Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Edit functionality is currently unavailable.

Stephen D Zucker, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK071125 (ZUCKER, STEPHEN D) Feb 1, 2007 - Jan 31, 2013
    Anti-inflammatory Properties of Bilirubin
    Role: Principal Investigator
  2. R21CA119006 (ZUCKER, STEPHEN D) Dec 15, 2006 - Nov 30, 2009
    Role of Bilirubin in Colorectal Cancer Chemoprevention
    Role: Principal Investigator
  3. R21DK063954 (ZUCKER, STEPHEN D) Aug 15, 2003 - Jul 31, 2006
    Anti-inflammatory Properties of Unconjugated Bilirubin
    Role: Principal Investigator
  4. R01DK051679 (ZUCKER, STEPHEN D) May 1, 1997 - Sep 30, 1998
    Role: Principal Investigator
  5. K11DK002047 (ZUCKER, STEPHEN D) Aug 15, 1991 - Jul 31, 1996
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li M, Chan WW, Zucker SD. Association Between Atazanavir-Induced Hyperbilirubinemia and Cardiovascular Disease in Patients Infected with HIV. J Am Heart Assoc. 2020 Oct 20; 9(19):e016310. PMID: 32930032.
  2. Li M, Sack JS, Rahma OE, Hodi FS, Zucker SD, Grover S. Outcomes after resumption of immune checkpoint inhibitor therapy after high-grade immune-mediated hepatitis. Cancer. 2020 Sep 05. PMID: 32888341.
  3. Suzuki K, Claggett B, Minamisawa M, Packer M, Zile MR, Rouleau J, Swedberg K, Lefkowitz M, Shi V, McMurray JJV, Zucker SD, Solomon SD. Liver function and prognosis, and influence of sacubitril/valsartan in patients with heart failure with reduced ejection fraction. Eur J Heart Fail. 2020 May 14. PMID: 32407608.
  4. Gray M, Singh S, Zucker SD. Influence of Type 2 Diabetes Mellitus and Preoperative Hemoglobin A1c Levels on Outcomes of Liver Transplantation. Hepatol Commun. 2019 Apr; 3(4):574-586. PMID: 30976746.
  5. Zucker SD, Fried MW. Parsing the guidelines on guidelines: Balancing sensibility and conflict of interest. Hepatology. 2018 09; 68(3):798-800. PMID: 29431195.
    Citations:    Fields:    
  6. Bari K, Luckett K, Kaiser T, Diwan T, Cuffy M, Schoech MR, Safdar K, Blackard JT, Apewokin S, Paterno F, Sherman KE, Zucker SD, Anwar N, Shah SA. Hepatitis C transmission from seropositive, nonviremic donors to non-hepatitis C liver transplant recipients. Hepatology. 2018 05; 67(5):1673-1682. PMID: 29205441.
    Citations: 1     Fields:    Translation:HumansCells
  7. Vogel ME, Idelman G, Konaniah ES, Zucker SD. Bilirubin Prevents Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor-Deficient Mice by Inhibiting Endothelial VCAM-1 and ICAM-1 Signaling. J Am Heart Assoc. 2017 Apr 01; 6(4). PMID: 28365565.
    Citations: 4     Fields:    Translation:AnimalsCells
  8. Powell EA, Razeghi S, Zucker S, Blackard JT. Occult Hepatitis B Virus Infection in a Previously Vaccinated Injection Drug User. Hepat Mon. 2016 Feb; 16(2):e34758. PMID: 27148386.
    Citations: 2     
  9. Vogel ME, Zucker SD. Bilirubin acts as an endogenous regulator of inflammation by disrupting adhesion molecule-mediated leukocyte migration. Inflamm Cell Signal. 2016; 3(1). PMID: 26925435.
    Citations: 5     
  10. Zucker SD, Vogel ME, Kindel TL, Smith DL, Idelman G, Avissar U, Kakarlapudi G, Masnovi ME. Bilirubin prevents acute DSS-induced colitis by inhibiting leukocyte infiltration and suppressing upregulation of inducible nitric oxide synthase. Am J Physiol Gastrointest Liver Physiol. 2015 Nov 15; 309(10):G841-54. PMID: 26381705.
