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Xin Yu, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21NS121642 (YU, XIN) Sep 20, 2021 - Feb 28, 2023
    NIH
    Development of a multi-modal MRI methodology to map paravascular clearance linked to astrocyte dysfunction in fetal-onset hydrocephalus
    Role: Principal Investigator
  2. 2123971 (YU, XIN) Sep 1, 2021 - Aug 31, 2025
    NSF
    Collaborative Research: NCS-FR: Understanding the neuropeptide modulation of brain circuits by advanced nanomaterials and imaging
    Role: Co-Principle Investigator
  3. R01NS122904 (YU, XIN) Aug 1, 2021 - May 31, 2026
    NIH
    Investigating the thalamic regulation of neuro-glio-vascular restoration underlying acute coma recovery with multi-modal fMRI in a brainstem coma rodent model
    Role: Principal Investigator
  4. R01NS120594 (BONMASSAR, GIORGIO) Jun 1, 2021 - May 31, 2024
    NIH
    Simultaneous functional MRI and Micro-Magnetic Nervous System Stimulation
    Role: Co-Principal Investigator
  5. S10MH124733 (ROSEN, BRUCE R) Sep 11, 2020 - Sep 10, 2021
    NIH
    Bridging the cellular and microvascular anatomy and functional dynamics: Upgrade the 14T horizontal MR for rodent and ex-vivo imaging
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Choi S, Zeng H, Chen Y, Sobczak F, Qian C, Yu X. Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI. Cereb Cortex. 2022 10 08; 32(20):4492-4501. PMID: 35107125; PMCID: PMC9574235.
    Citations:    Fields:    Translation:Animals
  2. Castaneda-Vega S, Beer-Hammer S, Leiss V, Napieczynska H, Vuozzo M, Schmid AM, Zeng H, He Y, Kohlhofer U, Gonzalez-Menendez I, Quintanilla-Martinez L, Hempel JM, Gollasch M, Yu X, Pichler BJ, Nürnberg B. Cerebrovascular Gi Proteins Protect Against Brain Hypoperfusion and Collateral Failure in Cerebral Ischemia. Mol Imaging Biol. 2022 Sep 08. PMID: 36074223.
    Citations: 1     Fields:    
  3. Zeng H, Jiang Y, Beer-Hammer S, Yu X. Awake Mouse fMRI and Pupillary Recordings in the Ultra-High Magnetic Field. Front Neurosci. 2022; 16:886709. PMID: 35903811; PMCID: PMC9318598.
    Citations: 1     
  4. Duy PQ, Weise SC, Marini C, Li XJ, Liang D, Dahl PJ, Ma S, Spajic A, Dong W, Juusola J, Kiziltug E, Kundishora AJ, Koundal S, Pedram MZ, Torres-Fernández LA, Händler K, De Domenico E, Becker M, Ulas T, Juranek SA, Cuevas E, Hao LT, Jux B, Sousa AMM, Liu F, Kim SK, Li M, Yang Y, Takeo Y, Duque A, Nelson-Williams C, Ha Y, Selvaganesan K, Robert SM, Singh AK, Allington G, Furey CG, Timberlake AT, Reeves BC, Smith H, Dunbar A, DeSpenza T, Goto J, Marlier A, Moreno-De-Luca A, Yu X, Butler WE, Carter BS, Lake EMR, Constable RT, Rakic P, Lin H, Deniz E, Benveniste H, Malvankar NS, Estrada-Veras JI, Walsh CA, Alper SL, Schultze JL, Paeschke K, Doetzlhofer A, Wulczyn FG, Jin SC, Lifton RP, Sestan N, Kolanus W, Kahle KT. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nat Neurosci. 2022 04; 25(4):458-473. PMID: 35379995; PMCID: PMC9664907.
    Citations:    Fields:    Translation:HumansAnimals
  5. Chen Y, Wang Q, Choi S, Zeng H, Takahashi K, Qian C, Yu X. Focal fMRI signal enhancement with implantable inductively coupled detectors. Neuroimage. 2022 02 15; 247:118793. PMID: 34896291.
    Citations: 2     Fields:    Translation:Animals
  6. Pais-Roldán P, Mateo C, Pan WJ, Acland B, Kleinfeld D, Snyder LH, Yu X, Keilholz S. Contribution of animal models toward understanding resting state functional connectivity. Neuroimage. 2021 12 15; 245:118630. PMID: 34644593; PMCID: PMC9031339.
    Citations: 6     Fields:    Translation:Animals
  7. Chen X, Jiang Y, Choi S, Pohmann R, Scheffler K, Kleinfeld D, Yu X. Assessment of single-vessel cerebral blood velocity by phase contrast fMRI. PLoS Biol. 2021 09; 19(9):e3000923. PMID: 34499636; PMCID: PMC8454982.
