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Ole Isacson, Dr.Med.Sci, M.B.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Korecka JA, Talbot S, Osborn TM, de Leeuw SM, Levy SA, Ferrari EJ, Moskites A, Atkinson E, Jodelka FM, Hinrich AJ, Hastings ML, Woolf CJ, Hallett PJ, Isacson O. Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation. Stem Cell Reports. 2019 Jan 08; 12(1):29-41. PMID: 30595548.
    Citations:    Fields:    
  2. Brekk OR, Moskites A, Isacson O, Hallett PJ. Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age. Sci Rep. 2018 Oct 12; 8(1):15207. PMID: 30315256.
    Citations:    Fields:    
  3. Moloney EB, Moskites A, Ferrari EJ, Isacson O, Hallett PJ. The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress. Neurobiol Dis. 2018 12; 120:1-11. PMID: 30149180.
    Citations: 1     Fields:    
  4. Hallett PJ, Huebecker M, Brekk OR, Moloney EB, Rocha EM, Priestman DA, Platt FM, Isacson O. Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain. Neurobiol Aging. 2018 07; 67:189-200. PMID: 29735433.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Osborn TM, Beagan J, Isacson O. Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression. Neurobiol Dis. 2018 02; 110:218-230. PMID: 29113829.
    Citations:    Fields:    
  6. Klemann CJHM, Martens GJM, Sharma M, Martens MB, Isacson O, Gasser T, Visser JE, Poelmans G. Integrated molecular landscape of Parkinson's disease. NPJ Parkinsons Dis. 2017; 3:14. PMID: 28649614.
    Citations: 4     
  7. Engelender S, Isacson O. The Threshold Theory for Parkinson's Disease. Trends Neurosci. 2017 01; 40(1):4-14. PMID: 27894611.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  8. Kordower JH, Vinuela A, Chu Y, Isacson O, Redmond DE. Parkinsonian monkeys with prior levodopa-induced dyskinesias followed by fetal dopamine precursor grafts do not display graft-induced dyskinesias. J Comp Neurol. 2017 02 15; 525(3):498-512. PMID: 27418401.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Xiong N, Li N, Martin E, Yu J, Li J, Liu J, Lee DY, Isacson O, Vance J, Qing H, Wang T, Lin Z. hVMAT2: A Target of Individualized Medication for Parkinson's Disease. Neurotherapeutics. 2016 07; 13(3):623-34. PMID: 27137201.
    Citations: 1     Fields:    Translation:HumansCells
  10. Wang X, Li N, Xiong N, You Q, Li J, Yu J, Qing H, Wang T, Cordell HJ, Isacson O, Vance JM, Martin ER, Zhao Y, Cohen BM, Buttner EA, Lin Z. Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease. Mol Neurobiol. 2017 05; 54(4):2878-2888. PMID: 27021023.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  11. Jeon J, Kim W, Jang J, Isacson O, Seo H. Gene therapy by proteasome activator, PA28?, improves motor coordination and proteasome function in Huntington's disease YAC128 mice. Neuroscience. 2016 Jun 02; 324:20-8. PMID: 26944602.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  12. Mazzulli JR, Zunke F, Isacson O, Studer L, Krainc D. a-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models. Proc Natl Acad Sci U S A. 2016 Feb 16; 113(7):1931-6. PMID: 26839413.
    Citations: 33     Fields:    Translation:HumansCells
  13. Korecka JA, Levy S, Isacson O. In vivo modeling of neuronal function, axonal impairment and connectivity in neurodegenerative and neuropsychiatric disorders using induced pluripotent stem cells. Mol Cell Neurosci. 2016 06; 73:3-12. PMID: 26691153.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  14. Rocha EM, Smith GA, Park E, Cao H, Brown E, Hayes MA, Beagan J, McLean JR, Izen SC, Perez-Torres E, Hallett PJ, Isacson O. Glucocerebrosidase gene therapy prevents a-synucleinopathy of midbrain dopamine neurons. Neurobiol Dis. 2015 Oct; 82:495-503. PMID: 26392287.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  15. Smith GA, Jansson J, Rocha EM, Osborn T, Hallett PJ, Isacson O. Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition. Mol Neurobiol. 2016 10; 53(8):5161-77. PMID: 26399642.
