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Avinash Sahu, Ph.D.

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Biography
2020 - 2025
K99/R00 Pathway to Independence Award
2019
Michelson Prize, Human Vaccine Project
2020
40 promising young scientists in Cancer Immunology
2016
National Inst. Minority Health and Health Disparity Fellowship
2014
German Govt fellowship
2013
GPP fellowship
2012
Dean Fellowship
2011
EDIC Swiss Fellowship
2010
Research Scholar

Overview
My research interests lie in the area of Immunology, Statistics, and Artificial Intelligence. My research programs are tailored toward collaborative research to obtain a conceptual understanding of disease biology that enables developing personalized drugs, with emphasis on cancer-immunology. My group also addresses the need for statistical methods for Single- cell high-throughput sequencing and immunological aspects of COVID-19.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 1K99CA248953-01 (Avinash Sahu) Sep 16, 2020
    NCI
    IDENTIFYING DRUG SYNERGISTIC WITH CANCER IMMUNOTHERAPY
    Role Description: Combining immunotherapies with other cancer drugs has emerged as a new hope for late-stage cancer patients, however, the lack of a principled approach to identify such effective combinations often led to poorly designed clinical trials. The proposed research engages state-of-art Artificial Intelligence techniques with drug-induced transcriptomic changes to identify drugs that synergize with immunotherapies and prioritize them for clinical trials. Its application, as well as the career development pursued by the investigator, will rationalize clinical trials, identify new treatments for advanced cancers, and advance precision immuno-oncology.
    Role: PI
  2. (Avinash Sahu) Sep 30, 2018 - Sep 30, 2021
    Michelson Foundation
    AI predictor to identify drugs that boost immunotherapy
    Role: PI

