesis. Int J Biochem Cell Biol. 2022 06; 147:106225. PMID: 35550926.
    Citations:    Fields:    Translation:AnimalsCells
  5. Ghaisas S, Harischandra DS, Palanisamy B, Proctor A, Jin H, Dutta S, Sarkar S, Langley M, Zenitsky G, Anantharam V, Kanthasamy A, Phillips GJ, Kanthasamy A. Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study. Environ Health Perspect. 2021 08; 129(8):87005. PMID: 34410835; PMCID: PMC8375672.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Sarkar S, Feany MB. Precision Medicine on the Fly: Using Drosophila to Decipher Gene-Environment Interactions in Parkinson's Disease. Toxicol Sci. 2021 08 03; 182(2):159-167. PMID: 34076689; PMCID: PMC8331128.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  7. Sarkar S. Mechanism of Gene-Environment Interactions Driving Glial Activation in Parkinson's Diseases. Curr Environ Health Rep. 2021 09; 8(3):203-211. PMID: 34043217.
    Citations:    Fields:    Translation:HumansCells
  8. Sarkar S, Bardai F, Olsen AL, Lohr KM, Zhang YY, Feany MB. Oligomerization of Lrrk controls actin severing and a-synuclein neurotoxicity in vivo. Mol Neurodegener. 2021 05 24; 16(1):33. PMID: 34030727; PMCID: PMC8142648.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Sarkar S, Olsen AL, Sygnecka K, Lohr KM, Feany MB. a-synuclein impairs autophagosome maturation through abnormal actin stabilization. PLoS Genet. 2021 02; 17(2):e1009359. PMID: 33556113.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  10. Sarkar S, Murphy MA, Dammer EB, Olsen AL, Rangaraju S, Fraenkel E, Feany MB. Comparative proteomic analysis highlights metabolic dysfunction in a-synucleinopathy. NPJ Parkinsons Dis. 2020 Dec 11; 6(1):40. PMID: 33311497.
    Citations: 4     
  11. Sarkar S, Nguyen HM, Malovic E, Luo J, Langley M, Palanisamy BN, Singh N, Manne S, Neal M, Gabrielle M, Abdalla A, Anantharam P, Rokad D, Panicker N, Singh V, Ay M, Charli A, Harischandra D, Jin LW, Jin H, Rangaraju S, Anantharam V, Wulff H, Kanthasamy AG. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease. J Clin Invest. 2020 08 03; 130(8):4195-4212. PMID: 32597830; PMCID: PMC7410064.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  12. Sarkar S, Dammer EB, Malovic E, Olsen AL, Raza SA, Gao T, Xiao H, Oliver DL, Duong D, Joers V, Seyfried N, Huang M, Kukar T, Tansey MG, Kanthasamy AG, Rangaraju S. Molecular Signatures of Neuroinflammation Induced by aSynuclein Aggregates in Microglial Cells. Front Immunol. 2020; 11:33. PMID: 32082315.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  13. Ghaisas S, Langley MR, Palanisamy BN, Dutta S, Narayanaswamy K, Plummer PJ, Sarkar S, Ay M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome changes of Parkinson's disease. Neurotoxicology. 2019 12; 75:186-199. PMID: 31505196.
    Citations: 13     Fields:    Translation:Animals
  14. Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, Anantharam V, Kanthasamy AG, Kanthasamy A. Fyn kinase regulates misfolded a-synuclein uptake and NLRP3 inflammasome activation in microglia. J Exp Med. 2019 06 03; 216(6):1411-1430. PMID: 31036561; PMCID: PMC6547864.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  15. Harischandra DS, Rokad D, Neal ML, Ghaisas S, Manne S, Sarkar S, Panicker N, Zenitsky G, Jin H, Lewis M, Huang X, Anantharam V, Kanthasamy A, Kanthasamy AG. Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of a-synuclein. Sci Signal. 2019 03 12; 12(572). PMID: 30862700; PMCID: PMC6435331.
