Harvard Catalyst Profiles

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Yuriy Baglaenko, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ferri DM, Nassar C, Manion KP, Kim M, Baglaenko Y, Muñoz-Grajales C, Wither JE. Elevated levels of interferon-a act directly on B cells to breach multiple tolerance mechanisms promoting autoantibody production. Arthritis Rheumatol. 2023 Feb 20. PMID: 36807718.
    Citations:    Fields:    
  2. Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price AL, Lecca L, Murray MB, Moody DB, Raychaudhuri S. Single-cell eQTL models reveal dynamic T cell state dependence of disease loci. Nature. 2022 06; 606(7912):120-128. PMID: 35545678; PMCID: PMC9842455.
    Citations: 8     Fields:    Translation:HumansCells
  3. Baglaenko Y, Macfarlane D, Marson A, Nigrovic PA, Raychaudhuri S. Genome editing to define the function of risk loci and variants in rheumatic disease. Nat Rev Rheumatol. 2021 08; 17(8):462-474. PMID: 34188205.
    Citations: 5     Fields:    Translation:HumansAnimals
  4. Nathan A, Beynor JI, Baglaenko Y, Suliman S, Ishigaki K, Asgari S, Huang CC, Luo Y, Zhang Z, Lopez K, Lindestam Arlehamn CS, Ernst JD, Jimenez J, Calderón RI, Lecca L, Van Rhijn I, Moody DB, Murray MB, Raychaudhuri S. Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease. Nat Immunol. 2021 06; 22(6):781-793. PMID: 34031617.
    Citations: 14     Fields:    Translation:HumansCells
  5. Manion KP, Baglaenko Y, Chang NH, Talaei N, Wither JE. Impaired B cell anergy is not sufficient to breach tolerance to nuclear antigen in V?8/3H9 lupus-prone mice. PLoS One. 2020; 15(7):e0236664. PMID: 32722684.
    Citations:    Fields:    Translation:AnimalsCells
  6. Gracey E, Hromadová D, Lim M, Qaiyum Z, Zeng M, Yao Y, Srinath A, Baglaenko Y, Yeremenko N, Westlin W, Masse C, Müller M, Strobl B, Miao W, Inman RD. TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis. J Clin Invest. 2020 04 01; 130(4):1863-1878. PMID: 32149730; PMCID: PMC7108927.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  7. Gutierrez-Arcelus M, Baglaenko Y, Arora J, Hannes S, Luo Y, Amariuta T, Teslovich N, Rao DA, Ermann J, Jonsson AH, Navarrete C, Rich SS, Taylor KD, Rotter JI, Gregersen PK, Esko T, Brenner MB, Raychaudhuri S. Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci. Nat Genet. 2020 03; 52(3):247-253. PMID: 32066938; PMCID: PMC7135372.
    Citations: 39     Fields:    Translation:HumansCells
  8. Korsunsky I, Millard N, Fan J, Slowikowski K, Zhang F, Wei K, Baglaenko Y, Brenner M, Loh PR, Raychaudhuri S. Fast, sensitive and accurate integration of single-cell data with Harmony. Nat Methods. 2019 12; 16(12):1289-1296. PMID: 31740819; PMCID: PMC6884693.
    Citations: 943     Fields:    Translation:HumansAnimalsCells
  9. Luo Y, Suliman S, Asgari S, Amariuta T, Baglaenko Y, Martínez-Bonet M, Ishigaki K, Gutierrez-Arcelus M, Calderon R, Lecca L, León SR, Jimenez J, Yataco R, Contreras C, Galea JT, Becerra M, Nejentsev S, Nigrovic PA, Moody DB, Murray MB, Raychaudhuri S. Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians. Nat Commun. 2019 08 21; 10(1):3765. PMID: 31434886.
    Citations: 19     Fields:    Translation:HumansCells
  10. Nathan A, Baglaenko Y, Fonseka CY, Beynor JI, Raychaudhuri S. Multimodal single-cell approaches shed light on T cell heterogeneity. Curr Opin Immunol. 2019 12; 61:17-25. PMID: 31430664.
