Harvard Catalyst Profiles

As a faculty member with joint appointments in both Biostatistics and Epidemiology, I have focused my research over the last 25 years on environmental epidemiology studies and on HIV-related clinical trials and observational studies, with a common focus on reproductive outcomes and child development. A major focus of my HIV-related research is the safety evaluation of reproductive health outcomes in infants exposed in utero to antiretroviral agents, such as congenital anomalies, preterm birth, and low birth weight, in addition to longer term outcomes such as cardiotoxicity, neurodevelopment and behavioral functioning. My other active area of research is reproductive epidemiology in relation to environmental, nutritional, and other prenatal exposures. I have particular interest in birth and reproductive outcomes associated with prenatal exposures to endocrine disrupting chemicals (EDCs), such as phthalates, dioxins, pesticides, and heavy metals such as lead.

My statistical interests are broad and include mediation analysis, survival outcomes, clustered data, and statistical methods for evaluation of mixtures. I mentor many doctoral and masters students in biostatistics and epidemiology, and also mentor other research staff through my involvement in many collaborative studies.