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profileMichael Edward Charness, M.D.

TitleProfessor of Neurology
InstitutionVeterans Affairs Boston Healthcare System
DepartmentNeurology
AddressWest Roxbury VA Hospital
Neurology (127)
1400 VFW Pkwy
West Roxbury MA 02132
Phone857/203-6011
Fax857/203-5500
vCardDownload vCard (login for email)
Other Positions
TitleFaculty Associate Dean for Veterans Hospital Programs
InstitutionVeterans Affairs Boston Healthcare System
DepartmentAcademic and Clinical Programs


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Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
I01BX002374     (CHARNESS, MICHAEL EDWARD)Oct 1, 2014 - Sep 30, 2018
VA
Alcohol Antagonists
Role: Principal Investigator

R01AA012974     (CHARNESS, MICHAEL EDWARD)May 1, 2001 - Jan 31, 2017
NIH/NIAAA
Alcohol and Cell Adhesion
Role: Principal Investigator

R37AA012974     (CHARNESS, MICHAEL EDWARD)May 1, 2001 - Jan 31, 2012
NIH/NIAAA
ALCOHOL AND CELL ADHESION
Role: Principal Investigator

R01AA011297     (CHARNESS, MICHAEL EDWARD)Apr 1, 1997 - Mar 31, 2001
NIH/NIAAA
ALCOHOL INTERACTION WITH L1 CELL ADHESION MOLECULE
Role: Principal Investigator

R01AA009669     (CHARNESS, MICHAEL EDWARD)Sep 30, 1994 - Aug 31, 1999
NIH/NIAAA
ALCOHOL INHIBITION OF NEURONAL CELL ADHESION
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hoyme HE, Kalberg WO, Elliott AJ, Blankenship J, Buckley D, Marais AS, Manning MA, Robinson LK, Adam MP, Abdul-Rahman O, Jewett T, Coles CD, Chambers C, Jones KL, Adnams CM, Shah PE, Riley EP, Charness ME, Warren KR, May PA. Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders. Pediatrics. 2016 Aug; 138(2). PMID: 27464676; PMCID: PMC4960726 [Available on 08/01/17].
  2. Charness ME, Riley EP, Sowell ER. Drinking During Pregnancy and the Developing Brain: Is Any Amount Safe? Trends Cogn Sci. 2016 Feb; 20(2):80-2. PMID: 26801950; PMCID: PMC4788102 [Available on 02/01/17].
  3. Dou X, Charness ME. Effect of lipid raft disruption on ethanol inhibition of l1 adhesion. Alcohol Clin Exp Res. 2014 Nov; 38(11):2707-11. PMID: 25421507; PMCID: PMC4278581.
  4. Sowell ER, Charness ME, Riley EP. Pregnancy: No safe level of alcohol. Nature. 2014 Sep 11; 513(7517):172. PMID: 25209788.
    View in: PubMed
  5. Charness ME. Brain surgery for musician's dystonia. Ann Neurol. 2013 Nov; 74(5):627-9. PMID: 23893466.
    View in: PubMed
  6. Dou X, Wilkemeyer MF, Menkari CE, Parnell SE, Sulik KK, Charness ME. Mitogen-activated protein kinase modulates ethanol inhibition of cell adhesion mediated by the L1 neural cell adhesion molecule. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5683-8. PMID: 23431142; PMCID: PMC3619378.
  7. Chen S, Charness ME. Ethanol disrupts axon outgrowth stimulated by netrin-1, GDNF, and L1 by blocking their convergent activation of Src family kinase signaling. J Neurochem. 2012 Nov; 123(4):602-12. PMID: 22924694; PMCID: PMC3472116.
  8. Fitzgerald DM, Charness ME, Leite-Morris KA, Chen S. Effects of ethanol and NAP on cerebellar expression of the neural cell adhesion molecule L1. PLoS One. 2011; 6(9):e24364. PMID: 21931691; PMCID: PMC3169602.
  9. Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA, Kranzler HR, Jr MC, Nixon SJ, Riley EP, Schuckit MA, Sher KJ, Thomas JD. How Should Addiction-Related Research at the National Institutes of Health be Reorganized? Front Psychiatry. 2011; 2:2. PMID: 21629835; PMCID: PMC3098615.