    Citations: 5     Fields:    Translation:HumansCells
  16. Rocha EM, Smith GA, Park E, Cao H, Graham AR, Brown E, McLean JR, Hayes MA, Beagan J, Izen SC, Perez-Torres E, Hallett PJ, Isacson O. Sustained Systemic Glucocerebrosidase Inhibition Induces Brain a-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice. Antioxid Redox Signal. 2015 Aug 20; 23(6):550-64. PMID: 26094487.
    Citations: 9     Fields:    Translation:AnimalsCells
  17. Isacson O. Lysosomes to combat Parkinson's disease. Nat Neurosci. 2015 Jun; 18(6):792-3. PMID: 26007211.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  18. Isacson O. Sorting the wheat from the chaff in dopamine neuron-based cell therapies. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):4512-3. PMID: 25848026.
    Citations: 2     Fields:    Translation:AnimalsCells
  19. Smith GA, Rocha EM, Rooney T, Barneoud P, McLean JR, Beagan J, Osborn T, Coimbra M, Luo Y, Hallett PJ, Isacson O. A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). PLoS One. 2015; 10(3):e0121072. PMID: 25815475.
    Citations: 11     Fields:    Translation:AnimalsCells
  20. Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson O. Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell. 2015 Mar 05; 16(3):269-74. PMID: 25732245.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  21. Rocha EM, Smith GA, Park E, Cao H, Brown E, Hallett P, Isacson O. Progressive decline of glucocerebrosidase in aging and Parkinson's disease. Ann Clin Transl Neurol. 2015 Apr; 2(4):433-8. PMID: 25909088.
    Citations: 22     
  22. Hallett PJ, Cooper O, Sadi D, Robertson H, Mendez I, Isacson O. Long-term health of dopaminergic neuron transplants in Parkinson's disease patients. Cell Rep. 2014 Jun 26; 7(6):1755-61. PMID: 24910427.
    Citations: 32     Fields:    Translation:HumansCells
  23. McLean JR, Smith GA, Rocha EM, Osborn TM, Dib S, Hayes MA, Beagan JA, Brown TB, Lawson TF, Hallett PJ, Robertson J, Isacson O. ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress. Exp Neurol. 2014 Nov; 261:217-29. PMID: 24907400.
    Citations: 2     Fields:    Translation:HumansCells
  24. McLean JR, Smith GA, Rocha EM, Hayes MA, Beagan JA, Hallett PJ, Isacson O. Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection. Neurosci Lett. 2014 Jul 25; 576:73-8. PMID: 24882721.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  25. Zhang J, Saur T, Duke AN, Grant SG, Platt DM, Rowlett JK, Isacson O, Yao WD. Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95. J Neurogenet. 2014 Mar-Jun; 28(1-2):98-111. PMID: 24702501.
    Citations: 10     Fields:    Translation:AnimalsCells
  26. Smith GA, Rocha EM, McLean JR, Hayes MA, Izen SC, Isacson O, Hallett PJ. Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Hum Mol Genet. 2014 Sep 01; 23(17):4510-27. PMID: 24728190.