    Citations: 2     Fields:    Translation:Animals
  8. Sobczak F, Pais-Roldán P, Takahashi K, Yu X. Decoding the brain state-dependent relationship between pupil dynamics and resting state fMRI signal fluctuation. Elife. 2021 08 31; 10. PMID: 34463612; PMCID: PMC8460262.
    Citations: 2     Fields:    Translation:Animals
  9. Raimondo L, Knapen T, Oliveira LAF, Yu X, Dumoulin SO, van der Zwaag W, Siero JCW. A line through the brain: implementation of human line-scanning at 7T for ultra-high spatiotemporal resolution fMRI. J Cereb Blood Flow Metab. 2021 11; 41(11):2831-2843. PMID: 34415208; PMCID: PMC8756483.
    Citations: 1     Fields:    Translation:Humans
  10. Xin Yu and Patricia Pais-Roldán. Imaging Modalities for Biological and Preclinical Research: A Compendium, Volume 2 Parts II–IV: In vivo preclinical imaging, multimodality imaging and outlook; Andreas Walter, Julia G Mannheim and Carmel J Caruana. Functional magnetic resonance imaging. 2021; 2:II.7.b-1-14.
  11. Mächler P, Broggini T, Mateo C, Thunemann M, Fomin-Thunemann N, Doran PR, Sencan I, Kilic K, Desjardins M, Uhlirova H, Yaseen MA, Boas DA, Linninger AA, Vergassola M, Yu X, Lewis LD, Polimeni JR, Rosen BR, Sakadžic S, Buxton RB, Lauritzen M, Kleinfeld D, Devor A. A Suite of Neurophotonic Tools to Underpin the Contribution of Internal Brain States in fMRI. Curr Opin Biomed Eng. 2021 Jun; 18. PMID: 33959688; PMCID: PMC8095678.
    Citations: 1     
  12. Sobczak F, He Y, Sejnowski TJ, Yu X. Predicting the fMRI Signal Fluctuation with Recurrent Neural Networks Trained on Vascular Network Dynamics. Cereb Cortex. 2021 01 05; 31(2):826-844. PMID: 32940658.
    Citations: 4     Fields:    Translation:HumansAnimals
  13. Qian W, Yu X, Qian C. Wireless Powered Encoding and Broadcasting of Frequency Modulated Detection Signals. IEEE Access. 2020; 8:200450-200460. PMID: 33828933.
    Citations:    
  14. Chen Y, Sobczak F, Pais-Roldán P, Schwarz C, Koretsky AP, Yu X. Mapping the Brain-Wide Network Effects by Optogenetic Activation of the Corpus Callosum. Cereb Cortex. 2020 10 01; 30(11):5885-5898. PMID: 32556241.
    Citations: 5     Fields:    Translation:Animals
  15. Choi S, Takahashi K, Jiang Y, Köhler S, Zeng H, Wang Q, Ma Y, Yu X. Real-Time fMRI Brain Mapping in Animals. J Vis Exp. 2020 09 24; (163). PMID: 33044460.
    Citations:    Fields:    Translation:Animals
  16. Drew PJ, Mateo C, Turner KL, Yu X, Kleinfeld D. Ultra-slow Oscillations in fMRI and Resting-State Connectivity: Neuronal and Vascular Contributions and Technical Confounds. Neuron. 2020 09 09; 107(5):782-804. PMID: 32791040.
    Citations: 25     Fields:    Translation:HumansAnimals
  17. Qian W, Yu X, Qian C. Wireless Reconfigurable RF Detector Array for Focal and Multiregional Signal Enhancement. IEEE Access. 2020; 8:136594-136604. PMID: 33747678.
    Citations: 1     
  18. Pais-Roldán P, Takahashi K, Sobczak F, Chen Y, Zhao X, Zeng H, Jiang Y, Yu X. Indexing brain state-dependent pupil dynamics with simultaneous fMRI and optical fiber calcium recording. Proc Natl Acad Sci U S A. 2020 03 24; 117(12):6875-6882. PMID: 32139609.
    Citations: 24     Fields:    Translation:Animals
  19. Ovsepian SV, Jiang Y, Sardella TCP, Malekzadeh-Najafabadi J, Burton NC, Yu X, Ntziachristos V. Visualizing cortical response to optogenetic stimulation and sensory inputs using multispectral handheld optoacoustic imaging. Photoacoustics. 2020 Mar; 17:100153. PMID: 32154103; PMCID: PMC7052434.