    Citations: 4     Fields:    Translation:AnimalsCells
  11. Idelman G, Smith DLH, Zucker SD. Bilirubin inhibits the up-regulation of inducible nitric oxide synthase by scavenging reactive oxygen species generated by the toll-like receptor 4-dependent activation of NADPH oxidase. Redox Biol. 2015 Aug; 5:398-408. PMID: 26163808.
    Citations: 9     Fields:    Translation:AnimalsCells
  12. Barry CT, Avissar U, Asebrook M, Sostok MA, Sherman KE, Zucker SD. Use of a standardized patient exercise to assess core competencies during fellowship training. J Grad Med Educ. 2010 Mar; 2(1):111-7. PMID: 21975896.
    Citations: 1     Fields:    
  13. Smith DL, Keshavan P, Avissar U, Ahmed K, Zucker SD. Sodium taurocholate inhibits intestinal adenoma formation in APCMin/+ mice, potentially through activation of the farnesoid X receptor. Carcinogenesis. 2010 Jun; 31(6):1100-9. PMID: 20194350.
    Citations: 9     Fields:    Translation:Animals
  14. Ahmed K, Zucker SD. Giant cell hepatitis in a teenage woman. Clin Gastroenterol Hepatol. 2008 Jan; 6(1):A26-26.e1. PMID: 18166469.
    Citations:    Fields:    Translation:HumansCells
  15. Limketkai BN, Zucker SD. Hyperammonemic encephalopathy caused by carnitine deficiency. J Gen Intern Med. 2008 Feb; 23(2):210-3. PMID: 18080167.
    Citations: 14     Fields:    Translation:Humans
  16. Zucker SD, Benedict M, Sherman KE. Serum bilirubin and risk of colorectal cancer. Aliment Pharmacol Ther. 2006 Oct 15; 24(8):1257-9; author reply 1259-61. PMID: 17014585.
    Citations: 1     Fields:    Translation:Humans
  17. Zucker SD. Cirrhosis-associated mortality: frankly, scarlet, do we really make a damn? Gastroenterology. 2006 Jul; 131(1):320-2. PMID: 16831615.
    Citations:    Fields:    
  18. Smith DL, Shire NJ, Watts NB, Schmitter T, Szabo G, Zucker SD. Hyperbilirubinemia is not a major contributing factor to altered bone mineral density in patients with chronic liver disease. J Clin Densitom. 2006 Jan-Mar; 9(1):105-13. PMID: 16731439.
    Citations: 9     Fields:    Translation:HumansAnimals
  19. Chun S, Zucker SD. Combination therapy for chronic hepatitis B: a one-two knockout punch, or a swing and a miss? Gastroenterology. 2006 Feb; 130(2):613-4; discussion 514-5. PMID: 16472619.
    Citations:    Fields:    Translation:HumansCells
  20. Zucker SD. Response to Rigato et al.: bilirubin and non-hepatic disease--a jaundiced view. Trends Mol Med. 2005 Jul; 11(7):313-4; author reply 314-5. PMID: 15955742.
    Citations:    Fields:    Translation:Humans
  21. Keshavan P, Deem TL, Schwemberger SJ, Babcock GF, Cook-Mills JM, Zucker SD. Unconjugated bilirubin inhibits VCAM-1-mediated transendothelial leukocyte migration. J Immunol. 2005 Mar 15; 174(6):3709-18. PMID: 15749910.
    Citations: 33     Fields:    Translation:AnimalsCells
  22. Zucker SD. Ironing out the cryptic intestinal defect in hereditary hemochromatosis. Gastroenterology. 2005 Mar; 128(3):794-6; discussion 796-7. PMID: 15765418.
    Citations:    Fields:    
  23. Keshavan P, Schwemberger SJ, Smith DL, Babcock GF, Zucker SD. Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization. Int J Cancer. 2004 Nov 10; 112(3):433-45. PMID: 15382069.
    Citations: 24     Fields:    Translation:HumansCells
  24. Zucker SD, Horn PS, Sherman KE. Serum bilirubin levels in the U.S. population: gender effect and inverse correlation with colorectal cancer. Hepatology. 2004 Oct; 40(4):827-35. PMID: 15382174.
    Citations: 36     Fields:    Translation:Humans
  25. Holt AF, Zucker SD. Hepatitis C infection with normal transaminases: is the treatment worse than the disease? Gastroenterology. 2004 Aug; 127(2):677-9. PMID: 15300601.