    Citations: 19     Fields:    Translation:AnimalsCells
  27. Sundberg M, Isacson O. Advances in stem-cell--generated transplantation therapy for Parkinson's disease. Expert Opin Biol Ther. 2014 Apr; 14(4):437-53. PMID: 24437368.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  28. Davies SE, Hallett PJ, Moens T, Smith G, Mangano E, Kim HT, Goldberg AL, Liu JL, Isacson O, Tofaris GK. Enhanced ubiquitin-dependent degradation by Nedd4 protects against a-synuclein accumulation and toxicity in animal models of Parkinson's disease. Neurobiol Dis. 2014 Apr; 64:79-87. PMID: 24388974.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  29. Sanders LH, Laganière J, Cooper O, Mak SK, Vu BJ, Huang YA, Paschon DE, Vangipuram M, Sundararajan R, Urnov FD, Langston JW, Gregory PD, Zhang HS, Greenamyre JT, Isacson O, Schüle B. LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction. Neurobiol Dis. 2014 Feb; 62:381-6. PMID: 24148854.
    Citations: 50     Fields:    Translation:HumansCells
  30. Sundberg M, Bogetofte H, Lawson T, Jansson J, Smith G, Astradsson A, Moore M, Osborn T, Cooper O, Spealman R, Hallett P, Isacson O. Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells. 2013 Aug; 31(8):1548-62. PMID: 23666606.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  31. Olanow CW, Isacson O. Stem cells for Parkinson's disease: advancing science but protecting patients. Mov Disord. 2012 Oct; 27(12):1475-7. PMID: 23032987.
    Citations: 3     Fields:    Translation:HumansCells
  32. Wray S, Self M, Lewis PA, Taanman JW, Ryan NS, Mahoney CJ, Liang Y, Devine MJ, Sheerin UM, Houlden H, Morris HR, Healy D, Marti-Masso JF, Preza E, Barker S, Sutherland M, Corriveau RA, D'Andrea M, Schapira AH, Uitti RJ, Guttman M, Opala G, Jasinska-Myga B, Puschmann A, Nilsson C, Espay AJ, Slawek J, Gutmann L, Boeve BF, Boylan K, Stoessl AJ, Ross OA, Maragakis NJ, Van Gerpen J, Gerstenhaber M, Gwinn K, Dawson TM, Isacson O, Marder KS, Clark LN, Przedborski SE, Finkbeiner S, Rothstein JD, Wszolek ZK, Rossor MN, Hardy J. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLoS One. 2012; 7(8):e43099. PMID: 22952635.
    Citations: 19     Fields:    Translation:HumansCells
  33. Smith GA, Isacson O, Dunnett SB. The search for genetic mouse models of prodromal Parkinson's disease. Exp Neurol. 2012 Oct; 237(2):267-73. PMID: 22819262.
    Citations: 7     Fields:    Translation:HumansAnimals
  34. Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM, Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, Isacson O. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med. 2012 Jul 04; 4(141):141ra90. PMID: 22764206.
    Citations: 132     Fields:    Translation:HumansCells
  35. Hallett PJ, McLean JR, Kartunen A, Langston JW, Isacson O. a-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits. Neurobiol Dis. 2012 Aug; 47(2):258-67. PMID: 22549133.
    Citations: 20     Fields:    Translation:HumansAnimals
  36. Deleidi M, Isacson O. Viral and inflammatory triggers of neurodegenerative diseases. Sci Transl Med. 2012 Feb 15; 4(121):121ps3. PMID: 22344685.
    Citations: 10     Fields:    Translation:Humans
  37. Lindvall O, Barker RA, Brüstle O, Isacson O, Svendsen CN. Clinical translation of stem cells in neurodegenerative disorders. Cell Stem Cell. 2012 Feb 03; 10(2):151-5. PMID: 22305565.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  38. Cooper O, Parmar M, Isacson O. Characterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy. Prog Brain Res. 2012; 200:265-76. PMID: 23195423.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  39. Cooper O, Hallett P, Isacson O. Using stem cells and iPS cells to discover new treatments for Parkinson's disease. Parkinsonism Relat Disord. 2012 Jan; 18 Suppl 1:S14-6. PMID: 22166414.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  40. McLean JR, Hallett PJ, Cooper O, Stanley M, Isacson O. Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression. Mol Cell Neurosci. 2012 Feb; 49(2):230-9. PMID: 22155155.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  41. Deleidi M, Hargus G, Hallett P, Osborn T, Isacson O. Development of histocompatible primate-induced pluripotent stem cells for neural transplantation. Stem Cells. 2011 Jul; 29(7):1052-63. PMID: 21608081.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  42. Deleidi M, Cooper O, Hargus G, Levy A, Isacson O. Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons. PLoS One. 2011; 6(5):e19926. PMID: 21655272.
