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Zhuoran Yin, Ph.D., M.D.


University of Groningen, Groningen, the NetherlandsPhD03/2017Neuroscience
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaMD06/2011Medicine
2015 - 2016
Jan Kornelis De Cock Stichting
Outstanding Graduate Student Award

My research interests are microglia phenotypes and the regulating mechanisms under various disease conditions, e.g., Alzheimer's disease, delirium, retinitis pigmentosa. Understanding the interaction between immune system and neurodegenerative disease paves a road for my study. I have a long-term interest in developing novel therapeutic approaches for neurodegenerative diseases.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Margeta MA, Yin Z, Madore C, Pitts KM, Letcher SM, Tang J, Jiang S, Gauthier CD, Silveira SR, Schroeder CM, Lad EM, Proia AD, Tanzi RE, Holtzman DM, Krasemann S, Chen DF, Butovsky O. Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. Immunity. 2022 09 13; 55(9):1627-1644.e7. PMID: 35977543; PMCID: PMC9488669.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  2. Madore C, Yin Z, Leibowitz J, Butovsky O. Microglia, Lifestyle Stress, and Neurodegeneration. Immunity. 2020 02 18; 52(2):222-240. PMID: 31924476.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  3. Yin Z, Raj DD, Schaafsma W, van der Heijden RA, Kooistra SM, Reijne AC, Zhang X, Moser J, Brouwer N, Heeringa P, Yi CX, van Dijk G, Laman JD, Boddeke EWGM, Eggen BJL. Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging. Front Mol Neurosci. 2018; 11:65. PMID: 29593493; PMCID: PMC5857900.
    Citations: 17     
  4. Raj D, Yin Z, Breur M, Doorduin J, Holtman IR, Olah M, Mantingh-Otter IJ, Van Dam D, De Deyn PP, den Dunnen W, Eggen BJL, Amor S, Boddeke E. Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain. Front Mol Neurosci. 2017; 10:206. PMID: 28713239; PMCID: PMC5492660.
    Citations: 69     
  5. Yin Z, Raj D, Saiepour N, Van Dam D, Brouwer N, Holtman IR, Eggen BJL, Möller T, Tamm JA, Abdourahman A, Hol EM, Kamphuis W, Bayer TA, De Deyn PP, Boddeke E. Immune hyperreactivity of Aß plaque-associated microglia in Alzheimer's disease. Neurobiol Aging. 2017 07; 55:115-122. PMID: 28434692.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  6. Yin Z, Valkenburg F, Hornix BE, Mantingh-Otter I, Zhou X, Mari M, Reggiori F, Van Dam D, Eggen BJL, De Deyn PP, Boddeke E. Progressive Motor Deficit is Mediated by the Denervation of Neuromuscular Junctions and Axonal Degeneration in Transgenic Mice Expressing Mutant (P301S) Tau Protein. J Alzheimers Dis. 2017; 60(s1):S41-S57. PMID: 28222529.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  7. Holtman IR, Raj DD, Miller JA, Schaafsma W, Yin Z, Brouwer N, Wes PD, Möller T, Orre M, Kamphuis W, Hol EM, Boddeke EW, Eggen BJ. Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis. Acta Neuropathol Commun. 2015 May 23; 3:31. PMID: 26001565; PMCID: PMC4489356.
    Citations: 229     Fields:    Translation:HumansAnimalsCells
  8. Wu W, Xu Y, He X, Lu Y, Guo Y, Yin Z, Xie J, Zhao J. IL-33 promotes mouse keratinocyte-derived chemokine, an IL-8 homologue, expression in airway smooth muscle cells in ovalbumin-sensitized mice. Asian Pac J Allergy Immunol. 2014 Dec; 32(4):337-44. PMID: 25543045.
    Citations: 1     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.