    Citations:    Fields:    
  26. Wang WW, Smith DL, Zucker SD. Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats. Hepatology. 2004 Aug; 40(2):424-33. PMID: 15368447.
    Citations: 36     Fields:    Translation:AnimalsCells
  27. Zucker SD, Sherman KE. Beyond interferon for hepatitis C: living in the present while hoping for the future. Gastroenterology. 2004 May; 126(5):1487-8. PMID: 15131814.
    Citations:    Fields:    
  28. Zucker SD. Can de-bugging the system prevent complications of cirrhosis? The answer may be no. Gastroenterology. 2004 Mar; 126(3):926-8; discussion 928. PMID: 14988851.
    Citations: 1     Fields:    
  29. Doshi S, Zucker SD. Liver emergencies during pregnancy. Gastroenterol Clin North Am. 2003 Dec; 32(4):1213-27, ix. PMID: 14696304.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  30. Morelli MS, Zucker SD. A role for the appendix in inflammatory bowel disease? Cut it out. Gastroenterology. 2003 Oct; 125(4):1270-2; discussion 1272. PMID: 15108715.
    Citations:    Fields:    
  31. Zucker SD. Is it HELLPful to consider the hanging LCHAD in pregnancy-associated liver disease? Gastroenterology. 2003 May; 124(5):1548-50; discussion 1550. PMID: 15534983.
    Citations:    Fields:    
  32. Chauhan SS, Zucker SD. Hypercholesterolemia in primary biliary cirrhosis: getting to the heart of the matter? Gastroenterology. 2003 Mar; 124(3):854-6. PMID: 12612923.
    Citations: 1     Fields:    
  33. Zucker SD. All kidding aside with the use of lamivudine in children with chronic hepatitis B. Gastroenterology. 2002 Nov; 123(5):1741-3; discussion 1743. PMID: 12404253.
    Citations:    Fields:    Translation:Humans
  34. Zucker SD. Some TIPS for the prevention of recurrent variceal hemorrhage? Gastroenterology. 2002 Jul; 123(1):384-6; discussion 386-7. PMID: 12105872.
    Citations:    Fields:    Translation:Humans
  35. Zucker SD. Whomsoever ignores the natural history of the hepatitis C virus is doomed to treat it. Gastroenterology. 2002 Feb; 122(2):578-9. PMID: 11832473.
    Citations: 1     Fields:    Translation:HumansCells
  36. Weisiger RA, Zucker SD. Transfer of fatty acids between intracellular membranes: roles of soluble binding proteins, distance, and time. Am J Physiol Gastrointest Liver Physiol. 2002 Jan; 282(1):G105-15. PMID: 11751163.
    Citations: 10     Fields:    Translation:AnimalsCells
  37. Zucker SD, Qin X, Rouster SD, Yu F, Green RM, Keshavan P, Feinberg J, Sherman KE. Mechanism of indinavir-induced hyperbilirubinemia. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12671-6. PMID: 11606755.
    Citations: 42     Fields:    Translation:Animals
  38. Zucker SD, Goessling W, Bootle EJ, Sterritt C. Localization of bilirubin in phospholipid bilayers by parallax analysis of fluorescence quenching. J Lipid Res. 2001 Sep; 42(9):1377-88. PMID: 11518756.
    Citations: 4     Fields:    Translation:Cells
  39. Zucker SD. A potential new hepatitis agent: making SEN-se of the data. Gastroenterology. 2001 Sep; 121(3):734-5. PMID: 11522760.
    Citations:    Fields:    Translation:HumansCells
  40. Zucker SD. The hepatitis B vaccine: sorting through the B.S. about M.S. Gastroenterology. 2001 Jun; 120(7):1880-2. PMID: 11375973.
    Citations:    Fields:    Translation:HumansPHPublic Health
  41. Pilla JA, Zucker SD. Cesarean for C? Possibly... Gastroenterology. 2001 May; 120(6):1555-7. PMID: 11313330.
    Citations:    Fields:    Translation:Humans
  42. Zucker SD. Kinetic model of protein-mediated ligand transport: influence of soluble binding proteins on the intermembrane diffusion of a fluorescent fatty acid. Biochemistry. 2001 Jan 30; 40(4):977-86. PMID: 11170419.
