Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Scott A. Holmes, Ph.D.

Profile Picture

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01EY034686 (Eric Moulton) Sep 30, 2022 - Aug 31, 2027
    Differentiation of clinical phenotypes of inflammatory and neuropathic ocular pain conditions with morphologic measures and functional brain imaging
    Role: Co-Investigator
  2. R01NS125265 (Scott Holmes / Alyssa Lebel) Sep 1, 2022 - Sep 1, 2027
    Pediatric chronic headache and COVID-19: Use of Machine learning and bio behavioral analysis to classify headache mechanism and optimize treatment course
    Role: Co-Principal Investigator
  3. PR180737 (Scott Holmes / Christine Sieberg) Aug 15, 2019 - Aug 14, 2023
    Department of Defense
    Defining the Role for Descending Pain Modulation and Reward-Aversion Processes Towards the Development of Chronic Pain in Endometriosis
    Role: Co-Principal Investigator
  4. R01NS095655 (Scott Holmes) Sep 15, 2015 - Jun 30, 2021
    Post-Traumatic Headache (PTH) in Children: Alterations of Brain Function, Blood flow and Inflammatory Processes
    Role: Principal Investigator
  5. R01HD083133 (David Borsook) Jul 1, 2015 - Nov 30, 2022
    Central and peripheral measures of pain: Recovery and Resistance
    Role: Co-Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Holmes S, Mari J, Lemme J, Maallo A, Lebel A, Simons L, O’Brien M, Zurakowski D, Borra R, Borsook D. Evidence of chronic complement activation in asymptomatic pediatric brain injury patients: A pilot study. Children. 2023; 1(10).
  2. Holmes SA, Mar'i J, Lemme J, Maallo AM, Lebel A, Simons L, O'Brien MJ, Zurakowski D, Burnstein R, Borsook D. Evidence of Chronic Complement Activation in Asymptomatic Pediatric Brain Injury Patients: A Pilot Study. Children (Basel). 2022 Dec 26; 10(1). PMID: 36670596; PMCID: PMC9856304.
  3. Gombaut C, Holmes SA. Sensorimotor Integration and Pain Perception: Mechanisms Integrating Nociceptive Processing. A Systematic Review and ALE-Meta Analysis. Front Integr Neurosci. 2022; 16:931292. PMID: 35990591; PMCID: PMC9390858.
  4. Holmes SA, Mar’I J, Green S, Borsook D . Towards a deeper understanding of pain: How machine learning and deep learning algorithms are needed to provide the next generation of pain medicine for use in the clinic. Neurobiology of Pain. 2022; 12:100108.
  5. Szabo E, Chang YC, Shulman J, Sieberg CB, Sethna NF, Borsook D, Holmes SA, Lebel AA. Alterations in the structure and function of the brain in adolescents with new daily persistent headache: A pilot MRI study. Headache. 2022 07; 62(7):858-869. PMID: 35861130.
    Citations: 2     Fields:    Translation:Humans
  6. Forstenpointner J, Maallo AMS, Elman I, Holmes S, Freeman R, Baron R, Borsook D. The solitary nucleus connectivity to key autonomic regions in humans. Eur J Neurosci. 2022 07; 56(2):3938-3966. PMID: 35545280.
    Citations:    Fields:    Translation:HumansAnimals
  7. Holmes S, Mar'i J, Simons LE, Zurakowski D, LeBel AA, O'Brien M, Borsook D. Integrated Features for Optimizing Machine Learning Classifiers of Pediatric and Young Adults With a Post-Traumatic Headache From Healthy Controls. Front Pain Res (Lausanne). 2022; 3:859881. PMID: 35655747; PMCID: PMC9152124.
  8. Holmes SA, Staffa SJ, Karapanagou A, Lopez N, Karian V, Borra R, Zurakowski D, Lebel A, Borsook D. Biological laterality and peripheral nerve DTI metrics. PLoS One. 2021; 16(12):e0260256. PMID: 34914714; PMCID: PMC8675689.
