Harvard Catalyst Profiles

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Bryan Spring, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA226855 (SPRING, BRYAN QUILTY) Apr 1, 2020 - Mar 31, 2025
    Multiplexed and dynamically targeted photoimmunotherapy of heterogeneous, chemoresistant micrometastases guided by online in vivo optical imaging of cell-surface biomarkers
    Role: Principal Investigator
  2. K22CA181611 (SPRING, BRYAN QUILTY) Sep 23, 2015 - Aug 31, 2018
    Online monitoring and image-guided treatment of chemoresistant micrometastases
    Role: Principal Investigator
  3. F32CA144210 (SPRING, BRYAN QUILTY) Sep 30, 2010 - Sep 29, 2013
    Hyperspectral Microendscopy to Monitor VEGF During Pancreatic Cancer Therapy
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhang K, Timilsina S, Waguespack M, Kercher EM, Spring BQ. An open-source LED array illumination system for automated multiwell plate cell culture photodynamic therapy experiments. Sci Rep. 2022 11 11; 12(1):19341. PMID: 36369334; PMCID: PMC9652332.
    Citations:    Fields:    
  2. Harman RC, Lang RT, Kercher EM, Leven P, Spring BQ. Denoising multiplexed microscopy images in n-dimensional spectral space. Biomed Opt Express. 2022 Aug 01; 13(8):4298-4309. PMID: 36032573; PMCID: PMC9408246.
  3. Bekker RA, Zahid MU, Binning JM, Spring BQ, Hwu P, Pilon-Thomas S, Enderling H. Rethinking the immunotherapy numbers game. J Immunother Cancer. 2022 07; 10(7). PMID: 35793871; PMCID: PMC9260835.
    Citations:    Fields:    Translation:Humans
  4. Kercher EM, Spring BQ. Photodynamic Treatments for Disseminated Cancer Metastases Using Fiber-Optic Technologies. Methods Mol Biol. 2022; 2451:185-201. PMID: 35505019.
    Citations:    Fields:    Translation:Humans
  5. Lang RT, Spring BQ. Two-photon peak molecular brightness spectra reveal long-wavelength enhancements of multiplexed imaging depth and photostability. Biomed Opt Express. 2021 Sep 01; 12(9):5909-5919. PMID: 34692224; PMCID: PMC8515958.
  6. Sadiki A, Kercher EM, Lu H, Lang RT, Spring BQ, Zhou ZS. Site-specific Bioconjugation and Convergent Click Chemistry Enhances Antibody-Chromophore Conjugate Binding Efficiency. Photochem Photobiol. 2020 05; 96(3):596-603. PMID: 32080860.
    Citations: 2     Fields:    Translation:HumansCells
  7. Kercher EM, Zhang K, Waguespack M, Lang RT, Olmos A, Spring BQ. High-power light-emitting diode array design and assembly for practical photodynamic therapy research. J Biomed Opt. 2020 04; 25(6):1-13. PMID: 32297489.
    Citations: 4     Fields:    Translation:Cells
  8. Lang RT, Tatz J, Kercher EM, Palanisami A, Brooks DH, Spring BQ. Multichannel correlation improves the noise tolerance of real-time hyperspectral microimage mosaicking. J Biomed Opt. 2019 12; 24(12):1-9. PMID: 31828983; PMCID: PMC6905180.
    Citations: 2     Fields:    Translation:AnimalsCells
  9. Zhang K, Davoudzadeh N, Ducourthial G, Spring BQ. Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy. J Vis Exp. 2019 11 22; (153). PMID: 31814618.
    Citations:    Fields:    
  10. Kercher EM, Nath S, Rizvi I, Spring BQ. Cancer Cell-targeted and Activatable Photoimmunotherapy Spares T Cells in a 3D Coculture Model. Photochem Photobiol. 2020 03; 96(2):295-300. PMID: 31424560.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  11. Spring BQ, Lang RT, Kercher EM, Rizvi I, Wenham RM, Conejo-Garcia JR, Hasan T, Gatenby RA, Enderling H. Illuminating the Numbers: Integrating Mathematical Models to Optimize Photomedicine Dosimetry and Combination Therapies. Front Phys. 2019 Apr; 7. PMID: 31123672; PMCID: PMC6529192.
  12. Davoudzadeh N, Ducourthial G, Spring BQ. Custom fabrication and mode-locked operation of a femtosecond fiber laser for multiphoton microscopy. Sci Rep. 2019 03 12; 9(1):4233. PMID: 30862800.