    Citations: 6     
  20. Handwerker J, Pérez-Rodas M, Beyerlein M, Vincent F, Beck A, Freytag N, Yu X, Pohmann R, Anders J, Scheffler K. A CMOS NMR needle for probing brain physiology with high spatial and temporal resolution. Nat Methods. 2020 01; 17(1):64-67. PMID: 31768059.
    Citations: 1     Fields:    Translation:Animals
  21. Chen X, Sobczak F, Chen Y, Jiang Y, Qian C, Lu Z, Ayata C, Logothetis NK, Yu X. Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus. Nat Commun. 2019 11 20; 10(1):5239. PMID: 31748553; PMCID: PMC6868210.
    Citations: 20     Fields:    Translation:AnimalsCells
  22. He Y, Wang M, Yu X. High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI. J Cereb Blood Flow Metab. 2020 10; 40(10):2098-2114. PMID: 31696765; PMCID: PMC7786852.
    Citations: 5     Fields:    Translation:Animals
  23. Chen Y, Pais-Roldan P, Chen X, Frosz MH, Yu X. MRI-guided robotic arm drives optogenetic fMRI with concurrent Ca2+ recording. Nat Commun. 2019 06 10; 10(1):2536. PMID: 31182714; PMCID: PMC6557837.
    Citations: 12     Fields:    Translation:Animals
  24. Pais-Roldán P, Edlow BL, Jiang Y, Stelzer J, Zou M, Yu X. Multimodal assessment of recovery from coma in a rat model of diffuse brainstem tegmentum injury. Neuroimage. 2019 04 01; 189:615-630. PMID: 30708105; PMCID: PMC6642798.
    Citations: 6     Fields:    Translation:Animals
  25. Pais-Roldán P, Biswal B, Scheffler K, Yu X. Identifying Respiration-Related Aliasing Artifacts in the Rodent Resting-State fMRI. Front Neurosci. 2018; 12:788. PMID: 30455623; PMCID: PMC6230988.
    Citations: 11     
  26. He Y, Wang M, Chen X, Pohmann R, Polimeni JR, Scheffler K, Rosen BR, Kleinfeld D, Yu X. Ultra-Slow Single-Vessel BOLD and CBV-Based fMRI Spatiotemporal Dynamics and Their Correlation with Neuronal Intracellular Calcium Signals. Neuron. 2018 02 21; 97(4):925-939.e5. PMID: 29398359.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  27. Wang M, He Y, Sejnowski TJ, Yu X. Brain-state dependent astrocytic Ca2+ signals are coupled to both positive and negative BOLD-fMRI signals. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1647-E1656. PMID: 29382752; PMCID: PMC5816146.
    Citations: 48     Fields:    Translation:AnimalsCells
  28. CHEN YI, Yu XIN, YU SHANYI. POSITIONING SYSTEM FOR AN IMAGING DEVICE. 2017. View Publication.
  29. Chung S, Jeong JH, Ko S, Yu X, Kim YH, Isaac JTR, Koretsky AP. Peripheral Sensory Deprivation Restores Critical-Period-like Plasticity to Adult Somatosensory Thalamocortical Inputs. Cell Rep. 2017 06 27; 19(13):2707-2717. PMID: 28658619.
    Citations: 9     Fields:    Translation:HumansAnimals
  30. Xin Yu. Small Animal Imaging: Basics and Practical Guide; Fabian Kiessling, Bernd J. Pichler, Peter Hauff . When Photons Meet Protons: Optogenetics, Calcium Signal Detection, and fMRI in Small Animals. 2017; 773-791.
  31. Yu XIN, JIANG YUANYUAN, RUSSEL PHILIP ST J, FROSZ MICHAEL H, SCHLÜSENER JAN K. IN VIVO IMAGING DEVICE WITH FIBER OPTIC . 2017. View Publication.
  32. Pais-Roldán P, Singh AP, Schulz H, Yu X. High magnetic field induced otolith fusion in the zebrafish larvae. Sci Rep. 2016 Apr 11; 6:24151. PMID: 27063288.
    Citations: 2     Fields:    Translation:AnimalsCells
  33. Yu X, He Y, Wang M, Merkle H, Dodd SJ, Silva AC, Koretsky AP. Sensory and optogenetically driven single-vessel fMRI. Nat Methods. 2016 Apr; 13(4):337-40. PMID: 26855362; PMCID: PMC6298439.
    Citations: 52     Fields:    Translation:Animals
  34. Yu X, Koretsky AP. Interhemispheric plasticity protects the deafferented somatosensory cortex from functional takeover after nerve injury. Brain Connect. 2014 Nov; 4(9):709-17. PMID: 25117691.