    Citations:    Fields:    Translation:HumansCells
  9. Holmes SA, Karapanagou A, Staffa SJ, Zurakowski D, Borra R, Simons LE, Sieberg C, Lebel A, Borsook D. DTI and MTR Measures of Nerve Fiber Integrity in Pediatric Patients With Ankle Injury. Front Pediatr. 2021; 9:656843. PMID: 34660471; PMCID: PMC8511521.
  10. Maallo AMS, Moulton EA, Sieberg CB, Giddon DB, Borsook D, Holmes SA. A lateralized model of the pain-depression dyad. Neurosci Biobehav Rev. 2021 08; 127:876-883. PMID: 34090918; PMCID: PMC8289740.
    Citations: 1     Fields:    Translation:Humans
  11. Sieberg CB, Lebel A, Silliman E, Holmes S, Borsook D, Elman I. Left to themselves: Time to target chronic pain in childhood rare diseases. Neurosci Biobehav Rev. 2021 07; 126:276-288. PMID: 33774086.
    Citations: 1     Fields:    Translation:Humans
  12. Lemme J, Holmes S, Sibai D, Mari J, Simons LE, Burstein R, Zurakowski D, Lebel A, O'Brien M, Upadhyay J, Borsook D. Altered Brain Network Connectivity Underlies Persistent Post-Traumatic Headache following Mild Traumatic Brain Injury in Youth. J Neurotrauma. 2021 06 15; 38(12):1632-1641. PMID: 33183144; PMCID: PMC8165471.
    Citations: 4     Fields:    Translation:Humans
  13. Holmes SA, Kim A, Borsook D. The brain and behavioral correlates of motor-related analgesia (MRA). Neurobiol Dis. 2021 01; 148:105158. PMID: 33157210.
    Citations: 2     Fields:    Translation:HumansAnimals
  14. Lunde CE, Szabo E, Holmes SA, Borsook D, Sieberg CB. Commentary: Novel Use of Offset Analgesia to Assess Adolescents and Adults with Treatment Resistant Endometriosis-Associated Pain. J Pain Res. 2020; 13:2775-2782. PMID: 33204144; PMCID: PMC7660453.
  15. McEvoy H, Borsook D, Holmes SA. Clinical features and sex differences in pediatric post-traumatic headache: A retrospective chart review at a Boston area concussion clinic. Cephalalgia. 2020 06; 40(7):701-711. PMID: 31865762.
    Citations: 6     Fields:    Translation:Humans
  16. Holmes SA, Upadhyay J, Borsook D. Delineating conditions and subtypes in chronic pain using neuroimaging. Pain Rep. 2019 Jul-Aug; 4(4):e768. PMID: 31579859; PMCID: PMC6727994.
    Citations: 4     
  17. Holmes SA, Singh-Saluja R, Chen JK, Gagnon I, Ptito A. Evaluating task-based brain network activity in pediatric subjects with an mTBI: mechanisms of functional compensation are symptom-level dependent. Brain Inj. 2019; 33(3):383-393. PMID: 30507312.
    Citations: 5     Fields:    Translation:Humans
  18. Zhong J, Chen DQ, Nantes JC, Holmes SA, Hodaie M, Koski L. Combined structural and functional patterns discriminating upper limb motor disability in multiple sclerosis using multivariate approaches. Brain Imaging Behav. 2017 Jun; 11(3):754-768. PMID: 27146291.
    Citations: 10     Fields:    Translation:Humans
  19. Nantes JC, Proulx S, Zhong J, Holmes SA, Narayanan S, Brown RA, Hoge RD, Koski L. GABA and glutamate levels correlate with MTR and clinical disability: Insights from multiple sclerosis. Neuroimage. 2017 08 15; 157:705-715. PMID: 28131894.
    Citations: 16     Fields:    Translation:Humans
  20. Nantes JC, Zhong J, Holmes SA, Whatley B, Narayanan S, Lapierre Y, Arnold DL, Koski L. Corrigendum to "Intracortical inhibition abnormality during the remission phase of multiple sclerosis is related to upper limb dexterity and lesions" [Clin. Neurophysiol. 127 (2016) 1503-1511]. Clin Neurophysiol. 2017 02; 128(2):393. PMID: 28073643.