    Citations: 50     Fields:    Translation:AnimalsCells
  16. Sarkar S, Rokad D, Malovic E, Luo J, Harischandra DS, Jin H, Anantharam V, Huang X, Lewis M, Kanthasamy A, Kanthasamy AG. Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells. Sci Signal. 2019 01 08; 12(563). PMID: 30622196; PMCID: PMC6420319.
    Citations: 35     Fields:    Translation:AnimalsCells
  17. Neal M, Luo J, Harischandra DS, Gordon R, Sarkar S, Jin H, Anantharam V, Désaubry L, Kanthasamy A, Kanthasamy A. Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes. Glia. 2018 10; 66(10):2137-2157. PMID: 30277602.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  18. Singh N, Lawana V, Luo J, Phong P, Abdalla A, Palanisamy B, Rokad D, Sarkar S, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events. Neurobiol Dis. 2018 09; 117:82-113. PMID: 29859868; PMCID: PMC6108448.
    Citations: 25     Fields:    Translation:AnimalsCells
  19. Sarkar S, Malovic E, Sarda D, Lawana V, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults. Neurotoxicology. 2018 07; 67:129-140. PMID: 29775624.
    Citations: 8     Fields:    Translation:AnimalsCells
  20. Sharma S, Carlson S, Puttachary S, Sarkar S, Showman L, Putra M, Kanthasamy AG, Thippeswamy T. Role of the Fyn-PKCd signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy. Neurobiol Dis. 2018 02; 110:102-121. PMID: 29197620; PMCID: PMC5753797.
    Citations: 25     Fields:    Translation:AnimalsCells
  21. Anantharam P, Whitley EM, Mahama B, Kim DS, Sarkar S, Santana C, Chan A, Kanthasamy AG, Kanthasamy A, Boss GR, Rumbeiha WK. Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model. Ann N Y Acad Sci. 2017 11; 1408(1):61-78. PMID: 29239480; PMCID: PMC5734662.
    Citations: 7     Fields:    Translation:Animals
  22. Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, Palanisamy BN, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinsons Dis. 2017; 3:30. PMID: 29057315; PMCID: PMC5645400.
    Citations: 79     
  23. Sarkar S, Malovic E, Harischandra DS, Ngwa HA, Ghosh A, Hogan C, Rokad D, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes. Neurotoxicology. 2018 01; 64:204-218. PMID: 28539244.
    Citations: 45     Fields:    Translation:AnimalsCells
  24. Lawana V, Singh N, Sarkar S, Charli A, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System. J Neuroimmune Pharmacol. 2017 Dec; 12(4):624-660. PMID: 28466394.
    Citations: 32     Fields:    Translation:AnimalsCells
  25. Sarkar S, Malovic E, Plante B, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility. J Vis Exp. 2017 04 13; (122). PMID: 28447995.
    Citations: 13     Fields:    Translation:HumansCells
  26. Langley M, Ghosh A, Charli A, Sarkar S, Ay M, Luo J, Zielonka J, Brenza T, Bennett B, Jin H, Ghaisas S, Schlichtmann B, Kim D, Anantharam V, Kanthasamy A, Narasimhan B, Kalyanaraman B, Kanthasamy AG. Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxid Redox Signal. 2017 Nov 10; 27(14):1048-1066. PMID: 28375739; PMCID: PMC5651937.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  27. Gordon R, Singh N, Lawana V, Ghosh A, Harischandra DS, Jin H, Hogan C, Sarkar S, Rokad D, Panicker N, Anantharam V, Kanthasamy AG, Kanthasamy A. Protein kinase Cd upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiol Dis. 2016 09; 93:96-114. PMID: 27151770; PMCID: PMC4995107.
    Citations: 40     Fields:    Translation:AnimalsCells
  28. Panicker N, Saminathan H, Jin H, Neal M, Harischandra DS, Gordon R, Kanthasamy K, Lawana V, Sarkar S, Luo J, Anantharam V, Kanthasamy AG, Kanthasamy A. Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease. J Neurosci. 2015 Jul 08; 35(27):10058-77. PMID: 26157004; PMCID: PMC4495236.
    Citations: 72     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.