  10. Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA, Kranzler HR, Mitchell MC, Nixon SJ, Riley EP, Schuckit MA, Sher KJ, Thomas JD. Should the reorganization of addiction-related research across all the National Institutes of Health be structural?--The devil is truly in the details. Alcohol Clin Exp Res. 2011 Apr; 35(4):572-80. PMID: 21443646; PMCID: PMC3068603.
  11. Dou X, Menkari CE, Shanmugasundararaj S, Miller KW, Charness ME. Two alcohol binding residues interact across a domain interface of the L1 neural cell adhesion molecule and regulate cell adhesion. J Biol Chem. 2011 May 06; 286(18):16131-9. PMID: 21367865; PMCID: PMC3091222.
  12. Chen S, Charness ME. Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19962-7. PMID: 19047645; PMCID: PMC2604983.
  13. Arevalo E, Shanmugasundararaj S, Wilkemeyer MF, Dou X, Chen S, Charness ME, Miller KW. An alcohol binding site on the neural cell adhesion molecule L1. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):371-5. PMID: 18165316; PMCID: PMC2224219.
  14. Parnell SE, Chen SY, Charness ME, Hodge CW, Dehart DB, Sulik KK. Concurrent dietary administration of D-SAL and ethanol diminishes ethanol's teratogenesis. Alcohol Clin Exp Res. 2007 Dec; 31(12):2059-64. PMID: 17949468.
    View in: PubMed
  15. Parnell SE, Dehart DB, Wills TA, Chen SY, Hodge CW, Besheer J, Waage-Baudet HG, Charness ME, Sulik KK. Maternal oral intake mouse model for fetal alcohol spectrum disorders: ocular defects as a measure of effect. Alcohol Clin Exp Res. 2006 Oct; 30(10):1791-8. PMID: 17010146.
    View in: PubMed
  16. Zhang TA, Hendricson AW, Wilkemeyer MF, Lippmann MJ, Charness ME, Morrisett RA. Synergistic effects of the peptide fragment D-NAPVSIPQ on ethanol inhibition of synaptic plasticity and NMDA receptors in rat hippocampus. Neuroscience. 2005; 134(2):583-93. PMID: 15963648.
    View in: PubMed
  17. Chen SY, Charness ME, Wilkemeyer MF, Sulik KK. Peptide-mediated protection from ethanol-induced neural tube defects. Dev Neurosci. 2005 Jan-Feb; 27(1):13-9. PMID: 15886480.
    View in: PubMed
  18. Wilkemeyer MF, Chen SY, Menkari CE, Sulik KK, Charness ME. Ethanol antagonist peptides: structural specificity without stereospecificity. J Pharmacol Exp Ther. 2004 Jun; 309(3):1183-9. PMID: 14762101.
    View in: PubMed
  19. Charness ME, Schlaug G. Brain mapping in musicians with focal task-specific dystonia. Adv Neurol. 2004; 94:231-8. PMID: 14509678.
    View in: PubMed
  20. Wilkemeyer MF, Chen SY, Menkari CE, Brenneman DE, Sulik KK, Charness ME. Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPVSIPQ prevention of ethanol-induced developmental toxicity. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8543-8. PMID: 12808140; PMCID: PMC166265.
  21. Simon DK, Friedman J, Breakefield XO, Jankovic J, Brin MF, Provias J, Bressman SB, Charness ME, Tarsy D, Johns DR, Tarnopolsky MA. A heteroplasmic mitochondrial complex I gene mutation in adult-onset dystonia. Neurogenetics. 2003 Aug; 4(4):199-205. PMID: 12756609.
    View in: PubMed
  22. Riley EP, Guerri C, Calhoun F, Charness ME, Foroud TM, Li TK, Mattson SN, May PA, Warren KR. Prenatal alcohol exposure: advancing knowledge through international collaborations. Alcohol Clin Exp Res. 2003 Jan; 27(1):118-35. PMID: 12544016.
    View in: PubMed
  23. Wilkemeyer MF, Menkari CE, Charness ME. Novel antagonists of alcohol inhibition of l1-mediated cell adhesion: multiple mechanisms of action. Mol Pharmacol. 2002 Nov; 62(5):1053-60. PMID: 12391267.