    Citations: 12     Fields:    Translation:AnimalsCells
  43. Zucker SD. Management of refractory ascites: are tips or taps tops? Gastroenterology. 2001 Jan; 120(1):311-2. PMID: 11208744.
    Citations:    Fields:    Translation:Humans
  44. Goessling W, Zucker SD. Role of apolipoprotein D in the transport of bilirubin in plasma. Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G356-65. PMID: 10915645.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  45. Zucker SD, Goessling W. Mechanism of hepatocellular uptake of albumin-bound bilirubin. Biochim Biophys Acta. 2000 Feb 15; 1463(2):197-208. PMID: 10675499.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  46. Zucker SD, Goessling W, Hoppin AG. Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes. J Biol Chem. 1999 Apr 16; 274(16):10852-62. PMID: 10196162.
    Citations: 27     Fields:    Translation:AnimalsCells
  47. Albalak A, Zeidel ML, Zucker SD, Jackson AA, Donovan JM. Effects of submicellar bile salt concentrations on biological membrane permeability to low molecular weight non-ionic solutes. Biochemistry. 1996 Jun 18; 35(24):7936-45. PMID: 8672496.
    Citations: 4     Fields:    Translation:AnimalsCells
  48. Zucker SD, Goessling W, Gollan JL. Intracellular transport of small hydrophobic compounds by the hepatocyte. Semin Liver Dis. 1996 May; 16(2):159-67. PMID: 8781021.
    Citations: 2     Fields:    Translation:HumansAnimals
  49. Gollan JL, Zucker SD. A new voyage of discovery: transport through the hepatocyte. Trans Am Clin Climatol Assoc. 1996; 107:48-55; discussion 55-6. PMID: 8725559.
    Citations:    Fields:    Translation:HumansAnimalsCells
  50. Zucker SD, Goessling W, Ransil BJ, Gollan JL. Influence of glutathione S-transferase B (ligandin) on the intermembrane transfer of bilirubin. Implications for the intracellular transport of nonsubstrate ligands in hepatocytes. J Clin Invest. 1995 Oct; 96(4):1927-35. PMID: 7560084.
    Citations: 5     Fields:    Translation:AnimalsCells
  51. Zucker S, Lysik RM, DiMassimo BI, Zarrabi HM, Moll UM, Grimson R, Tickle SP, Docherty AJ. Plasma assay of gelatinase B: tissue inhibitor of metalloproteinase complexes in cancer. Cancer. 1995 Aug 15; 76(4):700-8. PMID: 8625169.
  52. Zucker SD, Goessling W, Gollan JL. Kinetics of bilirubin transfer between serum albumin and membrane vesicles. Insight into the mechanism of organic anion delivery to the hepatocyte plasma membrane. J Biol Chem. 1995 Jan 20; 270(3):1074-81. PMID: 7836362.
    Citations: 11     Fields:    Translation:HumansAnimals
  53. Zucker SD, Goessling W, Zeidel ML, Gollan JL. Membrane lipid composition and vesicle size modulate bilirubin intermembrane transfer. Evidence for membrane-directed trafficking of bilirubin in the hepatocyte. J Biol Chem. 1994 Jul 29; 269(30):19262-70. PMID: 8034688.
    Citations: 8     Fields:    Translation:AnimalsCells
  54. Zucker SD, Storch J, Zeidel ML, Gollan JL. Mechanism of the spontaneous transfer of unconjugated bilirubin between small unilamellar phosphatidylcholine vesicles. Biochemistry. 1992 Mar 31; 31(12):3184-92. PMID: 1554704.
    Citations: 9     Fields:    
  55. Moll UM, Lane B, Zucker S, Suzuki K, Nagase H. Localization of collagenase at the basal plasma membrane of a human pancreatic carcinoma cell line. Cancer Res. 1990 Nov 01; 50(21):6995-7002. PMID: 2170014.
  56. Zucker S, Lysik RM, Friedman S. Diminished bone marrow responsiveness to erythropoietin in myelophthisic anemia. Cancer. 1976 Mar; 37(3):1308-15. PMID: 1260653.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Zucker's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (261)
Co-Authors (11)
Similar People (60)
Same Department 
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.