Harvard Catalyst Profiles

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Kyle J. Korshavn, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Korshavn KJ, Wales TE, Bird GH, Engen JR, Walensky LD. A redox switch regulates the structure and function of anti-apoptotic BFL-1. Nat Struct Mol Biol. 2020 Jul 13. PMID: 32661419.
  2. Guerra RM, Bird GH, Harvey EP, Dharia NV, Korshavn KJ, Prew MS, Stegmaier K, Walensky LD. Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer. Cell Rep. 2018 09 25; 24(13):3393-3403.e5. PMID: 30257201.
    Citations:    Fields:    
  3. Wang J, Yamamoto T, Bai J, Cox SJ, Korshavn KJ, Monette M, Ramamoorthy A. Real-time monitoring of the aggregation of Alzheimer's amyloid-ß via1H magic angle spinning NMR spectroscopy. Chem Commun (Camb). 2018 Feb 20; 54(16):2000-2003. PMID: 29411841.
    Citations: 2     Fields:    
  4. Rodriguez Camargo DC, Korshavn KJ, Jussupow A, Raltchev K, Goricanec D, Fleisch M, Sarkar R, Xue K, Aichler M, Mettenleiter G, Walch AK, Camilloni C, Hagn F, Reif B, Ramamoorthy A. Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate. Elife. 2017 11 17; 6. PMID: 29148426.
    Citations: 4     Fields:    Translation:HumansCells
  5. Beck MW, Derrick JS, Suh JM, Kim M, Korshavn KJ, Kerr RA, Cho WJ, Larsen SD, Ruotolo BT, Ramamoorthy A, Lim MH. Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease. ChemMedChem. 2017 11 22; 12(22):1828-1838. PMID: 28990338.
    Citations:    Fields:    Translation:HumansCells
  6. Jones MR, Mathieu E, Dyrager C, Faissner S, Vaillancourt Z, Korshavn KJ, Lim MH, Ramamoorthy A, Wee Yong V, Tsutsui S, Stys PK, Storr T. Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease. Chem Sci. 2017 Aug 01; 8(8):5636-5643. PMID: 28989601.
    Citations: 2     
  7. Korshavn KJ, Satriano C, Lin Y, Zhang R, Dulchavsky M, Bhunia A, Ivanova MI, Lee YH, La Rosa C, Lim MH, Ramamoorthy A. Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-ß. J Biol Chem. 2017 03 17; 292(11):4638-4650. PMID: 28154182.
    Citations: 8     Fields:    Translation:HumansCells
  8. Lee HJ, Korshavn KJ, Nam Y, Kang J, Paul TJ, Kerr RA, Youn IS, Ozbil M, Kim KS, Ruotolo BT, Prabhakar R, Ramamoorthy A, Lim MH. Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer's Disease. Chemistry. 2017 Feb 21; 23(11):2706-2715. PMID: 28004889.
    Citations: 1     Fields:    Translation:HumansCells
  9. Kang J, Lee SJ, Nam JS, Lee HJ, Kang MG, Korshavn KJ, Kim HT, Cho J, Ramamoorthy A, Rhee HW, Kwon TH, Lim MH. An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation. Chemistry. 2017 Jan 31; 23(7):1645-1653. PMID: 27862428.
    Citations: 1     Fields:    Translation:HumansCells
  10. Bera S, Korshavn KJ, Kar RK, Lim MH, Ramamoorthy A, Bhunia A. Biophysical insights into the membrane interaction of the core amyloid-forming Aß40 fragment K16-K28 and its role in the pathogenesis of Alzheimer's disease. Phys Chem Chem Phys. 2016 Jun 22; 18(25):16890-901. PMID: 27282693.
    Citations: 3     Fields:    
  11. Derrick JS, Kerr RA, Korshavn KJ, McLane MJ, Kang J, Nam E, Ramamoorthy A, Ruotolo BT, Lim MH. Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-ß, and Oxidative Stress in Alzheimer's Disease. Inorg Chem. 2016 05 16; 55(10):5000-13. PMID: 27119456.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Jones MR, Dyrager C, Hoarau M, Korshavn KJ, Lim MH, Ramamoorthy A, Storr T. Multifunctional quinoline-triazole derivatives as potential modulators of amyloid-ß peptide aggregation. J Inorg Biochem. 2016 05; 158:131-138. PMID: 27133802.
    Citations: 1     Fields:    Translation:Humans
  13. Korshavn KJ, Bhunia A, Lim MH, Ramamoorthy A. Amyloid-ß adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation. Chem Commun (Camb). 2016 Jan 18; 52(5):882-5. PMID: 26553596.
    Citations: 6     Fields:    Translation:Cells
  14. Korshavn KJ, Jang M, Kwak YJ, Kochi A, Vertuani S, Bhunia A, Manfredini S, Ramamoorthy A, Lim MH. Reactivity of Metal-Free and Metal-Associated Amyloid-ß with Glycosylated Polyphenols and Their Esterified Derivatives. Sci Rep. 2015 Dec 10; 5:17842. PMID: 26657338.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. Derrick JS, Kerr RA, Nam Y, Oh SB, Lee HJ, Earnest KG, Suh N, Peck KL, Ozbil M, Korshavn KJ, Ramamoorthy A, Prabhakar R, Merino EJ, Shearer J, Lee JY, Ruotolo BT, Lim MH. A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms. J Am Chem Soc. 2015 Nov 25; 137(46):14785-97. PMID: 26575890.
    Citations: 4     Fields:    Translation:HumansCells
  16. Lee HJ, Korshavn KJ, Kochi A, Derrick JS, Lim MH. Cholesterol and metal ions in Alzheimer's disease. Chem Soc Rev. 2014 Oct 07; 43(19):6672-82. PMID: 24710074.
    Citations: 5     Fields:    Translation:Humans
  17. Savelieff MG, Liu Y, Senthamarai RR, Korshavn KJ, Lee HJ, Ramamoorthy A, Lim MH. A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-ß implicated in Alzheimer's disease. Chem Commun (Camb). 2014 May 25; 50(40):5301-3. PMID: 24326305.
    Citations: 7     Fields:    Translation:Humans
  18. Yu G, Bayer AR, Galloway MM, Korshavn KJ, Fry CG, Keutsch FN. Glyoxal in aqueous ammonium sulfate solutions: products, kinetics and hydration effects. Environ Sci Technol. 2011 Aug 01; 45(15):6336-42. PMID: 21721547.
    Citations: 3     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.