    View in: PubMed
  24. Wilkemeyer MF, Menkari CE, Spong CY, Charness ME. Peptide antagonists of ethanol inhibition of l1-mediated cell-cell adhesion. J Pharmacol Exp Ther. 2002 Oct; 303(1):110-6. PMID: 12235240.
    View in: PubMed
  25. Chen SY, Wilkemeyer MF, Sulik KK, Charness ME. Octanol antagonism of ethanol teratogenesis. FASEB J. 2001 Jul; 15(9):1649-51. PMID: 11427515.
    View in: PubMed
  26. Friedman JR, Klein C, Leung J, Woodward H, Ozelius LJ, Breakefield XO, Charness ME. The GAG deletion of the DYT1 gene is infrequent in musicians with focal dystonia. Neurology. 2000 Nov 14; 55(9):1417-8. PMID: 11087801.
    View in: PubMed
  27. Shiromani PJ, Basheer R, Thakkar J, Wagner D, Greco MA, Charness ME. Sleep and wakefulness in c-fos and fos B gene knockout mice. Brain Res Mol Brain Res. 2000 Aug 14; 80(1):75-87. PMID: 11039731.
    View in: PubMed
  28. Wilkemeyer MF, Sebastian AB, Smith SA, Charness ME. Antagonists of alcohol inhibition of cell adhesion. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3690-5. PMID: 10725368; PMCID: PMC16301.
  29. Charness ME. Intracranial voyeurism: revealing the mammillary bodies in alcoholism. Alcohol Clin Exp Res. 1999 Dec; 23(12):1941-4. PMID: 10630614.
    View in: PubMed
  30. Wilkemeyer MF, Pajerski M, Charness ME. Alcohol inhibition of cell adhesion in BMP-treated NG108-15 cells. Alcohol Clin Exp Res. 1999 Nov; 23(11):1711-20. PMID: 10591586.
    View in: PubMed
  31. Wilkemeyer MF, Charness ME. Characterization of ethanol-sensitive and insensitive fibroblast cell lines expressing human L1. J Neurochem. 1998 Dec; 71(6):2382-91. PMID: 9832136.
    View in: PubMed
  32. Perides G, Charness ME, Tanner LM, Péter O, Satz N, Steere AC, Klempner MS. Matrix metalloproteinases in the cerebrospinal fluid of patients with Lyme neuroborreliosis. J Infect Dis. 1998 Feb; 177(2):401-8. PMID: 9466528.
    View in: PubMed
  33. Ross MH, Charness ME, Sudarsky L, Logigian EL. Treatment of occupational cramp with botulinum toxin: diffusion of toxin to adjacent noninjected muscles. Muscle Nerve. 1997 May; 20(5):593-8. PMID: 9140366.
    View in: PubMed
  34. Charness ME. Evaluation of suspected dementia. N Engl J Med. 1996 Dec 26; 335(26):1996-7; author reply 1997-8. PMID: 8975128.
    View in: PubMed
  35. Charness ME. Direct effects of ethanol on signaling proteins. Alcohol Clin Exp Res. 1996 Nov; 20(8 Suppl):157A-161A. PMID: 8947256.
    View in: PubMed
  36. Charness ME, Ross MH, Shefner JM. Ulnar neuropathy and dystonic flexion of the fourth and fifth digits: clinical correlation in musicians. Muscle Nerve. 1996 Apr; 19(4):431-7. PMID: 8622720.
    View in: PubMed
  37. Ramanathan R, Wilkemeyer MF, Mittal B, Perides G, Charness ME. Alcohol inhibits cell-cell adhesion mediated by human L1. J Cell Biol. 1996 Apr; 133(2):381-90. PMID: 8609170; PMCID: PMC2120806.
  38. Gasser T, Bove CM, Ozelius LJ, Hallett M, Charness ME, Hochberg FH, Breakefield XO. Haplotype analysis at the DYT1 locus in Ashkenazi Jewish patients with occupational hand dystonia. Mov Disord. 1996 Mar; 11(2):163-6. PMID: 8684386.