    Citations: 2     Fields:    
  13. Spring BQ, Kessel D. 3D Culture Models of Malignant Mesothelioma Reveal a Powerful Interplay Between Photodynamic Therapy and Kinase Suppression Offering Hope to Reduce Tumor Recurrence. Photochem Photobiol. 2019 01; 95(1):462-463. PMID: 30485439.
    Citations: 2     Fields:    Translation:Humans
  14. Obaid G, Spring BQ, Bano S, Hasan T. Activatable clinical fluorophore-quencher antibody pairs as dual molecular probes for the enhanced specificity of image-guided surgery. J Biomed Opt. 2017 Aug; 22(12):1-6. PMID: 28853247.
    Citations: 11     Fields:    Translation:Animals
  15. Spring BQ, Bryan Sears R, Zheng LZ, Mai Z, Watanabe R, Sherwood ME, Schoenfeld DA, Pogue BW, Pereira SP, Villa E, Hasan T. A photoactivable multi-inhibitor nanoliposome for tumour control and simultaneous inhibition of treatment escape pathways. Nat Nanotechnol. 2016 Apr; 11(4):378-87. PMID: 26780659.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  16. Tangutoori S, Spring BQ, Mai Z, Palanisami A, Mensah LB, Hasan T. Simultaneous delivery of cytotoxic and biologic therapeutics using nanophotoactivatable liposomes enhances treatment efficacy in a mouse model of pancreatic cancer. Nanomedicine. 2016 Jan; 12(1):223-34. PMID: 26390832.
    Citations: 22     Fields:    Translation:Animals
  17. Mallidi S, Spring BQ, Hasan T. Optical Imaging, Photodynamic Therapy and Optically Triggered Combination Treatments. Cancer J. 2015 May-Jun; 21(3):194-205. PMID: 26049699.
    Citations: 19     Fields:    Translation:Humans
  18. Spring BQ, Rizvi I, Xu N, Hasan T. The role of photodynamic therapy in overcoming cancer drug resistance. Photochem Photobiol Sci. 2015 Aug; 14(8):1476-91. PMID: 25856800; PMCID: PMC4520758.
    Citations: 76     Fields:    Translation:HumansAnimals
  19. Spring BQ, Palanisami A, Hasan T. Microscale receiver operating characteristic analysis of micrometastasis recognition using activatable fluorescent probes indicates leukocyte imaging as a critical factor to enhance accuracy. J Biomed Opt. 2014 Jun; 19(6):066006. PMID: 24919449.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  20. Spring BQ, Abu-Yousif AO, Palanisami A, Rizvi I, Zheng X, Mai Z, Anbil S, Sears RB, Mensah LB, Goldschmidt R, Erdem SS, Oliva E, Hasan T. Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):E933-42. PMID: 24572574.
    Citations: 57     Fields:    Translation:Animals
  21. Chen YC, Spring BQ, Clegg RM. Fluorescence lifetime imaging comes of age how to do it and how to interpret it. Methods Mol Biol. 2012; 875:1-22. PMID: 22573433.
    Citations: 1     Fields:    
  22. Kolossov VL, Spring BQ, Clegg RM, Henry JJ, Sokolowski A, Kenis PJ, Gaskins HR. Development of a high-dynamic range, GFP-based FRET probe sensitive to oxidative microenvironments. Exp Biol Med (Maywood). 2011 Jun 01; 236(6):681-91. PMID: 21606117.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  23. Celli JP, Spring BQ, Rizvi I, Evans CL, Samkoe KS, Verma S, Pogue BW, Hasan T. Imaging and photodynamic therapy: mechanisms, monitoring, and optimization. Chem Rev. 2010 May 12; 110(5):2795-838. PMID: 20353192.
    Citations: 342     Fields:    Translation:HumansAnimals
  24. Kolossov VL, Spring BQ, Sokolowski A, Conour JE, Clegg RM, Kenis PJ, Gaskins HR. Engineering redox-sensitive linkers for genetically encoded FRET-based biosensors. Exp Biol Med (Maywood). 2008 Feb; 233(2):238-48. PMID: 18222979.
    Citations: 27     Fields:    Translation:AnimalsCells
  25. Spring BQ, Clegg RM. Fluorescence measurements of duplex DNA oligomers under conditions conducive for forming M-DNA (a metal-DNA complex). J Phys Chem B. 2007 Aug 23; 111(33):10040-52. PMID: 17665942.
    Citations: 6     Fields:    Translation:Cells
  26. Knox RS, Spring BQ. Dipole strengths in the chlorophylls. Photochem Photobiol. 2003 May; 77(5):497-501. PMID: 12812291.
    Citations: 26     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.