Harvard Catalyst Profiles

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Edward Charles Twomey, Ph.D.

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Columbia University, New York, NYPh.D.05/2018Biophysics
Columbia University, New York, NYM.Phil. 12/2016Biophysics
Columbia University, New York, NYM.A.05/2015Biophysics
Seton Hall University, South Orange, NJB.S.12/2012Biochemistry

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F31NS093838 (TWOMEY, EDWARD C) Sep 1, 2016 - Aug 31, 2019
    Structural elucidation of ionotropic glutamate receptor states with cryoelectron microscopy
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Twomey EC, Yelshanskaya MV, Sobolevsky AI. Structural and functional insights into transmembrane AMPA receptor regulatory protein complexes. J Gen Physiol. 2019 12 02; 151(12):1347-1356. PMID: 31615831.
  2. Twomey EC, Ji Z, Wales TE, Bodnar NO, Ficarro SB, Marto JA, Engen JR, Rapoport TA. Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science. 2019 08 02; 365(6452). PMID: 31249135.
  3. Twomey EC, Yelshanskaya MV, Vassilevski AA, Sobolevsky AI. Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron. 2018 09 05; 99(5):956-968.e4. PMID: 30122377.
    Citations:    Fields:    
  4. Singh AK, McGoldrick LL, Twomey EC, Sobolevsky AI. Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6. Sci Adv. 2018 08; 4(8):eaau6088. PMID: 30116787.
    Citations:    Fields:    
  5. McGoldrick LL, Singh AK, Saotome K, Yelshanskaya MV, Twomey EC, Grassucci RA, Sobolevsky AI. Opening of the human epithelial calcium channel TRPV6. Nature. 2018 01 11; 553(7687):233-237. PMID: 29258289.
    Citations: 11     Fields:    Translation:HumansCells
  6. Twomey EC, Sobolevsky AI. Structural Mechanisms of Gating in Ionotropic Glutamate Receptors. Biochemistry. 2018 01 23; 57(3):267-276. PMID: 29037031.
    Citations: 4     Fields:    Translation:HumansCells
  7. Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI. Channel opening and gating mechanism in AMPA-subtype glutamate receptors. Nature. 2017 09 07; 549(7670):60-65. PMID: 28737760.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  8. Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI. Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes. Neuron. 2017 May 03; 94(3):569-580.e5. PMID: 28472657.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  9. Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI. Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy. Science. 2016 Jul 01; 353(6294):83-6. PMID: 27365450.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  10. Twomey EC, Cordasco DF, Kozuch SD, Wei Y. Substantial conformational change mediated by charge-triad residues of the death effector domain in protein-protein interactions. PLoS One. 2013; 8(12):e83421. PMID: 24391764.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Twomey EC, Cordasco DF, Wei Y. Profound conformational changes of PED/PEA-15 in ERK2 complex revealed by NMR backbone dynamics. Biochim Biophys Acta. 2012 Dec; 1824(12):1382-93. PMID: 22820249.
    Citations: 3     Fields:    Translation:Cells
  12. Twomey EC, Wei Y. High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions. Biochem Biophys Res Commun. 2012 Jul 20; 424(1):141-6. PMID: 22732408.
    Citations: 4     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.