    View in: PubMed
  39. Ross MH, Charness ME, Lee D, Logigian EL. Does ulnar neuropathy predispose to focal dystonia? Muscle Nerve. 1995 Jun; 18(6):606-11. PMID: 7753123.
    View in: PubMed
  40. Shiromani PJ, Magner M, Winston S, Charness ME. Time course of phosphorylated CREB and Fos-like immunoreactivity in the hypothalamic supraoptic nucleus after salt loading. Brain Res Mol Brain Res. 1995 Mar; 29(1):163-71. PMID: 7769993.
    View in: PubMed
  41. Perides G, Jensen FE, Edgecomb P, Rueger DC, Charness ME. Neuroprotective effect of human osteogenic protein-1 in a rat model of cerebral hypoxia/ischemia. Neurosci Lett. 1995 Feb 24; 187(1):21-4. PMID: 7617293.
    View in: PubMed
  42. Charness ME, Safran RM, Perides G. Ethanol inhibits neural cell-cell adhesion. J Biol Chem. 1994 Mar 25; 269(12):9304-9. PMID: 8132668.
    View in: PubMed
  43. Tarsy D, Sudarsky L, Charness ME. Limb dystonia following electrical injury. Mov Disord. 1994 Mar; 9(2):230-2. PMID: 8196690.
    View in: PubMed
  44. Saver JL, Liu GT, Charness ME. Idiopathic striopallidodentate calcification with prominent supranuclear abnormality of eye movement. J Neuroophthalmol. 1994 Mar; 14(1):29-33. PMID: 8032477.
    View in: PubMed
  45. Perides G, Safran RM, Downing LA, Charness ME. Regulation of neural cell adhesion molecule and L1 by the transforming growth factor-beta superfamily. Selective effects of the bone morphogenetic proteins. J Biol Chem. 1994 Jan 07; 269(1):765-70. PMID: 8276880.
    View in: PubMed
  46. Charness ME, Hu G, Edwards RH, Querimit LA. Ethanol increases delta-opioid receptor gene expression in neuronal cell lines. Mol Pharmacol. 1993 Dec; 44(6):1119-27. PMID: 8264548.
    View in: PubMed
  47. Perides G, Hu G, Rueger DC, Charness ME. Osteogenic protein-1 regulates L1 and neural cell adhesion molecule gene expression in neural cells. J Biol Chem. 1993 Nov 25; 268(33):25197-205. PMID: 8227084.
    View in: PubMed
  48. Hu G, Querimit LA, Downing LA, Charness ME. Ethanol differentially increases alpha 2-adrenergic and muscarinic acetylcholine receptor gene expression in NG108-15 cells. J Biol Chem. 1993 Nov 05; 268(31):23441-7. PMID: 8226869.
    View in: PubMed
  49. Charness ME. Brain lesions in alcoholics. Alcohol Clin Exp Res. 1993 Feb; 17(1):2-11. PMID: 8452204.
    View in: PubMed
  50. Perides G, Safran RM, Rueger DC, Charness ME. Induction of the neural cell adhesion molecule and neuronal aggregation by osteogenic protein 1. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10326-30. PMID: 1438217; PMCID: PMC50331.
  51. Liu GT, Crenner CW, Logigian EL, Charness ME, Samuels MA. Midbrain syndromes of Benedikt, Claude, and Nothnagel: setting the record straight. Neurology. 1992 Sep; 42(9):1820-2. PMID: 1513475.
    View in: PubMed
  52. Charness ME, Liu GT. Central retinal artery occlusion in giant cell arteritis: treatment with nitroglycerin. Neurology. 1991 Oct; 41(10):1698-9. PMID: 1922829.
    View in: PubMed
  53. Liu GT, Carrazana EJ, Charness ME. Unilateral oculomotor palsy and bilateral ptosis from paramedian midbrain infarction. Arch Neurol. 1991 Sep; 48(9):983-6. PMID: 1953423.
    View in: PubMed
  54. Liu GT, Greene JM, Charness ME. Brown-Séquard syndrome in a patient with systemic lupus erythematosus. Neurology. 1990 Sep; 40(9):1474-5. PMID: 2392244.