    Citations:    Fields:    
  21. Saluja RS, Holmes SA, Chen JK, Guberman G. Sports concussion: A complete guide to recovery and management. Emerging diagnosis technology: What is coming up in terms of the use of imaging technology in concussion care?. 2017.
  22. Zhong J, Nantes JC, Holmes SA, Gallant S, Narayanan S, Koski L. Abnormal functional connectivity and cortical integrity influence dominant hand motor disability in multiple sclerosis: a multimodal analysis. Hum Brain Mapp. 2016 12; 37(12):4262-4275. PMID: 27381089.
    Citations: 8     Fields:    Translation:Humans
  23. Nantes JC, Zhong J, Holmes SA, Narayanan S, Lapierre Y, Koski L. Cortical Damage and Disability in Multiple Sclerosis: Relation to Intracortical Inhibition and Facilitation. Brain Stimul. 2016 Jul-Aug; 9(4):566-73. PMID: 27053387.
    Citations: 8     Fields:    Translation:Humans
  24. Nantes JC, Zhong J, Holmes SA, Whatley B, Narayanan S, Lapierre Y, Arnold DL, Koski L. Intracortical inhibition abnormality during the remission phase of multiple sclerosis is related to upper limb dexterity and lesions. Clin Neurophysiol. 2016 Feb; 127(2):1503-1511. PMID: 26394909.
    Citations: 7     Fields:    Translation:Humans
  25. Heath M, Davarpanah Jazi S, Holmes SA. An Inverse Grip Starting Posture Gives Rise to Time-Dependent Adherence to Weber's Law: A Reply to Ganel et al. (2014). J Vis. 2015; 15(6):1. PMID: 26024449.
    Citations: 4     Fields:    Translation:Humans
  26. Cusimano MD, Holmes SA, Sawicki C, Topolovec-Vranic J. Assessing aggression following traumatic brain injury: a systematic review of validated aggression scales. J Head Trauma Rehabil. 2014 Mar-Apr; 29(2):172-84. PMID: 23407424.
    Citations: 1     Fields:    Translation:Humans
  27. Holmes SA, Lohmus J, McKinnon S, Mulla A, Heath M. Distinct visual cues mediate aperture shaping for grasping and pantomime-grasping tasks. J Mot Behav. 2013; 45(5):431-9. PMID: 23971991.
    Citations: 14     Fields:    Translation:Humans
  28. Holmes SA, Heath M. Goal-directed grasping: the dimensional properties of an object influence the nature of the visual information mediating aperture shaping. Brain Cogn. 2013 Jun; 82(1):18-24. PMID: 23501700.
    Citations: 25     Fields:    Translation:Humans
  29. Heath M, Holmes SA, Mulla A, Binsted G. Grasping time does not influence the early adherence of aperture shaping to Weber's law. Front Hum Neurosci. 2012; 6:332. PMID: 23267323.
    Citations: 16     
  30. Weiler J, Holmes SA, Mulla A, Heath M. Pro- and antisaccades: dissociating stimulus and response influences the online control of saccade trajectories. J Mot Behav. 2011; 43(5):375-81. PMID: 21861629.
    Citations: 4     Fields:    Translation:Humans
  31. Holmes SA, Mulla A, Binsted G, Heath M. Visually and memory-guided grasping: aperture shaping exhibits a time-dependent scaling to Weber's law. Vision Res. 2011 Sep 01; 51(17):1941-8. PMID: 21777599.
    Citations: 17     Fields:    Translation:HumansCells
  32. Heath M, Mulla A, Holmes SA, Smuskowitz LR. The visual coding of grip aperture shows an early but not late adherence to Weber's law. Neurosci Lett. 2011 Mar 03; 490(3):200-4. PMID: 21194553.
    Citations: 18     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Holmes's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (100)
Co-Authors (11)
Similar People (60)
Same Department 
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.