    Citations: 7     Fields:    Translation:HumansCells
  11. Baglaenko Y, Chang NH, Johnson SR, Hafiz W, Manion K, Ferri D, Noamani B, Bonilla D, Rusta-Sellehy S, Lisnevskaia L, Silverman E, Bookman A, Landolt-Marticorena C, Wither J. The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease. Arthritis Res Ther. 2018 11 29; 20(1):264. PMID: 30486869; PMCID: PMC6263058.
    Citations: 13     Fields:    Translation:HumansCells
  12. Shinde R, Hezaveh K, Halaby MJ, Kloetgen A, Chakravarthy A, da Silva Medina T, Deol R, Manion KP, Baglaenko Y, Eldh M, Lamorte S, Wallace D, Chodisetti SB, Ravishankar B, Liu H, Chaudhary K, Munn DH, Tsirigos A, Madaio M, Gabrielsson S, Touma Z, Wither J, De Carvalho DD, McGaha TL. Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans. Nat Immunol. 2018 06; 19(6):571-582. PMID: 29760532; PMCID: PMC5976527.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  13. Wu CM, Roth TL, Baglaenko Y, Ferri DM, Brauer P, Zuniga-Pflucker JC, Rosbe KW, Wither JE, Marson A, Allen CDC. Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins. J Immunol Methods. 2018 06; 457:33-40. PMID: 29614266; PMCID: PMC6124898.
    Citations: 23     Fields:    Translation:HumansCells
  14. Chang NH, Manion KP, Loh C, Pau E, Baglaenko Y, Wither JE. Multiple tolerance defects contribute to the breach of B cell tolerance in New Zealand Black chromosome 1 congenic mice. PLoS One. 2017; 12(6):e0179506. PMID: 28628673.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Baglaenko Y, Cruz Tleugabulova M, Gracey E, Talaei N, Manion KP, Chang NH, Ferri DM, Mallevaey T, Wither JE. Invariant NKT Cell Activation Is Potentiated by Homotypic trans-Ly108 Interactions. J Immunol. 2017 05 15; 198(10):3949-3962. PMID: 28373584.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  16. Gracey E, Qaiyum Z, Almaghlouth I, Lawson D, Karki S, Avvaru N, Zhang Z, Yao Y, Ranganathan V, Baglaenko Y, Inman RD. IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis. Ann Rheum Dis. 2016 Dec; 75(12):2124-2132. PMID: 27165176.
    Citations: 107     Fields:    Translation:HumansCells
  17. Baglaenko Y, Manion KP, Chang NH, Gracey E, Loh C, Wither JE. IL-10 Production Is Critical for Sustaining the Expansion of CD5+ B and NKT Cells and Restraining Autoantibody Production in Congenic Lupus-Prone Mice. PLoS One. 2016; 11(3):e0150515. PMID: 26964093.
    Citations: 12     Fields:    Translation:AnimalsCells
  18. Gracey E, Yao Y, Green B, Qaiyum Z, Baglaenko Y, Lin A, Anton A, Ayearst R, Yip P, Inman RD. Sexual Dimorphism in the Th17 Signature of Ankylosing Spondylitis. Arthritis Rheumatol. 2016 Mar; 68(3):679-89. PMID: 26473967.
    Citations: 62     Fields:    Translation:HumansCells
  19. Gracey E, Baglaenko Y, Prayitno N, Van Rooijen N, Akram A, Lin A, Chiu B, Inman RD. Pulmonary Chlamydia muridarum challenge activates lung interstitial macrophages which correlate with IFN-? production and infection control in mice. Eur J Immunol. 2015 Dec; 45(12):3417-30. PMID: 26344246.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Baglaenko Y, Manion KP, Chang NH, Loh C, Lajoie G, Wither JE. Suppression of autoimmunity by CD5(+) IL-10-producing B cells in lupus-prone mice. Genes Immun. 2015 Jul-Aug; 16(5):311-20. PMID: 25973757.
    Citations: 11     Fields:    Translation:AnimalsCells
  21. Loh C, Pau E, Lajoie G, Li TT, Baglaenko Y, Cheung YH, Chang NH, Wither JE. Epistatic suppression of fatal autoimmunity in New Zealand black bicongenic mice. J Immunol. 2011 May 15; 186(10):5845-53. PMID: 21464090.
    Citations: 5     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.