    View in: PubMed
  55. Charness ME, Simon RP, Greenberg DA. Ethanol and the nervous system. N Engl J Med. 1989 Aug 17; 321(7):442-54. PMID: 2668759.
    View in: PubMed
  56. Charness ME. Ethanol and opioid receptor signalling. Experientia. 1989 May 15; 45(5):418-28. PMID: 2542082.
    View in: PubMed
  57. Charness ME, Querimit LA, Henteleff M. Ethanol differentially regulates G proteins in neural cells. Biochem Biophys Res Commun. 1988 Aug 30; 155(1):138-43. PMID: 3137933.
    View in: PubMed
  58. Charness ME, DeLaPaz RL. Mamillary body atrophy in Wernicke's encephalopathy: antemortem identification using magnetic resonance imaging. Ann Neurol. 1987 Nov; 22(5):595-600. PMID: 3426166.
    View in: PubMed
  59. Charness ME, Querimit LA, Diamond I. Ethanol increases the expression of functional delta-opioid receptors in neuroblastoma x glioma NG108-15 hybrid cells. J Biol Chem. 1986 Mar 05; 261(7):3164-9. PMID: 3005282.
    View in: PubMed
  60. Charness ME, Morady F, Scheinman MM. Frequent neurologic toxicity associated with amiodarone therapy. Neurology. 1984 May; 34(5):669-71. PMID: 6538658.
    View in: PubMed
  61. Charness ME, Gordon AS, Diamond I. Interaction of ethanol with neural cells in culture: a model of intoxication, tolerance and withdrawal. Ciba Found Symp. 1984; 105:73-84. PMID: 6563992.
    View in: PubMed
  62. Charness ME, Gordon AS, Diamond I. Ethanol modulation of opiate receptors in cultured neural cells. Science. 1983 Dec 16; 222(4629):1246-8. PMID: 6316506.
    View in: PubMed
  63. Guidotti TL, Charness ME, Lamon JM. Acute intermittent porphyria and the Klüver -- Bucy syndrome. Johns Hopkins Med J. 1979 Dec; 145(6):233-5. PMID: 513431.
    View in: PubMed
  64. Charness ME, Fishman JA, Robertson D. Exacerbation of angina pectoris by prazosin. South Med J. 1979 Sep; 72(9):1213-4. PMID: 472855.
    View in: PubMed
  65. Charness ME. Clinical conferences at The Johns Hopkins Hospital. Hypokalemic periodic paralysis. Johns Hopkins Med J. 1978 Oct; 143(4):148-53. PMID: 556353.
    View in: PubMed
  66. U'Prichard DC, Charness ME, Robertson D, Snyder SH. Prazosin: differential affinities for two populations of alpha-noradrenergic receptor binding sites. Eur J Pharmacol. 1978 Jul 01; 50(1):87-9. PMID: 28235.
    View in: PubMed
  67. Bylund DB, Charness ME, Snyder SH. Beta adrenergic receptor labeling in intact animals with 125I-hydroxybenzylpindolol. J Pharmacol Exp Ther. 1977 Jun; 201(3):644-53. PMID: 194026.
    View in: PubMed
  68. Enna SJ, Bennett JP, Bylund DB, Creese I, Burt DR, Charness ME, Yamamura HI, Simantov R, Snyder SH. Neurotransmitter receptor binding: regional distribution in human brain. J Neurochem. 1977 Jan; 28(1):233-6. PMID: 13155.
    View in: PubMed
  69. Charness ME, Bylund DB, Beckman BS, Hollenberg MD, Snyder SH. Independent variation of beta-adrenergic receptor binding and catecholamine-stimulated adenylate cyclase activity in rat erythrocytes. Life Sci. 1976 Jul 15; 19(2):243-9. PMID: 957867.
    View in: PubMed
  70. Charness ME, Amit Z, Taylor M. Morphine induced stereotypic behavior in rat. Behav Biol. 1975 Jan; 13(1):71-80. PMID: 1167447.
    View in: PubMed
  71. Amit Z, Corcoran ME, Charness ME, Shizgal P. Intake of diazepam and hashish by alcohol preferring rats deprived of alcohol. Physiol Behav. 1973 Mar; 10(3):523-7. PMID: 4708516.
    View in: PubMed
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