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Sian Victoria Owen, Ph.D.

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Siân Owen completed her PhD and a short postdoctoral fellowship at the University of Liverpool, UK, in the group of Professor Jay Hinton. Sian's research explored the biological contribution of temperate bacteriophages to an emerging variant of Salmonella enterica serovar Typhimurium that is associated with an epidemic of bloodstream infections in sub-Saharan Africa. She is currently working in the Baym Lab in the Department of Biomedical Informatics and the Laboratory of Systems Pharmacology using experimental evolution and computational approaches to study the phenomenon of antibiotic resistance in bacteria.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Silpe JE, Wong JWH, Owen SV, Baym M, Balskus EP. The bacterial toxin colibactin triggers prophage induction. Nature. 2022 03; 603(7900):315-320. PMID: 35197633; PMCID: PMC8907063.
    Citations: 9     Fields:    Translation:Cells
  2. Owen SV, Wenner N, Dulberger CL, Rodwell EV, Bowers-Barnard A, Quinones-Olvera N, Rigden DJ, Rubin EJ, Garner EC, Baym M, Hinton JCD. Prophages encode phage-defense systems with cognate self-immunity. Cell Host Microbe. 2021 11 10; 29(11):1620-1633.e8. PMID: 34597593.
    Citations: 13     Fields:    Translation:Cells
  3. Honeycutt JD, Wenner N, Li Y, Brewer SM, Massis LM, Brubaker SW, Chairatana P, Owen SV, Canals R, Hinton JCD, Monack DM. Genetic variation in the MacAB-TolC efflux pump influences pathogenesis of invasive Salmonella isolates from Africa. PLoS Pathog. 2020 08; 16(8):e1008763. PMID: 32834002.
    Citations: 4     Fields:    Translation:AnimalsCells
  4. Preciado-Llanes L, Aulicino A, Canals R, Moynihan PJ, Zhu X, Jambo N, Nyirenda TS, Kadwala I, Sousa Gerós A, Owen SV, Jambo KC, Kumwenda B, Veerapen N, Besra GS, Gordon MA, Hinton JCD, Napolitani G, Salio M, Simmons A. Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease. Proc Natl Acad Sci U S A. 2020 08 25; 117(34):20717-20728. PMID: 32788367; PMCID: PMC7456131.
    Citations: 7     Fields:    Translation:HumansCells
  5. Qian J, Lu ZX, Mancuso CP, Jhuang HY, Del Carmen Barajas-Ornelas R, Boswell SA, Ramírez-Guadiana FH, Jones V, Sonti A, Sedlack K, Artzi L, Jung G, Arammash M, Pettit ME, Melfi M, Lyon L, Owen SV, Baym M, Khalil AS, Silver PA, Rudner DZ, Springer M. Barcoded microbial system for high-resolution object provenance. Science. 2020 06 05; 368(6495):1135-1140. PMID: 32499444.
    Citations: 11     Fields:    Translation:CellsPHPublic Health
  6. Owen SV, Canals R, Wenner N, Hammarlöf DL, Kröger C, Hinton JCD. A window into lysogeny: revealing temperate phage biology with transcriptomics. Microb Genom. 2020 02; 6(2). PMID: 32022660.
    Citations: 11     Fields:    Translation:Cells
  7. Canals R, Chaudhuri RR, Steiner RE, Owen SV, Quinones-Olvera N, Gordon MA, Baym M, Ibba M, Hinton JCD. The fitness landscape of the African Salmonella Typhimurium ST313 strain D23580 reveals unique properties of the pBT1 plasmid. PLoS Pathog. 2019 09; 15(9):e1007948. PMID: 31560731.
    Citations: 6     Fields:    Translation:AnimalsCells
  8. Lacharme-Lora L, Owen SV, Blundell R, Canals R, Wenner N, Perez-Sepulveda B, Fong WY, Gilroy R, Wigley P, Hinton JCD. The use of chicken and insect infection models to assess the virulence of African Salmonella Typhimurium ST313. PLoS Negl Trop Dis. 2019 07; 13(7):e0007540. PMID: 31348776; PMCID: PMC6685681.
    Citations: 9     Fields:    Translation:AnimalsCells
  9. Canals R, Hammarlöf DL, Kröger C, Owen SV, Fong WY, Lacharme-Lora L, Zhu X, Wenner N, Carden SE, Honeycutt J, Monack DM, Kingsley RA, Brownridge P, Chaudhuri RR, Rowe WPM, Predeus AV, Hokamp K, Gordon MA, Hinton JCD. Adding function to the genome of African Salmonella Typhimurium ST313 strain D23580. PLoS Biol. 2019 01; 17(1):e3000059. PMID: 30645593.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  10. Hammarlöf DL, Kröger C, Owen SV, Canals R, Lacharme-Lora L, Wenner N, Schager AE, Wells TJ, Henderson IR, Wigley P, Hokamp K, Feasey NA, Gordon MA, Hinton JCD. Role of a single noncoding nucleotide in the evolution of an epidemic African clade of Salmonella. Proc Natl Acad Sci U S A. 2018 03 13; 115(11):E2614-E2623. PMID: 29487214; PMCID: PMC5856525.
    Citations: 40     Fields:    Translation:HumansCellsPHPublic Health
  11. Ashton PM, Owen SV, Kaindama L, Rowe WPM, Lane CR, Larkin L, Nair S, Jenkins C, de Pinna EM, Feasey NA, Hinton JCD, Dallman TJ. Public health surveillance in the UK revolutionises our understanding of the invasive Salmonella Typhimurium epidemic in Africa. Genome Med. 2017 10 31; 9(1):92. PMID: 29084588.
    Citations: 33     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  12. Faulkner M, Rodriguez-Ramos J, Dykes GF, Owen SV, Casella S, Simpson DM, Beynon RJ, Liu LN. Direct characterization of the native structure and mechanics of cyanobacterial carboxysomes. Nanoscale. 2017 Aug 03; 9(30):10662-10673. PMID: 28616951.
    Citations: 35     Fields:    Translation:Cells
  13. Owen SV, Wenner N, Canals R, Makumi A, Hammarlöf DL, Gordon MA, Aertsen A, Feasey NA, Hinton JC. Characterization of the Prophage Repertoire of African Salmonella Typhimurium ST313 Reveals High Levels of Spontaneous Induction of Novel Phage BTP1. Front Microbiol. 2017; 8:235. PMID: 28280485; PMCID: PMC5322425.
    Citations: 29     
  14. Connor TR, Owen SV, Langridge G, Connell S, Nair S, Reuter S, Dallman TJ, Corander J, Tabing KC, Le Hello S, Fookes M, Doublet B, Zhou Z, Feltwell T, Ellington MJ, Herrera S, Gilmour M, Cloeckaert A, Achtman M, Parkhill J, Wain J, De Pinna E, Weill FX, Peters T, Thomson N. What's in a Name? Species-Wide Whole-Genome Sequencing Resolves Invasive and Noninvasive Lineages of Salmonella enterica Serotype Paratyphi B. mBio. 2016 08 23; 7(4). PMID: 27555304; PMCID: PMC4999539.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  15. Srikumar S, Kröger C, Hébrard M, Colgan A, Owen SV, Sivasankaran SK, Cameron AD, Hokamp K, Hinton JC. RNA-seq Brings New Insights to the Intra-Macrophage Transcriptome of Salmonella Typhimurium. PLoS Pathog. 2015; 11(11):e1005262. PMID: 26561851; PMCID: PMC4643027.
    Citations: 107     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.