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Sietske Anna Maria Sikkes, Ph.D., M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Jutten RJ, Papp KV, Hendrix S, Ellison N, Langbaum JB, Donohue MC, Hassenstab J, Maruff P, Rentz DM, Harrison J, Cummings J, Scheltens P, Sikkes SAM. Why a clinical trial is as good as its outcome measure: A framework for the selection and use of cognitive outcome measures for clinical trials of Alzheimer's disease. Alzheimers Dement. 2022 Sep 10. PMID: 36086926.
    Citations:    Fields:    
  2. Dubbelman MA, Verrijp M, Terwee CB, Jutten RJ, Postema MC, Barkhof F, Berckel BNM, Gillissen F, Teeuwen V, Teunissen C, van de Flier WM, Scheltens P, Sikkes SAM. Determining the Minimal Important Change of Everyday Functioning in Dementia: Pursuing Clinical Meaningfulness. Neurology. 2022 08 30; 99(9):e954-e964. PMID: 35641309; PMCID: PMC9502738.
    Citations:    Fields:    
  3. Jutten RJ, Thompson L, Sikkes SAM, Maruff P, Molinuevo JL, Zetterberg H, Alber J, Faust D, Gauthier S, Gold M, Harrison J, Lee AKW, Snyder PJ. A Neuropsychological Perspective on Defining Cognitive Impairment in the Clinical Study of Alzheimer's Disease: Towards a More Continuous Approach. J Alzheimers Dis. 2022; 86(2):511-524. PMID: 35124638.
    Citations:    Fields:    Translation:Humans
  4. Jutten RJ, Sikkes SAM, Van der Flier WM, Scheltens P, Visser PJ, Tijms BM. Finding Treatment Effects in Alzheimer Trials in the Face of Disease Progression Heterogeneity. Neurology. 2021 06 01; 96(22):e2673-e2684. PMID: 34550903; PMCID: PMC8205463.
    Citations: 7     Fields:    Translation:Humans
  5. Marshall GA, Sikkes SAM, Amariglio RE, Gatchel JR, Rentz DM, Johnson KA, Langford O, Sun CK, Donohue MC, Raman R, Aisen PS, Sperling RA, Galasko DR. Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study. Alzheimers Dement (Amst). 2020; 12(1):e12118. PMID: 33163609; PMCID: PMC7596668.
    Citations: 2     
  6. Rabin JS, Neal TE, Nierle HE, Sikkes SAM, Buckley RF, Amariglio RE, Papp KV, Rentz DM, Schultz AP, Johnson KA, Sperling RA, Hedden T. Multiple markers contribute to risk of progression from normal to mild cognitive impairment. Neuroimage Clin. 2020; 28:102400. PMID: 32919366; PMCID: PMC7491146.
    Citations: 3     Fields:    Translation:Humans
  7. Babapour Mofrad R, Tijms BM, Scheltens P, Barkhof F, van der Flier WM, Sikkes SAM, Teunissen CE. Sex differences in CSF biomarkers vary by Alzheimer disease stage and APOE e4 genotype. Neurology. 2020 10 27; 95(17):e2378-e2388. PMID: 32788242.
    Citations: 8     Fields:    Translation:HumansCells
  8. Vijverberg EGB, Gossink F, Krudop W, Sikkes S, Kerssens C, Prins N, Stek M, Scheltens P, Pijnenburg Y, Dols A. The Diagnostic Challenge of the Late-Onset Frontal Lobe Syndrome: Clinical Predictors for Primary Psychiatric Disorders Versus Behavioral Variant Frontotemporal Dementia. J Clin Psychiatry. 2017 Nov/Dec; 78(9):e1197-e1203. PMID: 29099546.
    Citations: 4     Fields:    Translation:Humans
  9. van Kooten J, van der Wouden JC, Sikkes SAM, Smalbrugge M, Hertogh CMPM, Stek ML. Pain, Neuropsychiatric Symptoms, and Quality of Life of Nursing Home Residents With Advanced Dementia in The Netherlands: A Cross-sectional Study. Alzheimer Dis Assoc Disord. 2017 Oct-Dec; 31(4):315-321. PMID: 28486239.