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gu SS, Wang X, Hu X, Jiang P, Li Z, Traugh N, Bu X, Tang Q, Wang C, Zeng Z, Fu J, Meyer C, Zhang Y, Cejas P, Lim K, Wang J, Zhang W, Tokheim C, Sahu AD, Xing X, Kroger B, Ouyang Z, Long H, Freeman GJ, Brown M, Liu XS. Clonal tracing reveals diverse patterns of response to immune checkpoint blockade. Genome Biol. 2020 10 15; 21(1):263. PMID: 33059736.
    Citations:    Fields:    
  2. Li Z, Wang B, Gu S, Jiang P, Sahu A, Chen CH, Han T, Shi S, Wang X, Traugh N, Liu H, Liu Y, Wu Q, Brown M, Xiao T, Boland GM, Shirley Liu X. CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma. Genomics Proteomics Bioinformatics. 2020 02; 18(1):26-40. PMID: 32413516.
    Citations:    Fields:    
  3. A DAS, JS Lee, E Ruppin. Computer System And Methods For Harnessing Synthetic Rescues And Applications Thereof. 2019.
  4. Zhang J, Hu X, Wang J, Sahu AD, Cohen D, Song L, Ouyang Z, Fan J, Wang B, Fu J, Gu S, Sade-Feldman M, Hacohen N, Li W, Ying X, Li B, Liu XS. Immune receptor repertoires in pediatric and adult acute myeloid leukemia. Genome Med. 2019 11 26; 11(1):73. PMID: 31771646.
    Citations: 3     Fields:    Translation:HumansCells
  5. Pathria G, Lee JS, Hasnis E, Tandoc K, Scott DA, Verma S, Feng Y, Larue L, Sahu AD, Topisirovic I, Ruppin E, Ronai ZA. Translational reprogramming marks adaptation to asparagine restriction in cancer. Nat Cell Biol. 2019 12; 21(12):1590-1603. PMID: 31740775.
    Citations: 4     Fields:    
  6. Magen A, Das Sahu A, Lee JS, Sharmin M, Lugo A, Gutkind JS, Schäffer AA, Ruppin E, Hannenhalli S. Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer. Cell Rep. 2019 07 23; 28(4):938-948.e6. PMID: 31340155.
    Citations: 2     Fields:    Translation:Humans
  7. Howard AD, Wang X, Prasad M, Sahu AD, Aniba R, Miller M, Hannenhalli S, Chang YC. Allele-specific enhancers mediate associations between LCAT and ABCA1 polymorphisms and HDL metabolism. PLoS One. 2019; 14(4):e0215911. PMID: 31039173.
    Citations:    Fields:    Translation:HumansCells
  8. Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, Sahu A, Zarecki R, Marie K, Feng Y, Khateb A, Frederick DT, Ashkenazi SK, Kim H, Perez EG, Day CP, Segura Muñoz RS, Schmaltz R, Yooseph S, Tam MA, Zhang T, Avitan-Hersh E, Tzur L, Roizman S, Boyango I, Bar-Sela G, Orian A, Kaufman RJ, Bosenberg M, Goding CR, Baaten B, Levesque MP, Dummer R, Brown K, Merlino G, Ruppin E, Flaherty K, Ramer-Tait A, Long T, Peterson SN, Bradley LM, Ronai ZA. Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice. Nat Commun. 2019 04 02; 10(1):1492. PMID: 30940817.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  9. Sahu AD, S Lee J, Wang Z, Zhang G, Iglesias-Bartolome R, Tian T, Wei Z, Miao B, Nair NU, Ponomarova O, Friedman AA, Amzallag A, Moll T, Kasumova G, Greninger P, Egan RK, Damon LJ, Frederick DT, Jerby-Arnon L, Wagner A, Cheng K, Park SG, Robinson W, Gardner K, Boland G, Hannenhalli S, Herlyn M, Benes C, Flaherty K, Luo J, Gutkind JS, Ruppin E. Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy. Mol Syst Biol. 2019 03 11; 15(3):e8323. PMID: 30858180.
    Citations:    Fields:    Translation:Humans
  10. Sanyal P, Mukherjee T, Barui S, Das A, Gangopadhyay P. Artificial Intelligence in Cytopathology: A Neural Network to Identify Papillary Carcinoma on Thyroid Fine-Needle Aspiration Cytology Smears. J Pathol Inform. 2018; 9:43. PMID: 30607310.
    Citations: 1     
  11. Pathria G, Scott DA, Feng Y, Sang Lee J, Fujita Y, Zhang G, Sahu AD, Ruppin E, Herlyn M, Osterman AL, Ronai ZA. Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival. EMBO J. 2018 10 15; 37(20). PMID: 30209241.
    Citations: 5     Fields:    Translation:HumansCells
  12. Jiang P, Gu S, Pan D, Fu J, Sahu A, Hu X, Li Z, Traugh N, Bu X, Li B, Liu J, Freeman GJ, Brown MA, Wucherpfennig KW, Liu XS. Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nat Med. 2018 10; 24(10):1550-1558. PMID: 30127393.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  13. Wang K, Wu D, Zhang H, Das A, Basu M, Malin J, Cao K, Hannenhalli S. Comprehensive map of age-associated splicing changes across human tissues and their contributions to age-associated diseases. Sci Rep. 2018 Jul 19; 8(1):10929. PMID: 30026530.
    Citations: 1     Fields:    Translation:HumansCells
  14. Lee JS, Das A, Jerby-Arnon L, Arafeh R, Auslander N, Davidson M, McGarry L, James D, Amzallag A, Park SG, Cheng K, Robinson W, Atias D, Stossel C, Buzhor E, Stein G, Waterfall JJ, Meltzer PS, Golan T, Hannenhalli S, Gottlieb E, Benes CH, Samuels Y, Shanks E, Ruppin E. Harnessing synthetic lethality to predict the response to cancer treatment. Nat Commun. 2018 06 29; 9(1):2546. PMID: 29959327.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  15. Nair NU, Das A, Amit U, Robinson W, Park SG, Basu M, Lugo A, Leor J, Ruppin E, Hannenhalli S. Putative functional genes in idiopathic dilated cardiomyopathy. Sci Rep. 2018 01 08; 8(1):66. PMID: 29311597.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  16. Amit U, Kain D, Wagner A, Sahu A, Nevo-Caspi Y, Gonen N, Molotski N, Konfino T, Landa N, Naftali-Shani N, Blum G, Merquiol E, Karo-Atar D, Kanfi Y, Paret G, Munitz A, Cohen HY, Ruppin E, Hannenhalli S, Leor J. New Role for Interleukin-13 Receptor a1 in Myocardial Homeostasis and Heart Failure. J Am Heart Assoc. 2017 May 20; 6(5). PMID: 28528324.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  17. Sarda S, Das A, Vinson C, Hannenhalli S. Distal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters. Genome Res. 2017 04; 27(4):553-566. PMID: 28223400.
    Citations: 6     Fields:    Translation:HumansCells
  18. Das A, Morley M, Moravec CS, Tang WH, Hakonarson H, Margulies KB, Cappola TP, Jensen S, Hannenhalli S. Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability. Nat Commun. 2015 Oct 12; 6:8555. PMID: 26456756.
    Citations: 14     Fields:    Translation:Humans
  19. Wang K, Das A, Xiong ZM, Cao K, Hannenhalli S. Phenotype-Dependent Coexpression Gene Clusters: Application to Normal and Premature Ageing. IEEE/ACM Trans Comput Biol Bioinform. 2015 Jan-Feb; 12(1):30-9. PMID: 26357076.
    Citations: 1     Fields:    Translation:HumansCells
  20. Nair NU, Lin Y, Manasovska A, Antic J, Grnarova P, Sahu AD, Bucher P, Moret BM. Study of cell differentiation by phylogenetic analysis using histone modification data. BMC Bioinformatics. 2014 Aug 08; 15:269. PMID: 25104072.
    Citations: 4     Fields:    Translation:Humans
  21. Sahu AD, Aniba R, Chang YP, Hannenhalli S. Epigenomic model of cardiac enhancers with application to genome wide association studies. Pac Symp Biocomput. 2013; 92-102. PMID: 23424115.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  22. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012 Sep 06; 489(7414):57-74. PMID: 22955616.
    Citations: 5072     Fields:    Translation:HumansAnimalsCells
  23. Nair NU, Sahu AD, Bucher P, Moret BM. ChIPnorm: a statistical method for normalizing and identifying differential regions in histone modification ChIP-seq libraries. PLoS One. 2012; 7(8):e39573. PMID: 22870189.
    Citations: 15     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.