    Citations: 11     Fields:    Translation:AnimalsCells
  43. Tsui A, Isacson O. Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease. J Neurol. 2011 Aug; 258(8):1393-405. PMID: 21544566.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  44. Deleidi M, Hallett PJ, Koprich JB, Chung CY, Isacson O. The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration. J Neurosci. 2010 Dec 01; 30(48):16091-101. PMID: 21123556.
    Citations: 28     Fields:    Translation:Animals
  45. Isacson O, Mendez I. Being too inclusive about synuclein inclusions. Nat Med. 2010 Sep; 16(9):960-1; author reply 961. PMID: 20823871.
    Citations: 1     Fields:    Translation:HumansCells
  46. Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci U S A. 2010 Sep 07; 107(36):15921-6. PMID: 20798034.
    Citations: 141     Fields:    Translation:HumansAnimalsCells
  47. Seo H, Isacson O. The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome. J Neurochem. 2010 Sep; 114(6):1819-26. PMID: 20698932.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  48. Hedlund E, Karlsson M, Osborn T, Ludwig W, Isacson O. Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection. Brain. 2010 Aug; 133(Pt 8):2313-30. PMID: 20826431.
    Citations: 18     Fields:    Translation:AnimalsCells
  49. Cooper O, Hargus G, Deleidi M, Blak A, Osborn T, Marlow E, Lee K, Levy A, Perez-Torres E, Yow A, Isacson O. Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Mol Cell Neurosci. 2010 Nov; 45(3):258-66. PMID: 20603216.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  50. Chung CY, Licznerski P, Alavian KN, Simeone A, Lin Z, Martin E, Vance J, Isacson O. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain. 2010 Jul; 133(Pt 7):2022-31. PMID: 20573704.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  51. Lin Z, Zhao Y, Chung CY, Zhou Y, Xiong N, Glatt CE, Isacson O. High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life. FASEB J. 2010 Jul; 24(7):2191-200. PMID: 20181938.
    Citations: 9     Fields:    Translation:HumansCells
  52. Chung CY, Koprich JB, Hallett PJ, Isacson O. Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22474-9. PMID: 20007772.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  53. Chung S, Leung A, Han BS, Chang MY, Moon JI, Kim CH, Hong S, Pruszak J, Isacson O, Kim KS. Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell. 2009 Dec 04; 5(6):646-58. PMID: 19951692.
    Citations: 62     Fields:    Translation:AnimalsCells
  54. Pruszak J, Ludwig W, Blak A, Alavian K, Isacson O. CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells. Stem Cells. 2009 Dec; 27(12):2928-40. PMID: 19725119.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  55. Pruszak J, Just L, Isacson O, Nikkhah G. Isolation and culture of ventral mesencephalic precursor cells and dopaminergic neurons from rodent brains. Curr Protoc Stem Cell Biol. 2009 Dec; Chapter 2:Unit 2D.5. PMID: 19960452.
    Citations: 16     Fields:    Translation:AnimalsCells
  56. Isacson O. Cell therapy ahead for Parkinson's disease. Science. 2009 Nov 20; 326(5956):1060. PMID: 19965408.
    Citations: 3     Fields:    Translation:Humans
  57. Hallett PJ, Cooper O, Isacson O. No evidence for disease-like processes in fetal transplants. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):E104; author reply E105. PMID: 19805203.
    Citations: 1     Fields:    Translation:HumansCells
  58. Cooper O, Astradsson A, Hallett P, Robertson H, Mendez I, Isacson O. Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients. J Neurol. 2009 Aug; 256 Suppl 3:310-6. PMID: 19711122.