    Citations: 8     Fields:    Translation:Humans
  10. Wu YH, Vidal JS, de Rotrou J, Sikkes SAM, Rigaud AS, Plichart M. Can a tablet-based cancellation test identify cognitive impairment in older adults? PLoS One. 2017; 12(7):e0181809. PMID: 28742136.
    Citations: 5     Fields:    Translation:Humans
  11. Costa A, Bak T, Caffarra P, Caltagirone C, Ceccaldi M, Collette F, Crutch S, Della Sala S, Démonet JF, Dubois B, Duzel E, Nestor P, Papageorgiou SG, Salmon E, Sikkes S, Tiraboschi P, van der Flier WM, Visser PJ, Cappa SF. The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group. Alzheimers Res Ther. 2017 Apr 17; 9(1):27. PMID: 28412978.
    Citations: 24     Fields:    Translation:Humans
  12. Jutten RJ, Peeters CFW, Leijdesdorff SMJ, Visser PJ, Maier AB, Terwee CB, Scheltens P, Sikkes SAM. Detecting functional decline from normal aging to dementia: Development and validation of a short version of the Amsterdam IADL Questionnaire. Alzheimers Dement (Amst). 2017; 8:26-35. PMID: 28462387; PMCID: PMC5403784.
    Citations: 27     
  13. Smart CM, Karr JE, Areshenkoff CN, Rabin LA, Hudon C, Gates N, Ali JI, Arenaza-Urquijo EM, Buckley RF, Chetelat G, Hampel H, Jessen F, Marchant NL, Sikkes SAM, Tales A, van der Flier WM, Wesselman L. Non-Pharmacologic Interventions for Older Adults with Subjective Cognitive Decline: Systematic Review, Meta-Analysis, and Preliminary Recommendations. Neuropsychol Rev. 2017 Sep; 27(3):245-257. PMID: 28271346.
    Citations: 33     Fields:    Translation:Humans
  14. Jutten RJ, Harrison J, de Jong FJ, Aleman A, Ritchie CW, Scheltens P, Sikkes SAM. A composite measure of cognitive and functional progression in Alzheimer's disease: Design of the Capturing Changes in Cognition study. Alzheimers Dement (N Y). 2017 Jan; 3(1):130-138. PMID: 29067324; PMCID: PMC5651369.
    Citations: 17     
  15. Oort Q, Dirven L, Meijer W, Sikkes SA, Uitdehaag BM, Reijneveld JC, Taphoorn MJ. Development of a questionnaire measuring instrumental activities of daily living (IADL) in patients with brain tumors: a pilot study. J Neurooncol. 2017 03; 132(1):145-153. PMID: 28150189; PMCID: PMC5352794.
    Citations: 8     Fields:    Translation:Humans
  16. Van Mierlo LD, Wouters H, Sikkes SA, Van der Flier WM, Prins ND, Bremer JA, Koene T, Van Hout HP. Screening for Mild Cognitive Impairment and Dementia with Automated, Anonymous Online and Telephone Cognitive Self-Tests. J Alzheimers Dis. 2017; 56(1):249-259. PMID: 27911296; PMCID: PMC5389042.
    Citations: 5     Fields:    Translation:Humans
  17. Krudop WA, Dols A, Kerssens CJ, Eikelenboom P, Prins ND, Möller C, Schouws S, Rhebergen D, van Exel E, van der Flier WM, Sikkes S, Scheltens P, Stek ML, Pijnenburg YAL. The Pitfall of Behavioral Variant Frontotemporal Dementia Mimics Despite Multidisciplinary Application of the FTDC Criteria. J Alzheimers Dis. 2017; 60(3):959-975. PMID: 28984605.