    Citations: 7     Fields:    Translation:Animals
  35. Qian C, Yu X, Pothayee N, Dodd S, Bouraoud N, Star R, Bennett K, Koretsky A. Live nephron imaging by MRI. Am J Physiol Renal Physiol. 2014 Nov 15; 307(10):F1162-8. PMID: 25186296.
    Citations: 15     Fields:    Translation:Animals
  36. Yu X, Qian C, Chen DY, Dodd SJ, Koretsky AP. Deciphering laminar-specific neural inputs with line-scanning fMRI. Nat Methods. 2014 Jan; 11(1):55-8. PMID: 24240320.
    Citations: 64     Fields:    Translation:AnimalsCells
  37. Qian C, Yu X, Chen DY, Dodd S, Bouraoud N, Pothayee N, Chen Y, Beeman S, Bennett K, Murphy-Boesch J, Koretsky A. Wireless amplified nuclear MR detector (WAND) for high-spatial-resolution MR imaging of internal organs: preclinical demonstration in a rodent model. Radiology. 2013 Jul; 268(1):228-36. PMID: 23392428; PMCID: PMC3689449.
    Citations: 25     Fields:    Translation:Animals
  38. Yu X, Chung S, Chen DY, Wang S, Dodd SJ, Walters JR, Isaac JT, Koretsky AP. Thalamocortical inputs show post-critical-period plasticity. Neuron. 2012 May 24; 74(4):731-42. PMID: 22632730.
    Citations: 38     Fields:    Translation:AnimalsCells
  39. Yu X, Glen D, Wang S, Dodd S, Hirano Y, Saad Z, Reynolds R, Silva AC, Koretsky AP. Direct imaging of macrovascular and microvascular contributions to BOLD fMRI in layers IV-V of the rat whisker-barrel cortex. Neuroimage. 2012 Jan 16; 59(2):1451-60. PMID: 21851857.
    Citations: 47     Fields:    Translation:Animals
  40. Yu X, Nieman BJ, Sudarov A, Szulc KU, Abdollahian DJ, Bhatia N, Lalwani AK, Joyner AL, Turnbull DH. Morphological and functional midbrain phenotypes in Fibroblast Growth Factor 17 mutant mice detected by Mn-enhanced MRI. Neuroimage. 2011 Jun 01; 56(3):1251-8. PMID: 21356319.
    Citations: 7     Fields:    Translation:Animals
  41. Yu X, Wang S, Chen DY, Dodd S, Goloshevsky A, Koretsky AP. 3D mapping of somatotopic reorganization with small animal functional MRI. Neuroimage. 2010 Jan 15; 49(2):1667-76. PMID: 19770051.
    Citations: 16     Fields:    Translation:Animals
  42. Yu X, Zou J, Babb JS, Johnson G, Sanes DH, Turnbull DH. Statistical mapping of sound-evoked activity in the mouse auditory midbrain using Mn-enhanced MRI. Neuroimage. 2008 Jan 01; 39(1):223-30. PMID: 17919926.
    Citations: 21     Fields:    Translation:Animals
  43. Yu X, Sanes DH, Aristizabal O, Wadghiri YZ, Turnbull DH. Large-scale reorganization of the tonotopic map in mouse auditory midbrain revealed by MRI. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12193-8. PMID: 17620614; PMCID: PMC1913547.
    Citations: 37     Fields:    Translation:Animals
  44. Deans AE, Wadghiri YZ, Bernas LM, Yu X, Rutt BK, Turnbull DH. Cellular MRI contrast via coexpression of transferrin receptor and ferritin. Magn Reson Med. 2006 Jul; 56(1):51-9. PMID: 16724301.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  45. Yu X, Wadghiri YZ, Sanes DH, Turnbull DH. In vivo auditory brain mapping in mice with Mn-enhanced MRI. Nat Neurosci. 2005 Jul; 8(7):961-8. PMID: 15924136; PMCID: PMC2034206.
    Citations: 112     Fields:    Translation:Animals
  46. Wadghiri YZ, Blind JA, Duan X, Moreno C, Yu X, Joyner AL, Turnbull DH. Manganese-enhanced magnetic resonance imaging (MEMRI) of mouse brain development. NMR Biomed. 2004 Dec; 17(8):613-9. PMID: 15761950.
    Citations: 35     Fields:    Translation:Animals
  47. Yu X, Mao X, Blake AD, Li WX, Chang SL. Morphine and endomorphins differentially regulate micro-opioid receptor mRNA in SHSY-5Y human neuroblastoma cells. J Pharmacol Exp Ther. 2003 Aug; 306(2):447-54. PMID: 12754318.
    Citations: 14     Fields:    Translation:HumansCells
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