    Citations: 15     Fields:    Translation:HumansCells
  59. Astradsson A, Jenkins BG, Choi JK, Hallett PJ, Levesque MA, McDowell JS, Brownell AL, Spealman RD, Isacson O. The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies. Neurobiol Dis. 2009 Sep; 35(3):348-51. PMID: 19501164.
    Citations: 13     Fields:    Translation:Animals
  60. Chung CY, Koprich JB, Siddiqi H, Isacson O. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. J Neurosci. 2009 Mar 18; 29(11):3365-73. PMID: 19295143.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  61. Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 2009 Mar 06; 136(5):964-77. PMID: 19269371.
    Citations: 519     Fields:    Translation:HumansCells
  62. Zhang J, Xu TX, Hallett PJ, Watanabe M, Grant SG, Isacson O, Yao WD. PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex. J Neurosci. 2009 Mar 04; 29(9):2948-60. PMID: 19261890.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  63. Lin L, Lesnick TG, Maraganore DM, Isacson O. Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics. Trends Neurosci. 2009 Mar; 32(3):142-9. PMID: 19162339.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  64. Pruszak J, Isacson O. Molecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy. Adv Exp Med Biol. 2009; 651:112-23. PMID: 19731556.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  65. Hedlund E, Isacson O. ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells. Cell Stem Cell. 2008 Dec 04; 3(6):575-6. PMID: 19041769.
    Citations: 7     Fields:    Translation:HumansCells
  66. Isacson O, Kordower JH. Future of cell and gene therapies for Parkinson's disease. Ann Neurol. 2008 Dec; 64 Suppl 2:S122-38. PMID: 19127583.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  67. Vinuela A, Hallett PJ, Reske-Nielsen C, Patterson M, Sotnikova TD, Caron MG, Gainetdinov RR, Isacson O. Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. Brain. 2008 Dec; 131(Pt 12):3361-79. PMID: 18988638.
    Citations: 11     Fields:    Translation:AnimalsCells
  68. Sanchez-Pernaute R, Lee H, Patterson M, Reske-Nielsen C, Yoshizaki T, Sonntag KC, Studer L, Isacson O. Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease. Brain. 2008 Aug; 131(Pt 8):2127-39. PMID: 18669499.
    Citations: 21     Fields:    Translation:AnimalsCells
  69. Seo H, Kim W, Isacson O. Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients. Hum Mol Genet. 2008 Oct 15; 17(20):3144-53. PMID: 18640989.
    Citations: 9     Fields:    Translation:HumansAnimals
  70. de Chevigny A, Cooper O, Vinuela A, Reske-Nielsen C, Lagace DC, Eisch AJ, Isacson O. Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum. Stem Cells. 2008 Sep; 26(9):2349-60. PMID: 18556510.
    Citations: 17     Fields:    Translation:AnimalsCells
  71. Sanchez-Pernaute R, Wang JQ, Kuruppu D, Cao L, Tueckmantel W, Kozikowski A, Isacson O, Brownell AL. Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates. Neuroimage. 2008 Aug 01; 42(1):248-51. PMID: 18501638.
    Citations: 14     Fields:    Translation:AnimalsCells
  72. Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli V, Constantine-Paton M, Isacson O, Jaenisch R. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5856-61. PMID: 18391196.
    Citations: 381     Fields:    Translation:AnimalsCells
  73. Mendez I, Viñuela A, Astradsson A, Mukhida K, Hallett P, Robertson H, Tierney T, Holness R, Dagher A, Trojanowski JQ, Isacson O. Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Nat Med. 2008 May; 14(5):507-9. PMID: 18391961.
    Citations: 113     Fields:    Translation:HumansCells
  74. Hedlund E, Pruszak J, Lardaro T, Ludwig W, Viñuela A, Kim KS, Isacson O. Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease. Stem Cells. 2008 Jun; 26(6):1526-36. PMID: 18388307.