    Citations: 8     Fields:    Translation:Humans
  18. Molinuevo JL, Rabin LA, Amariglio R, Buckley R, Dubois B, Ellis KA, Ewers M, Hampel H, Klöppel S, Rami L, Reisberg B, Saykin AJ, Sikkes S, Smart CM, Snitz BE, Sperling R, van der Flier WM, Wagner M, Jessen F. Implementation of subjective cognitive decline criteria in research studies. Alzheimers Dement. 2017 Mar; 13(3):296-311. PMID: 27825022; PMCID: PMC5344703.
    Citations: 137     Fields:    Translation:Humans
  19. Lemstra AW, de Beer MH, Teunissen CE, Schreuder C, Scheltens P, van der Flier WM, Sikkes SA. Concomitant AD pathology affects clinical manifestation and survival in dementia with Lewy bodies. J Neurol Neurosurg Psychiatry. 2017 Feb; 88(2):113-118. PMID: 27794030.
    Citations: 41     Fields:    Translation:HumansCells
  20. Dols A, van Liempt S, Gossink F, Krudop WA, Sikkes S, Pijnenburg YA, Stek ML. Identifying Specific Clinical Symptoms of Behavioral Variant Frontotemporal Dementia Versus Differential Psychiatric Disorders in Patients Presenting With a Late-Onset Frontal Lobe Syndrome. J Clin Psychiatry. 2016 Oct; 77(10):1391-1395. PMID: 27380626.
    Citations: 7     Fields:    Translation:Humans
  21. Hattink B, Droes RM, Sikkes S, Oostra E, Lemstra AW. Evaluation of the Digital Alzheimer Center: Testing Usability and Usefulness of an Online Portal for Patients with Dementia and Their Carers. JMIR Res Protoc. 2016 Jul 21; 5(3):e144. PMID: 27444209; PMCID: PMC4974452.
    Citations: 19     
  22. Wu YH, de Rotrou J, Sikkes SA, Rigaud AS, Plichart M. Clinical utility of the K-T cancellation test in a memory clinic population. J Clin Exp Neuropsychol. 2016 12; 38(10):1094-102. PMID: 27349139.
    Citations: 5     Fields:    Translation:Humans
  23. Gossink FT, Dols A, Krudop WA, Sikkes SA, Kerssens CJ, Prins ND, Scheltens P, Stek ML, Pijnenburg YA. Formal Psychiatric Disorders are not Overrepresented in Behavioral Variant Frontotemporal Dementia. J Alzheimers Dis. 2016; 51(4):1249-56. PMID: 26967225.
    Citations: 3     Fields:    Translation:Humans
  24. Krudop WA, Dols A, Kerssens CJ, Prins ND, Möller C, Schouws S, Barkhof F, van Berckel BN, Teunissen CE, van der Flier WM, Scheltens P, Sikkes SA, Stek ML, Pijnenburg YA. Impact of Imaging and Cerebrospinal Fluid Biomarkers on Behavioral Variant Frontotemporal Dementia Diagnosis within a Late-Onset Frontal Lobe Syndrome Cohort. Dement Geriatr Cogn Disord. 2016; 41(1-2):16-26. PMID: 26473985.
    Citations: 5     Fields:    Translation:Humans
  25. Rabin LA, Smart CM, Crane PK, Amariglio RE, Berman LM, Boada M, Buckley RF, Chételat G, Dubois B, Ellis KA, Gifford KA, Jefferson AL, Jessen F, Katz MJ, Lipton RB, Luck T, Maruff P, Mielke MM, Molinuevo JL, Naeem F, Perrotin A, Petersen RC, Rami L, Reisberg B, Rentz DM, Riedel-Heller SG, Risacher SL, Rodriguez O, Sachdev PS, Saykin AJ, Slavin MJ, Snitz BE, Sperling RA, Tandetnik C, van der Flier WM, Wagner M, Wolfsgruber S, Sikkes SA. Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies. J Alzheimers Dis. 2015 Sep 24; 48 Suppl 1:S63-86. PMID: 26402085; PMCID: PMC4617342.
