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Alice Elizabeth Kane, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mach J, Gemikonakli G, Logan C, Vander Wyk B, Allore H, Ekambareshwar S, Kane AE, Howlett SE, de Cabo R, Le Couteur DG, Hilmer SN. Chronic polypharmacy with increasing Drug Burden Index (DBI) exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice. J Gerontol A Biol Sci Med Sci. 2020 Mar 09. PMID: 32147704.
    Citations:    
  2. Keller K, Kane A, Heinze-Milne S, Grandy SA, Howlett SE. Chronic Treatment With the ACE Inhibitor Enalapril Attenuates the Development of Frailty and Differentially Modifies Pro- and Anti-inflammatory Cytokines in Aging Male and Female C57BL/6 Mice. J Gerontol A Biol Sci Med Sci. 2019 07 12; 74(8):1149-1157. PMID: 30256910.
    Citations:    
  3. Kane AE, Howlett SE. Spelunking the biology of frailty. Mech Ageing Dev. 2019 09; 182:111123. PMID: 31301316.
    Citations:    
  4. Kane AE, Sinclair DA. Frailty biomarkers in humans and rodents: Current approaches and future advances. Mech Ageing Dev. 2019 06; 180:117-128. PMID: 31002925.
    Citations:    
  5. Kane AE, Sinclair DA. Epigenetic changes during aging and their reprogramming potential. Crit Rev Biochem Mol Biol. 2019 02; 54(1):61-83. PMID: 30822165.
    Citations:    
  6. Kane AE, Keller KM, Heinze-Milne S, Grandy SA, Howlett SE. A Murine Frailty Index Based on Clinical and Laboratory Measurements: Links Between Frailty and Pro-inflammatory Cytokines Differ in a Sex-Specific Manner. J Gerontol A Biol Sci Med Sci. 2019 02 15; 74(3):275-282. PMID: 29788087.
    Citations: 1     Fields:    
  7. Kane AE, Sinclair DA. Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circ Res. 2018 09 14; 123(7):868-885. PMID: 30355082.
    Citations:    Fields:    
  8. Kane AE, Shin S, Wong AA, Fertan E, Faustova NS, Howlett SE, Brown RE. Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer's Disease. Front Aging Neurosci. 2018; 10:172. PMID: 29946252.
    Citations:    
  9. Kane AE, Sinclair DA, Mitchell JR, Mitchell SJ. Sex differences in the response to dietary restriction in rodents. Curr Opin Physiol. 2018 Dec; 6:28-34. PMID: 31231711.
    Citations:    
  10. Kane AE, Howlett SE. Differences in Cardiovascular Aging in Men and Women. Adv Exp Med Biol. 2018; 1065:389-411. PMID: 30051398.
    Citations:    
  11. Kane AE, Howlett SE. Advances in Preclinical Models of Frailty. J Gerontol A Biol Sci Med Sci. 2017 07 01; 72(7):867-869. PMID: 28531256.
    Citations:    Fields:    
  12. Kane AE, Huizer-Pajkos A, Mach J, Mitchell SJ, de Cabo R, Le Couteur DG, Howlett SE, Hilmer SN. A Comparison of Two Mouse Frailty Assessment Tools. J Gerontol A Biol Sci Med Sci. 2017 Jul 01; 72(7):904-909. PMID: 28549083.
    Citations: 1     Fields:    Translation:HumansAnimals
  13. Yorke A, Kane AE, Hancock Friesen CL, Howlett SE, O'Blenes S. Development of a Rat Clinical Frailty Index. J Gerontol A Biol Sci Med Sci. 2017 Jul 01; 72(7):897-903. PMID: 28158648.
    Citations: 3     Fields:    Translation:HumansAnimals
  14. Kane AE, Ayaz O, Ghimire A, Feridooni HA, Howlett SE. Implementation of the mouse frailty index. Can J Physiol Pharmacol. 2017 Oct; 95(10):1149-1155. PMID: 28463656.
    Citations:    Fields:    Translation:HumansAnimals
  15. Kane AE, Gregson E, Theou O, Rockwood K, Howlett SE. The association between frailty, the metabolic syndrome, and mortality over the lifespan. Geroscience. 2017 04; 39(2):221-229. PMID: 28281219.
    Citations: 6     Fields:    Translation:Humans
  16. Kane AE, Howlett SE. Novel cardioprotection strategies for the aged heart: evidence from pre-clinical studies. Clin Exp Pharmacol Physiol. 2016 12; 43(12):1251-1260. PMID: 27626269.
    Citations: 1     Fields:    Translation:HumansAnimals
  17. Kane AE, Hilmer SN, Mach J, Mitchell SJ, de Cabo R, Howlett SE. Animal models of frailty: current applications in clinical research. Clin Interv Aging. 2016; 11:1519-1529. PMID: 27822024.
    Citations: 6     Fields:    Translation:HumansAnimals
  18. Kane AE, Huizer-Pajkos A, Mach J, McKenzie C, Mitchell SJ, de Cabo R, Jones B, Cogger V, Le Couteur DG, Hilmer SN. N-Acetyl cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice. Fundam Clin Pharmacol. 2016 Jun; 30(3):263-75. PMID: 26821200.
    Citations:    Fields:    Translation:Animals
  19. Kane AE, Mitchell SJ, Mach J, Huizer-Pajkos A, McKenzie C, Jones B, Cogger V, Le Couteur DG, de Cabo R, Hilmer SN. Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type. Exp Gerontol. 2016 Jan; 73:95-106. PMID: 26615879.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Mach J, Huizer-Pajkos A, Mitchell SJ, McKenzie C, Phillips L, Kane A, Jones B, de Cabo R, Cogger V, Le Couteur DG, Hilmer SN. The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats. Fundam Clin Pharmacol. 2016 Feb; 30(1):23-34. PMID: 26454000.
    Citations:    
  21. Huizer-Pajkos A, Kane AE, Howlett SE, Mach J, Mitchell SJ, de Cabo R, Le Couteur DG, Hilmer SN. Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging. J Gerontol A Biol Sci Med Sci. 2016 May; 71(5):571-7. PMID: 25940962.
    Citations: 7     Fields:    Translation:HumansAnimals
  22. Kane AE, Hilmer SN, Huizer-Pajkos A, Mach J, Nines D, Boyer D, Gavin K, Mitchell SJ, de Cabo R. Factors that Impact on Interrater Reliability of the Mouse Clinical Frailty Index. J Gerontol A Biol Sci Med Sci. 2015 Jun; 70(6):694-5. PMID: 25838548.
    Citations: 3     Fields:    Translation:HumansAnimals
  23. Kane AE, Hilmer SN, Boyer D, Gavin K, Nines D, Howlett SE, de Cabo R, Mitchell SJ. Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index. J Gerontol A Biol Sci Med Sci. 2016 Mar; 71(3):333-9. PMID: 25711530.
    Citations: 19     Fields:    Translation:Animals
  24. Kane A, Mitchell SJ, Carroll PR, Matthews S, Hilmer SN. Characteristics of older and younger patients with suspected paracetamol toxicity. Australas J Ageing. 2012 Sep; 31(3):190-3. PMID: 22950592.
    Citations:    
  25. Mitchell SJ, Kane AE, Hilmer SN. Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Curr Gerontol Geriatr Res. 2011; 2011:624156. PMID: 21765826.
    Citations: 11     
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.