    Citations: 44     Fields:    Translation:AnimalsCells
  75. Viaro R, Sanchez-Pernaute R, Marti M, Trapella C, Isacson O, Morari M. Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism. Neurobiol Dis. 2008 Jun; 30(3):430-8. PMID: 18413287.
    Citations: 18     Fields:    Translation:Animals
  76. Koprich JB, Reske-Nielsen C, Mithal P, Isacson O. Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease. J Neuroinflammation. 2008 Feb 27; 5:8. PMID: 18304357.
    Citations: 77     Fields:    Translation:AnimalsCells
  77. Astradsson A, Cooper O, Vinuela A, Isacson O. Recent advances in cell-based therapy for Parkinson disease. Neurosurg Focus. 2008; 24(3-4):E6. PMID: 18341409.
    Citations: 10     Fields:    Translation:HumansAnimals
  78. Hong S, Kang UJ, Isacson O, Kim KS. Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons. J Neurochem. 2008 Jan; 104(2):316-24. PMID: 17944878.
    Citations: 24     Fields:    Translation:HumansCells
  79. Hedlund E, Hefferan MP, Marsala M, Isacson O. Cell therapy and stem cells in animal models of motor neuron disorders. Eur J Neurosci. 2007 Oct; 26(7):1721-37. PMID: 17897390.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  80. Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O. Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci U S A. 2007 Sep 04; 104(36):14430-5. PMID: 17726113.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  81. Redmond DE, Vinuela A, Kordower JH, Isacson O. Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson's disease. Neurobiol Dis. 2008 Jan; 29(1):103-16. PMID: 17920901.
    Citations: 18     Fields:    Translation:Animals
  82. Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ. Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease. PLoS Med. 2007 Aug; 4(8):e262. PMID: 17760499.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  83. Chung CY, Koprich JB, Endo S, Isacson O. An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease. J Neurosci. 2007 Aug 01; 27(31):8314-23. PMID: 17670978.
    Citations: 15     Fields:    Translation:HumansAnimals
  84. Brunlid G, Pruszak J, Holmes B, Isacson O, Sonntag KC. Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system. Stem Cells. 2007 Oct; 25(10):2551-8. PMID: 17615270.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  85. Hong S, Hwang DY, Yoon S, Isacson O, Ramezani A, Hawley RG, Kim KS. Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells. Mol Ther. 2007 Sep; 15(9):1630-9. PMID: 17609656.
    Citations: 41     Fields:    Translation:AnimalsCells
  86. Pruszak J, Sonntag KC, Aung MH, Sanchez-Pernaute R, Isacson O. Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations. Stem Cells. 2007 Sep; 25(9):2257-68. PMID: 17588935.
    Citations: 97     Fields:    Translation:HumansCells
  87. Sánchez-Pernaute R, Jenkins BG, Choi JK, Iris Chen YC, Isacson O. In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias. Neurobiol Dis. 2007 Aug; 27(2):220-7. PMID: 17588764.
    Citations: 21     Fields:    Translation:Animals
  88. Isacson O. Ole Isacson: development of new therapies for Parkinson's disease (interview). J Vis Exp. 2007; (3):189. PMID: 18978995.
    Citations: 1     Fields:    Translation:Humans
  89. Zhang J, Vinuela A, Neely MH, Hallett PJ, Grant SG, Miller GM, Isacson O, Caron MG, Yao WD. Inhibition of the dopamine D1 receptor signaling by PSD-95. J Biol Chem. 2007 May 25; 282(21):15778-89. PMID: 17369255.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  90. Seo H, Sonntag KC, Kim W, Cattaneo E, Isacson O. Proteasome activator enhances survival of Huntington's disease neuronal model cells. PLoS One. 2007 Feb 28; 2(2):e238. PMID: 17327906.
    Citations: 37     Fields:    Translation:Humans