    Citations: 141     Fields:    Translation:Humans
  26. Krudop WA, Bosman S, Geurts JJ, Sikkes SA, Verwey NA, Stek ML, Scheltens P, Rozemuller AJ, Pijnenburg YA. Clinico-Pathological Correlations of the Frontal Lobe Syndrome: Results of a Large Brain Bank Study. Dement Geriatr Cogn Disord. 2015; 40(3-4):121-9. PMID: 26088035.
    Citations: 1     Fields:    Translation:Humans
  27. Wu YH, Vidal JS, de Rotrou J, Sikkes SA, Rigaud AS, Plichart M. A Tablet-PC-Based Cancellation Test Assessing Executive Functions in Older Adults. Am J Geriatr Psychiatry. 2015 Nov; 23(11):1154-61. PMID: 26238229.
    Citations: 5     Fields:    Translation:Humans
  28. Krudop WA, Kerssens CJ, Dols A, Prins ND, Möller C, Schouws S, van der Flier WM, Scheltens P, Sikkes S, Stek ML, Pijnenburg YA. Identifying bvFTD Within the Wide Spectrum of Late Onset Frontal Lobe Syndrome: A Clinical Approach. Am J Geriatr Psychiatry. 2015 Oct; 23(10):1056-66. PMID: 25921226.
    Citations: 4     Fields:    Translation:Humans
  29. Jekel K, Damian M, Wattmo C, Hausner L, Bullock R, Connelly PJ, Dubois B, Eriksdotter M, Ewers M, Graessel E, Kramberger MG, Law E, Mecocci P, Molinuevo JL, Nygård L, Olde-Rikkert MG, Orgogozo JM, Pasquier F, Peres K, Salmon E, Sikkes SA, Sobow T, Spiegel R, Tsolaki M, Winblad B, Frölich L. Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review. Alzheimers Res Ther. 2015; 7(1):17. PMID: 25815063.
    Citations: 144     Fields:    
  30. Koster N, Knol DL, Uitdehaag BM, Scheltens P, Sikkes SA. The sensitivity to change over time of the Amsterdam IADL Questionnaire(©). Alzheimers Dement. 2015 Oct; 11(10):1231-40. PMID: 25598195.
    Citations: 23     Fields:    Translation:Humans
  31. Tijms BM, Yeung HM, Sikkes SA, Möller C, Smits LL, Stam CJ, Scheltens P, van der Flier WM, Barkhof F. Single-subject gray matter graph properties and their relationship with cognitive impairment in early- and late-onset Alzheimer's disease. Brain Connect. 2014 Jun; 4(5):337-46. PMID: 24735020.
    Citations: 29     Fields:    Translation:Humans
  32. Ossenkoppele R, van der Flier WM, Verfaillie SC, Vrenken H, Versteeg A, van Schijndel RA, Sikkes SA, Twisk J, Adriaanse SM, Zwan MD, Boellaard R, Windhorst AD, Barkhof F, Scheltens P, Lammertsma AA, van Berckel BN. Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions. Neurology. 2014 May 20; 82(20):1768-75. PMID: 24748672.
    Citations: 21     Fields:    Translation:Humans
  33. Sikkes SA, Rotrou Jd. A qualitative review of instrumental activities of daily living in dementia: what's cooking? Neurodegener Dis Manag. 2014; 4(5):393-400. PMID: 25405652.
    Citations: 14     Fields:    Translation:Humans
  34. Sikkes SA, Pijnenburg YA, Knol DL, de Lange-de Klerk ES, Scheltens P, Uitdehaag BM. Assessment of instrumental activities of daily living in dementia: diagnostic value of the Amsterdam Instrumental Activities of Daily Living Questionnaire. J Geriatr Psychiatry Neurol. 2013 Dec; 26(4):244-50. PMID: 24212244.
    Citations: 20     Fields:    Translation:HumansPHPublic Health
  35. Sikkes SA, Knol DL, Pijnenburg YA, de Lange-de Klerk ES, Uitdehaag BM, Scheltens P. Validation of the Amsterdam IADL Questionnaire©, a new tool to measure instrumental activities of daily living in dementia. Neuroepidemiology. 2013; 41(1):35-41. PMID: 23712106.
    Citations: 31     Fields:    Translation:Humans
  36. Sikkes SA, de Lange-de Klerk ES, Pijnenburg YA, Gillissen F, Romkes R, Knol DL, Uitdehaag BM, Scheltens P. A new informant-based questionnaire for instrumental activities of daily living in dementia. Alzheimers Dement. 2012 Nov; 8(6):536-43. PMID: 23102123.
    Citations: 32     Fields:    Translation:Humans
  37. Sikkes SA, Visser PJ, Knol DL, de Lange-de Klerk ES, Tsolaki M, Frisoni GB, Nobili F, Spiru L, Rigaud AS, Frölich L, Rikkert MO, Soininen H, Touchon J, Wilcock G, Boada M, Hampel H, Bullock R, Vellas B, Pijnenburg YA, Scheltens P, Verhey FR, Uitdehaag BM. Do instrumental activities of daily living predict dementia at 1- and 2-year follow-up? Findings from the Development of Screening guidelines and diagnostic Criteria for Predementia Alzheimer's disease study. J Am Geriatr Soc. 2011 Dec; 59(12):2273-81. PMID: 22188074.
    Citations: 16     Fields:    Translation:Humans
  38. Sikkes SA, Knol DL, van den Berg MT, de Lange-de Klerk ES, Scheltens P, Klein M, Pijnenburg YA, Uitdehaag BM. An informant questionnaire for detecting Alzheimer's disease: are some items better than others? J Int Neuropsychol Soc. 2011 Jul; 17(4):674-81. PMID: 22882809.
    Citations: 2     Fields:    Translation:Humans
  39. Sikkes SA, van den Berg MT, Knol DL, de Lange-de Klerk ES, Scheltens P, Uitdehaag BM, Klein M, Pijnenburg YA. How useful is the IQCODE for discriminating between Alzheimer's disease, mild cognitive impairment and subjective memory complaints? Dement Geriatr Cogn Disord. 2010; 30(5):411-6. PMID: 21071942.
    Citations: 11     Fields:    Translation:Humans
  40. Sikkes ME, Kooistra MP, Weijs PJ. Improved nutrition after conversion to nocturnal home hemodialysis. J Ren Nutr. 2009 Nov; 19(6):494-9. PMID: 19616453.
    Citations: 10     Fields:    Translation:Humans
  41. Gehring K, Sitskoorn MM, Gundy CM, Sikkes SA, Klein M, Postma TJ, van den Bent MJ, Beute GN, Enting RH, Kappelle AC, Boogerd W, Veninga T, Twijnstra A, Boerman DH, Taphoorn MJ, Aaronson NK. Cognitive rehabilitation in patients with gliomas: a randomized, controlled trial. J Clin Oncol. 2009 Aug 01; 27(22):3712-22. PMID: 19470928.
    Citations: 92     Fields:    Translation:Humans
  42. Sikkes SA, de Lange-de Klerk ES, Pijnenburg YA, Scheltens P, Uitdehaag BM. A systematic review of Instrumental Activities of Daily Living scales in dementia: room for improvement. J Neurol Neurosurg Psychiatry. 2009 Jan; 80(1):7-12. PMID: 19091706.
    Citations: 73     Fields:    Translation:Humans
  43. Sikkes SA, Klerk ES, Pijnenburg YA. Instrumental activities of daily living in the screening of dementia in population studies: comment on Castilla-Rilo et al. (2007). Int J Geriatr Psychiatry. 2007 Sep; 22(9):934-5; author reply 932-3. PMID: 17721901.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.